Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of carnosic acid powder in China. Please feel free to wholesale high quality carnosic acid powder for sale here from our factory. For price consultation, contact us.
Carnosic Acid Powder (CA) manufacturer/ supplier
As a manufacturer of rosemary extract, KINTAIBIO® has launched a high-content carnosic acid powder. As a diterpenoid monomer, it has strong antioxidant properties and can effectively extend the shelf life of food. It also has excellent properties such as safety, non-toxicity, and high-temperature resistance. Our carnosic acid content is as high as 25%-98%, so using it as an antioxidant can also ensure the purity of your product. It can be widely used in your food additive formulations and skin care ingredients. In addition, it also has rich traditional pharmacological value and can be used as a pharmaceutical raw material.
| KINTAIBIO® Flow Chart Of Rosemary Extract Powder Specification | |||
| Plant Source | Product Name | Specifications | Test Method |
| Rosmarinus Officinalis (Rosemary) Leaf | Rosmarinic Acid Powder | 5% | HPLC |
| 20% | HPLC | ||
| 98% | HPLC | ||
| Carnosic Acid Powder | 10% (oil) | HPLC | |
| 20% | HPLC | ||
| 95% | HPLC | ||
| Ursolic Acid powder | 50% | HPLC | |
| 90% | HPLC | ||
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We utilize environmentally friendly extraction and purification technologies, eliminating the export risks associated with solvent residues. Furthermore, through end-to-end quality control, our products possess high purity, non-toxicity, and high-temperature resistance, completely overcoming the bottleneck of traditional natural antioxidants decomposing upon heating. We are committed to providing the global food, cosmetics, and pharmaceutical industries with authentic, reliable, and traceable high-content Carnosic Acid powder.We not only offer Carnosic Acid extracted from rosemary leaves, but also rosmarinic acid powder and ursolic acid powder in various grades. Please contact us at sales@kintaibio.com.
Carnosic Acid Powder sources
As a company specializing in the research and large-scale production of high-purity caryopsisic acid (CA) powder, we use rosemary (Rosmarinus officinalis L.) as our sole natural source. This plant, belonging to the Lamiaceae family, is native to Southern Europe and has also been successfully introduced to Hunan, Guizhou, Hainan and other places in China. Its leaves are rich in caryopsisic acid, rosmarinic acid and other diterpenoid active ingredients, which endow the extract with excellent antioxidant potential.
how to extract carnosic acid from rosemary?
The preparation of 60% Carnosic acid from rosemary by KINTAIBIO® was performed as follows:
a.Configure solvent: Mix sodium citrate and ethanol together, heat, and stir until fully dissolved.
b.Add rosemary:Add dried rosemary leaves to the reactor, continue heating and stirring until well mixed.
c.Extraction: Carnosic acid and other related compounds are extracted from rosemary at a certain time, temperature and pH.
d.Separation of extracts: The extracts are separated and concentrated using acid-base conditioning and phase separation techniques. An appropriate amount of hydrochloric acid was added and the extract solution was extracted with organic solvents such as ethyl acetate. Then the phase separation operation was performed to obtain the product of Carnosic acid.
e.Purification:Further purification was carried out by organic solvents such as anhydrous acetic acid to achieve higher purity requirements. At the same time, processes such as precision filtration and apatite adsorption are used to remove unnecessary components such as impurities from the product.
f.Crystallization:The purified Carnosic acid is crystallized to obtain crystals of 60% Carnosic acid powder.
COA Of Carnosic Acid Powder
Quality control and testing
We strictly adhere to the testing methods in the national standard "GB1886.172-2016" and use high-performance liquid chromatography (HPLC) for quality control. All peaks in this period, from the retention time of the carnosine peak to the retention time of the carnosic acid peak, are counted as diterpenes. This ensures that the purity and content of carnosic acid meet the highest standards.
At the same time, we also use ultraviolet spectrophotometry (UV) testing, that is, carnosic acid 98% as a reference substance, at a wavelength of 230nm as a basis for quality control to ensure the stability and safety of the product.In addition, during the production process, we strictly control factors such as temperature, humidity, and pH to prevent carnosic acid from being converted into carnosin during drying, storage, and transportation, thereby protecting carnosic acid from being converted and ensuring the high-quality of our products.
what are the Benefits of Carnosic acid powder?
carnosic acid benefits for hair
Rosemary leaf extract and its key active components have demonstrated a clear mechanism of action and clinical potential in promoting hair growth. Studies have shown that topical application of rosemary leaf extract can significantly reverse testosterone-induced hair growth interruption and promote hair regeneration in shaved mice. The core mechanism lies in its highly effective inhibition of 5α-reductase: at concentrations of 200 µg/mL and 500 µg/mL, the extract inhibited this enzyme by 82.4% and 94.6%, respectively, thereby reducing the production of dihydrotestosterone (DHT), a key pathogenic factor in androgenetic alopecia.
