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Betulinic Acid Manufacturer/ supplier
Betulinic acid is a naturally occurring pentacyclic triterpenoid compound with a typical lupane-type pentacyclic triterpenoid skeleton. Its unique chemical structure, containing hydroxyl and carboxyl functional groups, endows it with excellent biological activity. KINTAIBIO® produces Betulinic Acid powder in various grades, including those with HPLC-tested purity of 95% and 98%. The products are manufactured under a comprehensive quality management system with strict quality control throughout the entire process.
In recent years, numerous studies have demonstrated that betulinic acid possesses broad and significant biological activities. It exhibits good inhibitory effects on various tumor cells while showing relatively low toxicity to normal cells. Furthermore, betulinic acid also possesses antiviral, anti-inflammatory, antioxidant, hepatoprotective, immunomodulatory, and metabolic regulatory activities. With the continuous deepening of research on natural bioactive substances, betulinic acid and its derivatives have become one of the important lead compounds in new drug development.
With its excellent bioactivity and promising development prospects, Betulinic Acid Powder has been widely used in various fields such as pharmaceutical research and development, natural drug screening, pharmaceutical intermediate development, dietary supplements, functional foods, and high-end cosmetics. Relying on mature biotransformation processes, a rigorous quality control system, stable supply capabilities, and professional technical support, KINTAIBIO® continuously provides global customers with high-quality, high-purity, and traceable White Birch Bark Extract Betulinic Acid raw materials.
betulinic acid structure
|
CAS Number |
472-15-1 |
Molecular Weight |
456.700 |
|
Density |
1.1±0.1 g/cm3 |
Boiling Point |
550.0±33.0 °C at 760 mmHg |
|
Molecular Formula |
C30H48O3 |
Melting Point |
295-298 °C (dec.)(lit.) |
|
Common Name |
Betulinic acid |
Flash Point |
300.5±21.9 °C |
TDS of Betulinic Acid
|
Product name |
Betulonic Acid |
|
Extract source |
Birch bark |
|
Extraction Solvent |
Ethyl alcohol |
|
Appearance |
White powder |
|
Solubility |
Soluble in: chloroform, ethanol, acetone, methanol, ether; very slightly soluble in benzene |
|
Identification |
HPLC |
|
Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay |
Min. 95.0% |
|
Residual Solvents |
|
|
- N-hexane |
NMT 290 PPM |
|
- Methanol |
NMT 3000 PPM |
|
- Acetone |
NMT 5000 PPM |
|
- Ethyl Acetate |
NMT 5000 PPM |
|
- Ethanol |
NMT 5000 PPM |
|
Pesticide Residues |
|
|
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT) |
NMT 0.05 PPM |
|
- Aldrin, Endrin, Dieldrin |
NMT 0.01 PPM |
|
Microbiological Quality (Total viable aerobic count) |
|
|
- Bacteria, CFU/g, not more than |
NMT 103 |
|
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
|
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine. |
|
Shelf life |
2 years |
betulinic acid benefits
Betulinic Acid Cardiovascular System
Studies have shown that betulinic acid exhibits promising research potential in cardiovascular protection, with its cardioprotective effects closely related to multi-target and multi-pathway regulatory mechanisms. Existing research has found that betulinic acid can exert antioxidant, anti-inflammatory, anti-apoptotic, and abnormal cell proliferation-inhibiting biological effects by regulating multiple signaling pathways such as NRF2, NF-κB, MAPK, and NFAT. Simultaneously, it can improve vascular endothelial function by regulating nitric oxide (NO)-related signaling pathways and help reduce lipid accumulation, thus participating in the maintenance of cardiovascular homeostasis at multiple levels.
Due to its favorable physicochemical properties, high structural modifiability, and relatively mature synthetic strategies, betulinic acid is considered a promising natural cardioprotective lead compound and has attracted widespread attention in the fields of cardiovascular pharmacology and innovative drug development.
Betulinic Acid Antioxidant stress activation
BA has a protective effect on normal cells and the body, which is related to antioxidant stress. For example, Betulonic Acid has protective effects on ischemia-reperfusion injury in the brain, kidneys, and heart. BA has protective effects on cerebral ischemia-reperfusion injury in mice through antioxidant stress, anti-nitrogen stress, and increased blood flow.
Betulinic Acid Anti-inflammatory effect
Most pentacyclic triterpenes have anti-inflammatory activities. Both betulin and Betulonic Acid have mild anti-inflammatory properties at higher concentrations, and their anti-inflammatory properties may depend on their inhibition of protein kinase C, without involving any neurogenic inflammatory mechanisms. There are also studies indicating that its activity is the result of interaction with glucocorticoid receptors.
The anti-inflammatory effect of Betulinic Acid has been verified in vitro and in vivo model systems. Betulonic Acid can inhibit the production of PGE2 and alleviate inflammatory reactions.
