Kintaibio® Herbal Loquat Leaf Extract Ursolic Acid Powder Manufacturer
Herbal Loquat Leaf Extract Ursolic Acid Powder, a standardized botanical extract sourced from the leaves of Eriobotrya japonica (Loquat). Utilizing advanced extraction and purification technologies, including solvent extraction and macroporous resin separation, we efficiently concentrate Ursolic Acid, the primary bioactive constituent.
To cater to diverse formulation needs, we offer this high-quality ursolic acid powder for sale in two primary standardized specifications: 25% and 90%. This ingredient is ideally suited for dietary supplements, functional foods, and liquid formulations, where it is primarily utilized to support respiratory wellness and promote overall immune health, capitalizing on the traditional use of loquat leaf.
When is our Herbal Loquat Leaf Extract Ursolic Acid Powder suitable for your product development?
We recommend prioritizing our loquat leaf extract ursolic acid powder in the following scenarios:
- When your product is clearly positioned for respiratory health: If you are developing products targeting respiratory support such as coughs and sore throats, loquat leaf extract has a clear history of traditional use and is a focus of modern research, making it a more direct and reliable raw material choice.
- When pursuing a positioning of "plant tradition + modern science": If your brand philosophy emphasizes the combination of the traditional plant origins of the ingredients with modern standardized production, this product perfectly embodies this narrative, aligning with the European and American markets' perception of "Traditional Herbal Medicine" and the "Clean-label" trend.
- When flexible purity and cost options are required: You can flexibly choose from our strengths ranging from 25% to 90% based on the final product's dosage form (e.g., high purity for tablets, low purity for liquids) and budget. We can also customize the content to match your product, ultimately achieving the best cost-effectiveness.
We are committed to providing high-quality, standardized plant raw materials and look forward to cooperating with you. For more information or a quote, please contact our team at sales@kintaibio.com
What is the Common source of ursolic acid?
Ursolic acid (UA) is a naturally occurring pentacyclic triterpenoid compound widely distributed in the plant kingdom. It serves as a key component in the waxy coatings of many fruits and leaves, playing a protective role for the plant. For industrial sourcing, ursolic acid is commonly extracted from several key botanical categories, making it accessible for commercial-scale production.
Primary Industrial Sources of Ursolic Acid:
- Fruit : Apple peels are one of the most well-known sources, though concentration can be variable. Other fruits like cranberries, prunes, and elderberries also contain ursolic acid.
- Herbs: Many herbs in the Lamiaceae family are particularly rich in ursolic acid. This includes Rosemary, Oregano, Thyme, Sage, and Lavender. Rosemary extract, often standardized for carnosic acid, is a major commercial source for ursolic acid as well.
- Traditional Botanicals (From Pharmacopoeias): Several plants listed in traditional materia medica, such as Crataegus (Hawthorn), Ligustrum (Privet), and Eriobotrya japonica (Loquat Leaf), are established and reliable sources.
From Natural Abundance to Your Reliable Raw Material
While ursolic acid is found in many plants, only a few sources are suitable for consistent, high-quality commercial extraction. The variability in content and the challenges in purification make source selection critical for manufacturers.
For businesses seeking a reliable and standardized supply, our Herbal Loquat Extract Ursolic Acid Powder offers an optimal solution. Sourced from Eriobotrya japonica, a plant with a well-documented history of use, we provide an extract that is consistently standardized to 25% or 90% Ursolic Acid. This ensures batch-to-batch consistency, simplifies your formulation process, and provides a potent, traceable ingredient for your dietary supplement and functional food products.
If you are looking for a scalable and high-purity source of Ursolic Acid, we invite you to evaluate our product for your next development project.
How to get ursolic acid? - kintaibio® extract from herbal Loquat Leaves
As a specialized manufacturer of Kintaibio® Herbal Loquat Leaf Extract Ursolic Acid Powder, we utilize an optimized and industrially scalable process to obtain high-purity Ursolic Acid from Loquat Leaves (Eriobotrya japonica).
