Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of chlorogenic acid powder in China. Please feel free to wholesale high quality chlorogenic acid powder for sale here from our factory. For price consultation, contact us.
chlorogenic acid powder manufacturer/ supplier
KINTAIBIO®, a professional manufacturer of chlorogenic acid powder, produces chlorogenic acid (CGA), also known as caffeic tannin, a condensed phenolic acid formed from caffeic acid and quinic acid. Our products are made from carefully selected high-quality green coffee beans, honeysuckle, and eucommia leaves, among other natural plant raw materials. Specifications include 5%, 10%, 20%, 25%, 30%, 50%, and 98% chlorogenic acid. We employ advanced extraction and purification processes to provide high-quality products.
Chlorogenic acid possesses a variety of definite biological activities with well-defined mechanisms of action: it exerts antioxidant activity by scavenging free radicals, protecting organs from reactive oxygen species damage; it inhibits inflammatory responses in the body; it reduces the amount of glucose entering the bloodstream after meals by inhibiting the activity of α-glucosidase, thereby regulating blood sugar levels; it also regulates the activity of HMG-CoA, a key enzyme in cholesterol metabolism, lowering LDL cholesterol and exerting hepatoprotective and choleretic effects; furthermore, it improves blood rheology, prevents cardiovascular diseases, and has antipyretic, nerve tissue protective, and broad-spectrum antibacterial and antiviral effects.
98% Chlorogenic Acid Powder Powder
25% Chlorogenic Acid Powder Powder
Solubility of KINTAIBIO® chlorogenic acid powder: good water solubility, the solubility in water at 25°C is about 4%, it is easily soluble in hot water, ethanol, and acetone, high-purity chlorogenic acid can be completely dissolved, and is very slightly soluble in ethyl acetate. This provides a reliable guarantee for its convenient use in different application scenarios.
Based on this scientific support, chlorogenic acid powder has been widely used in many industries such as food, medicine, health products and daily chemicals. For example, it is used as a natural antioxidant in functional foods and dietary supplements, in the development of antibacterial and anti-inflammatory drugs, and as an anti-aging ingredient added to skin care formulas.
KINTAIBIO® Chlorogenic acid Source
As a natural polyphenol, the product produced by KINTAIBIO® is widely found in higher dicotyledonous plants and ferns. It is an important component of the plant defense system and is commonly found in plants such as Lonicerae, Eucommiaceae, Asteraceae, and Rosaceae. Among them, the chlorogenic acid content in the bark of Eucommia ulmoides can reach 5%, the honeysuckle flower can reach 5%, and coffee beans contain about 2%. It is also found in wild chrysanthemums, apples, carrots, kiwis, wheat, potatoes and other vegetables and fruits as well as daily foods. The chlorogenic acid powder we produce mainly include Green Coffee Bean Extract Powder Chlorogenic Acid, Lonicera Japonica Honeysuckle Flower Extract Chlorogenic Acid, and Eucommia Ulmoides Leaf Extract Chlorogenic Acid.
KINTAIBIO®'s chlorogenic acid is mainly extracted from the following natural plants:
- Eucommia ulmoides extract (HPLC 5%-30%, 50%-98%)
- Green coffee bean extract (HPLC 45%-50%, 90%)
Our 98% Chlorogenic acid powder extract from Eucommia ulmoides leaves achieves cost-effectiveness.
Certificate Of Analysis & Liquid Chromatography Analysis Report OF chlorogenic acid
Certificate of Analysis
Liquid Chromatography Analysis Report
chlorogenic acid mechanism of action
Raw Material Acceptance and Pretreatment
Before production starts, the purchased dried Eucommia ulmoides leaves undergo quality inspection to ensure their chlorogenic acid content is within the range of 1.0% to 5.0%. The qualified leaves are then pulverized to a suitable particle size and precisely weighed according to the feeding plan to provide a uniform raw material base for subsequent extraction.
Dynamic Water Extraction
The weighed Eucommia ulmoides leaves are placed in the extraction tank, and purified water is added at a ratio of 10 to 14 times the weight of the medicinal material. The pH of the extraction system is adjusted to a slightly acidic range of 6 to 7 using acid. Stirring or dynamic circulation is started, and the extraction temperature is stably controlled between 60°C and 80°C. Each extraction lasts 0.5 to 1.5 hours, and 1 to 3 extractions are repeated based on the target transfer rate. After each extraction, the extract is filtered and collected, and the extracts from all extractions are combined and transferred to the next process.
