Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of Citrus Aurantium Extract in China. Please feel free to wholesale high quality Citrus Aurantium Extract for sale here from our factory. For price consultation, contact us.
Citrus aurantium extract manufacturer/ supplier
KINTAIBIO® is a professional manufacturer of Citrus aurantium extract . Our Citrus Aurantium Extract (Bitter Orange Extract / Citrus Extract Powder ) products are primarily derived from the dried immature fruit of Citrus aurantium L. and its cultivated varieties; however, compliant raw materials from other citrus species-such as Citrus sinensis Osbeck-may also be utilized depending on product specifications and customer requirements. We offers a wide range of Citrus aurantium extracts and related natural active ingredients, including Synephrine (6%–98% HPLC), Hesperidin (90%–95% HPLC / 98% UV), Neohesperidin (95% HPLC), Naringin (98% HPLC), and Citrus aurantium Flavonoids (20%–85% HPLC, including water-soluble grades of 10%–40%). Additionally, we supply Diosmin in various specifications, such as EP, BR, USR, 90:10 ratios, micronized powder, and granules.
For clients requiring micronized purified flavonoid fractions, we offer MPFF (Micronized Purified Flavonoid Fraction) consisting of 90% Diosmin and 10% Hesperidin, as well as premixed micronized powders containing 81% Diosmin and 9% Hesperidin. Micronization levels can be controlled to meet project requirements, such as D50 < 5 μm or D90 < 10 μm. We also support customization of specifications, particle sizes, and product forms to suit specific application needs.
Synephrine is a signature alkaloid found in Citrus aurantium and serves as a key quality indicator for standardized products in the international market. Current research focuses primarily on its adrenergic receptor activity, effects on energy metabolism, and applications in sports nutrition. Meanwhile, Hesperidin, Naringin, and Neohesperidin are representative flavonoids found in plants, supported by a robust body of research regarding their antioxidant properties and other biological activities. Depending on the specific standardization criteria, the product can be developed into Aurantium extract standardized to synephrine, or into citrus flavonoid ingredients standardized to hesperidin, naringin, neohesperidin, or total flavonoids.
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If you are interested in our high-quality Citrus aurantium extract -available in various specifications-please feel free to contact sales@kintaibio.com for product information and details.
COA Of Citrus aurantium extract
How to make Citrus aurantium extract ?
Raw Material Pulverization and Acidic Extraction
First, the raw material is pulverized to thoroughly disrupt the plant tissue, facilitating subsequent extraction. The pulverized material is subjected to extraction in an acidic solution; upon completion, the mixture is filtered to yield the extracted solid residue and the filtrate. This stage primarily serves to transfer water-soluble components from the raw material into the extraction liquid, laying the foundation for the subsequent separation of compounds such as synephrine.
Filtrate Concentration, Decolorization, and Pectin Separation
The obtained filtrate undergoes concentration and decolorization, followed by the addition of ethanol to precipitate the pectin. Filtration yields crude pectin and the pectin-depleted filtrate. The crude pectin is further purified to produce the final pectin product, while the pectin-depleted filtrate proceeds to the next stage.
Synephrine Separation via Macroporous Resin
The pectin-depleted filtrate is concentrated, dried, and reconstituted with water to create a solution suitable for column loading; it is then passed through a macroporous resin column for adsorption and elution. Through resin separation and elution, synephrine is recovered from the Citrus Aurantium Extract.
Extraction of Residue Using Sodium Carbonate Solution
The solid residue remaining after acidic extraction is not discarded; instead, it is washed with water and subjected to a second extraction. This washed material is extracted using a sodium carbonate solution and then filtered, yielding a second extract and a secondary solid residue.
Extraction with Sodium Hydroxide Solution and Hesperidin Separation
The secondary solid residue is further extracted using a sodium hydroxide solution and filtered, yielding a third extract and a tertiary solid residue. The third extract is then subjected to crystallization under acidic conditions, followed by solid-liquid separation to obtain crystals and a filtrate. The resulting crystals are dried to produce hesperidin.
Combining Extracts and Spray Drying
The filtrate obtained after hesperidin crystallization is combined with the second extract. The mixture is then spray-dried to yield the final total flavonoids product. This process enables the full utilization of constituents with varying polarities and solubility characteristics found in raw material, allowing for the separate recovery of products such as synephrine, hesperidin, and total Citrus aurantium flavonoids.
citrus aurantium extract benefits
citrus aurantium extract Antioxidant
C. aurantium is clearly an excellent source of natural antioxidants. Its leaves are used medicinally in many folk traditions: among the Basques of Europe for insomnia, stomach pains and heart palpitations, and in South America and Mexico as a laxative, relaxant for insomnia and sedative for nervous fatigue.
Antibacterial
Citrus extracts can act as natural antimicrobial agents, providing the ability to be used in a variety of food applications. Aqueous, ethanol and chloroform extracts of Aurantium fructus leaves showed antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae).
citrus aurantium extract weight loss
C. aurantium extract contains p-synephrine obtained from the skin, which works in combination with other compounds such as caffeine to promote weight loss. This combination has been shown to be effective in promoting weight loss by increasing thermogenesis and lipolysis in animals and humans.
anxiety
Numerous studies have demonstrated the anxiolytic effects of C. aurantium. The effect of Citrus aurantium essential oil on anxiety associated with bone marrow aspiration surgery in patients with chronic myeloid leukemia (CML). Inhalation of C. aurantium essential oil resulted in decreased State-Trait Anxiety Inventory (STAI) psychometric scale scores and changes in physiological measures leading to its anxiolytic effects.
