Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of dihydromyricetin powder in China. Please feel free to wholesale high quality dihydromyricetin powder for sale here from our factory. For price consultation, contact us.
Dihydromyricetin (DHM) manufacturer
KINTAIBIO®'s 98% Dihydromyricetin Powder is a natural active ingredient mainly extracted from vine tea. The high-quality vine tea extract we produce can achieve a dihydromyricetin content of more than 98%. our dihydromyricetin powder factory currently has stock available for immediate sale. In addition, we have also passed third-party testing on important indicators such as heavy metal, aflatoxin, and solvent residues and can provide you with high-quality Vine Tea Extract Dihydromyricetin and high-safety raw materials.
KINTAIBIO®'s 98% Dihydromyricetin powder has a variety of biological activities and can currently be used in the daily chemical industry, the pharmaceutical industry - hangover and liver protection, and dihydromyricetin dietary supplements. It has been clinically proven that as a dietary supplement, it has antioxidant, anti-inflammatory, blood pressure and blood sugar lowering effects, and has anti-fatigue, anti-liver damage, and cardiovascular protection effects.
Vine tea
98%DHM powder
dihydromyricetin powder manufacturers produces dihydromyricetin natural sources
- Product Name: Dihydromyricetin (DHM)
- Other name: Ampelopsin, Dihydromyricetin, DMY
- Specifications: Dihydromyricetin ≥ 98% (HPLC)
- Extracted Plant: Ampelopsis Grossedentata (Hand.-Mazz.) W. T. Wang
- Extracted Part: Stems and Leaves of Ampelopsis Grossedentata
KINTAIBIO® Selection of natural sources for dihydromyricetin extract:
Our researchers compared the effects of different origins, parts and processing techniques on the dihydromyricetin content in vine tea. Ampelopsis grossedentata (Hand.-Mazz.) W. T. Wang is a wild woody deciduous vine of the genus Ampelopsis in the family Vitaceae, commonly known as vine tea, white tea, etc. Its production areas are mainly distributed in Hunan, Hubei, Yunnan, Guizhou, Guangdong, Guangxi, Fujian, and other places in China.
Research shows that the content of dihydromyricetin in vine tea from different origins varies significantly. Among them, produced in Jiangkou County, Guizhou Province is particularly outstanding in terms of active ingredient content and stability.
Kintai Origin of Vine Tea
Fresh vine tea
Fresh vine tea
Dry Vine Tea for producing
dihydromyricetin powder Origin of raw materials
Jiangkou County, Guizhou Province: Vine tea has become an ideal raw material for high-quality dihydromyricetin due to its unique geographical and climatic conditions. Jiangkou County is located at the foot of Fanjing Mountain. It has a superior ecological environment and fertile soil, which is suitable for the growth of vine tea. After plant produced here is naturally dried, the dihydromyricetin content in the bud tips is the highest, showing significant quality advantages, making it the first choice for our company to purchase raw materials.
dihydromyricetin powder Raw material parts
Harvesting methods and parts: Harvesting methods are divided into manual harvesting and machine harvesting. The harvesting parts include bud tips, young leaves, thick old leaves and tea stems. Research has found that there are significant differences in the content of DHM in different parts of vine tea. The best is the shoot tips and young leaves, as these parts have the highest dihydromyricetin DHM content. In contrast, the content of thick old leaves and tea stems is low and affects the overall quality and efficacy . Therefore, in the production process, selecting shoot tips and young leaves as raw materials is an important measure for us to ensure product quality.
dihydromyricetin powder Selection of processing technology
Natural sun drying: The processing technology of vine tea also has a significant impact on the content of dihydromyricetin. The natural sun-drying process can retain the dihydromyricetin to the greatest extent. Therefore, when purchasing raw materials , we prefers natural sun-drying methods for processing vine tea, which can significantly improve the extraction efficiency of vine tea extract dihydromyricetin.
Extraction process of dihydromyricetin powder manufacturers
spec. & Third-party test report of dihydromyricetin powder manufacturers
Specification of DHM
Third-party test report For DHM heavy metal
Before each shipment, our quality inspection department will test according to the above specification table, so we can ensure that the quality of our china dihydromyricetin powder in each batch meets your requirements.
Delivery picture of 98% dihydromyricetin powder
Water Solubility of our Dihydromyricetin Powder
About the Vine tea extract 98% Dihydromyricetin Powder manufactured by KINTAIBIO®, the maximum solubility is: 335ml water can dissolve 500mg DHM in 60-70℃. It has good solubility in hot water, almost completely dissolved at 75°C, and no crystals precipitate out when the temperature drops to room temperature.
