Rosemary Extract Ursolic Acid powder

KINTAIBIO^® Rosemary Extract Ursolic Acid Powder is a plant-sourced active ingredient extracted from rosemary leaves, supplied in fine powder form for industrial manufacturing. Available in standardized concentrations of 25%, 50%, 80%,90% and 98% ursolic acid, it provides consistent composition and reliable performance for pharmaceutical, nutraceutical, and cosmetic applications. The ingredient is recognized for its antioxidant, anti-inflammatory, antimicrobial, and metabolic support functions.

 

Rosemary Extract Ursolic Acid Powder specification

 

Rosemary Extract Ursolic acid 25%

Rosemary Extract Ursolic Acid 50%

Rosemary Extract Ursolic Acid 90%

Rosemary Extract Ursolic Acid Powder formulation is designed for seamless integration into various production processes, including capsule filling, tableting, and powdered blend formulations. For high-concentration requirements, we offer pharmaceutical-grade ursolic acid with purity levels exceeding 90%, verified by HPLC analysis. All variants are manufactured under strict quality control protocols, ensuring batch-to-batch consistency and compliance with international standards for industrial applications.You are welcome to contact us at sales@kintaibio.com for the latest product information.

Email us for samples: sales@kintaibio.com

Rosemary Extract Ursolic Acid 90% for sales

Bulk Rosemary Extract Ursolic Acid 90% for Sales

COA of ursolic acid 90%

HPLC anlysis of ursolic acid 90%

Why choose kintaibio^® Rosemary Extract Ursolic Acid Powder?

• Pure natural extraction: Using pure natural rosemary leaves as raw materials, it is obtained through a professional extraction process and does not contain any chemical compounds.
• High Purity: With 90% ursolic acid, optimized extraction and purification processes ensure product quality and the stability of active ingredients.

Raw Material Pre-Treatment

For our ursolic acid powder, we primarily select rosemary leaves or loquat leaves as natural sources of ursolic acid. The plant raw materials are dried and pulverized to an appropriate particle size (typically 20–60 mesh), then moistened with warm water to ensure uniform water absorption, thereby facilitating the subsequent enzymatic hydrolysis.

Pre-Fermentation Treatment

A complex enzyme preparation is added to the plant raw materials that have been moistened with warm water. This complex enzyme consists of either solid or liquid cellulase, or a mixture of cellulase and other enzymes. The dosage added ranges from 1% to 10% of the plant material's weight, with a range of 2% to 8% being commonly used. The mixture undergoes pre-fermentation treatment at room temperature (20–30°C) for 24 to 72 hours. Upon completion of the fermentation, the mixture is filtered to remove the enzymatic hydrolysate, retaining the solid extract residue.

Drying And Ethanol Reflux Extraction

The solid extract residue obtained after pre-fermentation is dried to an appropriate moisture content (generally ≤10%). Ethanol is then added in a ratio of 7 to 10 times the weight of the extract. The ethanol concentration used ranges from 50% to 98%, with 95% (industrial or food grade) being the preferred choice. Reflux extraction is performed under heating conditions for 2 to 3 cycles, with each cycle lasting 1 to 2 hours. After each extraction cycle, the mixture is filtered, and the resulting liquid extracts are combined. The combined extracts are then subjected to vacuum distillation to recover the ethanol solvent, yielding a concentrated extract paste.

Water Precipitation And Washing

The concentrated extract paste is subjected to precipitation washing with water for 2 to 3 cycles to remove water-soluble impurities (such as sugars, proteins, etc.). After each washing cycle, the mixture is allowed to stand and settle; the supernatant liquid is then decanted or filtered off.

Alkaline Purification Treatment

An impurity-removing agent is added to the washed extract paste: specifically, a 1% to 10% solution of a monovalent or divalent metal hydroxide. This agent may consist of sodium hydroxide, potassium hydroxide, calcium hydroxide, or a mixture thereof. A concentration of 2% to 8% is commonly employed. The purification treatment is carried out for 2 to 3 cycles. The treatment temperature is controlled within the range of room temperature up to the boiling point of the solution (in actual production, the mixture is often heated to 60–100°C to accelerate the reaction). After each purification cycle, the mixture is filtered to collect the resulting precipitate.

