Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of resveratrol powder in China. Please feel free to wholesale high quality resveratrol powder for sale here from our factory. For price consultation, contact us.
Resveratrol Powder Manufacturer
KINTAIBIO®, a professional manufacturer of high-quality resveratrol powder, produces resveratrol powder, a non-flavonoid polyphenolic organic compound. It is an antitoxin produced by many plants in response to stimulation, with the chemical formula C14H12O3. It repairs cells by activating the SIRT1 gene, and its potential benefits include cardiovascular protection, anti-cancer properties, skincare benefits, and improved neurological health. In vitro and animal studies have demonstrated that resveratrol possesses antioxidant, anti-inflammatory, anti-cancer, and cardiovascular protective effects.
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Our natural resveratrol powder sources are primarily extracted from natural plants such as grape skin resveratrol and Polygonum cuspidatum, and are available in various purity levels including 5%, 10%, 50%, and 98% resveratrol. Our high-purity 98% product is particularly suitable as a resveratrol bulk powder for the development of functional foods and dietary supplements. We also offer 99% fermented resveratrol obtained using modern bio-fermentation technology, mimicking the natural synthesis process through microbial transformation. This results in a product with high purity and avoids the risk of organic solvent residue. Furthermore, we also provide chemically synthesized 99% resveratrol, ensuring stable large-scale supply and cost advantages to meet the development needs of resveratrol products with different target markets.
In the cosmetics industry, resveratrol has been listed in the International Cosmetic Ingredient Standards Directory. Its ability to scavenge free radicals and inhibit tyrosinase and inflammatory factors makes it a core functional ingredient in whitening and anti-aging skincare products. Our high-purity resveratrol extract can be easily adapted to various serum, cream, and mask formulations. In the health food industry, it is widely used in dietary supplements and functional beverages. Due to its advantages in solubility and bioavailability, it has become an ideal raw material for capsules, tablets, and solid beverages.
COA Of Resveratrol Powder
How to make Resveratrol Powder?
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High-quality Chinese herbal medicine Polygonum cuspidatum is selected as raw material and placed in a soaking tank with sufficient purified water for 48 to 72 hours to allow the herb tissue to fully absorb water and swell, softening the cell walls. After soaking, the herb is removed, dried, and then pulverized in a grinder, passing through a 40-mesh sieve to obtain uniformly sized Polygonum cuspidatum powder.
The Polygonum cuspidatum powder is added to 10 times its volume of purified water and treated under 300 watts of ultrasound for 10 to 15 minutes to initially break down the cell walls using ultrasonic cavitation. Subsequently, 1% to 5% (by weight) of cellulase is added, and the pH of the reaction system is precisely controlled between 4.5 and 5.5 using an acidity adjuster. The enzymatic hydrolysis reaction is carried out at a constant temperature of 40 to 60°C for 60 to 120 minutes. After enzymatic hydrolysis, the precipitate is collected through solid-liquid separation.
The precipitate obtained after enzymatic hydrolysis is transferred to a supercritical extraction vessel. The extraction vessel pressure is set to 20–35 MPa and the temperature to 40–55 °C; the desorption vessel pressure is set to 5–7 MPa and the temperature to 40–55 °C. The circulation system is started, and a mixture of anhydrous ethanol and 2-propanol at a volume ratio of 7:3 to 8:2 is pumped in as a modifier. After continuous extraction for 60–120 minutes, the desorption vessel pressure is adjusted to 5–6.5 MPa and the temperature to 40–50 °C, and the extract rich in resveratrol is collected.
The obtained extract is concentrated under reduced pressure at 40–50 °C and a vacuum of -40 cmHg to -60 cmHg. The anhydrous ethanol and 2-propanol mixture modifier is recovered, yielding a concentrated filtrate containing resveratrol. The concentrated filtrate was loaded onto an activated and cleaned macroporous adsorption resin column for chromatographic separation. Utilizing the resin's selective adsorption capacity for components of different polarities, resveratrol was adsorbed onto the resin column, while impurities flowed out with the eluent. An appropriate concentration of eluent was used to desorb the resveratrol from the resin, and the high-purity target fraction was collected.
The high-purity eluent after chromatographic separation was collected and concentrated again under reduced pressure to remove the solvent, yielding a concentrated solution. This concentrated solution was transferred to a freeze-drying apparatus, where water sublimated at low temperature, ultimately obtaining a dried Resveratrol powder.