Loquat Leaves: A Superior Source of Ursolic Acid for Kintaibio
Loquat leaves demonstrate significant advantages when selecting raw materials for ursolic acid. Research data shows that the ursolic acid content in loquat leaves is far higher than that of many other common plant resources.
Specifically, the ursolic acid content in loquat leaves can reach 1.9 times that of privet leaves, 3.5 times that of selfheal, and 3.7 times that of plantain. This means that obtaining ursolic acid from loquat leaves offers higher raw material utilization efficiency.
More importantly, the content of oleanolic acid (an isomer of ursolic acid) impurities in loquat leaves is relatively low, less than 1/4 of the total ursolic acid content. This facilitates subsequent separation and purification, making it easier to obtain high-purity ursolic acid products.
The active compounds were screened and identified. Loquat extract (LE) was flowed through Agilent TC C18 column (A) or CysLTR1-immoblized column (B) in HPLC-DAD. The standards including corosolic acid, ursolic acid and oleanolic acid were also injected into the two columns for being identified. The elute collections were analyzed based on Mass Spectra of Peak1 (C) and Peak2 / Peak3 (D)
Ursolic Acid Extraction Process from Loquat Leaves
Our method ensures high yield and consistent quality, making our product a reliable raw material for your formulations.
1. Raw Material Preparation
We start with carefully selected Loquat Leaves, which are thoroughly dried and ground into a coarse powder(20-40 mesh). This step is crucial for maximizing the surface area to facilitate efficient solvent contact in the subsequent extraction stage.
2. Solvent Extraction
A common and efficient method is Heating Reflux Extraction using food ethanol as the solvent. The process is often repeated to ensure a high yield. Our optimized parameters use 80% ethanol with a solid-to-liquid ratio of 1:6-1:8, extracting at 80-85°C for 2-3 hours with double extraction. This traditional method ensures high yield and scalability.
3. Preliminary Purification
The combined crude extracts are then filtered and concentrated under reduced pressure. We use AB-8 or HPD-100 resins with optimal adsorption conditions of pH 6-7, flow rate 2-3 BV/h. Ursolic acid is then eluted with 80-90% ethanol, achieving recovery rates exceeding 85%. Through acid-base precipitation (adjusting pH to 2-3) and recrystallization from ethanol-water systems, we obtain high-purity ursolic acid crystals.
4. Advanced Purification
To achieve our high-purity specifications (25% and 90%), we implement advanced separation technologies.
For our 90% purity specification, we employ reverse-phase C18 column chromatography with methanol-water gradient elution.
For manufacturers seeking a reliable, high-quality source of ursolic acid for nutraceutical, functional food, or cosmetic applications, Kintaibio® provides a scientifically validated, industrially-proven solution. Our technical team can provide additional process details and specification sheets to support your product development requirements.
herbal loquat extract benefits
1. Regulating Metabolism and Anti-Diabetes - herbal loquat extract weight loss
Ursolic acid exhibits significant effects in regulating blood glucose and lipid metabolism. It enhances cellular glucose uptake by reducing the activity of protein tyrosine phosphatase 1B and promoting insulin receptor phosphorylation, directly helping to lower blood glucose levels.
Clinical studies have confirmed that ingesting 150 mg of ursolic acid before breakfast for 12 to 20 weeks significantly reduced blood glucose levels, body mass index, and weight in patients. Furthermore, it upregulates PPAR-α expression, effectively lowering cholesterol and triglyceride levels by reducing fatty acid synthesis and enhancing its oxidative breakdown in the liver, thus improving obesity and insulin resistance induced by a high-fat diet.
Simultaneously, ursolic acid protects pancreatic β-cells in diabetic models, blocking the progression of insulin resistance and glucose intolerance at its source, making it a natural, multifunctional agent for managing diabetes and its complications.
