Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of mango leaf extract in China. Please feel free to wholesale high quality mango leaf extract for sale here from our factory. For price consultation, contact us.
Mango Leaf Extract manufacturer/supplier
Mangiferin(MGF), as a natural flavonoid compound extracted from mango leaves (Mangifera indica), has attracted great attention from the market for its unique antioxidant, anti-inflammatory, anti-tumor and other pharmacological effects. Relying on advanced extraction technology and rich industry experience, XI'AN KINTAIBIO® is the first to launch a series of high-content Mango Leaf Extract products, including 95% mangiferin, 95% isomangiferin and 20% mango leaf flavonoids. These products have become the preferred raw materials for functional foods, cosmetics, medicines, daily chemicals and other industries due to their high purity, strong stability and remarkable effects.
Product introduction and specifications:
- New mangiferin (95%): High-purity new MGF is suitable for functional foods and pharmaceuticals with higher requirements for active ingredients, such as antioxidant and anti-tumor preparations.
- 95% isomangiferin: The structure of isomangiferin is similar to that of MGF, but it has unique biological effects and is suitable for use in healthcare products and anti-inflammatory products.
- 20% mango leaf flavonoids: rich in a variety of active flavonoids, widely used in antioxidant and antibacterial formulas to improve the functionality of the product.
| KINTAIBIO® Flow Chart Of Mangiferin Powder Specification | |||||
| Product Name | Plant Source | Active Ingredients | Specifications | Test Method | |
| Mangiferin Powder | Mango Leaves | Mangiferin(Soluble) | 15% | HPLC | |
| Mangiferin | 60% | HPLC | |||
| 95% | |||||
| 98% | |||||
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Additionally, if you require other specifications of mangiferin powder, we also offer 15% water-soluble mangiferin, as well as 60%, 95%, and 98% mangiferin. You are welcome to contact us at sales@kintaibio.com.
From the purchase of mango leaves to the delivery of finished products, we have passed standardized production. This ensures that the quality of our MGF products is consistent. They have undergone strict quality testing for content, moisture, heavy metals, pesticide residues and microorganisms. They comply with the CP2015 standard of the Chinese Pharmacopoeia and are produced according to GMP standards to ensure safety and stability.
As natural active ingredients, we mainly provide them in bulk powder form to facilitate secondary processing as functional raw materials by end product manufacturers. With their excellent physiological activity, these high-purity mangiferin powder have been widely exported to the United States, Europe, Southeast Asia and other regions, becoming one of the first choices for MGF-related products in the international market.
How to make Mango Leaf Extract?
Our Mango Leaf Extract process is divided into three main processes: alkaline water bath extraction, gel column separation and solvent recrystallization. These steps ensure the purity and activity of the extract.
- Alkaline water bath extraction: Crush mango leaves into coarse powder, and use an alkaline aqueous solution such as sodium hydroxide for initial extraction in a temperature-controlled water bath. This process can effectively dissolve MGF under milder conditions, making its components easier to separate.
- Gel column separation: The initially extracted solution is separated by Sephadex LH-20 gel column. This process includes water washing and high-concentration alcohol elution to remove impurities and variegated components and improve the purity of MGF.
Solvent recrystallization: In the final step, MGF is recrystallized using solvents such as methanol or ethanol to obtain a high-purity product.
This production process uses dual-phase countercurrent extraction technology, combined with a mixed solvent extraction system, to significantly increase the distribution coefficient of MGF in the organic phase, ensuring a yield of more than 90% and a solvent recovery rate of up to 92%. Compared with traditional processes, this extraction process can significantly increase production while reducing production costs and ensuring high purity and stability.
COA And Determination Method of Mango Leaf Extract powder
what are the mango extract benefits?
mango extract for weight loss
The potential of mangiferin in weight management is closely linked to its activating effects on brown adipose tissue (BAT). Studies have demonstrated that during the differentiation of brown adipocytes, mangiferin treatment significantly upregulates the expression levels of brown-fat-specific genes as well as genes associated with mitochondrial mass, thereby inducing the expression of uncoupling protein 1 (UCP1). Concurrently, mangiferin also upregulates key thermogenic regulators and promotes mitochondrial biogenesis.
Importantly, Mango Extract mangiferin treatment increases mitochondrial DNA content and enhances mitochondrial respiratory function by elevating the oxygen consumption rate. Furthermore, experiments involving small interfering RNA (siRNA)-mediated gene knockdown and competitive inhibition have confirmed that mangiferin likely promotes thermogenesis in brown preadipocytes by activating the AMPK signaling pathway. These findings suggest that mangiferin holds promise as a novel functional ingredient for combating obesity through the activation of brown adipose tissue.
mango extract for brain
Based on research findings, acute supplementation with soluble mango leaf extract can effectively alleviate symptoms such as mental fog, slowed thinking, and feelings of cognitive fatigue. The study revealed that following a single dose, participants experienced a significant reduction in feelings of tension, low mood, and confusion, accompanied by improvements in mental clarity and overall mood state.