What are the benefits of resveratrol?
resveratrol skincare
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What does resveratrol do for the skin?
Based on clinical research, the efficacy of our resveratrol powder in skin whitening and anti-aging has been verified by numerous experiments.In the field of skin whitening, resveratrol has a potent inhibitory effect on human tyrosinase (IC50 of 0.39 μg/mL) and can downregulate the gene expression of MITF transcription factor and tyrosinase, interfering with their protein maturation process and reducing melanin synthesis at its source.Simultaneously, it enhances cellular antioxidant defense by activating the Nrf2 pathway and promotes the degradation of existing pigments by inducing autophagy. Human trials have confirmed that a 1% resveratrol solution can significantly reduce UV-induced skin tanning and sunburn.
Source:https://www.mdpi.com/
- Can Resveratrol reverse skin aging?
In terms of anti-aging, resveratrol can activate SIRT1, inhibit the expression of inflammatory factors and matrix metalloproteinases (MMP-1, MMP-9) induced by UV radiation or pollutants, and protect the integrity of collagen. Clinical studies have shown that after 8 weeks of use of a formula containing 0.8% resveratrol triacetate (RTA), subjects experienced a significant reduction in facial wrinkle area, wrinkle volume, and skin laxity, while skin elasticity, density, and hydration were significantly improved.
Source:https://www.mdpi.com/
resveratrol cardiovascular health
KINTAIBIO®'s resveratrol powder also plays a significant role in cardiovascular health. Resveratrol effectively reduces vascular oxidative stress by activating the SIRT1 and AMPK signaling pathways and inhibiting NADPH oxidase activity. Simultaneously, it enhances endothelial nitric oxide synthase (eNOS) activity, promoting nitric oxide production, thereby exerting vasodilatory and antihypertensive effects. Human clinical trials have further confirmed that daily supplementation with 50 mg of resveratrol for two years, in addition to standard treatment, can effectively lower blood pressure levels in patients with essential hypertension; meta-analysis shows that the antihypertensive effect is more pronounced at daily doses exceeding 300 mg.
Source:https://www.mdpi.com/
In terms of cardiovascular protection, resveratrol can inhibit the expression of inflammatory factors (IL-1β, IL-6) and reduce matrix metalloproteinase activity, thereby slowing the progression of atherosclerosis. A study on patients with symptomatic heart failure showed that after daily supplementation with 100 mg of resveratrol for three months, patients experienced significant improvements in left ventricular function indicators, decreased serum NT-proBNP levels, reduced inflammatory factors, and improvements in exercise tolerance and quality of life.
Source:https://www.sciencedirect.com/
resveratrol inflammation
As a natural polyphenolic phytoalexin, our natural resveratrol powder exerts broad-spectrum anti-inflammatory activity through multiple pathways: At the signaling pathway level, it can inhibit the phosphorylation and nuclear translocation of nuclear factor κB (NF-κB) and STAT3, thereby downregulating the expression of various pro-inflammatory cytokines such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6).
Source:https://www.mdpi.com/
Simultaneously, resveratrol powder can activate silent signaling regulator 1 (SIRT1) and AMP-activated protein kinase (AMPK), thereby enhancing cellular antioxidant defense capabilities and mitigating the inflammatory cascade driven by oxidative stress at its source. At the disease model level, the anti-inflammatory effects of resveratrol have been validated in cardiovascular diseases, metabolic diseases, respiratory diseases, and neuroinflammation.
resveratrol weight loss
The mechanism of action of resveratrol powder in weight management has been systematically elucidated. Its core lies in promoting the "browning" transformation of white adipose tissue (WAT) into brown adipose tissue (BAT). Resveratrol activates the SIRT1 and AMPK signaling pathways, thereby upregulating the expression of key transcription factors such as PRDM16 and PGC-1α, and promoting the production of uncoupling protein 1 (UCP1), thus converting white adipose tissue, primarily used for energy storage, into brown adipose tissue with thermogenic and energy-consuming characteristics.
