Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of sanguinarine chelerythrine powder in China. Please feel free to wholesale high quality sanguinarine chelerythrine powder for sale here from our factory. For price consultation, contact us.
Sanguinarine Chelerythrine Powder Manufacturer
With the deepening implementation of the global livestock industry's "antibiotic ban, antibiotic restriction, and antibiotic reduction" policy, finding safe and efficient alternatives to feed growth-promoting antibiotics has become an urgent need for the industry's sustainable development. Macleaya cordata extract and its main active ingredient, sanguinarine, have become a highly sought-after antibiotic alternative due to their natural origin and significant anti-inflammatory, antibacterial, and growth-promoting properties.
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KINTAIBIO®'s Sanguinarine Chelerythrine powder uses carefully selected dried pods of high-quality Macleaya cordata as raw material. Advanced extraction technology ensures that the total alkaloid content in the product is no less than 60% (HPLC detection), with sanguinarine exceeding 40% and chelerythrine exceeding 15%, meeting the stringent requirements of animal nutrition and health care with high purity and high activity. For further inquiries or to customize Macleaya cordata extract powder, please feel free to contact our sales team: Sales@Kintaibio.Com.
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Sanguinarine Chelerythrine Powder Related Industry Regulations
- In 2004, Macleaya cordata extract (with sanguinarine as the main active ingredient) was officially approved by the European Union and included in the EU Feed Additives Regulation, allowing its use in animal feed.
- In China, Sanguinarine Chelerythrine Powder was approved as a Class II new veterinary drug by the Ministry of Agriculture in 2011, and in 2012 became one of the first batch of traditional Chinese veterinary medicine additives permitted for direct addition to feed production.
- Following the complete ban on antibiotics in feed in 2019, it became a safe and highly effective traditional Chinese veterinary medicine product that can be added to feed long-term without withdrawal periods, providing anti-inflammatory and growth-promoting effects. It has become a recognized safe and effective antibiotic alternative in the industry, gaining widespread acceptance from farmers and feed companies.
This series of domestic and international policy and regulatory endorsements fully demonstrates the compliance and application value of Sanguinarine Chelerythrine Powder as a green feed additive, and also provides KINTAIBIO® with a solid technical and regulatory basis for serving global customers.
Sanguinarine Chelerythrine Powder Benefits
Sanguinarine Chelerythrine Powder Antibacterial
Studies have shown that sanguinarine possesses broad-spectrum antibacterial activity, with a minimum inhibitory concentration (MIC) as low as 1.54 µM against Gram-positive bacteria such as Staphylococcus aureus and a MIC of 12.4 µM against Gram-negative bacteria such as Escherichia coli. It also exhibits significant inhibitory effects against drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA).
Source:https://www.sciencedirect.com
Its mechanism of action involves disrupting bacterial cell membranes, reducing intracellular ATP, and inhibiting biofilm formation. In aquaculture applications, sanguinarine shows an inhibition rate of over 90% against Aeromonas hydrophila. Furthermore, sanguinarine exhibits a synergistic effect when used in combination with EDTA or streptomycin, reducing the effective dose by 2 to 16 times. KINTAIBIO®'s Sanguinarine Chelerythrine Powder, with a sanguinarine content ≥40%, utilizes a high-purity extraction process to ensure batch-to-batch activity stability, providing a scientific and efficient natural antibiotic alternative for feed and aquaculture.
Sanguinarine Chelerythrine Powder dental
A clinical study has shown that using toothpaste and mouthwash containing sanguinarine significantly inhibits gingivitis recurrence after periodontal scaling and root planing. The study showed that after short-term chlorhexidine treatment, patients using sanguinarine products experienced a 26% reduction in gingival bleeding points at 8 weeks and a 32% reduction at 14 weeks, effectively maintaining gum health for up to 12 weeks.
Source:https://www.sciencedirect.com
Compared to commonly used chlorhexidine, sanguinarine's advantage lies in its lack of side effects such as extrinsic tooth staining with long-term use. Only some users may experience a transient, mild burning sensation, making it more suitable as a long-term maintenance solution after short-term intensive chlorhexidine treatment. This study confirms the reliable efficacy of sanguinarine chelerythrine powder in inhibiting plaque and improving gum health, providing a scientific basis for its application in oral care products.
Sanguinarine Chelerythrine Powder cancer
In the field of anti-tumor research, sanguinarine has attracted much attention due to its unique biphasic cytotoxic mechanism. As a natural alkaloid derived from plume poppy, it induces tumor cell death through both necrosis and apoptosis, exhibiting a clear dose-dependent effect.