Further, 12-methoxycarnosic acid, isolated and identified through activity-guided assays, not only possesses potent 5α-reductase inhibitory activity but also inhibits androgen-driven proliferation in LNCaP cells at a concentration of 5 µM and blocks the binding of DHT to androgen receptors. Carnosic Acid and its derivatives provide a reliable scientific basis for developing natural hair growth agents targeting androgenetic alopecia.
carnosic acid for brain
Carnosic Acid, a diterpenoid naturally found in plants of the Lamiaceae family such as rosemary and sage, has been shown to possess significant neuroprotective effects. Studies have demonstrated that carnosic acid rosemary, through its various biological activities including antioxidant and anti-inflammatory properties, exhibits promising therapeutic effects in combating diseases caused by neurological damage and offers a novel potential strategy for alleviating severe neurodegenerative diseases such as Alzheimer's and Parkinson's.
Although the physiological mechanisms by which Carnosic Acid powder plays a role in these diseases are still in the early stages of exploration, existing evidence sufficiently demonstrates that it can protect brain neurons and reduce oxidative stress and inflammatory damage by regulating key signaling pathways.
carnosic acid for skin benefits
Studies have shown that Carnosic Acid can dose-dependently reduce melanin deposition in the skin of juvenile zebrafish, while simultaneously inhibiting melanin production in melanoma cells and the transfer of melanosomes to keratinocytes. The research team further loaded Carnosic Acid into a liposome-hydrogel system for treating mouse skin wounds. Results showed that this system not only accelerated wound healing and repaired the structure of healed skin, but also significantly reduced the levels of local inflammatory factors IL-1β and TNF-α at the wound site.
Real-time PCR data further confirmed that carnosic acid extract downregulated the expression of key genes related to melanin production and melanosome transfer both in vitro and in vivo, while also inhibiting the expression of inflammatory cytokine genes. Based on these mechanisms of action, Carnosic Acid demonstrates significant potential for treating post-inflammatory hyperpigmentation through a dual pathway of inhibiting inflammatory responses and melanin deposition.
In addition, KINTAIBIO® carnosic acid has many other benefits:
- High antioxidant property: As a natural antioxidant, Carnosic Acid powder effectively resists oxidation. It is stable even at 200℃ and suitable for various food processing techniques, such as boiling, frying, deep-frying, baking, etc.
- Safe and non-toxic: Naturally extracted, green, and environmentally friendly, completely non-toxic and side effects when used in food, suitable for adding to a variety of foods.
- We use green and environmentally friendly technology in the production process, using alcohol extraction to extract carnosic acid, combined with water gradient precipitation technology to produce high-content carnosic acid powder without solvent residue. This technology ensures the high purity of the product and eliminates the problem of solvent residue, making it safer and more reliable in export and food applications.
- High-temperature resistance: Carnosic acid has excellent heat resistance and is an ideal antioxidant choice for high-temperature processed foods
Reference:https://pubmed.ncbi.nlm.nih.gov/22517595/
https://www.mdpi.com/1420-3049/28/5/2306
https://www.sciencedirect.com/science/article/pii/S0753332224014082
What is the uses of carnosic acid?
rosemary extract Carnosic Acid Powder for food
Our carnosic acid powder, as a highly effective natural carnosic acid antioxidant, is widely used in oily and fatty foods, such as fried foods, ham, and sausages. It can significantly extend shelf life and inhibit the fishy smell of frozen fish. It is also suitable for preventing oxidation of high-temperature fried foods and photodegradation after packaging.
What is carnosic acid good for?
- Prolong storage time: Carnosic acid can effectively prevent the oxidation process in oils and fat-containing foods, significantly improving the stability of food.
- Seasoning effect: It can be used as a natural seasoning for meat and fish, inhibiting oxidation, preventing fishy smell, and improving food flavor.
- Wide applicability: It is suitable for antioxidant protection of fried foods and preventing light deterioration of packaged foods.
Carnosic Acid Powder For Medical field
Carnosic acid powder can be developed as a dietary supplement, and consumers can choose carnosic acid supplement or convenient carnosic acid pills. It has shown excellent bioactivity in antibacterial, antitumor, anti-inflammatory, hepatoprotective and neuroprotective effects, especially in the treatment of colitis.Carnosic acid can enhance the integrity of the intestinal barrier by regulating the Keap1/Nrf2 pathway, providing strong protection for intestinal health.
- Liver protection: Studies have shown that CA inhibits liver fibrosis and promotes the regeneration of liver cells, with significant hepatoprotective effects. Therefore, it is favored by patients with liver disease.
- Hypoglycemic: CA can promote the secretion and utilization of insulin, thus helping to regulate blood sugar levels and alleviate the symptoms of diabetic patients.
- Anti-inflammatory: Studies have found that CA has some anti-inflammatory effects and can relieve inflammatory reactions and associated pain and discomfort.
- Antioxidant: CA is a potent natural antioxidant that neutralizes free radicals in the body, slowing down aging and protecting cells.
- Antibacterial: CA can have an inhibitory effect on a wide range of bacteria and has some bactericidal effects.