Reference:
https://www.sciencedirect.com/science/article/abs/pii/S0378874122005128
https://journals.sagepub.com/doi/10.1177/09731296221137432
2. Protecting Nerves and Promoting Brain Health
Ursolic acid has a powerful protective effect on the nervous system, primarily through its antioxidant and anti-inflammatory mechanisms. It can activate the Nrf2 pathway, a key antioxidant hub in the body, helping the brain resist oxidative stress attacks such as ischemic injury.
In Parkinson's disease models, ursolic acid has been shown to repair damaged dopamine levels, enhance cognitive abilities, and directly protect dopaminergic neurons. Furthermore, by inhibiting the NF-κB inflammatory pathway and activating the PI3K/Akt/mTOR signaling pathway, it not only reduces inflammatory damage after cerebral ischemia-reperfusion but also restores the synthesis of memory-related proteins, thereby improving cognitive deficits caused by lipopolysaccharide or cerebral ischemia. It also shows promising therapeutic potential for central nervous system diseases such as Alzheimer's disease, anxiety, and depression.
3. Broad-spectrum antibacterial and biofilm-disrupting effects.
Ursolic acid possesses broad-spectrum and unique antibacterial capabilities, particularly effective against drug-resistant bacteria. It inhibits both Gram-positive bacteria (such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci) and Gram-negative bacteria (such as carbapenem-resistant Klebsiella pneumoniae).
Its most prominent value lies in its ability to disrupt and inhibit bacterial biofilm formation key factor in the development of strong antibiotic resistance in bacteria. Ursolic acid penetrates the outer cell membrane, alters the inner membrane potential, downregulates the expression of biofilm-related genes such as gtfB and gtfC, and reduces the secretion of extracellular polymers, thus re-exposing bacteria protected by biofilms.
Scanning electron microscopy reveals that ursolic acid-treated bacteria exhibit cell membrane rupture, leakage of contents, and eventual inactivation. When used in combination with antibiotics such as polymyxin, it significantly reduces the minimum inhibitory concentration (MIC) of drug-resistant bacteria, restoring bacterial sensitivity to antibiotics and providing a novel solution for combating superbug infections.
4. Combating Inflammation and Regulating Immunity
Inflammation is a common underlying condition for many chronic diseases, and ursolic acid is a potent natural anti-inflammatory agent. It can significantly reduce the production of the key inflammatory factor TNF-α and inhibit the activity of inducible nitric oxide synthase and cyclooxygenase-2, thereby reducing the release of inflammatory mediators such as nitric oxide and prostaglandins.
Studies have shown that ursolic acid exhibits potent anti-inflammatory effects in both Mycobacterium tuberculosis-infected cell models and Con-A-stimulated spleen cells. It can even exert its anti-inflammatory effect by synergistically inhibiting COX-2 in conjunction with cranberry extract. This makes it suitable not only for chronic inflammatory diseases such as arthritis but also potentially an effective adjunct to antibiotic therapy for infectious diseases like tuberculosis, comprehensively suppressing excessive immune responses by regulating signaling pathways such as TLR4/NF-κB.
5. Skin Repair and Antioxidant Protection
In skincare, ursolic acid provides deep protection by acting directly on epidermal cells. In a hydrogen peroxide-induced oxidative damage model of human epidermal keratinocytes, ursolic acid pretreatment significantly increased the activity of intracellular catalase and glutathione peroxidase, while effectively reducing the content of malondialdehyde, a lipid peroxidation end product.
This mechanism indicates that it protects skin cells from oxidative stress damage not through superoxide dismutase, but by strengthening other key antioxidant enzyme systems and inhibiting the lipid peroxidation chain reaction, thereby maintaining skin cell health and vitality, delaying the skin aging process, and playing an important role in repairing skin damage caused by sun exposure and environmental pollutants.
6. Tumor Inhibition and Apoptosis Induction
Ursolic acid has shown clear potential in the field of anti-cancer, particularly against castration-resistant prostate cancer. Studies have shown that it can inhibit the proliferation of prostate cancer DU145 cells in a concentration- and time-dependent manner and induce typical apoptotic morphological changes.