In objective cognitive assessments, the extract significantly accelerated information processing speed and enhanced cognitive flexibility. These improvements began to manifest as early as 30 minutes after administration and persisted for at least five hours. Although no significant impact on verbal memory was observed, these results clearly demonstrate that mango leaf extract-acting as a natural nootropic-can help young adults maintain mental clarity and emotional stability in high-pressure academic or professional environments by rapidly mitigating mental fog and boosting the efficiency of executive functions.
mango extract for skin
According to scientific research, Mango Extract mangiferin-a naturally occurring and potent antioxidant molecule-demonstrates significant potential for application in the field of skincare. This study co-encapsulated mangiferin and naringin within phospholipid vesicles specifically engineered for dermal delivery. By incorporating sodium hyaluronate, two novel vesicle formulations-glycerol-hyalurosomes and ethanol-glycerol-hyalurosomes-were successfully developed. These novel vesicles not only exhibit superior stability but also efficiently deliver and deposit mangiferin and naringin throughout the entire skin tissue.
In vitro experiments confirmed that these vesicles possess excellent biocompatibility and effectively protect dermal fibroblasts against hydrogen peroxide-induced oxidative damage. Furthermore, in in vivo studies utilizing a mouse wound model, these vesicles effectively inhibited the progression of skin lesions-and even promoted wound healing-by virtue of their enhanced capacity to suppress myeloperoxidase activity and mitigate edema formation. This research conclusively demonstrates that mangiferin holds significant promise for future development in the prevention and amelioration of oxidative stress-induced skin damage, as well as in the adjunctive treatment of dermatological conditions such as psoriasis and atopic dermatitis.
Physiological And Pharmacological Effects Of Mango Leaf Extract
Anti-tumor effect: The anti-tumor properties of Mango Leaf Extract are reflected in its ability to inhibit telomerase activity and regulate cell cycle. Especially in the research on cancers such as leukemia, MGF has shown the potential to inhibit the proliferation of cancer cells and has been gradually used in the development of anti-cancer drugs.
Neuroprotective effect: MGF can regulate intracellular Ca2+ flow and oxidative stress, protecting neurons from glutamate-induced damage. Clinical trials have shown that it has potential efficacy in inhibiting neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Anti-diabetic effects: MGF has been shown to reduce blood sugar levels and improve insulin sensitivity in diabetic animal models. Long-term intake of MGF has adjunctive therapeutic effects in the management of diabetes and its complications.
References：
https://www.sciencedirect.com/science/article/abs/pii/S0278691520303057
https://www.mdpi.com/1424-8247/18/4/571
https://www.sciencedirect.com/science/article/pii/S1773224723011139
https://pmc.ncbi.nlm.nih.gov/articles/PMC5414237/
https://www.sciencedirect.com/topics/neuroscience/mangiferin
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/mangiferin
https://www.spandidos-publications.com/10.3892/mmr.2018.9529
what are the Mango Leaf Extract uses?
Pharmaceutical industry: MGF has gradually become one of the ingredients of antioxidant, anti-diabetic, anti-viral and anti-tumor drugs. With in-depth research, it is expected that its application in the treatment of chronic diseases, liver diseases, diabetes, etc. will be further expanded.
Cosmetics: The antioxidant properties of MGF are widely used in skin care products to delay skin aging, moisturize and repair. It is especially popular in high-end skin care products such as sunscreen and anti-wrinkle.
Functional food: Given its multifaceted benefits-including blood sugar reduction, antioxidant properties, and immune modulation-MGF is widely utilized in health supplements, functional beverages, and food additives, making it highly popular among health-conscious consumers. Furthermore, MGF is available in various forms-such as mango leaf extract supplements, mango extract pills, and mango leaf extract capsules-to facilitate convenient daily intake for consumers.
Feed additive: As a feed additive, MGF can improve the antioxidant and immune functions of animals and promote healthy growth. It is a high-quality choice in animal feed and breeding industries.
mango leaf extract side effects,safety,dosage
mango leaf extract dosage
Based on existing toxicological and clinical research data, mango leaf extract-a natural polyphenol compound-demonstrates a high safety profile when consumed at standard dosages. Human clinical studies indicate that healthy subjects experienced no adverse events after ingesting 300 mg of standardized extract daily for seven consecutive days; furthermore, neither a single dose as high as 900 mg nor a daily intake of 300 mg over a continuous 12-week period resulted in any observable abnormalities in liver or kidney function, nor any systemic side effects.
mango leaf extract side effects
Nevertheless, caution is warranted under specific circumstances: ingesting high doses of high-concentration mangiferin may trigger mild abdominal pain, diarrhea, or nausea. Due to its significant hypoglycemic activity, concurrent use with antidiabetic medications-such as metformin or gliclazide-could lead to hypoglycemia. Furthermore, certain animal and in vitro studies suggest that mango extract may interact with the anticoagulant warfarin, thereby increasing the risk of bleeding. Additionally, the urushiol present in mango peels may trigger contact dermatitis or systemic allergic reactions in individuals with allergic predispositions. In light of the foregoing, individuals planning to take high-dose mangiferin supplements are advised to consult a medical professional beforehand.
