Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of standardized milk thistle extract in China. Please feel free to wholesale high quality standardized milk thistle extract for sale here from our factory. For price consultation, contact us.
Kintaibio® Supply Wholesale Price Milk Thistle Seed Extract Powder
Kintaibio's milk thistle extract is derived from carefully selected mature fruits of the Asteraceae plant, Silybum marianum (L.) Gaertn. Research has shown that milk thistle seeds are rich in protein, unsaturated fatty acids, and various minerals, and are a valuable source of numerous natural active ingredients. Using advanced extraction and purification technologies, we precisely extract and standardize the core active ingredient in milk thistle-a complex of flavonolignans, primarily silybin.
Our core product line meets international standards:
Silybin boasts a purity of up to 98%, providing strong support for high-end products.
Silymarin is available in various strengths (30%-80%) and complies with EP/USP standards, ensuring consistent efficacy.
Our innovative water-soluble silymarin (40%) overcomes the solubility issues of traditional extracts, expanding its application areas.
Through rigorous quality control systems (HPLC/UV), we ensure consistent ingredient content in every batch. This not only enhances the value of the raw material but also provides reliable assurance for highly effective and unique end products.
Products Description
Milk thistle's pharmacological activities, such as hepatoprotection and anti-inflammatory, stem from the synergistic effects of its diverse components. Kintaibio is dedicated to transforming this natural complexity into standardized, highly effective raw materials. Our extracts retain the key functional components identified in milk thistle, including flavonolignans (such as silybin and silymarin), flavonoids, phenolic acids, and other naturally occurring synergistic compounds.
To meet diverse needs, we offer a variety of strengths: For products seeking a single efficacy, choose 98% pure silybin; for products requiring a full spectrum of synergistic benefits, choose 80% standardized silymarin; and for aqueous solutions like beverages and oral solutions, 40% water-soluble silymarin provides an ideal, highly bioavailable solution. All products undergo rigorous testing to ensure clear composition and defined active ingredients. For more detailed specifications, please refer to the table below:
|
Active Ingredient |
Specification ＆ Test Method |
Solubility |
|
Silymarin extracted by acetone |
UV80% |
Insoluble in water, soluble in acetone |
|
Silymarin extracted by ethano |
UV80% |
Insoluble in water, soluble in ethanol |
|
Silymarin extracted by ethyl acetate |
UV80% |
Insoluble in water, soluble in ethyl acetate |
|
Water Soluble Silymarin |
UV20% |
Soluble in water and ethanol |
|
Silybin |
Silybin 80% |
Insoluble in water, soluble in acetone |
|
Organic silymarin |
70%UV |
Insoluble in water, soluble in ethanol |
Choosing kintaibio means you receive a scientifically validated active ingredient system, providing reliable, natural support for your pharmaceuticals and health supplements. If you are interested in our above specifications, please feel free to contact sales@kintaibio.com to obtain samples and for more detailed consultation.
sample COA OF Milk Thistle Seed Extract Water Soluble Silymarin 40%
If you need other specifications of COA, please contact sales@kintaibio.com.
Milk Thistle Seed Extract Production flow chart
Kintaibio® has always believed that excellent products are inseparable from precise processes. Through numerous experiments and optimization, we have determined the optimal extraction method for silymarin: repeated extractions using an ethanol solution of a specific concentration at precisely controlled temperature and time. The extract is then purified using a carefully selected resin, employing gradient elution to remove impurities and enrich the target component. This systematic extraction and purification process results in a light yellow product with a uniform texture and a stable silymarin content of over 80%, ensuring reliable efficacy.
To improve extraction efficiency and product quality, Kintaibio innovatively combined ultrasound-assisted extraction and dynamic countercurrent extraction technologies in 2025. Ultrasonic technology effectively disrupts cell walls, shortens extraction time, and operates at lower temperatures, fully protecting the heat-sensitive components in silymarin. Dynamic countercurrent extraction technology, on the other hand, maintains an optimal concentration difference between the raw material and solvent, resulting in an extraction yield of up to 98.2%. This combined process not only saves 30%-50% of solvent but also enables a more continuous and automated production process, ensuring stable and consistent product quality.
We also prioritize environmental protection and safety, strictly controlling every production step. We utilize a fully enclosed automated production system, ensuring that extraction, filtration, and concentration processes are all carried out under sealed conditions. Advanced solvent recovery technology effectively recycles solvents from medicinal residues, keeping residual levels below 500 ppm. This ensures production safety while enabling solvent recycling and reducing resource waste. Furthermore, the dried medicinal residues can be reused as feed or fertilizer, supporting a green, circular economy. This fully demonstrates that while we provide high-quality natural raw materials, we also fulfill our corporate environmental responsibility.