Betulinic Acid Bacteriostatic effect
It has been found that Betulonic Acid has a certain antibacterial effect, which can inhibit a variety of bacteria including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Staphylococcus epidermidis. However, studies have shown that its antibacterial activity is weak, which may be related to its belonging to lupine pentacyclic triterpenes, its structure is similar to that of hopane pentacyclic triterpenes, and the presence of substances on the bacterial membrane that can biosynthetically synthesize hopane pentacyclic triterpenes. Based on the existing research on the antibacterial ability of Betulinic Acid, its potential as an antibacterial agent is small.
Anti-tumor effect of Betulonic Acid
Betulinic Acid was first found to have extremely strong selective cytotoxicity in melanoma cells. In recent years, it has also been found to have a strong broad-spectrum activity to other tumor cells, such as glioblastoma, neuroblastoma, neuroblastoma, Ewing tumor and other malignant tumors, colon cancer, breast cancer, lung cancer, liver cancer, prostate cancer, kidney cell Ovarian or cervical cancer and leukemia have strong inhibitory effects.
Betulinic Acid Antiviral effect
Betulinic Acid has prominent antiviral activity, especially HIV activity, and has effective effects on anti-hepatitis C virus, anti-herpes simplex virus, anti-Eico virus, and anti-influenza virus.
Reference:https://www.sciencedirect.com/science/article/abs/pii/S0367326X25001868
betulinic acid uses
betulinic acid in cosmetics
(1) Skin whitening effect: low-concentration Betulinic Acid can be used as a skin conditioning aid, and it can be used in combination with ascorbic acid to promote the production of cortical collagen;
(2) Use in hair products can promote hair growth; Betulinic Acid has anti-inflammatory and anti-skin allergy effects, and it can reduce skin irritation when used in high SPF sunscreen lotion.
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betulinic acid Medicine
BA is a very valuable natural product. As biological agents, BA and its derivatives have shown great potential in anti-cancer and HIV treatment, play an important role in the body's anti-oxidative damage and immune regulation process, and are a class of promising drug lead compounds. It is of great value for the research and development of new drugs, and the NCI of the American Cancer Institute has included it in the Rapid Research and Development Program (RAID).
Betulonic Acid safety
CTFA uses Betulinic Acid as a cosmetic raw material, and it is included in the 2010 edition of the "International Cosmetic Raw Material Standard Chinese Name Catalogue" issued by the China Fragrance Association. Included, there is no report that it is unsafe for external use.
Betulonic Acid Dosage And Formulation
|
|
Moisturizing Lotion |
Soothing Cream |
Antioxidant Serum |
|
Formulas |
Betulonic Acid 0.5% Hyaluronic Acid 1.0% Glycerin 3.0% Wheat Protein 2.0% Natural Vitamin E 0.1% Rosemary Extract 0.5% Water 88.9% |
Betulonic Acid 0.3% Aloe Vera Extract 3.0% Glycerin 2.0% Pomegranate Seed Oil 5.0% Arnica Extract 1.0% Honey 2.0% Water 86.7% |
Betulonic Acid 0.8% Green Tea Extract 2.0% Natural Vitamin C 5.0% Mangosteen Seed Oil 4.0% Erigeron Extract 1.0% Coenzyme Q10 0.5% Water 86.7% |
|
|
The above three reference formulas are all developed based on the anti-oxidation, moisturizing, and anti-aging effects of BA. At the same time, when using Betulonic Acid, it is necessary to pay attention to controlling the dosage and matching other ingredients reasonably to fully exert its efficacy and ensure the safety and stability of the product. |
||
|
Dosage |
The dosage of BA is generally 0.1%~1.0%. In the formulation, it can be used in combination with other natural ingredients such as vitamin E, honey, aloe vera, green tea, licorice, etc. to form creams, lotions, essences, and other products with multiple functions such as maintenance, soothing, moisturizing, and anti-aging. |
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benefits Of KINTAIBIO To Produce Betulinic Acid
Introduction of three extraction methods of BA
- First, it is extracted and isolated from natural plants. This method consumes a lot of solvents, the yield is low, and the impurities are not easy to separate, so it is rarely used;
- Second, Betulinic Acid was obtained through organic synthesis using betulin as a precursor. This method has been applied in industrial production, and industrial-scale BA can be obtained, which is the main source of BA in the market now;
- Third, use betulin as a precursor to produce BA through microbial conversion. This approach represents a new direction for the future plant extraction industry and is the main advantage of KINTAIBIO® in producing this product.
where to buy Betulinic Acid?
If you are looking for a reliable Betulinic Acid Supplier, KINTAIBIO® offers high-quality White Birch Bark Extract Betulinic Acid Powder to customers worldwide. As a professional Betulinic Acid Powder Factory and experienced Birch Bark Extract Manufacturer, we offer a variety of product specifications and customized services to meet diverse R&D and industrial application needs.
Whether you are following the development trends of the Betulinic Acid Market, want to understand competitive Betulinic Acid Prices, or plan to purchase Betulinic Acid for product development or large-scale production, KINTAIBIO® can continuously provide you with high-quality Betulinic Acid Powder for Sale.
★If you want to get high-quality Betulinic acid, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
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