Source:https://www.sciencedirect.com/
In this process, resveratrol powder also regulates the secretion of various adipokines and myokines: it increases the levels of irisin and fibroblast growth factor 21 (FGF21), promoting thermogenesis and energy consumption in adipose tissue; simultaneously, it regulates leptin expression, improving leptin sensitivity. Animal experiments have confirmed that resveratrol intervention can significantly reduce adipose tissue mass in high-fat diet-induced obese mice and improve insulin resistance and glucose homeostasis.
resveratrol brain health
According to a review study, resveratrol powder can maintain nervous system health through multiple pathways: in terms of antioxidation, it can directly scavenge free radicals and induce the expression of endogenous antioxidant enzymes such as heme oxygenase-1 (HO-1), enhancing the neuronal resistance to oxidative stress; in terms of anti-inflammation, it inhibits microglial activation and the release of pro-inflammatory factors (TNF-α, COX-2), reducing neuroinflammation damage to brain tissue.
Source:https://www.sciencedirect.com/
Targeting β-amyloid protein (Aβ), a key pathological feature of Alzheimer's disease, resveratrol has been shown to promote its clearance, inhibit its accumulation, improve neuronal energy metabolism by activating the AMPK and SIRT1 pathways, and simultaneously regulate cell survival signaling pathways such as PKC and PI3K/Akt, inhibiting programmed cell death. Animal model studies have shown that resveratrol intervention can alleviate cerebral ischemia-reperfusion injury, protect dopaminergic neurons from neurotoxin damage, and reduce amyloid plaque deposition in the brain of transgenic Alzheimer's mice.
resveratrol for women
Studies have shown that resveratrol has positive effects on various female infertility-related diseases. Regarding age-related infertility, animal experiments have demonstrated that resveratrol can activate ovarian SIRT1 expression, improve oocyte mitochondrial function and ATP levels, and increase the number of high-quality follicles. Human studies also suggest it may improve oocyte quality in older women.
Source:https://www.mdpi.com/
Regarding polycystic ovary syndrome (PCOS), multiple randomized controlled trials have shown that daily supplementation with 800-1500 mg of resveratrol can significantly reduce total testosterone levels, improve insulin sensitivity, regulate menstrual cycles, and increase the rate of high-quality oocytes and embryos. In endometriosis, resveratrol reduces angiogenesis and invasiveness of ectopic lesions by inhibiting the expression of COX-2, VEGF, and matrix metalloproteinases (MMP-2/9), resulting in a significant reduction in lesion volume in animal models; human studies have also confirmed its ability to reduce inflammatory factor levels.
Furthermore, in chemotherapy-induced ovarian damage models, resveratrol has shown the potential to protect follicular reserve. Although a few studies suggest caution in its use during embryo transfer cycles, most evidence supports the promising future of resveratrol as a natural adjunct to improve women's reproductive health.
resveratrol for cancer
Resveratrol powder can selectively target the mitochondria of tumor cells to exert its anti-cancer effects: it can activate the mitochondrial-mediated endogenous apoptosis pathway, upregulate the expression of pro-apoptotic proteins Bax and Bak, while inhibiting the anti-apoptotic protein Bcl-2, prompting the release of cytochrome c from mitochondria, thereby initiating a cascade reaction to induce tumor cell apoptosis. At the metabolic level, resveratrol can effectively reverse the Warburg effect specific to tumor cells, inhibiting the activity of key enzymes in aerobic glycolysis (such as hexokinase HK2), reducing glucose uptake and lactate production, and depriving tumor cells of their energy supply.
Source:https://www.mdpi.com/
Simultaneously, it exhibits selective pro-oxidative properties in tumor cells, inducing oxidative stress damage by increasing the generation of reactive oxygen species (ROS) in mitochondria, while tending to exert antioxidant protective effects in normal cells. Furthermore, resveratrol can also regulate mitochondrial calcium homeostasis, inhibit tumor-associated inflammation and angiogenesis (VEGF), and target drug-resistant cancer stem cells. Preclinical studies have confirmed that resveratrol has shown effects in inhibiting proliferation, inducing apoptosis, and sensitizing chemotherapeutic drugs in various solid tumor models, including breast cancer, colorectal cancer, lung cancer, and prostate cancer.