Applications Of Milk Thistle Seed Extract
Our company produces high-purity milk thistle extract, whose core active ingredient is silymarin. Numerous scientific studies have confirmed that silymarin possesses multiple biological activities, including excellent liver protection, antioxidant, anti-inflammatory, glucose and lipid metabolism regulation, and antibacterial properties. These activities provide a solid theoretical and practical basis for its widespread application in the pharmaceutical, health product, feed, and food industries.
1. Pharmaceutical and Health Products Industry
Silymarin is an internationally recognized natural liver protectant with a well-defined mechanism of action:
- Strong liver protection: By preventing lipid peroxidation, scavenging free radicals, and increasing liver glutathione (GSH) levels, it effectively repairs liver cell damage and combats chemical liver damage.
- Metabolic regulation: By increasing insulin and glucagon expression, it helps regulate blood sugar; and by improving dyslipidemia, it exerts cardiovascular protection.
- Renal protection: It can inhibit the elevation of nephrotoxicity markers such as serum creatinine, uric acid, and blood urea nitrogen.
- Anti-cancer and anti-inflammatory: It exerts anti-inflammatory effects by inhibiting the NF-κB pathway and COX-2 activity; and exhibits anti-cancer potential by inducing cell cycle arrest.
Applications: It can be used as a core ingredient in prescription and over-the-counter medications, including liver-protecting tablets and capsules. It can also be used as a functional ingredient in the development of health foods that assist in regulating blood sugar and lipids, provide antioxidant benefits, and promote hangover relief and liver protection.
2. Feed Additive Industry
2.1. Sow Farming
Recommended Formula: Add a nutrient pack containing 1% silymarin extract to the base diet at a rate of 100 g/day per head.
This dosage improves sow performance: significantly increasing average daily feed intake from 1 to 21 days postpartum and effectively boosting milk production. It also promotes piglet growth, significantly increasing suckling piglet weights at 14 and 21 days of age, as well as average daily weight gain from 1 to 21 days of age.
2.2. Aquaculture
Recommended Formula (Grouper): Add 0.2 to 0.6 g/kg of silymarin to the feed.
This significantly increases the weight gain rate of hybrid grouper juveniles and reduces feed conversion ratios. It can also improve animal liver cell morphology, reduce cellular vacuoles, and significantly lower serum total cholesterol, triglyceride, and transaminase levels.
In terms of antioxidant activity, silymarin can significantly increase the activity of antioxidant enzymes such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the liver.
Recommended Formula (Mandarin Fish): Add 2.0‰ to 3.5‰ silymarin to the feed. This dose significantly improves the survival rate of Mandarin Fish in culture. It can be used to optimize feed utilization and reduce feed conversion ratio.
2.3. Poultry Farming
Recommended Formula (Layering Plum Blossom Chicken): Add 100-400 mg/kg of silymarin (silymarin core monomer) to the base diet.
Improves Egg Production Performance: Significantly increases egg production rate and average egg weight, and reduces feed-to-egg ratio.
Improves Egg Quality: Increases yolk index, reduces malondialdehyde (MDA) content in egg yolk, and enhances antioxidant levels.
3. Food Industry: Natural Preservation, Safety Assurance
Silymarin and its derivatives possess excellent natural antioxidant and broad-spectrum antibacterial properties, making them ideal for food preservation. Adding 0.05% of silymarin seed extract to silymarin seed oil effectively inhibits oil oxidation and rancidity. Its antioxidant effect surpasses that of the synthetic antioxidant DL-α-tocopherol, significantly extending the shelf life of the product.
It exhibits significant inhibitory effects against common foodborne pathogens such as Staphylococcus aureus (MIC 0.5-0.8 mg/mL) and Salmonella. Its mechanisms include disrupting cell membrane structure, affecting energy metabolism, and inhibiting biofilm formation.
Preservation Applications: A composite preservative coating made with chitosan as the film-forming matrix and 2%-8% silymarin added is used for refrigerated pork.
It effectively inhibits the growth of total bacterial counts in pork, slows pH rise, reduces juice loss, and significantly inhibits fat oxidation (reducing TBARS) and protein breakdown (reducing TVB-N), maintaining the excellent sensory quality of pork.
