Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of cytisine powder in China. Please feel free to wholesale high quality cytisine powder for sale here from our factory. For price consultation, contact us.
Cytisine powder manufacturer
In recent years, the various biological activities of cytisine have been gradually discovered, showing broad application prospects in multiple therapeutic areas. In smoking cessation, Thermopsis Lanceolata Extract can act as a selective local agonist, reducing smokers' dependence on nicotine; in anticancer activity, Thermopsis Lanceolata Extract can induce apoptosis in cancer cells and has been widely used in research on inhibiting the proliferation of various tumor cells; in analgesia and respiratory stimulation, Cytisinicline can reflexively stimulate respiration and has been used in clinical surgery as an adjunct to anesthesia.
KINTAIBIO®'s cytisine powder is primarily sourced from high-quality germplasm resources of the legume Thermopsis lanceolata. As a long-established tricyclic quinolone alkaloid, its unique chemical structure endows the molecule with extremely high affinity for nerve receptors. Through advanced extraction processes, we can provide cytisine ≥99%. If you are looking for a manufacturer or supplier of cytisine powder, please contact us.
How to make Cytisine Powder?
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Raw Material Preparation
We carefully select high-quality raw materials from leguminous plants, primarily using *Thermopsis lanceolata* as the extraction source. All raw materials undergo rigorous identification and content testing before entering the factory to ensure compliance with internal control standards. After acceptance, the plant materials are dried and processed into coarse powder of suitable particle size using pulverizing equipment to improve extraction efficiency.
Extraction
The raw material powder is first placed in an extraction tank, and petroleum ether or n-hexane is added for defatting to remove fat-soluble impurities. After solvent evaporation, the defatted residue is extracted by heating and reflux using an acidic aqueous solution (such as dilute sulfuric acid or hydrochloric acid) or an alcoholic solvent (such as ethanol or methanol). Under acidic or alcoholic conditions, Thermopsis Lanceolata Extract can be fully dissolved in the extraction solvent. After extraction, the plant residue is removed by filtration using solid-liquid separation equipment, and the clear extract rich in Thermopsis Lanceolata Extract is collected.
Purification and Concentration
After obtaining the extract, we slowly add alkaline substances such as sodium hydroxide or ammonia to convert Thermopsis Lanceolata Extract, which exists in the form of salt, into free alkali. This process requires precise control of the pH value to an alkaline range of 10-11. After alkalization, the solution is subjected to multiple liquid-liquid extractions using organic solvents such as chloroform and dichloromethane.
Based on the characteristic that freeThermopsis Lanceolata Extract is readily soluble in the organic phase, countercurrent extraction is used to transfer it from the aqueous phase to the organic solvent, achieving separation from a large number of water-soluble impurities. The organic solvent is recovered at low temperature under reduced pressure using a rotary evaporator to obtain crude cytisine. Further purification is carried out according to customer requirements using methods such as recrystallization or column chromatography to finally obtain cytisine powder. After drying, pulverizing, sieving, and homogenizing, it is packaged internally and externally in a GMP clean environment.
COA of Cytisine Powder
Cytisine powder benefits for smoking cessation
Cytisine has been used as an adjunct to smoking cessation in Central and Eastern Europe for over 50 years. Its target mechanism is well-defined, primarily exerting its effects through action on nicotinic acetylcholine receptors in neurons. Studies have shown that Cytisine can selectively bind to multiple nicotinic acetylcholine receptor subtypes in the central and peripheral nervous systems, effectively reducing nicotine cravings and withdrawal symptoms by regulating neurotransmitter release. More importantly, the relatively rigid molecular conformation of Cytisine not only ensures its high affinity for receptors but also makes it an ideal template for developing novel smoking cessation derivatives.
Source:https://www.sciencedirect.com
Currently, research on new compounds based on Cytisine structural modifications is expanding the boundaries of their biological effects. Some derivatives are even exhibiting novel non-nicotine receptor-mediated biological activities, providing ample room for the iterative development of future smoking cessation drugs. Our Cytisine Powder, based on this profound research foundation and well-defined mechanism of action, provides stable and reliable active ingredient support for global smoking cessation drug development.
- Highly effective smoking cessation ingredient: Cytisinicline selectively acts on nicotine receptors in the brain, significantly relieving smokers' withdrawal symptoms, reducing nicotine dependence, and reducing the pleasure of smoking. Its smoking cessation effect has been confirmed in multiple clinical trials, with significant efficacy
- Strong Clinical Support: In the two Phase III clinical trials of ORCA-2 and ORCA-3, Thermopsis Lanceolata Extract showed significant smoking cessation efficacy. The results of the test showed that during the 6-week and 12-week treatment cycles, the smoking cessation success rate of subjects using this ingredient was much higher than that of the placebo group, and the long-term smoking cessation rate was significantly improved.
In addition to its application in smoking cessation drugs, Cytisine Powder can also be used in the research and development of respiratory stimulants, and rescue emergency scenarios such as apnea caused by surgery and neonatal asphyxia.
Reference:https://www.sciencedirect.com/science/article/pii/S104366182100284X
Cytisine Powder fDA
- In September 2025, the U.S.Food and Drug Administration (FDA) formally accepted the New Drug Application (NDA) for cytisine, with a target approval date of June 2026.
- Prior to this, the FDA had granted Cytisinicline Breakthrough Therapy Designation for the treatment of nicotine dependence (including traditional cigarettes and e-cigarettes), a designation intended to expedite its development and review process.
- As a mature drug that has been used clinically in many countries for decades, cytisine's acceptance of this rigorous FDA review means it is poised to become the first new prescription drug approved for the treatment of nicotine dependence in nearly 20 years.
- This is not only a significant breakthrough in the global field of smoking cessation treatment, but also signifies that this naturally derived alkaloid is about to enter the mainstream global pharmaceutical market.
Cytisine Powder uses
- Smoking Cessation Medications
With a similar mechanism of action to FDA-approved smoking cessation medications, it exhibits significant clinical efficacy and is an ideal ingredient for smoking cessation support.
- Emergency and Respiratory Stimulants
Suitable for emergency treatment of postoperative respiratory arrest, neonatal asphyxia, and traumatic shock.
- For Health Supplements
Cytisine powder can be used in health supplements and dietary supplements. It can be formulated into cytisine tablets/pills to reduce nicotine cravings and help smokers maintain a smoke-free lifestyle long-term.
Cytisine Powder side effects
In clinical trials, the incidence of common adverse reactions such as insomnia and nausea was low, and no serious drug-related events were found, with excellent tolerability. Therefore, its safety is good.
cytisine drug interactions:Due to limited information, there is a lack of data on its use in combination with other smoking cessation medications; simultaneous use should be avoided.
where can i buy Cytisine Powder?
For partners worldwide seeking high-quality Thermopsis Lanceolata Extract raw materials, KINTAIBIO® is a reliable and stable supplier. We specialize in the production and supply of high-purity cytisine powder, with specifications up to 99%, strictly complying with US, Japanese, and EU pharmacopoeia standards. Our products are suitable for formulation development and clinical trials in fields such as smoking cessation drugs, respiratory stimulants, and anti-tumor research.
For inquiries about Cytisine Powder pricing or to arrange procurement, global clients are welcome to contact us directly. KINTAIBIO® not only provides internationally standardized Cytisine Powder for sale but also offers necessary registration documentation support to assist you in completing drug applications in the global market. Whether for bulk purchases or sample testing, you can conveniently buy Cytisine Powder online or submit inquiries through our official channels.
If you want to purchase high-quality Cytisine Powder, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
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