Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of cynara scolymus extract in China. Please feel free to wholesale high quality cynara scolymus extract for sale here from our factory. For price consultation, contact us.
Cynara Scolymus Extract supplier / manufacturer
As a professional manufacturer of Cynara Scolymus Extract powder, KINTAIBIO® provides Cynarin Scolymus Extract raw materials with clearly sourced and stable quality. The main specifications include Cynarin 2.5% and 5%, and customized services can be provided according to customer formulation needs. Cynara Scolymus Extract is derived from the leaves of the artichoke (Artichoke arborescens), a plant in the Asteraceae family. Modern plant extraction processes are used to enrich the natural active ingredients, retaining abundant polyphenols, flavonoids, and other plant active substances. Representative components include cynarin, chlorogenic acid, and silymarin derivatives.
Artichoke leaves have long been used in traditional European herbal applications to promote digestive health and maintain liver function. Modern research also shows that Cynara Scolymus Extract has strong antioxidant capabilities, helping to reduce oxidative stress-induced cell damage and supporting liver and gallbladder health and gastrointestinal function by promoting bile secretion and improving lipid metabolism.
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KINTAIBIO®'s Cynara Scolymus Extract exhibits good stability, safety, and batch-to-batch consistency. The company possesses a mature plant extraction technology system, enabling it to provide customized services for various activity indicators and specifications based on global customer needs, including OEM/ODM services. We also offer comprehensive technical support, including product specifications, testing reports, and application solutions, helping clients develop nutritional and health products that meet market demands. Please contact sales@kintaibio.com for pricing and the latest information on Cynara Scolymus Extract.
Cynara Scolymus Extract natural source
Cynara Scolymus Extract is derived from the perennial herbaceous plant Cynara scolymus L., belonging to the genus Cynara of the Asteraceae family. Also known as Korean artichoke, artichoke, and chrysanthemum artichoke, it originated in the Mediterranean region of Europe and has a long history of edible and medicinal use, having been used as a prized ingredient as early as ancient Greece and Rome. With the development of modern plant nutrition research, artichoke, due to its rich natural active ingredients and health benefits, has become a widely used plant functional ingredient in the European and American markets. China has established large-scale cultivation bases in Shanghai, Zhejiang, Hubei, Yunnan, and Guangxi, with areas such as Honghu in Hubei becoming important raw material suppliers for artichokes.
As a typical plant with both medicinal and edible properties, the edible parts of the artichoke are mainly the involucre and receptacle of the flower bud, while a large amount of the outer bracts, stems, and leaves are usually utilized as processing byproducts. Research has found that these traditionally non-edible parts, especially the artichoke leaves, are actually rich in various bioactive natural compounds, including polyphenols, flavonoids, caffeoylquinic acid derivatives, and other phytonutrients. Cynarin and chlorogenic acid are important components of artichoke extract, contributing to its antioxidant, liver-protective, and metabolic regulatory effects. KINTAIBIO® uses high-quality artichoke leaves as its main raw material, effectively enriching the natural active ingredients to produce high-quality Cynara Scolymus Extract powder.
COA Of Cynara Scolymus Extract
How to make Cynara Scolymus Extract?
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Raw Material Screening and Pretreatment
The production process begins with artichoke leaves that meet quality standards. After rigorous screening, the raw materials are washed to remove mud, impurities, and surface contaminants. They are then dried at low temperatures to reduce moisture content and minimize oxidation loss of active ingredients during processing. The dried artichoke leaves are mechanically pulverized to thoroughly break down the plant tissue, increasing the contact area between the raw material and the extraction solvent, thus improving subsequent extraction efficiency.
Water Reflux Extraction Process
The pulverized artichoke leaf raw material is added to purified water for reflux extraction. According to commercial production process requirements, 8-15 times the volume of water is added as the extraction solvent. Reflux extraction is performed under suitable temperature conditions, with each extraction lasting 1-2 hours, for 2-3 consecutive extractions to fully extract the water-soluble active ingredients from the artichoke leaves. Multiple extraction cycles improve the extraction rate of the effective components. The liquids from multiple extractions are combined to form a crude extract containing the target active ingredients.
Sedimentation, Filtration, and Preliminary Purification of the Extract
After water extraction, the combined extracts are treated with an appropriate amount of settling agent to cause non-target impurities such as plant fibers, proteins, polysaccharides, and colloids to settle. After a certain settling time, solid-liquid separation is performed using a filtration device to remove insoluble impurities, yielding a clear artichoke extract.