Reference:https://www.mdpi.com/2076-3921/8/9/332
https://www.mdpi.com/2079-9284/10/3/68
https://www.mdpi.com/2227-9059/11/11/2888
https://www.sciencedirect.com/science/article/abs/pii/S1043661814001388
https://www.mdpi.com/1422-0067/19/6/1812
https://www.sciencedirect.com/science/article/pii/S1043661819314045
https://www.sciencedirect.com/science/article/pii/S0925443914002920
https://www.mdpi.com/1422-0067/25/7/3613
https://www.mdpi.com/2076-3921/12/12/2056
what is resveratrol used for
Resveratrol Supplement
In the health supplement and nutritional supplement field, the resveratrol raw materials we provide are widely used in the formulation of resveratrol capsules, tablets, pills, and softgels, exerting antioxidant and anti-aging effects to help improve skin elasticity and delay the formation of wrinkles and age spots. Simultaneously, it can regulate lipid metabolism and lower low-density lipoprotein cholesterol (LDL-C), supporting cardiovascular health from multiple aspects. In terms of metabolic regulation, resveratrol can improve insulin sensitivity and assist in blood sugar control.
Resveratrol Cosmetics
In the cosmetics and personal care industry, products such as resveratrol cream for skin, resveratrol serum for skin, resveratrol face cream, resveratrol eye cream, and resveratrol night cream are increasingly favored by high-end brands. Our resveratrol can reduce melanin synthesis at its source, achieving whitening and spot-fading effects; on the other hand, it can effectively delay skin photoaging, reduce wrinkles, and its anti-inflammatory properties can soothe sensitive skin and alleviate skin problems such as acne and eczema.
Resveratrol Drinks
In the food and beverage industry, resveratrol, as a natural antioxidant, is added to resveratrol drinks, red wine, juices, and functional foods.
Resveratrol Side Effects & Safety
Is resveratrol safe?
Regarding regulations and safety, resveratrol has received GRAS (Generally Recognized As Safe) designation from the U.S. Food and Drug Administration (FDA). Multiple clinical studies have confirmed that resveratrol is well-tolerated within reasonable dosage ranges.
Does resveratrol have any side effects?
- Common resveratrol side effects: High doses may cause gastrointestinal discomfort, including nausea, abdominal pain, and diarrhea. Some sensitive individuals may experience allergic reactions such as skin itching and redness.
- Drug interactions: Resveratrol inhibits platelet aggregation. Concomitant use with anticoagulants (warfarin), antiplatelet drugs (aspirin, clopidogrel), and nonsteroidal anti-inflammatory drugs (ibuprofen) may increase the risk of bleeding.
Furthermore, resveratrol may affect the metabolism of various drugs by inhibiting the hepatic CYP450 enzyme system; therefore, those taking prescription medications should use it under the guidance of a physician.
Special population contraindications for resveratrol
- Due to a lack of sufficient safety data, resveratrol is not recommended for use in pregnant women, breastfeeding women, and children;
- It may inhibit platelet aggregation; therefore, patients with bleeding disorders or those taking anticoagulants should use it with caution under the guidance of a healthcare professional;
- Those with a history of allergy to resveratrol or its derivatives may experience allergic reactions such as itching and redness, and should avoid use;
- For patients with hepatic or renal insufficiency, it should be used strictly under the guidance of a physician to prevent the accumulation of metabolites.
We consistently provide high-quality raw materials that meet United States Pharmacopeia standards and recommend that end customers clearly indicate the above precautions in the product instructions to ensure safe and compliant use by consumers.
where can you buy resveratrol?
As a professional manufacturer of resveratrol powder, we provide one-stop sourcing services for global clients. Whether you are a bulk resveratrol buyer seeking wholesale resveratrol or a corporate client looking for direct cooperation with resveratrol powder manufacturers, we can meet your needs. We are committed to being your reliable resveratrol manufacturer, offering a complete product matrix from 98% high-purity naturally derived resveratrol to naturally fermented and chemically synthesized resveratrol. If you are looking for a bulk resveratrol supplier, our end-to-end quality control system ensures that every batch of products strictly complies with standards.
KINTAIBIO® supports third-party professional testing, allowing clients to verify purity, solvent residues, and heavy metal levels at any time, ensuring true quality transparency expected from a resveratrol bulk powder supplier. For companies requiring finished product development, we offer flexible customization services from raw materials to dosage forms, adaptable to various formats such as capsules, tablets, softgels, skin lotions, and beverages. Whether you want to buy resveratrol for dietary supplements, functional foods, or cosmetic development, we look forward to becoming your trusted resveratrol for sale partner. Feel free to contact us for bulk pricing: sales@kintaibio.com.
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