Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of vine tea extract in China. Please feel free to wholesale high quality vine tea extract for sale here from our factory. For price consultation, contact us.
Vine tea extract manufacturer/ supplier
KINTAIBIO®'s Vine tea extract comes from southern China. It is known as the "king of flavonoids" in Chinese tea culture. We extract the active ingredient Vine Tea Extract dihydromyricetin (DHM) from its young stems and leaves through modern refining technology. This active ingredient has multiple effects on liver protection, lowering blood lipids and blood sugar, anti-inflammatory, antibacterial and antioxidant. As a natural ingredient, Dihydromyricetin powder safety has been proven and it is widely used as a raw material for skin care products, health care products and pharmaceuticals.
The following documents are available,please contact us at sales@kintaibio.com.
*Specification
*Certificate of Analysis (CoA)
*Material Safety Data Sheet (MSDS)
*Manufacturing process flow chart
*High Performance Liquid Chromatography(HPLC) Detection Report
*Ecological impact data
*Impurities
*Efficacy data third-party test report
*Solvent residue third-party test report
*Heavy metal content third-party test report
*Aflatoxin third-party test report
*Water solubility experiment report
Vine Tea Extract specifcation& dihydromyricetin solubility
High-content 98% Vine tea extract
The high-content Vine tea extract we produce uses advanced purification technology to extract high-purity dihydromyricetin extract from the young stems and leaves of Ampelopsis grossedentata, ensuring that impurities are controlled within 0.5%. In addition, compared with traditional rattan tea extracts, this product greatly increases the concentration of DHM, making every milligram rich in powerful pharmacological activity.
30% water-soluble Vine tea extract
Although DHM Dihydromyricetin has rich pharmacological effects, it is not easily soluble in water and has a low absorption rate in the human body, which limits the bioavailability of the product. To solve this problem, we developed a 30% water-soluble customized dihydromyricetin powder. By encapsulating the DHM molecular structure, using sodium caseinate and β-cyclodextrin, we have greatly improved its solubility in water, making your application range wider. Currently, this specification is used in personal care, skin care products and food and beverage fields.
75% Vine tea extract: Breakthrough bioavailability improvement
The traditional bioavailability of Vine tea extract is only 4.21%, which means that most of the ingested DHM is not effectively absorbed and utilized by the human body. To address this problem, we have innovatively developed DHM with a bioavailability of up to 50%. This breakthrough technology enhances the stability and absorbability of DHM Dihydromyricetin Powder by molecularly modifying it, making it retain longer in the intestines, thereby significantly improving the absorption efficiency of DHM by the human body.
In this 75% DHM product, vine tea extract dihydromyricetin not only achieves a qualitative leap in bioavailability, but also retains all its original functionality. Whether in health foods, functional beverages, or pharmaceutical products, it can achieve better health effects with less dosage.
The physical and chemical properties of our Vine Tea Extract dihydromyricetin
KINTAIBIO® high-purity Vine Tea Extract is a white powder with low solubility at room temperature and in cold water. It is easily soluble in hot water, hot ethanol, methanol, and slightly soluble in ethyl acetate. Because it contains an o-triphenolic hydroxyl structure, it is easily oxidized and has poor stability. Many factors such as pH value, temperature, metal ions, and solvents have an impact on its stability.
According to our company's existing research, pH value is an important factor affecting its stability. Dihydromyricetin is stable under weakly acidic conditions with a pH value of ≤4, but an increase in pH value will accelerate its oxidation rate. Under alkaline conditions with a pH value of ≥9, it will be oxidized and turn yellow. The second factor is temperature. As the temperature increases, its instability will increase, and an irreversible oxidation reaction will occur. It has different sensitivities to different metal ions. Al3+, Fe3+, Cu2+, etc. play an inducing catalytic role in its oxidation, and contact needs to be avoided during application.
COA Of Vine Tea Extract
what are the Vine Tea Extract Benefits ?
Vine Tea Extract dihydromyricetin for cancer
DHM has demonstrated multi-mechanism potential in cancer intervention. Studies have shown that DHM can effectively inhibit the progression of various cancers, including lung cancer, hepatocellular carcinoma, and breast cancer, by suppressing tumor angiogenesis, inhibiting cell proliferation, inducing apoptosis, and inhibiting cancer cell invasion and migration. At the molecular level, Vine Tea Extract DHM can precisely regulate key mammalian signaling pathways and inhibit the epithelial-mesenchymal transition (EMT) process, thereby interfering with the malignant evolution of tumors at multiple stages.
