Lappaconitine Hydrobromide

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of lappaconitine hydrobromide in China. Please feel free to wholesale high quality lappaconitine hydrobromide for sale here from our factory. For price consultation, contact us.

KINTAIBIO^®'s Lappaconitine Hydrobromide powder is a diterpenoid alkaloid active ingredient carefully extracted and purified from the root of Aconitum sinomontanum Nakai, a plant in the Ranunculaceae family. The product is a white crystalline powder, odorless and bitter in taste. As a non-addictive analgesic raw material, this product has extremely high medicinal value and broad application prospects. High-performance liquid chromatography (HPLC) analysis shows a purity of over 98% and impurity content of less than 1%. We offer flexible packaging options to meet the needs of all levels, from laboratory research to industrial production.

Our company boasts modern production lines and a Class 100,000 cleanroom that meet GMP standards, equipped with multi-functional extraction, concentration, chromatography, crystallization, and drying equipment, achieving closed-loop control throughout the entire process from raw material pretreatment to finished product refining. We have established a rigorous quality control system, and our products have successively passed multiple international quality system certifications and product certifications, including US FDA registration, ISO9001, HACCP, and Halal. Each batch of products undergoes rigorous physicochemical testing and chromatographic analysis to ensure a high degree of consistency and stability in quality between batches, providing customers with safe, reliable, and traceable high-quality Lappaconitine Hydrobromide Powder products.

In addition to its sustained and potent analgesic effect, Lappaconitine Hydrobromide Powder also exhibits significant local anesthetic, antipyretic, and anti-inflammatory properties. Toxicological studies have confirmed that this product is non-addictive, animal studies have not shown teratogenic effects, and long-term use will not lead to cumulative poisoning. Based on its superior pharmacological properties and safety advantages, Lappaconitine Hydrobromide is widely used for postoperative pain, cancer pain, rheumatism, sciatica, toothache, gastrointestinal ulcer pain, and various moderate to severe pain. In recent years, its antiarrhythmic, anti-inflammatory, antitumor, and antiepileptic pharmacological activities have also received increasing attention.

As a leading professional supplier of plant extracts in China, KINTAIBIO^® is committed to driving corporate development through technological innovation. We have an independent R&D laboratory dedicated to providing global pharmaceutical companies with high-purity, high-quality, and highly stable Lappaconitine Hydrobromide APIs and pharmaceutical intermediates. Please contact us at sales@kintaibio.com.

• Production Excellence: Strength in manufacturing; Factory direct wholesale prices
• Quality Assurance： Strict material selection; Consistent batch stability
• Product Availability： Ready stock inventory; high purity specifications; Good water solubility
• Customer Support： Testing support; sample available

• Assay Determination by titration and HPLC 

KINTAIBIO^® selects Aconitum carmichaelii, a perennial herb belonging to the Ranunculaceae family, as its raw material. This species is mainly distributed in northwestern and central China, such as Gansu, Qinghai, Shaanxi, and Sichuan provinces, and commonly grows on grassy slopes or forest edges. To ensure the natural purity and authentic quality of the Lappaconitine Hydrobromide product from the source, our raw materials are sourced from high-altitude grasslands above 2500 meters in Xinjiang.

This region is pollution-free, has large diurnal temperature variations, and the soil is rich in minerals, allowing wild Aconitum carmichaelii to grow slowly under natural conditions, accumulating a richer amount of secondary metabolites. Thanks to this unique source and mature extraction process, the finished product, as detected by high-performance liquid chromatography, exhibits stable content and minimal batch-to-batch variation, fundamentally guaranteeing the high activity and consistency of each batch.

Herbal Base of Aconitum sinomontanum Nakai

Aconitum sinomontanum Nakai

Roots of Aconitum sinomontanum Nakai

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According to the latest pharmacological experiments, Lappaconitine hydrobromide has the following effects on health:

Lappaconitine Hydrobromide For analgesic

Lappaconitine is a diterpenoid alkaloid with analgesic activity, and its analgesic effect is closely related to the regulation of the voltage-gated sodium ion channel Nav1.7. Recent structural optimization studies using lappaconitine as the parent nucleus have shown that modification of the 20-N position significantly enhances its inhibitory ability on the human Nav1.7 channel. The representative derivative exhibits an 8.6-fold increase in inhibitory activity against Nav1.7 compared to lappaconitine, and further enhances its inhibitory effect on sodium current and action potential firing in dorsal root ganglion (DRG) neurons.