To solve the customer's concerns about dihydromyricetin solubility, our research and development department introduced 30% water-soluble dihydromyricetin. The results showed that 20g DHM could be dissolved in 500 ml of cold water.
If you would like to purchase water-soluble dihydromyricetin, please contact us here for bulk wholesale prices!
where to buy dihydromyricetin (DHM) powder?
As a top manufacturer of 98% dihydromyricetin (DHM), KINTAIBIO® is uniquely positioned to ensure the highest quality products and services to its customers. We have long been focused on the R&D and production of dihydromyricetin powder and have successfully solved the water-solubility problem that has long been a concern in the market. Therefore, our products have excellent water-solubility performance.
We have a first-class production factory that can provide ready goods at any time, the dihydromyricetin bulk powder quality is stable and reliable, and we have complete qualification certification. Our customized dihydromyricetin powder specifications are diverse to meet the needs of different customers, and the products we provide can be sold directly from the factory at a favorable price. We also support OEM/ODM customization services.
Whether you need bulk Dihydromyricetin powder or smaller quantities, XI'AN KINTAI BIOTECH INC. offers flexible supply solutions tailored to your specific requirements. Our 98% DHM powder is available for purchase directly from our factory, ensuring competitive pricing and consistent availability. As a trusted Dihydromyricetin supplier, we serve businesses of all sizes, providing reliable and efficient service to support your needs.
what are the Benefits of dihydromyricetin powder?
dihydromyricetin for hangovers
Studies have shown that DHM can serve as a novel anti-alcohol drug, effectively antagonizing acute alcohol poisoning and alleviating various symptoms during alcohol withdrawal, such as tolerance, increased anxiety, and susceptibility to seizures. In an intermittent alcohol intake model, DHM significantly reduced alcohol intake in subjects. dihydromyricetin DHM can both block acute alcohol-induced GABAA receptor enhancement and reverse receptor plasticity changes induced by long-term alcohol exposure and withdrawal, including reducing the abnormally high expression of the GABAA receptor α4 subunit in the hippocampus.
Importantly, these anti-alcohol effects can be blocked by the benzodiazepine receptor antagonist flumazenil, and vine tea extract dihydromyricetin competitively inhibits the binding of radioligands to benzodiazepine sites, thus clarifying the molecular basis for its alcohol-detoxifying and anti-dependence effects through interaction with benzodiazepine sites on GABAA receptors.
Dihydromyricetin Powder for Antibacterial effect
Pharmacological experiments have shown that dihydromyricetin DHM has an inhibitory effect on Staphylococcus aureus,Bacillus subtilis, Escherichia coli, Salmonella, Bacillus aeruginosa, Brewer's yeast, Saccharomyces cerevisiae, Penicillium, Aspergillus niger, Aspergillus flavus, Trichoderma reesei and Rhizoctoniae, especially on Gram-positive and Gram-negative cocci or bacilli
Dihydromyricetin Powder For blood pressure
The experiment shows that dihydromyricetin powder significantly reduces the elevation of blood glucose levels induced by alloxan, epinephrine and streptozotocin, and also increases the serum insulin level, significantly reduces the infiltration of lymphocytes into the pancreatic tissue and significantly reduces inflammation. The number has increased significantly.
Dihydromyricetin Powder For Liver
Dihydromyricetin Powder Dihydromycetin protects the liver, promotes rapid degradation of acetaldehyde, an ethanol metabolite, and converts it into non-toxic substances to reduce damage to hepatocytes. In addition, dihydromycetin improves the increase in serum lactate dehydrogenase activity caused by damage to hepatocytes, inhibits the formation of collagen fibers in liver M cells, This protects the liver and greatly reduces damage to the liver by ethanol.The microherbal test demonstrates that dihydromycetin protects the liver, facilitates the rapid degradation of acetaldehyde, a metabolite of ethanol, and converts it into non-toxic substances and reduces damage to hepatocytes. DHM Dihydromycetin is an excellent product with immediate efficacy and persistence, protecting the liver and softening hangover.
Dihydromyricetin Powder For Antioxidant
The effect of inhibiting MDA production increases with increasing levels of dihydromycetin. dihydromyricetin extract for diphenyl trinitro phenylhydrazine (DPPH) free radical in a 99% capture rate assay system. Dihydromycetin can significantly inhibit the formation of MDA in oil, and the higher the purity (60% to 90%) of dihydromycetin, the higher the antioxidant effect, and the potent antioxidant effect on animal oil and vegetable oil.
dihydromyricetin anxiety
Dihydromyricetin (DHM) has demonstrated pharmacological value in alleviating anxiety-induced behaviors caused by psychological stressors such as social isolation. Studies have shown that chronic social isolation leads to mitochondrial dysfunction, manifested as decreased expression of electron transport chain subunits and increased hydrogen peroxide levels, while also affecting the mitochondrial antioxidant enzyme system and autophagy-related proteins. Dihydromyricetin powder treatment can effectively reverse these abnormalities, significantly increasing the expression levels of multiple key antioxidant enzymes, thereby reducing oxidative stress damage.