Our milk thistle extract products, with their clear active ingredients, robust scientific research data, and extensive application scenarios, provide high-value natural ingredient solutions for customers across various downstream industries. Whether it's pharmaceuticals and health supplements to enhance human health, feed additives to improve animal production efficiency, or preservatives to ensure food quality and safety, we provide professional technical support and a stable product supply.
benefits of milk thistle extract
1. Liver protection and detoxification： Several studies have shown that Standardized Milk Thistle Extract and Silymarin Powder can protect the liver from damage caused by toxins, such as alcohol, drugs, and environmental pollutants. Silymarin helps to prevent free radical damage, stimulates the production of new liver cells, and promotes the regeneration of damaged liver tissue.
2. Anti-inflammatory and antioxidant properties： (5-LOX) is closely related to many inflammations and cancers, and because 5-LOX is expressed in various tissues and cells of the human body, it is now generally believed that 5-LOX is one of the initiators of the inflammatory cascade. Silymarin can act on 5-LOX, thereby reducing the production of inflammatory mediators leukotrienes and lipoxins, and reducing inflammatory responses. Silymarin can reduce the damage of oxygen free radicals such as ROS and superoxide anions to cells, especially in the face of environmental stress such as drugs. Silymarin can increase the production of glutathione and superoxide dismutase. In addition, although long-term high sugar intake can make people feel happy, it may induce the production of a large amount of superoxide to damage glomerular podocytes, and silymarin can start from two aspects. One is to enhance the activity of antioxidant enzymes in the kidney, such as catalase and glutathione peroxidase, and the other is to inhibit NADPH oxidase, thereby achieving the effect of protecting the kidney.
3. Lowering cholesterol levels: Studies have shown that Milk Thistle Seed Extract and Silymarin Powder can help to lower total cholesterol levels and improve the ratio of good (HDL) to bad (LDL) cholesterol in the blood. This makes them potentially useful in reducing the risk of heart disease.
4. Acts on the liver through intestinal bacteria
A long-term high-fat diet will greatly increase fat accumulation in the liver. Studies have shown that oral administration of silymarin can significantly change the structure of intestinal flora and greatly promote the colonization of related flora that can synthesize vitamin B12. The level of triglycerides in human serum is significantly negatively correlated with the content of VB12. The advantage of this is that it can improve the level of fatty acid degradation in the liver, thereby improving the accumulation of liver fat caused by high-fat diet levels.
5. Antiviral effects：
In terms of antiviral activity, most antiviral drugs or ingredients block the replication or spread of viruses at a single target or link, while silymarin and its derivatives can exert their effects at multiple links in the viral life cycle, thereby producing powerful antiviral activity. For example, the most intensively studied virus is hepatitis C virus HCV. Silymarin can not only enhance the antiviral effect of the JAK-STAT signaling pathway but also inhibit the activity of NS5B polymerase and the transcription of nuclear factor NF-κB, thereby blocking the virus from entering cells and replicating and spreading. For example, for the influenza A virus, silymarin can inhibit the synthesis of viral RNA and viral replication in the late stage of infection. For the dengue virus, silymarin and its derivatives have a very strong affinity with the non-structural protein NS4B of the virus, so they can also be used as targets for anti-dengue virus treatment.
our advantages
Packing And Shipping
Kintaibio is committed to providing high-quality milk thistle extract to customers across various sectors, becoming a reliable partner in your innovation journey. We offer a wide range of products tailored to specific needs, covering pharmaceuticals, health supplements, functional foods, and animal nutrition.
For high-end pharmaceutical applications, we offer Sibin, with a purity of up to 98%. For general health supplements, our 30%-80% standardized silymarin products are an ideal choice, offering excellent value and meeting pharmacopoeial standards. Furthermore, our 40% water-soluble silymarin is ideal for innovative products such as aqueous beverages, oral liquids, and gummies, addressing solubility and bioavailability challenges.
Through standardized production and rigorous quality control, we ensure batch-to-batch consistency, helping you stabilize your formulation, streamline your production process, and accelerate time to market. Kintaibio's milk thistle extract will provide strong support for your health product development.
If you want to Purchase high-quality Standardized Milk Thistle Extract, please feel free to contact us at Sales@Kintaibio.Com or feedback on the next page. Site web: www.kintai-bio.com
Hot Tags: standardized milk thistle extract, China standardized milk thistle extract manufacturers, suppliers, factory, Cordyceps Mycelium Extract, Mango Leaf Extract, Helicid Powder, Astilbin Powder , Green Coffee Bean Extract Powder Chlorogenic Acid, Black Bean Extract Anthocyanins