In a mouse model of postoperative pain, this derivative showed superior relief of mechanosensitive hyperalgesia compared to lappaconitine, while its acute safety margin was increased by more than 10 times. This demonstrates the good potential for developing novel analgesics based on lappaconitine and further proves the important research value and application prospects of lappaconitine as a natural diterpenoid alkaloid in the field of pain management.

Lappaconitine Hydrobromide For Anti-inflammatory

Aconitum root extract lappaconitine has anti-acute and chronic inflammatory effects;Recent metabolomics studies have provided more in-depth molecular-level evidence for the inflammatory analgesic mechanism of apigenin hydrobromide. Researchers systematically investigated its analgesic effect by treating rats with different doses of apigenin hydrobromide. Behavioral results showed that both doses of apigenin hydrobromide significantly shortened the paw withdrawal latency (PWL) in rats, indicating a clear analgesic effect. Histological sections further confirmed that the drug effectively reduced inflammation and swelling in the rat paws and ankles, and no significant abnormalities were observed in the dorsal root ganglion (DRG) tissue, suggesting good targeting and safety.

Metabolic analysis revealed that in inflammatory pain states, retinol and glycerophospholipid metabolism in the rat dorsal root ganglion are significantly affected, which may exacerbate the inflammatory response and induce persistent pain. After treatment with apigenin hydrobromide, α-linolenic acid metabolism was upregulated, while retinol metabolism was downregulated. These results collectively indicate that hydrobromide can effectively alleviate inflammatory pain, and its mechanism of action may be closely related to its regulation of lipid metabolism in the dorsal root ganglion of rats.

lappaconitine hydrobromide for lung

Recent studies have shown that lappaconitine hydrobromide exhibits potential protective effects in inflammatory lung injury. Research has found that LAH can act as a novel NR1H3 agonist, enhancing NR1H3 transcriptional activity and inhibiting TLR4 aggregation on lipid rafts, thereby blocking the activation of the TLR4-NLRP3 signaling pathway and further reducing NLRP3 inflammasome assembly and GSDMD-mediated pyroptosis.

In vitro and in vivo experiments showed that LAH significantly inhibited the activation of inflammation-related signals and alleviated inflammatory responses and pyroptosis by regulating the NR1H3-NLRP3-GSDMD axis. It effectively alleviated inflammatory lung tissue damage in a lipopolysaccharide- and cecal fecal plasma-induced mouse sepsis-related acute lung injury model. Transcriptomic and bioinformatics analyses further confirmed that genes related to interleukin-1β production, inflammatory response regulation, and innate immune responses underwent significant changes after LAH treatment, indicating that lappaconitine hydrobromide has potential research value in regulating lung inflammation and maintaining lung tissue homeostasis.

In addition, Lappaconitine Hydrobromide also has the following benefits:

• The anti-arrhythmic effect can significantly improve myocardial ischemic arrhythmia, thereby reducing the incidence of arrhythmia;
• Cooling and eliminating fever: It has a significant antipyretic effect on various types of fever and its cooling effect is equal to aspirin and other Western medicines.

Reference:https://www.sciencedirect.com/science/article/abs/pii/S0223523426001996

https://www.mdpi.com/2218-1989/12/10/923

https://www.sciencedirect.com/science/article/pii/S2095177926000869

Lappaconitine and its salt form, lappaconitine hydrobromide, have broad application prospects in clinical and drug development fields.

After long-term clinical application validation, lappaconitine hydrobromide has become a safe and effective non-addictive analgesic, mainly used to relieve cancer pain, postoperative pain, toothache, dysmenorrhea, and other moderate to severe pain. It can be prepared in various dosage forms such as tablets, injections, powders, and patches. In addition to its analgesic effect, it also has certain anti-inflammatory and anti-swelling effects.

