Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of androtec andrographolide in China. Please feel free to wholesale high quality androtec andrographolide for sale here from our factory. For price consultation, contact us.
1. Product Description
The Androtec Andrographolide powder produced by Kintai is extracted from the natural plant Andrographis paniculata. The main specifications are 10%, 20% and 98% andrographolide. It has been included in the pharmacopoeias of China, Europe and the United States. In the Chinese Pharmacopoeia, it has the effects of removing heat and detoxification, anti-inflammatory and analgesic. It also has special effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. It is one of the effective functional raw materials in the medical and cosmetic fields.
The solubility of andrographolide produced by Kintai: soluble in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water. The melting point is 224-230℃.
Andrographolide Suppliers
Kintai is committed to producing and providing you with the best Andrographolide. We provide bulk wholesale prices, conventional packaging room 25/kg cardboard barrels, sealed at room temperature, light-proof and moisture-proof storage can be stored for 24 months. If you are interested in our andrographolide, please contact us now to get a free sample!
KinTai Andrographis origin
Andrographis
Dried andrographis
Andrographolide
Product Quality Standard of Andrographolide：
|
Product name |
Andrographolide |
|
Extract source |
Andrographis paniculata whole grass or leaves |
|
Extraction Solvent |
Ethyl alcohol |
|
Appearance |
White powder |
|
Solubility |
Dissolve in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water or ether. |
|
Identification |
TLC , HPLC |
|
Sulphated Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NMT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay of Andrographolide (HPLC test, percent, Standard in House) |
Min. 98.0% |
|
Residual Solvents |
|
|
- N-hexane |
NMT 290 PPM |
|
- Methanol |
NMT 3000 PPM |
|
- Acetone |
NMT 5000 PPM |
|
- Ethyl Acetate |
NMT 5000 PPM |
|
- Ethanol |
NMT 5000 PPM |
|
Pesticide Residues |
|
|
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT) |
NMT 0.05 PPM |
|
- Aldrin, Endrin, Dieldrin |
NMT 0.01 PPM |
|
Microbiological Quality (Total viable aerobic count) |
|
|
- Bacteria, CFU/g, not more than |
NMT 103 |
|
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
|
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine. |
|
Shelf life |
24 months |
2. Extraction process of Andrographolide
3.HPLC detection method of Kintai andrographolide
3.1. Octadecylsilane bonded silica gel is used as filler; methanol-water (60:40) is used as mobile phase; detection wavelength is 225nm.
3.2. Preparation of reference solution:
Take an appropriate amount of reference, accurately weigh, add methanol to make a solution containing 0.1mg per 1ml, and obtain.
3.3. Preparation of test solution:
Take about 25mg of this product, accurately weigh, place in a 50ml volumetric flask, add methanol to dissolve and dilute to the scale, shake well. Accurately measure 5ml, place in a 25ml volumetric flask, add methanol to dilute to the scale, shake well, and obtain.
3.4. Determination method:
Accurately aspirate 10μl of reference solution and test solution respectively, inject into liquid chromatograph, determine, and obtain.
4. Benefits and Application
4.1 Health Benefits
According to the latest pharmacological experiments,Androtec Andrographolide has the following effects on health:
✔️ Microbial action of disease resistance agent.
✔️ Antipyretic action.
✔️ Anti-inflammatory effect.
✔️ Antifertility.
✔️ Cholagogic and liver protective effects.
✔️ Antitumor activity.
4.2 Application
The main active ingredients of Andrographis paniculata are diterpene lactones, which have anti-inflammatory, antibacterial, and antiviral effects. Among them, andrographolide and dehydroandrographolide have the highest content, and dehydroandrographolide is the most effective one in andrographolide compounds. Drugs made from andrographolide or dehydroandrographolide and their derivatives, such as andrographolide tablets, Chuanhuning injection, Yanhuning injection, etc., have been widely used clinically.
4.3 Clinical application
(1) Treatment of various infectious diseases;
(2) Treat typhoid fever;
(3) Treat pneumonia and other respiratory inflammation;
(4) Treatment of infantile dyspepsia and bacillary dysentery;
(5) Treatment of neurodermatitis and eczema;
(6) Cure snakebite.
5. What are the pharmacological effects of andrographolide related to COVID-19?
5.1 Anti-inflammatory and antipyretic effects
The diterpene bicyclic ring and five-membered lactone ring in the structure of Androtec Andrographolide are essential structures for its anti-inflammatory and antipyretic activity, and the position and number of double bonds determine the strength of its anti-inflammatory activity. Compounds with intracyclic double bonds have stronger anti-inflammatory effects than compounds with exocyclic double bonds. At the same time, structural modification of hydroxyl groups also has a greater impact on anti-inflammatory activity.
5.2 Antiviral effect
The mechanism of action mainly includes:
① Occupy the viral replication DNA and protein binding sites, prevent protein from encapsulating DNA fragments, so that the virus cannot replicate normally;
② Inhibit the cleavage of glycosyl protein fluorescent peptides on the surface of the viral envelope, and prevent the virus from invading cells;
③ Affect the virus-induced retinoic acid-induced gene protein I-like receptor (RLRs) signaling pathway.
5.3 Immunomodulatory effect
Andrographolide is a nonspecific immune function regulator that can activate macrophages (a type of immune cell) and promote the growth of lymphokine-activated killer cells LAK, help remove harmful substances, and improve immunity.
5.4 Cardiovascular protection
Andrographolide can also play a cardiovascular protective role, the mechanism includes:
① inhibiting inflammation;
② reducing plasma cholesterol levels;
③ regulating cholesterol synthesis;
④ improving the body's antioxidant capacity, regulating myocardial cell energy production, and affecting the balance of vasoactive substances;
⑤ inhibiting coagulation factors and thrombin activity, reducing fibrinogen content, and enhancing fibrinolytic activity.
5.5 Liver protection
Andrographolide reduces the degree of liver fibrosis, inhibits inflammatory response, and also plays an effective protective role in cholestatic liver damage.
6.Kintai-Factory
7.Kintai R&D center
8.Packing and shipping
9. Where to buy Andrographolide?
★If you want to get high-quality Androtec andrographolide, please feel free to contact us at cheney@kintaibio.com or feedback on the next page.
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