Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of vine tea extract dihydromyricetin in China. Please feel free to wholesale high quality vine tea extract dihydromyricetin for sale here from our factory. For price consultation, contact us.
Vine Tea Extract Dihydromyricetin supplier/ manufacturer
KINTAIBIO® is committed to producing and providing you with the best Vine Tea Extract Dihydromyricetin. The DHM content of the vine tea extract we produce is 30%, 50%, 75% and 98%.We choose high-quality vine tea as the extraction raw material, which ensures that the content of DMY, a flavonoid compound, produced by us is stable, and also guarantees the efficacy of the product. If you have Dihydromyricetin Powder other content requirements, please feel free to contact us at sales@kintaibio.com.
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It not only has general antibacterial and detoxification, liver protection, and improvement of cardiovascular function, but also has broad-spectrum anti-tumor effects such as anti-liver cancer, breast cancer, and ovarian cancer. Vine Tea Extract is also involved in regulating the nervous system function in a variety of nervous system diseases such as aging, Parkinson's disease, alcohol addiction, anxiety, and depression.
Vine Tea Extract 30% Water Soluble Dihydromyricetin
COA Of Vine Tea Extract DMY
Vine Tea Extract Dihydromyricetin mechanism of action
First, it has strong effects.
Generally speaking, there are many substances with the same effects, but substances with different molecular structures have different effects. For example, when it comes to sugar, sugar cane, apples, sweet radish, etc., because the sugar content is different, the sweetness is also different; when it comes to acid, the acidity of vinegar is different from that of hawthorn and orange. Compared with ginkgo flavonoids and salvia miltiorrhiza flavonoids, DMY has unique effects, more prominent medical and health effects, and higher scientific value.
Second, it has diverse effects.
DMY is the main force for rattan tea to exert its magical effects. It has many effects. Not only is it difficult for non-flavonoid substances to compete with it, but flavonoid substances are also far inferior to it.
Dihydromyricetin's natural sources
Because of the magical effects of vine tea (VT), VT flavonoids have become a hot spot in the international research and development of green drugs. Dihydromyricetin has many unique effects such as scavenging free radicals, anti-thrombosis, anti-oxidation, anti-aging, anti-radiation, anti-virus, anti-tumor, protecting eyesight, improving human immunity, lowering blood lipids, lowering blood sugar, and lowering blood pressure. DMY can inhibit platelet aggregation in vitro and blood clot formation in vivo, remove blood scale in the blood, regulate blood lipids, lower blood pressure, soften blood vessels, regulate the absorption function of renal tubules, regulate sleep, and improve symptoms such as frequent urination and urgency.
How to make DMY?
Raw Material Pretreatment and Multi-Stage Extraction
At the start of production, high-quality VT leaves are carefully selected as raw material. The raw material is first dried to reduce moisture content, ensuring stability and consistent product quality in subsequent extraction processes. The dried VT leaves are then pulverized, with the particle size controlled within the 10-20 mesh range to increase the contact area between the raw material and the solvent, thereby improving the extraction efficiency of the active ingredients.
Subsequently, food-grade ethanol is used as the extraction solvent for three consecutive extractions to fully recover the DMY component in the VT, improving raw material utilization and product yield:
- First Extraction: The solvent volume is 8 times the weight of the raw material, extracted at 80℃ for 120 minutes; the extract is filtered through a 200-mesh filter before proceeding to the next step;
- Second Extraction: The solvent volume is 6 times the weight of the raw material, extracted at 70℃ for 90 minutes; filtered again through a 200-mesh filter;
- Third Extraction: The solvent volume is 8 times the weight of the raw material, extracted at 70℃ for 80 minutes; finally, the extract is filtered through a 200-mesh filter to obtain the final extract.
Decolorization, Purification, and Crystallization Refining
First, activated carbon adsorption decolorization is performed. Food-grade activated carbon (300 mesh) is added at 80℃ to remove pigments and some impurities through adsorption, improving the purity and appearance of the extract. After decolorization, the activated carbon is removed by filtration, yielding a relatively clear ethanol solution of dihydromyricetin.