Dissolution, Alkalization, And Decolorization

Dissolve the precipitate in ethanol to form a solution. Adjust the pH of the solution to 9–12 (using an alkaline solution). Add a decolorizing agent (powdered or granular activated carbon, kaolin, or diatomaceous earth). The dosage is 1–10 grams per liter of solution (typically 2–5 g/L). The decolorization process lasts for 20–120 minutes (typically 30–100 minutes). The temperature is controlled within the range of room temperature to boiling (in practice, it is often maintained at a gentle boil or 80–90°C). After decolorization, filter the mixture while still hot to obtain the filtrate (crude extract).

Acid Precipitation, Crystallization, And Purification

Adjust the pH of the aforementioned filtrate (crude extract) to 1–2 (using inorganic acids such as hydrochloric acid or sulfuric acid). Under acidic conditions, the solubility of ursolic acid decreases sharply, leading to the gradual precipitation of crystals. Perform the flocculation and crystallization operations. Separate the crystals; they may be further purified and refined through recrystallization using a suitable solvent.

Drying, Pulverizing, And Packaging

Dry the purified ursolic acid crystals at an appropriate temperature (typically 50–80°C) using a vacuum oven or forced-air dryer until the moisture content meets quality standards. Based on client requirements, the dried crystals are pulverized and sieved to produce ursolic acid powder of various specifications (e.g., 25%, 50%, 80%, 98%). High-Performance Liquid Chromatography (HPLC) is employed to determine purity and ensure compliance with the labeled content. Inner packaging is conducted within a cleanroom environment (using double-layer, food-grade plastic bags that are vacuum-sealed or nitrogen-flushed); outer packaging consists of cardboard drums or aluminum foil bags.

Through kintaibio many tests, it was found that rosemary from different origins in China has a large difference in the content of the three components. By comprehensively examining the content of these components, the quality of rosemary can be more scientifically evaluated. So we selected the local high-quality rosemary in Yuxi, Yunnan has been proven by experiments that the local rosemary in Yuxi, Yunnan contains the highest content of Rosemary Extract Uosolic Acid, ensuring the high content of Uosolic acid.

Rosemary Extract Ursolic Acid Powder benefits

 

Rosemary Extract Ursolic Acid Powder And Cancer

In the field of cancer prevention and treatment, ursolic acid-a naturally occurring pentacyclic triterpenoid compound-demonstrates dual potential as both a chemopreventive agent and a chemotherapeutic drug. Studies indicate that ursolic acid targets a diverse array of molecular targets closely implicated in inflammation and tumorigenesis, including pro-inflammatory transcription factors, cyclins, growth factors, kinases, cytokines, chemokines, adhesion molecules, and inflammation-related enzymes.

 

By modulating these critical signaling pathways, ursolic acid exerts inhibitory effects across multiple stages of cancer-specifically initiation, promotion, and progression-thereby effectively suppressing tumor onset, development, and metastasis. Over the past decade, extensive preclinical and clinical studies have further substantiated the therapeutic value of Rosemary Extract Ursolic Acid Powder against various types of malignant tumors. Its synergistic mechanism of action-characterized by multi-target and multi-pathway modulation-provides a robust scientific foundation for the development of novel anti-tumor adjuvant preparations or functional foods, positioning it as a highly promising natural active ingredient for comprehensive cancer prevention and treatment strategies.

Rosemary Extract Ursolic Acid Powder for Anti Inflammatory

Ursolic acid has demonstrated significant therapeutic effects on inflammatory skin diseases, such as atopic dermatitis (AD). Studies indicate that ursolic acid exerts its anti-inflammatory efficacy through a dual signaling pathway mechanism: on one hand, it inhibits the TLR4/NF-κB pathway; on the other, it activates the Nrf2/HO-1 pathway. In animal studies, ursolic acid significantly reduced dermatitis scores and ear thickness in AD model mice; it effectively suppressed epidermal hyperplasia and the infiltration of mast cells into the dermis, while also downregulating the expression levels of T helper cell-associated inflammatory cytokines.

 

Furthermore, ursolic acid modulates lipid peroxidation and enhances the activity of antioxidant enzymes, thereby ameliorating oxidative stress within AD model mice. In vitro experiments have further confirmed that ursolic acid inhibits the accumulation of reactive oxygen species (ROS) and the secretion of chemokines in TNF-α/IFN-γ-stimulated HaCaT keratinocytes. These findings suggest that Rosemary Extract Ursolic Acid Powder is capable of alleviating allergic skin inflammatory responses at their source by modulating two key pathways: inflammation and oxidative stress.

