Aconite Root Aconitum Kusnezoffii Extract

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of aconite root aconitum kusnezoffii extract in China. Please feel free to wholesale high quality aconite root aconitum kusnezoffii extract for sale here from our factory. For price consultation, contact us.

KINTAIBIO^® specializes in the research, development, production, and supply of high-quality Aconite Root Aconitum Kusnezoffii Extract, derived from the dried root tubers of Aconitum kusnezoffii Reichb., a plant in the Ranunculaceae family. Relying on standardized extraction processes and a rigorous quality management system, we are committed to providing pharmaceutical companies, research institutions, and the natural product development field with safe, reliable, and batch-stable plant-based active ingredients. Aconite extract is rich in various diterpenoid alkaloids, including diester-type, monoester-type, and other characteristic alkaloids, giving it significant medicinal and research value.

Planting Base of Aconitum sinomontanum Nakai

Roots of Aconitum sinomontanum Nakai

Dried Aconite Root

Lappaconitine Hydrobromide

Based on this, KINTAIBIO^® further enriches and prepares the main active ingredients using mature separation and purification technologies, providing pharmaceutical raw materials such as lappaconitine hydrobromide with a purity of up to 96%. During the production process, we strictly control the content and proportion of key diterpenoid alkaloids to ensure excellent product stability, good batch consistency, and reliable quality performance.

Aconite Root Aconitum Kusnezoffii Extract sample

Aconite Root Aconitum Kusnezoffii Extract packing details

With advanced extraction, purification, and crystallization processes, a comprehensive quality control system, and stable production capacity, KINTAIBIO^® can provide customized Lappaconitine Hydrobromide powder products of different specifications and continuous, stable supply support according to customer needs, serving a wide range of fields including drug development, natural product research, and the development of novel non-addictive analgesics and related formulations. Relying on a end-to-end quality traceability system from plant raw materials to high-purity active ingredients, We are committed to becoming a trusted supplier of aconite-derived natural active ingredients for global customers.Feel free to contact us online at sales@kintaibio.com. 

The primary active components of Aconite Root Extract are diterpenoid alkaloids, including:

• Diester-diterpenoid alkaloids: such as aconitine, hypaconitine, and mesaconitine. These compounds exhibit significant biological activity but are also the main source of toxicity.
• Monoester-diterpenoid alkaloids: such as benzoylaconine, which possess lower toxicity compared to diester-type alkaloids.
• Other alkaloids: from Aconitum kusnezoffii, additional alkaloids like deoxyaconitine, beiwutine, and 1,15-dimethoxy-3-hydroxy-14-benzoyl-16-ketooline have been isolated.

Table: Major Alkaloid Components in Aconite Root and Their Properties

Through standardized processes, our product-96% Lappaconite Hydrobromide-ensures strict control over the content and ratio of the three key diester-diterpenoid alkaloids. This guarantees consistent batch-to-batch stability and product quality, enhancing both efficacy and safety.

Key Component Control
Active Ingredient Content:Benzoylaconitine: 40.0%-55.0%; Other Monoester Alkaloids: 15.0%-25.0%
Toxic Component Limits: Aconitine: <0.005%; Mesaconitine: <0.004%  Hypaconitine: <0.003%

This product utilizes an innovative detoxification process to completely remove toxic components while retaining the active ingredients of Aconitum root. This provides high-quality raw materials for the safe production of lappaconitine hydrobromide. We look forward to establishing long-term, stable partnerships with major pharmaceutical companies to jointly advance the modernization of botanical medicines.

Primary Extraction and Component Enrichment

This product utilizes an optimized ethanol reflux method for primary extraction. By precisely controlling the solid-to-liquid ratio (1:10), ethanol concentration (75%), and extraction time (2 hours), efficient dissolution of diterpenoid alkaloids is achieved. Subsequently, the extract is subjected to gradient elution over NKA-II and X-4 macroporous adsorption resins for primary purification and enrichment of specific components. This step not only significantly increases the total alkaloid content from the initial 5.87% to 60.3%, but also effectively separates alkaloids of varying polarity, laying a solid foundation for subsequent high-purity purification.

Multi-stage Purification and Refining

Based on primary purification, we utilize reversed-phase preparative chromatography for further purification. This process utilizes C18 bonded silica as the stationary phase and an acetonitrile-phosphate buffer system as the mobile phase, effectively separating structurally similar alkaloid components. Through this purification step, we ensure a consistently high purity of key active ingredients exceeding 85%, achieving precise conversion from crude extracts to high-purity intermediates, fully meeting the stringent requirements for pharmaceutical raw materials.

Targeted Toxicity Reduction and Full-Process Quality Control

To ensure the ultimate safety of the final product, we have established a patented gradient pH-controlled hydrolysis process and a full-process toxic component tracking system. The hydrolysis process, conducted at a precise temperature of 60-80°C and a pH range of 3.5-5.5, efficiently and effectively converts highly toxic diester alkaloids into less toxic monoester alkaloids, achieving a diester alkaloid removal rate of ≥98.5% and active ingredient retention of ≥95%. Furthermore, we utilize HPLC-MS coupled technology (detection limit 0.1 μg/g) for real-time monitoring of aconitine, mesaconitine, and mesaconitine, strictly ensuring that the total amount of diester alkaloids in the final product is less than 0.01%, ensuring the safety of downstream pharmaceuticals from the source.

Aconite Root Extract has a wide range of applications in pharmaceuticals and topical products:

• Analgesic Applications: Suitable for managing chronic pain conditions such as rheumatoid arthritis, advanced cancer pain, frozen shoulder, lumbar muscle strain, back pain, and sciatica.
• Anti-Inflammatory Applications: It has ameliorative effects on various inflammatory diseases such as myofibrosarcoma, costochondritis, and herpes zoster.

• Topical Preparations: Our research has found that a gel formulation of Aconite kusnezoffii standardized extract offers advantages such as rapid drug release, uniform and smooth application, and comfortable application. It is also significantly safer than a solution formulation (the gel formulation has a 128-fold difference between the maximum dose and the effective dose, while the LD50 of the solution formulation is only approximately 5-fold different from the effective analgesic dose).

• Transdermal Drug Delivery System: The developed Aconite kusnezoffii standardized extract patch is a membrane-controlled release patch, utilizing a carbomer gel as a reservoir, an ethylene-vinyl acetate copolymer film as a controlled-release membrane, and a silicone pressure-sensitive adhesive as an adhesive layer. It maintains a constant transdermal rate for 48 hours.

KINTAIBIO^®'s Aconite Root Aconitum Kusnezoffii Extract combines the wisdom of traditional Chinese medicine with modern pharmaceutical technology to provide you with high-quality, standardized, and safe and reliable Aconitum kusnezoffii extract. Our Lappaconitine Hydrobromide
 products adhere to strict quality control standards, precisely controlling the content and ratio of active ingredients to ensure consistent efficacy and safety from batch to batch.

Whether used in pharmaceutical formulation development or topical product formulation, we can provide you with an excellent Aconite Root Aconitum Kusnezoffii Extract product experience. Please contact us for more information on product specifications, technical data, and collaboration opportunities. Please feel free to contact us at sales@kintaibio.com or provide feedback on the next page.

Hot Tags: Aconite Root Aconitum Kusnezoffii Extract, China Aconite Root Aconitum Kusnezoffii Extract manufacturers, suppliers, factory, Solgar Siberian Ginseng Root Extract, Engelhardia Roxburghiana Leaf Extract, Evodia Extract, Uncaria Extract, Eucommia Leaf Bark Extract, Cassia Tora Extract