What is Citrus aurantium extract used for?
Citrus aurantium extract and its key active constituents-synephrine, hesperidin, neohesperidin, and naringin-serve as plant-derived functional ingredients across various sectors. Synephrine, in particular, is a notable alkaloid component in standardized extracts; it exhibits activity related to adrenergic receptors, with research covering areas such as vasoconstriction, bronchodilation, and energy metabolism. Consequently, these constituents are suitable for the development of raw materials for pharmaceuticals and health products.
Citrus aurantium extract for food and nutritional supplements
Standardized Citrus aurantium extract can be utilized in the formulation of dietary supplements, nutritional products, and functional beverages. Its application in products such as teas and sports nutrition can be further evaluated based on target market regulations and usage guidelines. Additionally, the flavonoids-supported by research into their bioactivities, such as antioxidant properties-can serve as raw materials for research into food, nutrition, and bioactive plant ingredients.
citrus aurantium extract side effects,dosage,safety
side effects
The safety of Citrus aurantium extract depends primarily on its p-synephrine content, the actual dosage consumed, and whether it is used in combination with other stimulants such as caffeine. The U.S. NIH/NCCIH notes that while oral intake of it at levels typically found in food is generally considered safe, dietary supplements containing it have been associated with adverse events such as elevated heart rate, increased blood pressure, headaches, anxiety, and chest pain. Serious events-including heart rhythm abnormalities, myocardial infarction, and stroke-have also been reported; however, as many of these cases involved multi-ingredient products, it is impossible to determine whether the events were caused solely by p-synephrine.
dosage
Actual dosage should be evaluated by the manufacturer of the finished product and qualified professionals, taking into account the standardized p-synephrine content of the extract, the product's dosage form, its formulation, and regulations in the target market. Particular attention should be paid to the fact that combining the extract with caffeine or other stimulants may increase safety risks.
safety
Individuals who are pregnant or breastfeeding, or who have cardiovascular disease or hypertension, as well as those currently taking medication, should consult a healthcare professional before using finished products containing p-synephrine. The NCCIH also notes that there is insufficient data regarding the safety of Citrus aurantium use during pregnancy and breastfeeding.
where to buy citrus aurantium extract ?
If you are seeking a reliable manufacturer of Citrus aurantium extract, KINTAIBIO® supplies standardized Citrus aurantium extract and related active ingredients to overseas B2B clients. As a Chinese manufacturer, we offer products containing Synephrine, Hesperidin, Neohesperidin, Naringin, and Citrus aurantium flavonoids in various specifications, utilizing testing methods such as HPLC or UV as required. We support sample requests from overseas buyers and provide essential documentation-including COAs, specifications, TDS, MSDS/SDS, and batch-specific quality records-to assist with raw material screening, quality assessment, and project validation.
For buyers looking for wholesale Citrus aurantium extract or suppliers of the extract powder, we offer bulk purchasing and customized specifications. We also provide tailored raw material solutions based on your product positioning, alongside OEM/ODM services, sample testing, custom packaging, and comprehensive technical documentation. Please contact sales@kintaibio.com for more information.
FAQ
Q: What is the difference between Citrus aurantium extract and flavonoids?
A: This extract is generally a broad product category; its composition may include alkaloids (such as synephrine), flavonoids (such as hesperidin and naringin), and other plant-derived constituents. Citrus aurantium flavonoids, on the other hand, emphasize the content or composition of flavonoid compounds and are products standardized based on flavonoid markers. Differences may exist regarding target constituents, testing methods, and application requirements; therefore, purchasers should clarify whether they require the total extract, total flavonoids, or a specific flavonoid monomer. We can provide products with varying total flavonoid contents and water-solubility specifications based on your requirements; specific parameters are subject to the product specification sheet.
Q: What is the difference between Citrus aurantium extract and synephrine?
A: The extract is a mixture obtained through the extraction and processing of plant raw materials and may contain various alkaloids, flavonoids, and other plant constituents. Synephrine is a specific natural alkaloid with a defined chemical structure found within the extract and serves as a common standardization marker for related products. Synephrine content can vary significantly across different grades of this extract, and high-purity synephrine products cannot be equated directly with standard extract. Purchasers whose product formulations require control over synephrine intake should select products that clearly specify synephrine content, testing methods, and batch specifications, and calculate the synephrine level in the final formulation based on the actual dosage used.
Q: Is Citrus aurantium extract safe to use?
A: The safety of this extract must be assessed based on the specific product and conditions of use. The NCCIH notes that bitter orange is generally considered safe when consumed orally in amounts typically found in food; however, dietary supplements containing bitter orange raise concerns regarding cardiovascular safety, and research findings on this matter are inconsistent. Regarding standardized synephrine products, one cannot infer that all specifications, dosages, and combination formulations are safe simply because the ingredient is of natural plant origin or because a specific study found no significant adverse effects.
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