Chitosan Clarification and Coarse Filtration
The combined extracts were transferred hot into a settling tank, and chitosan, a natural clarifying agent, was added at a precise amount of 0.4% to 0.8% of the drug mass. The mixture was allowed to settle for 1.0 to 2.0 hours at a temperature of 50°C to 70°C. Chitosan effectively removed large molecular impurities such as proteins, pectin, and some pigments from the extract through flocculation, significantly reducing the viscosity of the solution. After settling, the pretreated solution was coarsely filtered through a membrane or filter cartridge with a pore size of 50 to 100 micrometers to prevent clogging of the subsequent resin column.
Macroporous Adsorption Resin Chromatography Purification
Non-polar or weakly polar macroporous adsorption resins were selected, and the column diameter-to-height ratio was ensured to be 1:4 to 1:8 during packing. During the sample loading stage, the feed flow rate is controlled at 3.0 to 5.0 column volumes per hour, and the adsorption loading is dynamically adjusted according to the ratio of medicinal material mass to column volume of 1:1 to 1:4. After sufficient adsorption, the resin column is first rinsed with 1.0 to 2.0 column volumes of purified water at a flow rate of 3.0 to 5.0 column volumes per hour to remove highly polar unadsorbed impurities such as sugars and inorganic salts. A 10% to 30% aqueous ethanol solution is used as the eluent at a flow rate of 4.0 to 6.0 column volumes per hour for desorption and elution. The eluent rich in chlorogenic acid is collected, and the initial and final impurities are discarded.
Voltage Concentration
The collected ethanol eluent is transferred to a vacuum concentration device. The concentration temperature is controlled between 50°C and 70°C, and the vacuum degree is maintained at a high vacuum condition of -0.07 MPa to -0.09 MPa. The ethanol in the eluent is recovered and evaporated, and the concentration continues until a clear paste with a relative density of 1.03 to 1.05 is obtained. Low-temperature vacuum operation effectively protects the heat-sensitive chlorogenic acid from high-temperature damage, while simultaneously recovering the ethanol solvent for recycling.
Spray Drying and Finished Product Packaging
The concentrated paste is pumped into a spray drying tower. The inlet temperature is set to 150°C to 170°C, and the outlet temperature to 60°C to 80°C. The paste is dispersed into fine droplets by an atomizer and comes into instantaneous contact with the hot air, causing rapid evaporation of moisture and obtaining a dry crude chlorogenic acid powder. After cooling, sieving, and mixing, the dried powder is packaged according to specifications (both inner and outer packaging). After passing quality inspection, it is stored as the finished chlorogenic acid powder.
What does chlorogenic acid do for your body?
chlorogenic acid antioxidant
Chlorogenic acid and caffeic acid exhibit clear mechanisms of action and protective effects in antioxidant support.In vitro studies have shown that the physiological importance of orally administered compounds depends on their intestinal absorption rate and interaction with target tissues. Researchers further evaluated their in vivo antioxidant activity using an intestinal ischemia-reperfusion model, finding that both chlorogenic acid and caffeic acid have protective effects against intestinal ischemia-reperfusion injury.
Given that caffeic acid has stronger antioxidant activity and that chlorogenic acid can be hydrolyzed into caffeic acid in the intestine, caffeic acid may play a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.
chlorogenic acid for weight loss
Chlorogenic acid powder can inhibit fatty acid synthesis, promote fat metabolism, increase cholesterol excretion, and thus achieve the effect of reducing body fat.With the increasing availability of green coffee bean extract products containing CGA on the market, the relationship between effective dosage and weight control has become a key research focus. A systematic review and meta-analysis rigorously integrated data from three randomized controlled trials. The results showed that daily supplementation with at least 500 mg of green coffee bean extract containing chlorogenic acid significantly reduced weight.
This strongly suggests that chlorogenic acid can play a clear role in supporting weight loss. Although the sample size and observation period of the existing studies are limited, and the long-term safety and efficacy still require further verification through more extensive clinical trials, this provides substantial evidence-based support for chlorogenic acid powder as a functional ingredient in natural weight management.
- Inhibition of fatty acid synthesis:CGA acts on the mitochondrial inner membrane of the liver and adipocytes, and inhibits the activity of carboxylase, a key enzyme in fatty acid synthesis, under the action of ATPase. It inhibits the biosynthesis and aggregation of fatty acids by regulating activity and reduces the plasma concentration of fatty acids.
- Promote the activity of triglyceride hydrolase:CGA acts on lipase in the liver and serum, synergistically acts on the activity of triglyceride hydrolase, promotes the hydrolysis of triglycerides into free fatty acids and glycerol, and thus reduces the concentration of triglycerides in plasma.
