Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of rosmarinic acid powder in China. Please feel free to wholesale high quality rosmarinic acid powder for sale here from our factory. For price consultation, contact us.
Rosmarinic Acid Powder manufacturer
As a manufacturer dedicated to the R&D and production of Rosmarinic Acid Powder, KINTAIBIO® offers you high-quality, naturally derived polyphenolic compounds. Our product specifications span a purity gradient ranging from 5% to 98% Rosmarinic Acid: lower-concentration grades (5%–60%) present as a yellow powder, while the high-purity grade (98%) appears as a white powder, thereby meeting the diverse requirements for active ingredient concentrations across various industries. We strictly select rosemary leaves (Rosmarinus officinalis) as our extraction source-an evergreen shrub belonging to the Lamiaceae family-whose leaves have traditionally been used for food flavoring, while modern extraction technologies enable the efficient enrichment of rosmarinic acid from this plant material.
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Experimental results indicate that rosemary extract rosmarinic acid possesses mild anti-thrombotic properties; its mechanism of action may be linked to the inhibition of platelet aggregation and an increase in fibrinolytic activity. Furthermore, it effectively protects cells against free radical damage and demonstrates a wide spectrum of health benefits, including anti-inflammatory and antimicrobial effects, immune system support, skin health maintenance, digestive health promotion, neuroprotection, and cardiovascular health support. Additionally, it exhibits anti-allergic and anti-anxiety properties, aids in blood sugar management and weight control, and contributes to anti-aging efforts. In terms of application, our Rosmarinic Acid Powder serves as a natural food preservative, an active ingredient in cosmetics, a raw material for health supplements, and an intermediate for pharmaceutical formulations; it is also widely utilized in pet nutrition, animal health products, and dietary supplements.
Rosmarinic acid raw material
Rosmarinus Leaf Extract
98% Rosmarinic acid
Rosmarinic acid sample
The Rosmarinic Acid Powder we supply features excellent water solubility and superior stability. Our standardized extraction process ensures consistent bioavailability across different production batches; lower-concentration products appear as a light brown powder, while higher-concentration products present as white. As a professional supplier of rosmarinic acid extract Powder in China, our company's key strengths include: over a decade of specialized extraction expertise, with a dedicated focus on the in-depth development of rosemary-derived products; highly competitive factory-direct wholesale pricing; and comprehensive product customization services-including various purity specifications and OEM/ODM manufacturing (such as capsules, tablets, and custom formulations)-enabling us to flexibly meet a wide spectrum of requirements, ranging from laboratory R&D to large-scale commercial production.You are welcome to contact our team at sales@kintaibio.com.
Rosmarinic Acid Powder plants sources
KINTAIBIO® as rosmarinic acid supplier Advantage
- Own planting base to ensure a stable supply of raw materials and cost advantages.
- Fresh leaf processing, and counter-current extraction, improve yield and extraction efficiency.
- In-depth development and comprehensive utilization to reduce the monomer cost of active ingredients.
- Multiple specifications are available from stock, and special requirements can be customized on demand: 18-98% Rosmarinic Acid Powder is available from stock.
- We can provide you with product customization services based on your market requirements, such as product solubility, color, application concentration dosage, etc.
98% rosmarinic acid manufactured by KINTAIBIO®
Certificate of Analysis of Rosmarinic Acid Powder
How to make Rosmarinic Acid Powder?
Raw Material Pre-treatment and Freeze-Drying
First, fresh or dried rosemary stems and leaves undergo pulping to form a uniform slurry. Immediately following pulping, the material is transferred to an industrial-grade vacuum freeze-dryer for deep dehydration. The freeze-drying temperature is strictly controlled between -70°C and -80°C, with a freezing duration of 40 to 60 hours and a vacuum pressure maintained between 10 and 30 Pa. Upon completion of freeze-drying, the material is pulverized to an appropriate fineness (typically 40–60 mesh) to yield a freeze-dried powder.
Ultrasonic-Assisted Extraction
Using an industrial ultrasonic extraction tank, an aqueous ethanol solution with a volume fraction of 50%–80% serves as the extraction solvent, with a solid-to-liquid ratio set between 1:50 and 1:100. The ultrasonic power is controlled within the range of 400 to 800 W, the extraction temperature is maintained between 40°C and 70°C, and the extraction duration is 30 to 120 minutes. After the extraction is complete, the mixture is discharged; the extraction process may be repeated 1 to 2 times, and the resulting extracts are combined to obtain a crude rosemary acid extract solution.