Rosemary Extract Ursolic Acid Powder for Skin

In the field of skin health, ursolic acid demonstrates unique anti-fibrotic properties, rendering it particularly applicable to pathological skin changes resulting from excessive collagen deposition. Studies have revealed that ursolic acid synergistically regulates collagen homeostasis through a dual mechanism involving both "inhibition of synthesis" and "promotion of degradation." On one hand, it significantly reduces collagen synthesis within dermal fibroblasts by inhibiting the TGF-β/Smad signaling pathway; on the other, it activates the Mitogen-Activated Protein Kinase (MAPK) pathway and Activator Protein-1 (AP-1), thereby enhancing the activity of Matrix Metalloproteinase-1 (MMP-1) and facilitating the breakdown of previously deposited collagen.

 

This dual regulatory mechanism has been validated in in vivo mouse models, wherein ursolic acid was shown to significantly attenuate bleomycin-induced skin fibrotic lesions. Based on these effects, Rosemary Extract Ursolic Acid Powder holds potential therapeutic value in addressing pathological scarring, scleroderma, and the abnormal accumulation of collagen associated with photoaging.

 

Reference:https://www.sciencedirect.com/science/article/abs/pii/S0006295213001871

https://www.sciencedirect.com/science/article/abs/pii/S1567576923004009

https://www.mdpi.com/2218-273x/15/3/365

Rosemary Extract Ursolic Acid Powder Supplements

Ursolic acid offers versatile formulation options, readily produced as Rosemary Extract Ursolic Acid Powder capsules, pills, or tablets. Its fine powder characteristics allow it to integrate seamlessly into oral dosage manufacturing processes-such as powder blending, tablet compression, and capsule filling-thereby meeting consumer demand for daily dietary supplements targeting weight management, muscle building, blood sugar regulation, and metabolic health.

Rosemary Extract Ursolic Acid Powder Creams

In the realm of daily personal care products, ursolic acid creams leverage the compound's exceptional antioxidant properties and its ability to support collagen maintenance. These formulations help the skin defend against external stressors-such as UV radiation and environmental pollution-while simultaneously improving skin elasticity, firmness, and overall texture by inhibiting excessive collagen deposition and promoting matrix metalloproteinase activity. Consequently, Rosemary Extract Ursolic Acid Powder has emerged as a highly sought-after active ingredient in anti-aging and anti-fibrotic skincare formulations.

Based on existing literature, ursolic acid (UA) has been associated with several biological effects and toxicity profiles. Research involving Wistar strain male albino rats demonstrated that intraperitoneal administration of UA at 5 mg/kg body weight resulted in the inhibition of spermatogenesis (98).

In addition to its impact on reproductive function, UA exhibits notable cytotoxic properties. One study found that a 50 μM concentration of UA purified from loquat (Eriobotrya japonica) induced cytotoxic effects in A549 (lung cancer cell line) and NTUB1 (human bladder cancer cell line) cells (99).

Acute toxicity evaluations further revealed substantial adverse effects associated with high UA doses. When administered orally to mice at 21.5 g/kg body weight, UA extracted from Ledum pulastre L. caused significant damage to both nervous and digestive systems. The study determined the LD50 value to be 9.26 g/kg (100).

As a direct manufacturer, KINTAIBIO^® provides you with a reliable channel for purchasing ursolic acid. If you are seeking professional manufacturers of ursolic acid or ursolic acid powder, our facility-a dedicated ursolic acid powder factory-stands out thanks to a rigorous quality control system. Every batch of our product undergoes purity verification via HPLC, ensuring exceptional batch-to-batch consistency, stable performance, and full traceability back to natural plant sources.

We possess large-scale supply capabilities, enabling us to offer wholesale ursolic acid powder, and we provide technical support and customized services tailored to your specific application scenarios. For the latest pricing information, or to purchase ursolic acid or ursolic acid powder directly, please feel free to contact our sales team. As trusted suppliers of ursolic acid and ursolic acid powder, we are committed to providing global clients with high-purity, high-stability Rosemary Extract Ursolic Acid Powder.

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