Subsequently, crystallization and recrystallization processes are carried out. By controlling the process conditions, dihydromyricetin crystals precipitate from the solution, and recrystallization further removes impurities, improving product purity. After recrystallization, the solution is filtered again to obtain even purer DMY crystals.
Drying, Granulation, and Quality Control
Vacuum drying is used at 85.5℃, with the vacuum level controlled at 0.08 MPa to effectively remove residual solvents and moisture, while minimizing the impact of high temperature on product quality. After drying, the product undergoes content inspection to confirm that the content of the active ingredient meets quality standards.
After passing inspection, the product undergoes smash and mixing to ensure that the particle size and batch uniformity meet requirements. The product then undergoes product testing to confirm key quality indicators. Once testing is passed, the product enters the finished Vine Tea Extract Dihydromyricetin product storage stage, awaiting packaging or shipment.
why choose Xi'an Kintai Biotech inc - DMY ?
Desolventization and decolorization
- Residual solvent removal: We use special processes to ensure that the residual solvent in the product meets international export standards and is safe and reliable.
- Decolorization technology: Due to the characteristics of flavonoid compounds, DMY are darker in color. We can perform decolorization according to customer needs. At present, we have successfully developed 20% water-soluble dihydromyricetin that is close to white, and more water-soluble products are also under continuous development to meet the requirements of different application fields.
Customization of water-soluble Vine Tea Extract Dihydromyricetin
As a flavonoid compound, DMY Powder has a 2-phenylchromone structure. Traditionally, it has poor solubility and dark color, which affects its bioavailability. With our strong R&D capabilities, we can optimize the solubility of dihydromyricetin according to customer needs, improve the application breadth of the product, and expand it to health foods, functional beverages, cosmetics and other fields.
Reasons to choose us
As an innovative enterprise focusing on high-quality natural extracts, we have significant advantages in the production and research and development of Dihydromyricetin:
- Advanced technology to ensure purity and efficacy: We use the most cutting-edge extraction and processing technology to ensure the high purity and stability of each batch of products, and maximize the activity and health benefits of DMY.
- Customized solutions: We can customize DMY with different concentrations and characteristics according to customer needs, especially water-soluble products, to help customers overcome the problem of poor solubility and improve the bioavailability of products.
- Wide application and market recognition: Our DMY - vine tea extract is widely used in pharmaceutical development, health foods, functional beverages and cosmetics, and is deeply recognized by the global market.
- Strict quality control: We adhere to the most stringent quality control system to ensure that each batch of products can meet or even exceed industry standards, and provide customers with safe and effective natural raw materials.
what are the Vine Tea Extract Dihydromyricetin benefits?
Vine Tea Extract Dihydromyricetin for sleep
DMY has demonstrated significant efficacy in improving memory impairment induced by acute sleep deprivation. Experiments have shown that gavage administration of DMY significantly reduces spatial learning and memory decline caused by sleep deprivation. Its mechanism of action is primarily attributed to Dihydromyricetin DMY 's effective reduction of oxidative stress levels in the brain-by regulating key indicators such as malondialdehyde, glutathione, and superoxide dismutase-while simultaneously restoring damaged synaptic plasticity, specifically by upregulating the expression of proteins closely related to learning and memory.
Furthermore, DMY also has a certain regulatory effect on GABA receptor subunits. Therefore, DMY can effectively combat cognitive dysfunction caused by sleep deprivation from both antioxidant and synaptic repair perspectives, providing a scientifically reliable nutritional intervention for memory decline caused by sleep disturbances, stress, or environmental factors.
The Liver Protection Mechanism Of DMY
Inflammatory injury is an important factor in many chronic liver diseases, often accompanied by the development of liver fibrosis, cirrhosis and hepatocellular carcinoma. Among them, NF-κB induces the expression of pro-inflammatory cytokines such as TNF-α and IL-1β, creating a cytotoxic environment, which further triggers the development of chronic inflammation and progressive liver fibrosis.