Anion Exchange Resin Adsorption Purification and Elution
The target active ingredient in the artichoke is selectively adsorbed onto the resin material, effectively separating natural compounds with acidic groups, such as cynarin, from other impurities. After adsorption, the resin is rinsed with purified water to remove sugars and some water-soluble impurities until the washings are nearly neutral. Elution is then performed with an acidic aqueous solution of 4-6 BV (resin bed volume) to release the target active ingredient adsorbed on the resin, yielding an eluent rich in cynarin.
Macroporous Resin Enrichment and Ethanol Elution
The anion exchange resin eluent is further purified and enriched using a macroporous resin column. After adsorption, the resin column is first rinsed with purified water to neutralize the system and remove unadsorbed or weakly adsorbed impurities. Elution is then performed using a 40-70% ethanol solution (5-8 BV). The resulting ethanol eluent is concentrated under reduced pressure to remove the ethanol solvent, concentrating it to a density of approximately 1.2-1.4. This concentrate is then allowed to crystallize, forming a crude crystalline product.
Recrystallization, Drying, and Finished Product Preparation
The crude crystals are first dissolved in deionized water, then refluxed and recrystallized using ethanol. This further removes residual impurities and increases the content of active ingredients by utilizing differences in solubility. The purified crystals are then dried under vacuum to reduce the product's moisture content and prevent degradation of heat-sensitive active ingredients. After drying, the product is pulverized, sieved, and quality tested to obtain a uniform and stable Cynara Scolymus extract powder.
Cynara Scolymus Extract benefits
Cynara Scolymus Liver
Modern research indicates that cynarin possesses strong antioxidant activity, which can help reduce oxidative stress-induced damage to hepatocytes and support normal liver metabolic function. One study demonstrated that extracts from the receptacle, stem, and bracts of artichoke showed protective effects in an acetaminophen-induced rat model of liver and kidney injury.
Cynara scolymus extracts were able to reduce serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in experimental models, suggesting their potential value in maintaining hepatocyte integrity and mitigating liver damage. Based on its rich polyphenol composition and natural antioxidant properties, cynara scolymus extract powder is frequently used in liver health dietary supplements, functional foods, and plant-based nutritional formulations.
Cynara Scolymus Diabetes
Oxidative stress is one of the core driving factors leading to the occurrence and development of major metabolic diseases such as diabetes. The polyphenolic compounds, such as cynarin and chlorogenic acid, abundant in the leaves and receptacles of Cynara scolymus, possess excellent antioxidant activity, effectively neutralizing excess free radicals in the body and preventing cellular oxidative damage, thereby reducing the risk of diabetes. Simultaneously, these polyphenolic components also exhibit significant anti-inflammatory activity, synergistically intervening with their antioxidant effects to intervene in diabetes-related inflammatory pathways.
Studies have found that the aqueous extract of Cynara scolymus leaves demonstrated a clear anti-diabetic effect in a streptozotocin-induced diabetic rat model, effectively improving liver function and restoring the histological and ultrastructural integrity of liver tissue. These improvements were achieved by reducing oxidative stress levels, inhibiting inflammatory responses, and enhancing the body's antioxidant defense system. Therefore, Cynara scolymus extract shows broad application prospects in assisting blood glucose regulation, improving insulin signaling, and delaying diabetes-related complications.
Reference:https://www.sciencedirect.com/science/article/abs/pii/S0378874119323323
https://www.mdpi.com/2072-6643/16/6/872
Cynara Scolymus Extract uses
- Cynara Scolymus Supplements: Cynara Scolymus Extract is commonly used for liver health support, bile secretion regulation, digestive improvement, cholesterol management, and antioxidant formulation development.
- Cynara Scolymus Medicinal Uses: Cynara Scolymus Extract can be used in the formulation of products for functional dyspepsia, bloating, and digestive function regulation by supporting bile secretion and lipid digestion processes.
- Cynara Scolymus Foods and Beverages: Cynara Scolymus Extract can be used as a functional additive of natural plant origin in the development of herbal beverages, nutritional foods, and compound plant-based formulations.
where to buy cynara scolymus extract?
If you are looking for a reliable cynara scolymus extract supplier or Cynara Scolymus Extract factory, KINTAIBIO® is a trustworthy partner for plant extract supply. As a professional China cynara scolymus extract manufacturer, we focus on the R&D, production, and supply of high-quality plant extracts, providing stable and reliable artichoke extract powder raw materials to global dietary supplement, functional food, nutritional health product, and plant formulation companies.
With the increasing global consumer demand for natural plant nutrition, liver health support, and functional foods, the cynara scolymus extract market is continuously expanding. KINTAIBIO®, with its mature production technology, stable supply capacity, and professional technical support, provides a one-stop service from raw material supply to product application support, helping clients quickly enter the ever-growing plant extract market.
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