Cynara Scolymus Extract

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Cynara Scolymus Extract also known as milk thistle extract, is obtained from the leaves of the artichoke (Cynarascolymus L.) of the Compositae plant. The main active ingredients of artichoke are cynarin and chlorogenic acid.

Artichoke extract is the water extract or alcohol extract of perennial artichoke, and its main active ingredients include polyphenols, flavonoids, terpenes, etc. It has pharmacological activities such as antioxidant, liver protection, cholesterol reduction, antibacterial and gastrointestinal improvement. Artichoke extracts can be used as food additives, feed additives, antioxidants and even medicines.

Artichoke extract can significantly improve the symptoms of functional dyspepsia, and its mechanism is to promote bile secretion. Studies have confirmed that artichoke extract has the effect of treating symptoms such as constipation, abdominal pain, bloating, diarrhea, nausea and vomiting. In addition, artichoke can also improve intestinal peristalsis, promote intestinal wall contraction, so that the substances in the intestine can be transported faster, to prevent the effects of constipation, detoxification, beauty, liver and kidney accumulation, diuresis and laxatives.

1.1 Source plant

Artichoke is an edible plant that was already used as a court dish for dignitaries in ancient Rome and Greece. Today, the main production areas of artichokes include Italy, Spain, France, Argentina, the United States and so on. The edible parts are inner bracts and vessels, and the inedible industrial by-products include outer bracts and stems and leaves, which account for approximately 80% of the fresh weight of the entire plant. However, the study on the functional active ingredients of artichoke showed that its inedible parts, especially the leaves, contain quite a lot of functional substances.

Artichoke Artichoke is a perennial plant in the Asteraceae family. It is native to the Mediterranean coast of Europe and an ancient medicinal and edible plant. Artichoke has a high nutritional value and is known as the "king of vegetables", it is also known as "rich vegetables" and "the most nutritious natural vegetables". It is sold as a high quality vegetable on the international market. Based on the function of artichoke to regulate fat metabolism and protect the liver, it is mainly due to the functional ingredients that contain polyphenolic structures. Most of these ingredients are naturally active and sensitive to conditions. Maintaining the content and functional activity of functional ingredients and improving product stability is the focus and difficulty of product development. It is evident that the provision of an artichoke extract with simple process steps and suitable for industrial production has become a technical problem that urgently needs to be solved by professionals.

The edible part of artichoke quark contains a variety of nutrients, including a higher protein, calcium and phosphorus content and more inulin (the content in the root is higher). Cynic acid, chlorogenic acid and other polyphenols, flavonoids and other functional compounds are not only contained in quark, but also in the leaves.

1.2 Chemical composition

(1). Phenolic compounds: Artichokeic acid, chlorogenic acid, 1-O-caffeoylquinic acid, 3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid extracted and separated from artichoke Acid, 5-O-caffeoylquinic acid, 1,3-dioxocaffeoylquinic acid, 3,4-dioxocaffeoylquinic acid, 3,5-dioxocaffeoylquinic acid, 1, 5-Dioxycaffeoylquinic acid, 4,5-dioxocaffeoylquinic acid; 2-methoxy-4-(2,3-dihydroxy-propionyl)-phenyl-1-O-( 6'-O-galloyl)-β-D-glucopyranoside, etc.

(2). Flavonoids: naringenin rutin, naringenin glucoside, apigenin-7-O-rutinoside, apigenin-7-O-glucoside, luteolin isolated from artichoke flower buds and leaves luteolin-7-O-rutinoside, luteolin-7-O-glucoside.

(3). Terpenoids: Cynarin, aguerinB, grosheimin, cynaracolosideA-C, cynarininB, dehydro-cynaropicrin, aguerinA, cynartriol, etc. were isolated from the ethyl acetate extract of artichoke leaves.

(4). Anthocyanin compounds: containing cyanidin-3,5-dioxo-glucoside, cyanidin-3-O-glucoside, cyanidin-3,5-malonyl glucoside.

(5). Other ingredients: It also contains inulin, plant sterols, volatile oils, minerals, amino acids, soluble sugars, etc.

Health Benefits

According to the latest pharmacological experiments, Cynara scolymus extract has the following effects on health:

Anti-oxidize effect

Protecting the liver

Artichoke root can be used as medicine, which has the effects of sterilization, hangover, and stimulation of bile secretion, and is very effective for liver damage caused by alcohol.

Antimicrobial activity

Chlorogenic acid, cynic acid, luteolin-7-rutinoside and stenoside of artichoke extract have relatively high antimicrobial activity, and the antifungal activity is stronger than the antibacterial activity. Artichoke leaf extract has obvious resistance to 7 kinds of bacteria, 4 of which are yeasts.

Cholesterol lowering

Treating indigestion

The mechanism of artichoke extract in treating indigestion is to promote the secretion of bile. Artichoke extract can be used to treat digestive system disorders and fat non-absorbable disease caused by insufficient bile secretion.

Lowering blood lipid and anti-atherosclerosis

Prevent the occurrence of cardiovascular disease.

Anti spasm

Preventing constipation.

Improving human immune function

Preventing osteoporosis Reduces liver toxins, especially aminotoxins.

Significant anti-cancer function;

Alleviating food allergy and rejection;

Suitable for diabetics.

Application

SALUS GALLEXIER artichoke, turmeric and dandelion tablets help digestion and nourish liver

German Double Heart Brand Doppelherz Artichoke Olive Oil Turmeric Health Capsules 30 Capsules

5.1 Extraction of artichoke phenolic acid
Take 0.1g of artichoke powder, weigh it accurately, add 30mL of 50% ethanol, soak for 30min, heat and reflux 3 times, each time for 2h, filter, combine the filtrate, put it in a 100mL measuring bottle, add 50% ethanol to dilute to the mark, and accurately Draw 10mL, put it in a 25mL measuring bottle, add 50% ethanol to make up to volume, filter, take the filtrate, and obtain.

5.2 Extraction Technology of Artichoke Total Polyphenols
Artichoke fresh sample→chopping→freeze drying→crushing→passing through a 60-mesh sieve→soaking in ethanol→microwave irradiation→centrifugation→vacuum drying→total polyphenols of artichoke. That is to say, the optimal technological conditions for extracting total polyphenols from artichoke by microwave method are: microwave power 600W, microwave radiation time 2min, extraction agent concentration 70%, liquid-solid ratio 15, and total polyphenol content 3.08%.

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