Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of pueraria isoflavones in China. Please feel free to wholesale high quality pueraria isoflavones for sale here from our factory. For price consultation, contact us.
Kudzu Pueraria lobata root extract powder Isoflavones 40% -90 % HPLC supplier
pueraria isoflavones is supplied by Kintaibio® (a GMP, ISO 22000/ISO 9001 certified company with 12 years of experience in the research and development of botanical active ingredients). It is made from the traditional Chinese medicinal plant Pueraria lobata (Kudzu root) via a low-temperature water extraction process. It boasts a stable isoflavone content of ≥40% (customizable from 40% to 90%).
Pueraria isoflavones possess multiple benefits, including antioxidant, anti-inflammatory, cardiovascular protection, endocrine regulation, and relief of menopausal symptoms. These benefits make them widely applicable in dietary supplements and functional skincare products. In the skincare industry, we recommend an additional level of 0.5-2%, with an acceptable pH range of 5.0-7.0, for formulations such as serums, lotions, and masks. If you have other requirements, please feel free to contact us at sales@kintaibio.com.
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kintaibio® also provides the following specifications:
| Product Name | Specification | Test Method |
| Puerarin | 10% - 99.5% | HPLC |
| Water Soluble Puerarin | 15%, 30% | HPLC |
| Puerarin Complex | Puerarin 30% (Total Flavones 60%) | HPLC (Puerarin) |
| Puerarin 15% (Total Flavones 40%) | UV (Flavones) | |
| Daidzein | 95%, 98% | HPLC |
| Pueraria Isoflavone | 40% - 90% | UV & HPLC |
| Pueraria Total Flavones | 30%, 40%, 80% | UV |
Global Regulatory Positioning of Pueraria Isoflavone
1. EFSA: Approved Article 13.1 claims for vascular function (ID 1414) & antioxidant activity (ID 1415)
2. FDA: GRAS Notice No. GRN 000791 (Soy Isoflavones) - Pueraria analogs accepted via bridge argumentation
3. Pharmacopeias:
USP-NF: Monograph in development (Preliminary PQRI 2023)
ChP 2020: Requires ≥40% total isoflavones for medicinal use
KINTAIBIO® Pueraria Mirifica Isoflavones 80% Specification Sheet
1. Basic Information
| Parameter | Specification Requirement | Testing Method |
|---|---|---|
| Appearance | Yellow-brown fine powder | Visual Inspection |
| Active Ingredient Purity | ≥80% Total Isoflavones | HPLC-UV |
2. Core Isoflavone Profile
| Component | Range | Functional Characteristics |
|---|---|---|
| Puerarin | 40% | Penetrates the blood-brain barrier, improves brain blood flow; α-glucosidase inhibitor |
| Daidzin | 15–25% | Plant estrogen precursor, antispasmodic, heart protection |
| Genistin | 10–15% | Tyrosine kinase inhibition, anti-tumor support |
| 3'-Methoxy Puerarin | 3–8% | Synergistic antioxidant, enhances stability |
| Puerarin-6''-Xyloside | 2–5% | Enhances bioavailability |
Note: Isoflavone glycosides (e.g., Daidzin, Genistin) account for >80%, enhancing water solubility and absorption.
Physicochemical & Safety Parameters
| Parameter | Specification Limit | Testing Standard/Method |
|---|---|---|
| Heavy Metal Residues | ≤10.0 ppm | ICP-MS |
| ‣ Arsenic (As) | ≤0.2 ppm | FDA 2023 |
| ‣ Lead (Pb) | ≤1.0 ppm | |
| Solvent Residues | ≤10 ppm (Ethanol) | USP <467> |
| Microbial Limit | EP 11.0 | |
| ‣ Total Aerobic Microorganisms (TAMC) | ≤1000 CFU/g | |
| ‣ Yeast/Mold | ≤100 CFU/g | |
| Batch Consistency | RSD ≤1.5% (12 Isoflavone Content) | UHPLC-Q-Orbitrap HRMS 8 |
Packaging & Storage
| Item | Requirement |
|---|---|
| Packaging | Double-layer plastic bag inside an aluminum foil bag (1 kg/bag), 25 kg/barrel |
| Storage | Keep away from light, ≤25°C, humidity ≤60% RH |
| Shelf Life | 24 months |
pueraria mirifica isoflavones Features & Advantages
Isoflavones are plant-based compounds that act like estrogen in the body. Their key characteristic is a benzopyran ring with a phenyl group attached at the C3 position, which distinguishes them from other flavonoids that have this group at the C2 position.
Isoflavones interact with the body in several unique ways:
- Selective binding to estrogen receptor β (ERβ): They bind to ERβ with much lower affinity compared to the body's natural estrogen (17β-estradiol), with binding strengths ranging from 0.1 to 10 μM.
- Inhibition of tyrosine kinases: Compounds like genistein block these enzymes at concentrations of 5-20 μM, which plays a role in cell signaling and growth regulation.
- ACE-inhibitory activity: Puerarin, a specific isoflavone, has shown the ability to inhibit angiotensin-converting enzyme (ACE) with an IC50 value of 0.15 mg/mL, potentially aiding in blood pressure regulation.
When it comes to Pueraria, a plant rich in isoflavones, there are some specific advantages:
- Predominantly glycoside form: Over 90% of isoflavones in Pueraria are in the form of β-glucosides, which makes them more soluble and easier for the body to absorb compared to the aglycone forms.
- Unique Puerarin structure: Puerarin is a C8-C-glucoside, which allows it to cross the blood-brain barrier more effectively, potentially offering neurological benefits.
- Synergistic balance: Standardized extracts of Pueraria typically contain a balanced ratio of Daidzin, Genistin, and Puerarin, in a 4:3:3 ratio, which may enhance the overall therapeutic effects of the extract.
What are the uses of Pueraria isoflavones?
1. Health Products and Functional Foods: Developing dietary supplements to regulate female endocrine function and alleviate menopausal symptoms, as well as functional drinks and nutrition bars that protect the liver, alleviate hangovers, and lower blood sugar and lipids.
2. Pharmaceuticals: As an active ingredient in the treatment of cardiovascular diseases (such as atherosclerosis), adjunctive diabetes medications, and osteoporosis medications, it works by enhancing insulin sensitivity and balancing bone metabolism.
3. Cosmetics: Utilizing its antioxidant and tyrosinase inhibitory properties, it is being developed into whitening and anti-aging skincare products (such as high-end products containing glabridin) and functional cosmetics that restore skin elasticity.
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