Competitiveness and prospects in the global market
With our patented extraction technology and efficient quality control methods, the high-purity MGF we produce has significant competitiveness in the global pharmaceutical market. The company's technical accumulation in the field of MGF production and its leading global market share provide reliable supply support for the pharmaceutical industry. With the expansion of MGF's application areas, the global demand for this product will continue to increase in the future, especially in the respiratory diseases, antiviral drugs, immunomodulators and auxiliary treatment of chronic diseases. There is huge growth potential.
KINTAIBIO® has always been committed to the research and development and improvement of natural plant extraction technology, and continuously improves the stability, purity and bioavailability of products to meet the needs of different customers. Against the background of the global pharmaceutical market's increasing attention to natural plant extracts, KINTAIBIO®'s MGF extract will become an important part of the field of natural plant medicines and health products, further promoting the development of the global plant medicine market.
where to buy Mango Leaf Extract?
KINTAIBIO® strictly controls the quality of mango leaves. From raw material procurement to product delivery, every step is subject to precise quality control. Before purchasing mango leaves, the company dispatched a professional team to track changes in MGF content in real time locally, analyze soil composition, monitor pesticide residues, and cooperate with local governments to encourage fruit farmers to use biopesticides. Before being put into storage, mango leaves will be tested for heavy metals, pesticide residues and active ingredient content to ensure that they meet the quality requirements of the corporate standard "KT2015-80".
During the production process, we strictly follow GMP standards. The finished products must be tested for content, moisture, heavy metals, pesticide residues, microorganisms and other indicators before packaging. They must pass the test before leaving the factory. The company also keeps samples of each batch of products with a traceability period of no less than three years to ensure product quality.
Technical advantages and market prospects
The company has achieved a significant improvement in the extraction efficiency of MGF through its independently innovative two-phase countercurrent extraction technology and mixed solvent extraction system. This technology not only improves product purity and yield, but also increases solvent recovery rate from 50% to more than 92%, significantly reducing production costs and further expanding the market competitiveness of MGF. Currently, Xi'an Ketai Biotech's annual output of Mango Leaf Extract has reached 18 tons, meeting the needs of domestic and foreign customers.
With the in-depth research on the pharmacological activity of MGF, the market demand has shown a rapid growth trend. It is expected that the production of MGF will continue to increase in the next five years and is widely used in medicine, cosmetics, functional foods and other fields. Relying on technological innovation and strong marketing capabilities, Cooltech Biotech will further expand its market share at home and abroad and promote the development of the MGF industry.
Future research and development directions and innovative applications of KINTAIBIO®
In order to further expand the application of MGF in various fields, XI'AN KINTAIBIO® will focus on the following research and development directions to enhance product innovation and competitiveness:
Develop water-soluble MGF derivatives: The current high content of MGF has poor solubility in water, limiting its application in drinks and other water-based products. Through chemical modification or compounding with other natural ingredients, the water solubility of MGF can be improved and its application in functional drinks and health drinks can be expanded.
Nanotechnology: Nanotechnology can increase the bioavailability of MGF, making it easier to be absorbed by the body. The development of nanoMGF will make it more efficient and provide more stable therapeutic effects in medicines and functional health products.
Functional compounding: compounding MGF with other antioxidant or anti-inflammatory ingredients (such as resveratrol, vitamin C) can enhance its antioxidant effect and add multiple effects to skin care products and health supplements to meet your needs Personalized health and beauty needs.
Innovative dosage forms: Explore various dosage forms of Mango Leaf Extract, including capsules, tablets, ointments, etc., to meet different consumer needs. For example, develop MGF essence, facial mask and other skin care product forms, and directly apply its antioxidant and anti-inflammatory skin care effects to beauty products.
Expand the field of animal health products: Study the role of MGF in animal health, such as immune enhancement and antioxidant effects on livestock and pets, so as to apply MGF to high-end pet food and animal feed additives to provide comprehensive health protection.
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KINTAIBIO® is committed to being your best Mango Leaf Extract supplier
Our high-purity Mangiferin Powder products have strong development potential amid growing demand in the global market. The company uses high standards of quality control and continuous R&D innovation to promote the wide application of MGF in health care, medicine, beauty and other fields. In the future, XI'AN Kintai Biotech Inc. will continue to optimize production processes, develop innovative products, and become a leading company in the MGF and plant extracts industry through international cooperation and market promotion. If you want to get high-quality Mango Leaf Extract, please feel free to contact us at sales@kintaibio.com or feedback on the next page.
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