In the cardiovascular field, lappaconitine hydrobromide is also used in research and clinical treatment of arrhythmias, and can be used to treat diseases such as premature ventricular contractions, atrial fibrillation, supraventricular tachycardia, and ventricular tachycardia.

Furthermore, as an active ingredient derived from natural plants, lappaconitine and its derivatives have received continuous attention in recent years in pain management, inflammation regulation, and related innovative drug development, demonstrating good application value and development potential.

In Russia and other countries, lappaconitine hydrobromide is also used as a clinical first-line drug for the treatment of arrhythmias such as ventricular premature beats, atrial fibrillation, supraventricular and ventricular tachycardia. Its preparations have become a new non-addictive analgesic drug independently developed by China, and are moderate analgesics specified in the "Guidelines for the Three-Step Pain Relief Therapy for Cancer Patients" of the Ministry of Health of China.

• Houginine hydrobromide tablets: 5 mg; 10 mg.
• Hovenine hydrobromide for injection: 4 mg; 8 mg.
• Urine hydrobromide injection: 4mg/2ml; 8mg/2ml.
• Urumine hydrobromide glucose injection: 250 ml (4 mg urine hydrobromide, 12.5 grams of 5) glucose); 500 ml (8 mg urine hydrobromide, 25 grams of glucose)

Lapaconitine Hydrobromide Safety

Lappaconitine and its salt preparations have a long history of research and clinical application in the field of analgesia, and generally have a good safety profile when used under standardized conditions.

Lappaconitine Hydrobromide Dosage

The specific dosage should be determined by a professional medical practitioner based on the dosage form, route of administration, indications, and individual patient conditions. Self-adjustment of the dosage is not recommended.

Lappaconitine Hydrobromide Side Effects

Existing research and clinical data show that adverse reactions to Lapaconitine Hydrobromide-related preparations are usually mild and reversible. Common manifestations include nausea, vomiting, gastrointestinal discomfort, dizziness, headache, rash, itching, and transient palpitations or tachycardia. Most symptoms can be relieved after discontinuation of the drug or adjustment of the dosage.

In rare cases, especially with high doses or injection, allergic reactions, arrhythmias, or other cardiovascular abnormalities may occur. Therefore, cardiovascular and neurological function should be monitored during use.

Drug Interactions with Lapaconitine Hydrobromide

Lapaconitine Hydrobromide should be avoided in individuals with known hypersensitivity to lappaconitine or its related components. Furthermore, its use in combination with medications that may affect cardiac conduction or the central nervous system should be under the guidance of a qualified medical professional.

In general, the safety of lappaconitine products should be comprehensively assessed considering the specific formulation, dosing regimen, and individual differences, and should be used in accordance with relevant regulations and medical guidelines to ensure its effectiveness and safety.

As the source manufacturer of Lappaconitine Hydrobromide powder, KINTAIBIO^®'s has the following production advantages:

why choose our products?

 

• Efficient extraction process: We use thermal reflux extraction technology, combined with alkalization and solvent extraction processes, to efficiently extract crude extracts from Aconitum root, improving extraction efficiency.

 

• Fine purification process: Through hydrochloric acid acidification and anhydrous sodium carbonate alkalization process, impurities can be effectively removed to obtain high-purity aconitine crude alkali, ensuring the quality and purity of the product.

 

• Impurity removal technology: The use of chromatographic alumina filtration to adsorb impurities can further purify the filtrate, reduce the impurity content, and improve the purity and quality of the product.

 

• Crystallization refining process: Using static crystallization and vacuum drying technology, the crystals can be fully crystallized and finely washed to obtain high-quality coarse crystals, which provides good raw material conditions for subsequent fine processing and reactions.

 

• Environmentally friendly and efficient: Our new process not only improves production efficiency and product quality, but also pays attention to environmental protection, reduces the emission of waste and pollutants, and is in line with the modern green production concept.

The above process enables us to produce high-quality, high-purity Lappaconitine Hydrobromide Powder , which meets our customers' needs for product quality and purity, while also improving our production efficiency and reducing production costs.

If you want to purchase high-quality Aconitum root extract Lappaconitine hydrobromide, please feel free to contact us at sales@kintaibio.com or feedback on the next page.

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