Lappaconitine Hydrobromide

We are a plant extraction factory specializing in the production of high-content active pharmaceutical ingredients (API). Over the past decade, we have focused on the production and refining of Aconitum root extract Lappaconitine Hydrobromide, and have used cutting-edge technology and strict quality control to meet the highest industry standards.

Homoaconitine Hydrobromide is an alkaloid that we carefully extract from the roots of Ranunculaceae plants, especially Aconitum. This powerful compound is mainly used as an intermediate ingredient for the treatment of arrhythmia and analgesia, and we ensure its purity and stability to achieve its therapeutic effects. Our Aconitum root extract is a fine white crystalline powder with less than 1% impurities, and it has been jointly tested by us and related pharmaceutical companies and found that it is not addictive to the human body, and its impurities have no adverse effects on the human body.

In a decade of development and research, KINTAI has successfully overcome key technical obstacles, achieved ultra-high purity levels and eliminated impurities in each batch. Our strict requirements for quality and commitment to customers ensure that each product meets strict pharmaceutical grade standards, providing global pharmaceutical manufacturers with an effective and safe pharmaceutical intermediate ingredient. As a trusted source of plant APIs, we have maintained a leading position in the field of plant extraction expertise and have become the largest producer of Aconitum root extract in China.

• Production Excellence: Strength in manufacturing; Factory direct wholesale prices
• Quality Assurance： Strict material selection; Consistent batch stability
• Product Availability： Ready stock inventory; high purity specifications; Good water solubility
• Customer Support： Testing support; sample available

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• Assay Determination by titration and HPLC 

All of Kintai's Aconitum sinomontanum Nakai roots grow on the alpine grasslands of Xinjiang above 2500 meters above sea level, pollution-free, green, and organic. Every year, we purchase about 200 tons of Aconitum sinomontanum Nakai roots from Xinjiang, and produce more than 800 kg of lappaconitine with a content of more than 96%.

Herbal Base of Aconitum sinomontanum Nakai

Aconitum sinomontanum Nakai

Roots of Aconitum sinomontanum Nakai

According to the latest pharmacological experiments, Lappaconitine hydrobromide has the following effects on health:

The analgesic effect: without obvious toxicity and addiction;

Anti-inflammatory effect: Aconitum root extract lappaconitine  has anti-acute and chronic inflammatory effects;

The anti-arrhythmic effect can significantly improve myocardial ischemic arrhythmia, thereby reducing the incidence of arrhythmia;

Cooling and eliminating fever: It has a significant antipyretic effect on various types of fever and its cooling effect is equal to aspirin and other Western medicines.

26 years of clinical application have proved that lappaconitine hydrobromide is an analgesic with a wide range of applications. It is mainly used clinically to treat moderate or above pain caused by various reasons, such as cancer pain, surgical pain, toothache, dysmenorrhea, etc. Whether our powder raw materials are made into tablets, water injections, powder injections, or patches, it has the effects of local anesthesia, cooling, antipyretic, anti-inflammatory, and detumescence. More importantly, it is non-addictive and has no side effects. It is a safe natural plant-extracted pharmaceutical raw material.

In Russia and other countries, lappaconitine hydrobromide is also used as a clinical first-line drug for the treatment of arrhythmias such as ventricular premature beats, atrial fibrillation, supraventricular and ventricular tachycardia. Its preparations have become a new non-addictive analgesic drug independently developed by China, and are moderate analgesics specified in the "Guidelines for the Three-Step Pain Relief Therapy for Cancer Patients" of the Ministry of Health of China.

1) Houginine hydrobromide tablets: 5 mg; 10 mg.
2) Hovenine hydrobromide for injection: 4 mg; 8 mg.
3) Urine hydrobromide injection: 4mg/2ml; 8mg/2ml.
4) Urumine hydrobromide glucose injection: 250 ml (4 mg urine hydrobromide, 12.5 grams of 5) glucose); 500 ml (8 mg urine hydrobromide, 25 grams of glucose)

As the source manufacturer of Lappaconitine Hydrobromide powder, KINTAI's has the following production advantages:

why choose our products

 

Efficient extraction process: We use thermal reflux extraction technology, combined with alkalization and solvent extraction processes, to efficiently extract crude extracts from Aconitum root, improving extraction efficiency.

 

Fine purification process: Through hydrochloric acid acidification and anhydrous sodium carbonate alkalization process, impurities can be effectively removed to obtain high-purity aconitine crude alkali, ensuring the quality and purity of the product.

 

Impurity removal technology: The use of chromatographic alumina filtration to adsorb impurities can further purify the filtrate, reduce the impurity content, and improve the purity and quality of the product.

 

Crystallization refining process: Using static crystallization and vacuum drying technology, the crystals can be fully crystallized and finely washed to obtain high-quality coarse crystals, which provides good raw material conditions for subsequent fine processing and reactions.

 

Environmentally friendly and efficient: Our new process not only improves production efficiency and product quality, but also pays attention to environmental protection, reduces the emission of waste and pollutants, and is in line with the modern green production concept.

The above process enables us to produce high-quality, high-purity aconitine hydrobromide powder, which meets our customers' needs for product quality and purity, while also improving our production efficiency and reducing production costs.

If you want to purchase high-quality Aconitum root extract Lappaconitine hydrobromide, please feel free to contact us at sales@kintaibio.com or feedback on the next page.

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