Dl Tetrahydropalmatine

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Dl tetrahydropalmatine also known as tetrahydropalmatine, tetrahydropalmatine. There are analgesic, sedative, hypnotic and stable effects. The analgesic effect is weaker than pethidine and morphine, but less addictive, and stronger than general antipyretic analgesics. The analgesic effect is good for chronic persistent dull pain, and the analgesic effect is poor for traumatic or postoperative pain or advanced cancer pain. Corydalis hydrochloride is the main active substance of Corydalis Corydalis, which has a significant effect on pain caused by gastrointestinal system and hepatobiliary system, and can also relieve labor pain, headache, concussion headache, etc. It is also used to eliminate mental tension such as irritability and anxiety and to treat neurasthenic insomnia.

Tetrahydropalmatine belongs to the group of isoquinoline alkaloids. It is an alkaloid extracted from the tuber of Chinese medicine Corydalis Corydalis. Colorless or light yellow flaky crystal, odorless, slightly bitter taste. The melting point is 147-149°C. When exposed to light, the color gradient becomes darker. Very easily soluble in ether, chloroform, soluble in ethanol, almost insoluble in water or alkali solution. Its hydrochloride and sulfate are soluble in water. It is a racemate. Effective is the levorotatory form, called Chemicalbook craniodin. The melting point is 147°C. The melting point of water of crystallization is 115°C.

Health benefits

According to the latest pharmacological experiments,Tetrahydropalmatine (dl-THP, tetrahydropalmatine)has the following effects on health:

It has analgesic, sedative, hypnotic and tranquilizing effects. Analgesic effect is not as good as pethidine, but stronger than general antipyretic and analgesic drugs.

The dull pain relieving effect of gastrointestinal and hepatobiliary system diseases is good, but the effect of acute pain such as trauma is poor.

It is used to relieve labor and dysmenorrhea.

It has good hypnotic and sedative effects. It can be used for temporary insomnia because it can fall asleep 20 to 30 minutes after taking it and last for 5 to 6 hours.

Application

Used in the field of medicine.

Vinegar corydalis slices

Compound Corydalis Tuberand Aluminium Hydroxyde Tablets

 Clinical application

1). The electrophysiological effect of intravenous injection of dl-THP on supraventricular tachycardia (SVT). It has no obvious effect, it prolongs the time of bypass pretransmission and the effective refractory period of bypass pretransmission, significantly prolongs the effective refractory period of atrium, and the effective rate of preventing programmed electrical stimulation from inducing SVT is 77.8%.
2). Antiarrhythmic effect
(1) Treatment of atrial fibrillation, such as rheumatic heart valve disease, coronary heart disease, hypertension.
(2) For paroxysmal supraventricular tachycardia: intravenous injection of dl-THP can quickly convert or slow down the ventricular rate for rapid supraventricular arrhythmia, especially for paroxysmal atrial fibrillation. There was a significant difference in heart rate slowdown after medication compared with before medication, and there was no serious side effect.
3). Antihypertensive effect
dl-THP has an effective antihypertensive effect, both systolic and diastolic blood pressure are significantly reduced, and the effect is long-lasting. Its antihypertensive mechanism is to relax blood vessels by inhibiting the voltage-dependent calcium channels present on the smooth muscle cell membrane, and it may be related to the blocking effect of dl-THP on α receptors.
4). Treatment of intractable hiccups.
5). Treat severe cough.
6). Dl tetrahydropalmatine acupoint injection in the auxiliary treatment of children with autumn diarrhea.
7). The combination of traditional Chinese and western medicine treats intractable nervous headache.

8). dl -THP treatment of angioneurotic headache.

Prepared from palmatine, the reaction formula is as follows:

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