The current study clearly shows that administration of TAA increases inflammation, oxidative stress, pro-fibrotic markers, and hepatotoxicity markers, and reduces liver function and liver histological abnormalities. However, DMY treatment improved the damaged liver structure and effectively reduced oxidative stress and hepatotoxicity markers. More importantly, DMY reversed TAA-induced liver fibrosis by inhibiting NF-κB-mediated inflammation and apoptotic proteins downstream of the TGF-β1-regulated PI3K/Akt signaling pathway.
Potential mechanism of Dihydromyricetin attenuating TAA-induced liver fibrosis. DMY reversed TAA-induced liver fibrosis by inhibiting HSC activation, NF-κB-mediated inflammatory infiltration and improving PI3K/Akt-mediated apoptosis, which may be the underlying mechanism of DMY's hepatoprotective effect.
Reference:https://www.sciencedirect.com/science/article/abs/pii/S0014299919301694
what are the Vine Tea Extract Dihydromyricetin uses?
Vine Tea Extract Dihydromyricetin Supplement
Traditional grapevine tea, represented by dihydromyricetin tea, is primarily used as a daily health supplement. Modern formulations, however, highly concentrate its active ingredients, resulting in various forms such as dihydromyricetin pills, capsules, and tablets to meet the needs of different groups.
① Combined use with antiarrhythmic drugs, angina pectoris drugs, and antihypertensive drugs can enhance efficacy;
② Combined use with sedative-hypnotic drugs can enhance drug efficacy, etc.
In summary, the antibacterial, anti-inflammatory, cardiovascular regulatory, and neuroprotective effects of DMY have been consistently confirmed.
DMY Cosmetics
In the field of topical care, dihydromyricetin cream, with its antioxidant and photoprotective properties, has become an effective ingredient in skincare and sunscreen products; dihydromyricetin foods, as food additives, not only maintain food freshness but also impart additional health benefits to products.
myricetin vs dihydromyricetin
As a professional manufacturer of Vine Tea Extract dihydromyricetin powder, we are frequently asked about the difference between DMY and myricetin:
Both are structurally similar natural flavonoids. DMY is the direct precursor of myricetin, appearing as a white crystalline powder, primarily concentrated in Ampelopsis makoyana (grapevine tea).Myricetin, on the other hand, is an oxidation product of DMY, appearing as a yellow powder and widely found in plants such as strawberries, apples, and the bark of myricetin trees.
While both possess excellent antioxidant, anti-inflammatory, and hepatoprotective effects-for example, in scavenging free radicals, DMY has a slightly better ability to scavenge DPPH, while myricetin is more effective at scavenging ABTS free radicals-they have different strengths in specific health applications.
DMY has attracted much attention for promoting alcohol metabolism, protecting the liver, and alleviating alcohol poisoning and withdrawal symptoms by regulating GABA_A receptors, making it an ideal supplement for hangover relief and liver protection. Myricetin, on the other hand, is being studied more for its potential in regulating blood sugar and lipids and improving insulin resistance, and is being used to support metabolic health.
where to buy Vine Tea Extract Dihydromyricetin?
Xi'an Kintai Biotech inc focuses on the R&D, production and sales of plant extracts and pharmaceutical intermediates. Improve high-quality dihydromyricetin Powder for you. Our company's philosophy is to do high content and high purity! Our leading products such as rosmarinic acid, mangiferin, baicalin, dihydroquercetin, matrine, Lappaconite Hydrobromide, chlorogenic acid, betulin, sanguinarine, Centella asiatica extract, Epimedium extract, etc.
KINTAIBIO® is committed to providing high-quality and innovative natural extracts to the global health industry and becoming your trusted partner. Choose us, you will get customized dihydromyricetin powder with higher efficiency and wider application potential. We look forward to exploring the infinite possibilities of the big health industry with you!Our healthcare natural products sell well in more than 30 countries including Europe, North America, Australia, Southeast Asia and Russia, and are widely used in medicine, health food, cosmetics, food and beverage, animal feed, and other fields.If you are interested in our Vine Tea Extract, please feel free to contact us.