- Increase cholesterol excretion:CGA can inhibit cholesterol absorption by regulating the activity of lipase and cholesterol esterase in small intestinal cells, while promoting cholesterol metabolism, enhancing bile excretion, and accelerating cholesterol excretion, thereby reducing the cholesterol content in plasma.
chlorogenic acid and blood pressure
In terms of cardiovascular health support, chlorogenic acid also demonstrates a clinically statistically significant positive effect. A systematic review and meta-analysis on the effects of CGA on blood pressure systematically searched electronic databases. The analysis results showed that chlorogenic acid supplementation significantly reduced systolic blood pressure by an average of 4.31 mmHg and diastolic blood pressure by an average of 3.68 mmHg, with moderate effect sizes. No adverse events were reported in any of the included studies.
The study concluded that published randomized controlled trial evidence shows that chlorogenic acid intake can lead to a statistically significant reduction in both systolic and diastolic blood pressure. Although the number of relevant clinical trials is currently limited, their design methodologies vary, and the study populations are limited to Asia, this meta-analysis provides a reference for chlorogenic acid powder as a functional component supporting blood pressure health.
Intestinal health: Chlorogenic acid also has the function of regulating intestinal flora, which can increase the abundance of beneficial bacteria in the intestine, maintain the integrity of the intestinal barrier, and reduce inflammatory responses.
Antibacterial effect: Chlorogenic acid exhibits significant broad-spectrum antibacterial effects on a variety of pathogenic bacteria, including Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhimurium, Yersinia enterocolitica, Shigella dysenteriae, Stenotrophomonas maltophilia, and Gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis, Streptococcus pyogenes, Streptococcus pneumoniae, etc. It also includes the inhibition of drug-resistant pathogens, especially in inhibiting bacterial biofilm formation and destroying cell metabolism. It has shown great potential.
Reference:https://pmc.ncbi.nlm.nih.gov/articles/PMC10503105/
https://www.sciencedirect.com/science/article/abs/pii/S0378517310007556
https://pubmed.ncbi.nlm.nih.gov/24943289/
what is chlorogenic acid used for?
chlorogenic acid drink & Food additives:
Enhance color stability
Antioxidant preservative
- Antioxidant preservative: has excellent antioxidant properties, which can protect lipids and other easily oxidizable components in food from oxidative damage and prolong the shelf life of food.
- Preservatives: Due to their antibacterial and antiseptic properties, CGAs can be used to inhibit the growth of microorganisms in food, reducing the risk of food spoilage.
- Enhance color stability: CGA can interact with pigments in food, enhance the stability of pigments, and prevent pigments from fading or losing color.
- Functional foods: CGA is believed to have certain health benefits, such as anti-inflammatory, anti-aging and lowering blood pressure. Therefore, it can also be applied in functional foods to provide consumers with more healthy choices.
chlorogenic acid supplement
As a natural antioxidant and metabolic regulator in health products, CGA can promote overall health.It is widely formulated into chlorogenic acid capsules, chlorogenic acid tablets, and chlorogenic acid pills to provide consumers with convenient daily antioxidant and metabolic support. Chlorogenic acid supplements have become a popular choice for people who are concerned about weight management and cardiovascular health.
Chlorogenic Acid Extract animal feed
Chlorogenic Acid Extract manufactured by KINTAIBIO® is a nutrient-rich natural plant extract widely used in the feed industry. It contains a variety of nutrients that are beneficial to animal growth and development, immunity, and stress resistance, and can be added to animal feed as a natural nutritional supplement for improving the nutritional value of feed and increasing the immunity and resistance of animals.
5%-98% CGA Suggested Dosage in feed
where to buy Chlorogenic Acid Powder?
As a trusted manufacturer of chlorogenic acid powder, KINTAIBIO® is committed to providing global customers with high-quality CGA products sourced directly from the origin. If you are looking for reliable chlorogenic acid suppliers or a high-quality chlorogenic acid factory in China, KINTAIBIO®, with its advanced extraction processes, ISO9001 and GMP-certified quality management system, and professional technical team, can provide you with Eucommia Ulmoides Leaf Extract Chlorogenic Acid with a purity of up to 98%.
Whether you need chlorogenic acid powder for food additives, health food ingredients, pharmaceutical intermediates, or daily chemical formulations, we can provide customized products in different specifications to meet your application needs. We maintain stable supply chain management and competitive chlorogenic acid prices, providing wholesale chlorogenic acid powder services with global shipping support. We also have a professional technical support team to assist in resolving issues related to product solubility, compatibility, and stability in formulations, ensuring the consistency of quality and efficacy for every batch of products.
We welcome global customers to contact us for more product details or to inquire about pricing. When you search for chlorogenic acid for sale or chlorogenic acid near me, we are your trusted long-term partner. For more information on buying chlorogenic acid, please contact our sales team at sales@kintaibio.com or visit our official website for product specifications, quality inspection reports, and technical support.
certifications OF KINTAIBIO chlorogenic acid
If you want to purchase high-quality chlorogenic Acid Powder, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
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