Furthermore, DHM extract can regulate the brain-derived neurotrophic factor-TrkB signaling pathway, which is suppressed by social isolation, and restore the normal phosphorylation levels of its downstream extracellular signal-regulated kinases, thereby supporting neuronal survival and plasticity. These comprehensive regulatory effects on mitochondrial function, redox balance, and neurotrophic signaling constitute part of the molecular mechanism of DHM's anti-anxiety effect.
dihydromyricetin weight loss
Dihydromyricetin (DHM) promotes browning by mediating mitochondrial fission in white adipose tissue, thus aiding in weight loss. The core mechanism lies in Dihydromyricetin DHM's ability to enhance mitochondrial fission and upregulate fusion-related proteins such as OPA1 and MFN2, thereby dynamically remodeling the mitochondrial network in white adipose tissue and inducing browning-the transformation of white adipose tissue from energy-storing cells into a beige/brown adipose-like phenotype with thermogenic functions.
In vitro experiments have also confirmed that dihydromyricetin extract powder can induce mature 3T3-L1 adipocytes to differentiate into brown-like adipocytes, and this browning-promoting effect can be blocked by the mitochondrial fission-specific inhibitor Mdivi-1, further confirming the crucial mediating role of mitochondrial fission in this process.
Reference:https://pmc.ncbi.nlm.nih.gov/articles/PMC3292407/
https://www.sciencedirect.com/science/article/pii/S2352289522000741
http://sciencedirect.com/science/article/abs/pii/S0014299922006069
what are the uses of dihydromyricetin powder?
dihydromyricetin foods and beverage industry
Dihydromyricetin foods can be used as natural antioxidants and preservatives to maintain the freshness and extend the shelf life of fruits, vegetables, candies, and beverages; meanwhile, dihydromyricetin tea, as a traditional form of consumption, also benefits from the health properties of DHM.
Dihydromyricetin Alcohol metabolism inhibitors
For people who drink alcohol, dihydromyricetin powder is widely used to inhibit alcohol metabolism, reduce blood alcohol concentration, relieve hangover symptoms, and protect against alcoholic liver damage. Dihydromyricetin supplements are often presented in the form of dihydromyricetin capsules, dihydromyricetin tablets, or dihydromyricetin pills for easy and precise dosage.
Dihydromyricetin Powder Drugs and health products
DHM Dihydromyricetin powder manufactured by KINTAIBIO® is used in some drugs and health products to provide antioxidant and anti-inflammatory effects, and has the effects of protecting cardiovascular, improving liver function, lowering blood sugar and blood lipids, etc.
dihydromyricetin cream and personal care products
DHM's antioxidant and photoprotective properties make it an important ingredient in some cosmetics and personal care products. It can be used in facial skin care products,Dihydromyricetin Cream, hair care products and more to protect the skin from free radical and UV damage.
Food and beverage industry
Alcohol metabolism inhibitors
Drugs and health products
Cosmetics and personal care products
Why dihydromyricetin powder can relieve alcohol and protect the liver?
Dihydromyricetin for Blocking the effect of alcohol on GABA receptors in the brain
Dihydromyricetin Powder can bind to GABA receptors in the brain and block the effect of alcohol on GABA receptors. This reduces the stimulant effects of alcohol on the central nervous system, thereby relieving hangover symptoms such as headaches, nausea, and fatigue.
Dihydromyricetin For Enhancing Alcohol Metabolizing Enzyme Activity
DHM can enhance the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver. These two enzymes are the key enzymes involved in the metabolism of alcohol. ADH metabolizes alcohol into acetaldehyde, while ALDH further metabolizes acetaldehyde into harmless acetic acid. By enhancing the activity of these enzymes, Dihydromyricetin Powder can accelerate the metabolism of alcohol and reduce the accumulation of acetaldehyde, thereby reducing alcohol damage to the liver.
Dihydromyricetin For Antioxidant
DHM has significant antioxidant properties that can neutralize free radicals in the body and reduce damage to body tissues caused by oxidative stress. Alcohol metabolism triggers a large number of free radicals, which can cause oxidative damage to the liver and other organs, and the antioxidant effect of dihydromyricetin extract can protect these organs from damage.
Dihydromyricetin Powder side effects,dosage,safety
Is dihydromyricetin safe?