Simultaneously, DHM Dihydromyricetin has a bidirectional regulatory effect on autophagy, exhibiting differentiated effects in different cancer types. Notably, when DHM is used in combination with clinical anticancer drugs such as doxorubicin and nedaplatin, it can significantly enhance efficacy and reverse tumor drug resistance, demonstrating good adjuvant therapeutic value.
Vine Tea Extract dihydromyricetin for skin
DHM, as a RAGE inhibitor, may delay skin aging. Studies have shown that DHM can effectively alleviate D-galactose-induced skin aging symptoms in rats, significantly improve skin elasticity and maintain collagen content, while promoting skin cell proliferation. In in vitro experiments, DHM powder treatment increased the proliferation capacity of senescent fibroblasts induced by advanced glycation end products (AGEs) by approximately 1.5 times and significantly reduced the expression of multiple aging-related biomarkers.
The core molecular mechanism lies in Vine Tea Extract 's ability to downregulate the expression of the AGER gene encoding the RAGE receptor and, with its high binding affinity, directly bind to RAGE, thereby competitively inhibiting the AGE-RAGE signaling pathway and its downstream cascade reactions, while simultaneously upregulating the expression of genes related to cell cycle and DNA repair.
Vine Tea Extract for Antioxidant Activity
Relevant researchers from our team have shown that our Vine Tea Extract has significant antioxidant capabilities. Among them, laboratory testing found that KINTAIBIO® dihydromyricetin has a scavenging rate of 73.3% to 91.5% of stable free radicals DPPH, and can inhibit linoleic acid peroxidation at a concentration of 0.01% to 0.04%. Its effect is similar to that of synthetic antioxidants. Oxidant TBHQ is comparable or even better. Its antioxidant mechanism in the linoleic acid peroxidation system triggered by FeSO4 is to complex Fe²⁺, thereby preventing the peroxidation reaction triggered by Fe²⁺.
In addition, it can effectively inhibit lipoxygenase, with a half inhibitory concentration (EC50) of 6.7 to 74.1 mmol, showing competitive inhibition of linoleic acid at the active site of lipoxygenase. It has a strong scavenging effect on free radicals O2⁻, ROO⁻ and OH⁻. Its scavenging ability for DPPH free radicals is stronger than vitamin C (Vc), and it significantly increases SOD (superoxide dismutase) activity. , reducing the MDA (malondialdehyde) content.
Vine Tea Extract for Antibacterial activity
KINTAIBIO®'s vine tea extract dihydromyricetin has broad-spectrum antibacterial effects on a variety of Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Fu Shigella, Bacillus subtilis, Klebsiella pneumoniae, Proteus mirabilis and Salmonella paratyphi b all showed significant antibacterial effects, and the minimum inhibitory concentration (MIC) was low.
Vine Tea Extract for Anti-inflammatory and anti-allergic effects
KINTAIBIO® researchers found that Vine Tea Extract dihydromyricetin has significant anti-inflammatory and anti-allergic effects. It inhibits the dilation and increase of permeability of auricular blood vessels in a dose-dependent manner, reduces the degree of edema, and shows strong efficacy. Inhibitory effect on acute inflammation. Its anti-inflammatory and anti-allergic mechanism mainly inhibits the production of leukotrienes, a metabolite of arachidonic acid, inhibits the synthesis or release of histamine, and scavenges oxygen free radicals.
Vine Tea Extract for Inhibition of tyrosinase activity
Researchers found that this ingredient has a significant inhibitory effect on the monophenolase and diphenolase of tyrosinase, with inhibition rates of 95.87% and 69.01% respectively. Vine Tea Extract DMY inhibits monophenolase by prolonging the lag time of the enzyme-catalyzed reaction (from 0.38 minutes to 0.97 minutes), and the inhibition of diphenolase shows a reversible mixed inhibition mode, indicating that dihydromyricetin is a natural tyrosinase Inhibitors.
Reference:https://www.mdpi.com/2072-6694/14/14/3487
https://www.mdpi.com/2072-6643/17/11/1862
what are the Vine Tea Extract uses?
According to the latest pharmacological experiments, Vine tea extract has the following effects on health:
1)antioxidant
2)Anticancer and anti-tumor effect
3)Liver and kidney protection
4)Hypolipidemic and hypotensive effects
5)Enhance and regulate immune function
6)Anti-inflammatory and bacteriostatic effects
7)Antithrombotic effect
Diversified application prospects
With our breakthrough in Vine tea extract extraction technology, these high-content DHM products can not only be used as the main ingredients of health products and functional foods, but can also be widely used in personal care, feed additives, agricultural seed growth regulators and other fields. By fully developing the diverse value of rattan tea extracts, we provide sustainable and healthy solutions for various industries.
★If you want to get high-quality Vine Tea Extract, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
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