Vacuum Filtration and Reduced-Pressure Concentration
Under a vacuum of -0.1 MPa, suction filtration is performed using double-layer filter paper with a pore size of 15–20 μm to effectively remove fine plant residues and suspended particles, yielding a clear filtrate. Subsequently, a large-scale rotary evaporator or reduced-pressure concentration tank is utilized to concentrate the filtrate under the following conditions: a vacuum of -0.1 MPa, a rotation speed of 115 rpm, an evaporation temperature of 45°C, and a circulating condensation temperature of 2°C. The majority of the ethanol is recovered for recycling, and the volume of the filtrate is concentrated to 1/10 to 1/20 of its original volume, resulting in a viscous crude rosemary acid extract (in the form of a paste).
Gel Column Chromatography Purification
The chromatography column is packed with Sephadex LH-20 gel, with the ratio of column diameter to column height strictly controlled between 1:40 and 1:60. Prior to sample loading, the crude rosmarinic acid extract is dissolved in a small volume of the starting solvent. The ratio of the sample loading volume to the gel column volume is maintained between 1:10 and 1:30, with 1:20 being preferred. The eluent consists of an ethanol solution with a volume fraction ranging from 30% to 90%; optimal conditions utilize 90% ethanol, with an elution volume of 2 to 3 column volumes and a flow rate set at 1.0 mL/min. During this process, impurities are preferentially eluted, yielding a high-purity rosmarinic acid eluate.
Post-processing and Drying
The purified eluate undergoes a second round of vacuum concentration to remove the ethanol and is further concentrated into an aqueous phase. For products with lower rosmarinic acid content, spray drying is employed to rapidly obtain a yellow rosmarinic acid powder; conversely, for high-content products, vacuum drying or freeze drying is utilized to yield a white to off-white, high-purity rosmarinic acid product. Throughout the entire drying process, temperature is strictly controlled to prevent thermal degradation. Once the final product has passed quality inspection, it is hermetically sealed in accordance with standard packaging specifications and stored in a cool, dry place away from light.
what is Rosmarinic Acid Powder good for?
Rosmarinic Acid Powder for antioxidant
In terms of antioxidant activity, Rosmarinic Acid Powder-a natural polyphenolic organic acid-demonstrates exceptional free radical-scavenging capabilities in cell-free systems. Studies indicate that rosmarinic acid and its two primary metabolites exhibit DPPH radical-scavenging activity comparable to that of the classic antioxidant, quercetin; this efficacy is primarily attributed to the potent electron-donating capacity conferred by the multiple phenolic hydroxyl groups present within its molecular structure.
It is worth noting that, under physiological pH conditions, rosmarinic acid extract powder undergoes a certain degree of ionization, which may to some extent influence the efficiency of its intracellular accumulation; nevertheless, its superior performance in in vitro chemical antioxidant systems has been substantiated by extensive research.
Rosmarinic Acid Powder for anxiety
In the field of neuropsychiatric health, rosmarinic acid in rosemary has demonstrated potential as an anxiolytic and antidepressant agent. Modern research indicates that depression and anxiety have emerged as significant global health concerns; however, conventional first-line pharmaceutical treatments often suffer from limitations such as insufficient efficacy, delayed onset of action, and a high incidence of side effects. Preclinical studies have confirmed that rosmarinic acid exerts significant therapeutic effects on a range of neuropsychiatric disorders, including anxiety and depression.
Its mechanism of action does not involve direct modulation of a single neurotransmitter; rather, it is closely linked to its potent antioxidant and anti-inflammatory properties. By scavenging excessive reactive oxygen species and inhibiting neuroinflammatory responses, rosmarinic acid exerts a protective effect on the central nervous system-acting specifically via oxidative stress and inflammatory pathways-thereby alleviating anxiety- and depression-like behaviors. Furthermore, rosmarinic acid powder possesses a multifaceted pharmacological profile, encompassing cardioprotective, hepatoprotective, and neuroprotective properties, among others.