Current preclinical and preliminary clinical studies indicate that Dihydromyricetin Powder is generally well-tolerated, with no clearly defined dose-dependent adverse reactions.
Dihydromyricetin DHM side effects
Some users may occasionally experience mild gastrointestinal discomfort at high doses, but there are currently no reports of systemic serious side effects. The NIH LiverTox considers the likelihood of it causing clinically significant liver damage to be extremely low. Nevertheless, any supplement should be used according to the recommended dosage, and individual differences should be considered.
Dihydromyricetin Powder drug interactions
Because DHM can act on the benzodiazepine site of the GABA_A receptor, individuals currently taking benzodiazepines (such as diazepam, alprazolam), sedative-hypnotics, antidepressants, or other central nervous system depressants should consult a healthcare professional before use. Due to insufficient safety data, it is not recommended for use in individuals with severely impaired liver function, pregnant women, or breastfeeding women.
our certification of dihydromyricetin powder manufacturers
dihydromyricetin powder near me
As a source factory specializing in the research and production of dihydromyricetin (DHM), we are committed to providing high-purity, batch-stable, high-quality dihydromyricetin powder to fully support application needs in multiple fields. Our factory directly supplies dihydromyricetin powder for sale. As a professional force among China dihydromyricetin powder manufacturers , we strictly implement a quality control system to ensure that every batch of dihydromyricetin powder meets high-purity standards (HPLC testing shows a purity of over 98%).
KINTAIBIO® is a trustworthy dihydromyricetin powder factory and Dihydromyricetin Powder supplier. Please contact us to request samples or inquire about the dihydromyricetin DHM latest price quotes.
★If you want to buy high-quality Dihydromyricetin powder, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
FAQ
Q: What is the difference between myricetin and dihydromyricetin?
A: Myricetin and dihydromyricetin (also known as amplepsin) are both naturally derived flavonoids with extremely similar chemical structures. The only difference lies in the bond type between C2 and C3 of the C ring. However, this subtle difference leads to significant differentiation in their biological activities and pharmacological effects. Molecular docking studies have revealed that both myricetin and dihydromyricetin can bind to the JNK1 protein through hydrophobic interactions and hydrogen bonds, thereby exerting protective effects against oxidative stress and apoptosis. However, due to the different bond types between C2 and C3 on the C ring, their binding modes with JNK1 differ significantly, resulting in different pharmacological effects. Furthermore, myricetin and dihydromyricetin also exhibit significantly different binding modes in their hydrogen bond interactions with α-glucosidase. In terms of antioxidant activity, dihydromyricetin is superior to myricetin in scavenging superoxide anion radicals (•O₂⁻) and DPPH radicals, but relatively weaker in scavenging ABTS radicals and reducing Cu²⁺. Overall, dihydromyricetin, due to its unique target and higher safety profile, has a far greater potential than myricetin in areas such as hangover relief, liver protection, anxiety reduction, and metabolic regulation.
Q: Can DHM improve sleep quality?
A: Multiple studies suggest that DHM has potential in improving sleep quality and alleviating stress-induced sleep disorders. DHM's main mechanism of action is through the modulation of GABA₂ receptors in the brain to exert its anxiolytic effect. As a known GABA₂ receptor modulator, DHM may improve secondary sleep quality decline by alleviating stress and anxiety. Furthermore, alcohol withdrawal can cause a "rebound" effect in the brain's GABAergic system, leading to anxiety, restlessness, and decreased sleep quality. DHM, by regulating GABA receptor signaling, helps restore normal brain function, thus supporting more restful sleep during hangover recovery. Therefore, DHM provides a natural adjunctive intervention strategy for sleep disturbances caused by factors such as stress, excessive use of electronic devices, or alcohol withdrawal, but its mechanism of action and clinical application are completely different from prescription hypnotics (such as benzodiazepines and Z-drugs).
Q: When to take DHM and how much dihydromyricetin should I take?
A: The timing and dosage depend on the specific purpose: For alcohol support and hangover relief: Multiple studies have shown that the effective dose is typically 300mg to 600mg. It is recommended to take it 30 minutes before drinking, during drinking, or immediately after drinking. DHM has a short half-life and is rapidly eliminated from the body; therefore, if drinking continues for several hours, consider supplementing with a dose every few hours. For first-time users, it is recommended to start with a lower dose. For daily health support and metabolic improvement: The NIH LiverTox review indicates that typical doses used in short-term human clinical studies range from 300 mg to 1000 mg daily. In a three-month, double-blind clinical trial, subjects taking 150 mg DHM capsules twice daily (i.e., a daily dose of 300 mg) showed good tolerability and metabolic improvement.
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