Source:https://www.sciencedirect.com
At higher concentrations, sanguinarine primarily induces cell necrosis, manifested as cell swelling, organelle expansion, and alteration of the expression of over 2500 genes, broadly activating pathways related to the cell cycle, protein synthesis, and immune response. At lower concentrations, it primarily induces classical apoptosis, altering the expression of over 1600 genes. This dual mechanism of action enables sanguinarine to exhibit inhibitory activity against various tumor cell lines, including leukemia, lymphoma, prostate cancer, breast cancer, and cervical cancer cells. Multiple safety assessments of oral administration have demonstrated that sanguinarine chelerythrine powder has good biocompatibility within reasonable dosage ranges.
Reference:https://www.sciencedirect.com/science/article/pii/S0753332224002907
https://pubmed.ncbi.nlm.nih.gov/10225548/
https://www.sciencedirect.com/topics/medicine-and-dentistry/sanguinarine
Sanguinarine Chelerythrine Powder uses
Sanguinarine Chelerythrine Powder feed additives
In the field of feed additives, sanguinarine is a core functional ingredient for replacing antibiotics. Its molecules can intercalate into the bacterial DNA double strand and disrupt the cell membrane, showing significant effects against Gram-positive bacteria. Studies have shown that adding sanguinarine chelerythrine powder (≥1.5%) to the diets of weaned piglets increases average daily weight gain by 6.5%, reduces feed conversion ratio by 4.8%, and decreases diarrhea rate by 50%, with effects comparable to chlortetracycline.
In poultry, sanguinarine can inhibit Clostridium, reduce the incidence of necrotic enteritis, and increase the intestinal villus height/crypt depth ratio, enhancing nutrient absorption. In ruminants, it selectively inhibits rumen methanogens, improving energy utilization and reducing methane emissions.
Sanguinarine Chelerythrine Powder Plant-derived pesticides
Studies have shown that Sanguinarine has significant contact and stomach poison effects against various crop pathogenic fungi and pests. Field trials have confirmed that 0.5% Sanguinarine wettable powder achieves a control efficacy of over 75% against cucumber powdery mildew, comparable to conventional chemical pesticides, while also possessing a shorter safety interval and environmentally friendly characteristics.
Sanguinarine Chelerythrine Powder mouthwash products
Clinical studies have shown that toothpaste and mouthwash containing sanguinarine can significantly reduce plaque buildup and improve gingivitis. Multiple randomized controlled trials have confirmed improvements in plaque index and gingivitis index of 30% to 50%. Compared to chlorhexidine, sanguinarine chelerythrine powder does not cause extrinsic tooth staining with long-term use, making it a safer option and one of its earliest commercially viable applications. It is worth noting, however, that data on its application in this area is still limited, and extreme caution must be exercised when using it.
Sanguinarine Chelerythrine Powder side effects
- Clinical observations show that even small doses can cause gastrointestinal reactions such as nausea and vomiting.
- Long-term or excessive intake may lead to neurological symptoms such as abdominal pain, diarrhea, dizziness, and visual changes.
- Furthermore, epidemiological studies suggest that long-term use of oral care products containing plume poppy sanguinarine may be associated with the development of oral leukoplakia, and high-dose exposure may also affect liver and kidney function and cause intestinal flora imbalance.
- Pregnant women, breastfeeding women, and children should avoid using products containing sanguinarine.
- For external use, corrosive ointments containing sanguinarine may cause severe skin damage and should not be used for self-treatment of skin lesions.
As a functional ingredient, the application of sanguinarine must follow professional guidance, and the dosage and usage scenarios must be strictly controlled to ensure safety and effectiveness.
where to buy Sanguinarine Chelerythrine Powder
KINTAIBIO®, a professional supplier of Sanguinarine and Chelerythrine Powder, is committed to providing standardized, high-purity Sanguinarine products to global customers. Our Macleaya Cordata Extract total alkaloids 60% Powder adheres to a core standard of at least 60% total alkaloids (HPLC), with a stable Sanguinarine content exceeding 40% and Chelerythrine exceeding 15%, fully complying with EU import standards for feed additives and plant-derived raw materials.
All our products undergo rigorous quality control testing to ensure batch-to-batch stability of active ingredients and absence of solvent residues. They can be widely used in the development and production of feed antibiotic alternatives, biopesticides and oral care products.
We deeply understand the importance of supply chain stability and compliance support for our partners. KINTAIBIO® not only provides a long-term, stable supply of Sanguinarine and Chelerythrine Powder but also offers Certificates of Authorization (COA) and various registration documents required for export, tailored to customer needs. Whether you are conducting initial sample testing or purchasing in bulk for large-scale production, you can easily submit an inquiry through our official channel: sales@kintaibio.com.
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