Rosmarinic Acid Powder benefits for skin
Rosmarinic Acid Powder demonstrates significant anti-inflammatory and anti-pruritic efficacy in the treatment of skin inflammation, offering particular therapeutic value for common dermatological conditions such as allergic contact dermatitis. Studies utilizing animal models of allergic contact dermatitis have shown that treatment with rosemary extract rosmarinic acid effectively attenuates epidermal hyperkeratosis and inflammatory cell infiltration, while simultaneously reducing the secretion levels of histamine and interleukin-13.
Rosmarinic acid acts by inhibiting the excessive activation and degranulation of mast cells, thereby alleviating skin itching and inflammation at the source. For patients who respond poorly to antihistamine therapies, this multi-targeted, naturally derived active ingredient offers a novel therapeutic solution. Consequently, our high-purity rosmarinic acid extract serves as a core ingredient in functional skincare formulations, anti-inflammatory and restorative serums, and anti-allergic dermatological products.
rosmarinic acid for cancer
Research indicates that rosmarinic acid exhibits a range of biological effects associated with cancer prevention and treatment, including anti-tumor, anti-angiogenic, anti-inflammatory, and antioxidant activities. These properties offer valuable leads for the development of adjunctive cancer therapies. Currently, most studies investigating the anti-cancer mechanisms of rosmarinic acid extract remain in the experimental preclinical phase and have not yet advanced to large-scale clinical trials; existing evidence, derived primarily from cell and animal models, suggests that it may inhibit tumor growth and metastasis by modulating multiple signaling pathways.
It is important to clarify that rosmarinic acid extract powder is not a direct therapeutic agent for cancer; however, its natural origin, multi-target action profile, and low potential for toxicity make it a highly promising candidate ingredient for research within the fields of functional foods, nutritional supplements, and adjunctive therapeutic products.
Reference:https://www.sciencedirect.com/science/article/abs/pii/S0887233317300164
https://www.sciencedirect.com/science/article/abs/pii/S1043661822003668
https://www.sciencedirect.com/science/article/abs/pii/S1567576923003247
https://www.sciencedirect.com/science/article/pii/S0753332223004754
what is rosmarinic acid Powder used for?
Rosmarinic Acid Powder medicinal uses
In the pharmaceutical field, rosmarinic acid extract powder-by virtue of its pharmacological properties such as anti-inflammatory, antioxidant, free radical-scavenging, and immunosuppressive effects-can be utilized to treat or aid in ameliorating various free radical-related disorders, including aging, arteriosclerosis, arthritis, allergies, coronary heart disease, and cancer; consequently, it holds broad prospects for the development of new drugs.
Rosmarinic Acid Powder supplement
rosmarinic acid in rosemary serves as a natural raw material for dietary supplements, supporting daily wellness through cardiovascular health maintenance, neuroprotection, and anti-inflammatory and antioxidant effects. Furthermore, rosmarinic acid can be developed into eye drops, providing ocular protection by reducing lipid peroxidation, mitigating DNA damage, and scavenging UV-induced free radicals. In the food industry, owing to its potent antioxidant properties, it has been developed as a natural food antioxidant used to preserve the color and prevent oxidative spoilage of oils, fat-rich foods, and food pigments.
Rosmarinic Acid Powder cosmetics
In the cosmetics sector, Rosmarinic Acid effectively guards against UV-induced damage, boosts cellular ATP levels, and safeguards the glutathione system, making it ideally suited for the formulation of sun protection and skin repair products. Our Rosmarinic Acid powder features consistent quality and excellent water solubility, offering versatile applicability across the aforementioned range of formulations and product development initiatives.
where to buy Rosmarinic Acid Powder?
As a globally trusted specialist manufacturer of Rosmarinic Acid Powder, KINTAIBIO® has dedicated over a decade to deep cultivation within the field of botanical extracts. With an annual production capacity exceeding 200 tons, the company is equipped with advanced analytical instruments-including HPLC, GC, and Atomic Absorption Spectrometry-to ensure the consistent quality of every product batch.
If you are seeking high-quality suppliers of rosmarinic acid, wish to inquire about pricing, or require wholesale rosmarinic acid powder, we offer raw materials available in various specifications-ranging from 5% to 98%-characterized by excellent water solubility and stability. You are welcome to submit a purchase inquiry for Rosmarinic Acid Powder via our official website at any time; we provide complimentary customization services and support your product development efforts with direct-from-factory pricing.
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