★If you want to get high-quality Vine tea extract Dihydromyricetin, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
FAQ
Q: Does DMY have any side effects?
A: Yes, DMY is generally considered safe, caffeine-free, and has extremely low toxicity. However, in cases of overdose or in individuals with specific constitutions, the following mild side effects may occur: Gastrointestinal discomfort: Mild nausea, diarrhea, or bloating, often related to excessive dosage or individual gastrointestinal sensitivity. Nervous system reactions: A very small number of users may report mild headaches or dizziness. Traditional Chinese medicine "cooling" reaction: VT is considered slightly cooling in Traditional Chinese Medicine; long-term or excessive consumption may cause gastrointestinal discomfort in individuals with weak spleen and stomach. In addition, special populations should note: Pregnant and breastfeeding women are advised to avoid use due to a lack of safety data; patients with low blood pressure may experience dizziness or fatigue due to its adjunctive antihypertensive effect; individuals with severely impaired liver or kidney function should use it under the guidance of a doctor. Overall, within the recommended dosage range, DHM side effects are rare and mild.
Q: Does DHM reduce the degree of intoxication (drunkenness)?
A: No. DMY does not reduce the degree of intoxication. While it can help the liver metabolize alcohol and alleviate hangover symptoms (such as headache, nausea, and fatigue), it does not lower blood alcohol concentration (BAC) or make you sober up faster. In other words, DHM does not affect your ability to drive or operate machinery, and you still need to follow safe drinking guidelines. Its main value lies in reducing oxidative damage to the liver caused by alcohol and alleviating withdrawal symptoms, not in accelerating the removal of alcohol from the bloodstream.
Q: Is it safe to take DHM every day?
A: Yes, you can take DHM daily, but it is more common to take it as needed (e.g., before or after drinking) rather than as a daily supplement. Existing animal models and short-term human studies have shown that DHM has a good safety profile with very few adverse reaction reports. For daily liver health or metabolic well-being, the typical dose is between 10 and 100 mg; for social drinking support, it is usually taken 30–60 minutes before or after drinking. However, you should pay attention to the following two points: Drug Interactions: DHM may affect drugs metabolized by the liver (such as sedatives, hypnotics, antihypertensives, hypoglycemics, and statins). Consult your doctor before using them together. Long-Term Human Data: Large-scale long-term human trials on continuous daily DHM supplementation are insufficient. Because dietary supplements are not strictly regulated by the FDA, it is recommended to consult a healthcare professional before starting daily use.
Q: Is DHM beneficial for kidneys?
A: Yes, existing research suggests that DHM /DMY may have a protective effect on the kidneys. DMY can protect the kidneys from damage by modulating the Nrf2/HO-1, MAPK, and NF-κB signaling pathways to reduce oxidative stress and inflammation. DMY has shown some therapeutic value, especially in acute kidney injury (AKI) models. It should be noted that these conclusions are mainly based on preclinical studies, and patients with pre-existing severe kidney disease should still consult their doctor before use.
Q: Can I take DHM with other medications? (Drug interactions)
A: DHM may affect the metabolic pathways of certain drugs in the body, especially those metabolized by the hepatic CYP450 enzyme system. If you are taking any of the following classes of medications, it is recommended to use them under the guidance of a physician to avoid unpredictable interactions: sedative-hypnotics (such as benzodiazepines and barbiturates); antihypertensive drugs; hypoglycemic drugs (including insulin); statins. In addition, because DHM itself has mild blood pressure and blood sugar lowering effects, its use in combination with the above-mentioned medications may lead to enhanced drug effects, requiring monitoring of blood pressure or blood sugar changes. Please be sure to inform your doctor that you are using DHM supplements.
Q: Is DHM safe for pregnant or breastfeeding women?
A: It is not recommended. Currently, there is a lack of clinical safety data for pregnant and breastfeeding women; therefore, for conservative reasons, it is recommended to avoid using DHM . Similarly, women planning to become pregnant should consult their obstetrician first.
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