Carnosic Acid Powder For Cosmetics and skin care
Because carnosic acid has anti-aging effects, it is widely used in skin care products, which can improve skin texture and slow down the skin aging process.
KINTAIBIO®'s carnosic acid powder has broad application prospects in the cosmetics industry and can be used in various skin care products, such as face creams, masks, serums,and shampoo, for example, in the form of carnosic acid cream.
| Creams | In general, the addition of sage acid is around 0.1% to 0.5% for creams of all skin types. In addition, for creams that require a strong moisturizing effect, the addition of sage acid can be appropriately increased to about 1%. |
| Mask | Generally speaking, the addition of sage acid is between 1%~5%, which can be chosen to be combined with other moisturizing ingredients and anti-inflammatory ingredients. It is important to note that high levels of sage acid may cause skin irritation, so it should be adjusted on a case-by-case basis. |
| Serums |
The amount of sage acid added to serums is usually low, usually between 0.1% and 1%. It can be used in combination with other antioxidants or whitening ingredients to enhance the efficacy of the product. |
| shampoo | Generally speaking, due to the great potential of our Carnosic Acid powder (5% Carnosic Acid) in promoting hair growth, it can be used to develop hair care products. |
It is important to note that the optimal amount of sage acid to be added depends on factors such as the structure and physicochemical properties of the product, so the optimal ratio should be experimented with and determined in the product formulation.
★ If you need any technical support, please contact sales@kintaibio.com.
carnosic acid side effects,Safety,dosage
carnosic acid side effects
As a naturally derived diterpenoid phenolic compound, Carnosic Acid powder has a well-established overall safety profile. Multiple independent studies consistently demonstrate that Carnosic Acid exhibits low levels of acute oral toxicity and rare side effects, showcasing promising safety prospects as a raw material for dietary supplements, pharmaceuticals, and skincare products.
carnosic acid dosage
Based on the level of no adverse effects in a 90-day rat feeding study (calculated as caryopsisic acid and caryopsisol), the Joint FAO/WHO Expert Committee on Food Additives established an acceptable daily intake of 0–0.6 mg/kg body weight for rosemary extract.
carnosic acid toxicity
It is worth noting that the US FDA has officially recognized rosemary extract as a Generally Recognized As Safe (GRAS) substance, allowing it to be used as a food additive and functional ingredient in various end products. A pharmacological review published in 2024 also confirmed that Carnosic Acid powder has low toxicity and very few side effects, and pointed out its potential as a novel therapeutic agent for the prevention and treatment of various diseases.
As one of the suppliers of Carnosic acid powder (CA), we have been committed to providing high-quality, safe, and reliable CA products. It can be used as a safe additive and can be used in human food and pharmaceuticals, among other applications.
Reference:https://www.sciencedirect.com/org/science/article/abs/pii/S221031552500054X
where to buy Carnosic Acid powder ?
As a supplier of carnosic acid powder in rosemary extract, we are committed to providing our customers with quality products and satisfactory services. Our products have passed several stringent tests and quality controls to ensure their high quality and safety reliability and can be purchased and used with confidence.
If you are looking for a reliable supplementary supplier of Carnosic Acid Powder, KINTAIBIO® Creatures can help you. to learn more about our products and how we meet your specific needs. please contact sales@kintaibio.com.
FAQ
Q: What are the health applications of carnosic acid powder in the supplement industry?
A: Due to its multiple bioactivities, carnosic acid's application value in dietary supplements is receiving increasing attention. Carnosic acid can act as a natural antioxidant to scavenge free radicals and delay cell aging, and it can be used in hepatoprotective formulations. Studies have found that carnosic acid can inhibit liver fibrosis and promote hepatocyte regeneration. In terms of metabolic health, research shows that carnosic acid can promote insulin secretion and utilization, helping to regulate blood sugar levels. For gut health, carnosic acid can enhance the integrity of the intestinal barrier by regulating the Keap1/Nrf2 pathway. Regarding anti-inflammatory effects, carnosic acid can alleviate inflammatory responses and related pain and discomfort by inhibiting the NFκB inflammatory signaling pathway. For consumers who need convenient supplementation, carnosic acid supplements taken in capsule or tablet form (carnosic acid pills) are also an ideal choice.
Q: How is carnosic acid powder used in skincare products and other daily chemical products? What are the effects?
A: Carnosic acid, with its antioxidant, anti-aging, and anti-inflammatory properties, is widely used in the development of various skincare products, including creams, serums, masks, and shampoos. Literature studies have shown that carnosic acid dose-dependently inhibits melanin deposition and the transfer of melanosomes to keratinocytes in the skin, while simultaneously activating the skin's natural antioxidant defense system by regulating the Nrf2 pathway. It is important to note that high concentrations of carnosic acid may cause irritation to some sensitive skin types. The specific dosage should be determined experimentally based on the target skin type and product formulation properties. We recommend conducting stable formulation compatibility testing before formal production.
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