S-Adenosylmethionine SAMe Powder

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of s-adenosylmethionine same powder in China. Please feel free to wholesale high quality s-adenosylmethionine same powder for sale here from our factory. For price consultation, contact us.

S-Adenosyl-L-Methionine p-Toluenesulfonic Acid Sulfate(CAS Registry No: 97540-22-2), internationally known as S-Adenosyl-L-Methionine Disulfate Tosylate, abbreviated as SAMe-DT (also known as S-Adenosylmethionine, SAMe, or SAM-e in the US, and adenosylmethionine in Europe, often abbreviated as SAM or AdoMet). The active ingredient in the product is S-Adenosyl-L-Methionine (SAMe), a key physiologically active molecule naturally present in all human cells.

KINTAIBIO^® provides S-Adenosylmethionine SAMe powder, typically a white to off-white crystalline powder, readily soluble in water, with good flowability and non-caking properties. Strict quality control is performed using high-performance liquid chromatography (HPLC), achieving a purity of up to 98% S-Adenosylmethionine, a high standard. This product utilizes proprietary fermentation and crystallization processes, resulting in significantly better control of key impurities compared to conventional products.

The United States Pharmacopeia (USP) has included "Ademetionine Disulfate Tosylate" and provided pharmaceutical-grade reference standards. This provides an authoritative basis for product quality analysis and control. This ingredient was included in the US FDA's New Dietary Ingredient (NDI) list in 2025, providing crucial support for its compliant use in dietary supplements. Based on clinical research, its main applications include: joint health, mood support, liver health, dietary supplements, and feed additives.Please contact us at sales@kintaibio.com for the latest product information.

S-Adenosylmethionine SAMe Powder for dogs

Our S-Adenosylmethionine SAMe Powder, a high-purity dietary supplement ingredient, provides a scientifically proven solution for canine health, particularly in the areas of cognitive function and liver support in older dogs. A double-blind, placebo-controlled trial in senior dogs showed that oral administration of SAMe supplement (tosylate form) at a dose of 18 mg/kg for two months significantly improved age-related cognitive impairment symptoms, demonstrating significant advantages in activity level and cognitive function scores, with a good safety profile.

Source:https://www.dogcancer.com

Another study confirmed that daily administration of 20 mg/kg of stable SAMe salt (1,4-butanedisulfonate form) helps reduce the pro-oxidative effects caused by long-term use of drugs such as prednisolone. The mechanism involves supporting the body's (including the liver's) synthesis of glutathione, an important endogenous antioxidant, thereby helping to maintain a healthy metabolic environment for liver cells. S-Adenosylmethionine SAMe Powder is an ideal core ingredient for developing pet nutritional supplements to support brain health in dogs (especially older dogs), delay cognitive decline, and assist in maintaining liver function and combating oxidative stress.

S-Adenosylmethionine SAMe Powder depression

The effectiveness of S-Adenosylmethionine (SAMe) Powder in the field of mood health has been supported by modern clinical research. A cutting-edge randomized, double-blind, controlled clinical trial published in 2024 showed that daily supplementation with 200 mg of SAMe (conjugated with a specific probiotic strain) for three months significantly reduced symptoms in patients with subclinical and mild to moderate depression, demonstrating clear improvements over placebo on the standard Hamilton Depression Rating Scale (HAM-D) and Patient Health Questionnaire-9 (PHQ-9) scores.

Source:https://www.sciencedirect.com

This provides an evidence-based dietary supplement option for those who may not be suitable for, cannot tolerate, or are insensitive to traditional prescription antidepressants. Its core mechanism of action lies in the fact that SAMe is a key methyl donor in the body, directly involved in the synthesis of key neurotransmitters affecting mood, such as serotonin and dopamine, thereby supporting the natural balance of mood.

S-Adenosylmethionine SAMe Powder in osteoarthritis

A systematic review analysis published in 2009, incorporating four early-stage clinical trials, showed that daily SAMe supplementation exhibited a potentially clinically significant positive trend in relieving pain associated with osteoarthritis of the knee or hip. While the improvement was mild, it was statistically significantly better than placebo.

Source:https://sbrmc.adam.com

The analysis also indicated that SAMe was well-tolerated, with no significant difference in the incidence of adverse events or the risk of withdrawal compared to placebo. This provides preliminary scientific evidence for S-Adenosylmethionine SAMe Powder as a dietary supplement to support joint comfort. Its possible mechanism of action lies in SAMe's role as a key methyl donor in the body, participating in the synthesis of cartilage matrix components (such as proteoglycans), and potentially alleviating joint discomfort by supporting the body's antioxidant state.

Reference:https://pubmed.ncbi.nlm.nih.gov/18597245/

https://pubmed.ncbi.nlm.nih.gov/15757136/

https://www.sciencedirect.com/science/article/pii/S0753332222013191

https://pmc.ncbi.nlm.nih.gov/articles/PMC7061276/

S-Adenosylmethionine SAMe powder, as an important dietary supplement ingredient, is widely used to support specific health needs in humans and companion animals (dogs/cats).

S-Adenosylmethionine SAMe Powder dietary supplement

In human dietary supplements, it is primarily used to support emotional well-being, maintain joint comfort, and promote liver health. Its application is based on its involvement in key biochemical reactions in the body, such as methylation and antioxidant synthesis.

S-Adenosylmethionine SAMe Powder dog/cat nutrition

In pet nutrition, this ingredient is also scientifically formulated in canine and feline dietary supplements to support cognitive function in senior pets, maintain liver health, and help manage oxidative stress that may be caused by age or medication use.

As a raw material manufacturer, we provide food-grade, highly stable SAMe powder, ensuring that downstream brands can develop safe, effective, and accurately dosed end products, providing consumers and their pets with a high-quality nutritional supplement option. Before using any dietary supplement, human or pet users are advised to consult a medical or veterinary professional.

S-Adenosylmethionine (SAMe) is generally safe under routine use, with common side effects being mild (such as gastrointestinal discomfort). However, it should be noted that individuals with bipolar disorder, those taking certain medications (such as levodopa or some antidepressants), and pregnant women should use this product under professional guidance. We recommend that end-products clearly label relevant precautions and instruct consumers to consult a medical or veterinary professional before use.

Each batch of our S-Adenosylmethionine SAMe powder comes with a detailed CoA, listing all key quality attribute test results. Production is carried out in a cleanroom that meets pharmaceutical Good Manufacturing Practice (cGMP) requirements. We have obtained international kosher certifications such as KOSHER and HALAL, as well as food safety management system certifications such as FSMA and HACCP.

Under suitable conditions (sealed, protected from light, dry, and cool, such as at room temperature or below), high-quality SAMe disalt products (such as p-toluenesulfonate) can have a shelf life exceeding 2 years. Excellent raw material stability allows for better tolerance during the manufacturing and processing of tablets, capsules, and beverages. Advanced granulation technology is used to adjust bulk density and improve solubility.

KINTAIBIO^® collaborates with numerous manufacturers worldwide, and our products are exported to many countries and regions. You are welcome to purchase S-Adenosylmethionine SAMe Powder or inquire about S-Adenosylmethionine SAMe Powder prices via sales@kintaibio.com.

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