One of its core mechanisms is the activation of the mitochondrial apoptosis pathway: ursolic acid regulates the ROCK/PTEN signaling pathway, promoting the translocation of cofilin-1 protein to mitochondria, leading to the release of cytochrome C from mitochondria into the cytoplasm, which in turn activates Caspase-9 and Caspase-3 sequentially, ultimately initiating programmed cell death. Simultaneously, it can also arrest the cancer cell cycle at the G0/G1 phase, preventing it from entering the S phase of DNA synthesis, thus exerting a synergistic anti-cancer effect through multiple pathways.
7. Promotes Muscle Growth and Anti-Atrophy
Ursolic acid has been shown to directly stimulate skeletal muscle protein synthesis in response to age-related sarcopenia. Skeletal muscle is a key tissue for metabolism and movement, and its loss severely impacts quality of life and bodily function.
Studies have found that ursolic acid can promote muscle protein production, increasing muscle mass and strength by activating multiple synthetic signaling pathways, including Akt/mTOR. This has significant application value in delaying age-related muscle function decline, enhancing physical endurance, and improving mobility impairments in the elderly, making it an effective supplement for sports nutrition and geriatric health management.
What is herbal loquat extract used for?
1. Adjunctive Management of Chronic Metabolic Diseases:
As an adjunctive treatment for type 2 diabetes, obesity, and lipid metabolism disorders, it helps patients improve overall metabolic health from the pathological root cause by regulating blood glucose, blood lipids, and insulin sensitivity through multiple targets. It can be used as a safe supplement to prescription drugs.
2. What is the medicinal use of loquat leaves? -Adjunctive Treatment of Neurological Diseases:
It can be used as a dietary supplement or a potential ingredient in neuroprotective drugs to prevent and slow the progression of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. It also supports the repair of post-stroke damage, improvement of cognitive and memory function, and relief of anxiety and depression.
3. Adjunctive Treatment of Inflammation and Drug-Resistant Infections:
With its excellent anti-inflammatory and unique anti-biofilm capabilities, it can be used to develop adjunctive treatment products for chronic arthritis, refractory bacterial infections (such as MRSA and VRE infections), and tuberculosis. Combined use with traditional drugs can enhance efficacy, reduce toxicity, and combat drug resistance.
4. Functional Skincare and Damage Repair:
As a core active ingredient in high-end functional skincare products, it is used to combat environmental oxidative damage, delay photoaging, and repair damaged skin barriers. It is particularly suitable for anti-aging, sensitive skin repair, and serums, creams, and other products targeting skin problems caused by oxidative stress.
5. Cancer Adjuvant Therapy and Prevention:
In the field of oncology, it can be used as part of nutritional support and supportive therapy, especially in comprehensive management programs for prostate cancer. Its properties of inducing cancer cell apoptosis and inhibiting proliferation provide patients with additional adjuvant therapy options and prevention strategies.
6. Sports Nutrition and Management of Sarcopenia in the Elderly:
In the sports nutrition and senior health market, as a natural supplement that promotes muscle synthesis and prevents muscle loss, it is favored by athletes and the elderly for enhancing physical fitness, improving athletic performance, combating age-related sarcopenia, and improving quality of life.
7. Green Livestock and Aquaculture:
In modern aquaculture, as a natural plant-based additive, it is mixed into feed to enhance the overall immunity, disease resistance, and growth performance of livestock, poultry, and fish. Its effectiveness in preventing and treating calf pneumonia and enhancing the antiviral capacity of fish helps reduce antibiotic use and promotes antibiotic-free aquaculture and sustainable agricultural development.
where to buy herbal loquat extract ursolic acid?
Loquat extract, thanks to the multiple pharmacological activities of its core component ursolic acid, has evolved from a traditional herbal ingredient into a natural substance spanning multiple industries, including functional foods, pharmaceuticals, skincare products, and modern agriculture. Its broad application prospects are built upon a solid and continuously deepening foundation of scientific research. If you would like to know more about the price information of the bearberry acid extracted from herbal loquat leaves, please contact our team at sales@kintaibio.com.
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