Bitter Orange Extract Powder

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of bitter orange extract powder in China. Please feel free to wholesale high quality bitter orange extract powder for sale here from our factory. For price consultation, contact us.

KINTAIBIO^®'s Bitter Orange Extract powder (Citrus aurantium extract) is a natural botanical extract derived from Citrus aurantium L. and related citrus species. We offer a wide range of specifications for bitter orange extracts and related citrus active ingredients to meet diverse customer needs regarding R&D, formulation design, and large-scale production. Available specifications include Synephrine (6%–98% via HPLC), Hesperidin (90%–95% via HPLC; 98% via UV), Neohesperidin (95% via HPLC), Naringin (98% via HPLC), and Citrus aurantium flavonoids (20%–85% via HPLC; 10%–40% water-soluble grades). Additional specifications are listed in the table below:

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We prioritize the alignment of raw material sourcing, active ingredient content, and product quality standards. We can provide natural citrus extract powder, standardized active ingredients, and customized specifications tailored to the customer's target compounds, application areas, and procurement requirements. Content analysis is conducted using appropriate methods-such as HPLC or UV-based on the specific product, while development focuses on parameters including active ingredient content, extraction ratio, water solubility, micronization level, and particle morphology. For pharmaceutical-grade raw materials like Diosmin, we provide documentation regarding pharmacopoeial or corporate standards, clearly outlining requirements (e.g., EP, BP, USP) and specific testing parameters.

As a traditional raw material, bitter orange extract is gaining attention in modern nutrition, food science, and the development of plant-based functional ingredients. Synephrine is a distinctive alkaloid found in bitter orange, while Hesperidin, Neohesperidin, and Naringin are citrus flavonoids of significant research interest. These ingredients are utilized in formulations for sports nutrition, weight management, and plant-based flavonoid products. It is important to note that traditional uses, experimental research findings, and clinical evidence for specific pharmaceutical preparations are not directly interchangeable; final product applications must comply with specific product regulations, quality standards, and the legal requirements of the target market. Please feel free to contact sales@kintaibio.com for information regarding our products.

Bitter orange extract is primarily derived from the dried immature fruit of the bitter orange , a plant in the Rutaceae family (citrus genus). Some related products may also utilize cultivated varieties or other citrus species-such as the sweet orange-as raw materials, depending on specific product standards and extraction processes. In traditional Chinese medicine, the raw material is obtained by collecting naturally shed immature fruit (typically between May and June) or by harvesting unripe fruit according to established protocols; the fruit then undergoes processing steps such as impurity removal, transverse slicing, and sun-drying or low-temperature drying. Bitter orange is traditionally cultivated in Chinese regions including Sichuan, Jiangxi, Fujian, and Jiangsu; its fruit is characterized by a distinctively bitter and astringent taste and serves as a key medicinal citrus ingredient.

The chemical composition of immature bitter orange fruit differs from that of mature sweet orange fruit; notably, synephrine is a distinctive alkaloid of particular interest. Through appropriate extraction, concentration, and drying processes, the target compounds within the plant material can be converted into a powdered form suitable for storage, transportation, and use in formulations.

bitter orange extract for weight loss

Bitter orange fruit extract is a citrus-derived ingredient attracting interest in the fields of weight management and energy metabolism research. A study investigated the effects of bitter orange fruit extract and p-octopamine on hepatic metabolism. The findings revealed that both substances promote glycogenolysis and glycolysis while increasing hepatic oxygen consumption and perfusion pressure; some of these effects were inhibited by alpha- and beta-adrenergic receptor antagonists. The study also observed that the impact of bitter orange extract on gluconeogenesis varied with experimental concentration, suggesting that its overall metabolic effects likely involve multiple constituents and diverse mechanisms of action. These results support further investigation into the relationship between bitter orange extract and energy metabolism.

Additionally, while some animal studies have suggested that synephrine may influence the metabolic activity of brown adipose tissue, the evidence is insufficient to establish its actual efficacy for weight loss in humans. Regarding the potential of bitter orange extract for weight management, it is important to distinguish between experimentally observed metabolic changes and weight-loss effects validated by human clinical trials; it cannot simply be characterized as having proven fat-burning, appetite-suppressing, or weight-reducing properties.

Furthermore, the potential effects of our bitter orange extract powder extend beyond energy metabolism to areas such as cardiovascular function and gastrointestinal physiology.

• blood pressure: Traditional pharmacological studies indicate that bitter orange extract and certain active constituents-such as p-hydroxy-synephrine and N-methyltyramine-can influence myocardial contractility, cardiac output, and vascular tone, potentially leading to changes in blood pressure.
• Gastrointestinal function: Bitter orange extract exhibits an antagonistic effect against intestinal smooth muscle contractions induced by acetylcholine or histamine, suggesting a potential role in the regulation of gastrointestinal motility.
• Uterine smooth muscle: Decoctions of bitter orange and Fructus Aurantii (immature bitter orange fruit) can exert varying effects on uterine smooth muscle depending on experimental conditions, including the inhibition or enhancement of contractions.
• Central nervous system: Under specific experimental conditions in animals, bitter orange extract has demonstrated sedative-like effects, though this does not equate to a hypnotic effect.
• Diuretic effect: Bitter orange may influence urine formation and sodium excretion by affecting cardiovascular activity and renal hemodynamics.

Reference:https://www.mdpi.com/1420-3049/17/5/5854

Bitter orange extract powder is a citrus-derived ingredient containing various active compounds; it is utilized in the development of nutritional supplements, sports nutrition products, plant-based functional formulations, and citrus flavonoid products. Synephrine is a key active constituent within the extract, and the ingredient is listed in the pharmacopoeias of the Nordic countries and Germany.

bitter orange extract supplement

Standardized bitter orange extract can be used to formulate dietary supplements, nutritional products, and functional beverages; its application in products such as teas and sports nutrition can be further evaluated based on the regulations and usage conditions of target markets. Research into relevant formulations primarily focuses on the potential link between synephrine and energy metabolism.

Meanwhile, citrus flavonoids-such as hesperidin, neohesperidin, and naringin-serve as bioactive plant ingredients for antioxidant research and the development of complex formulations. Additionally, diosmin and micronized purified flavonoid fraction (MPFF) can be used to develop pharmaceutical preparations for venous health, subject to compliance with applicable regulations.

Bitter orange extract dosage

There is currently no standardized recommended dosage applicable to all bitter orange extract powder products, nor can the dosages used in research studies serve directly as general usage guidelines. One study examined the use of up to 98 mg of synephrine daily under specific conditions and observed no significant adverse effects regarding the measured parameters; however, this does not imply that such a dosage is suitable for everyone or for long-term use.

Bitter orange extract side effects

Information from the U.S. National Institutes of Health (NIH) regarding dietary supplements indicates that bitter orange products may be associated with safety concerns such as elevated blood pressure and changes in heart rate. However, as most reported cases involved multi-ingredient products, it remains unclear whether bitter orange or synephrine was the direct cause. Therefore, it is advisable to consult a healthcare professional to assess your individual situation before use.

Is bitter orange extract safe?

Synephrine-as studied in clinical trials-may raise blood pressure and heart rate, and there is insufficient evidence to prove it effectively promotes weight loss. Consequently, individuals with cardiovascular disease or hypertension, those taking medication, and pregnant or breastfeeding women should exercise caution and seek professional medical guidance. They should avoid self-administering high doses or combining the extract with stimulants such as caffeine.

If you are seeking a reliable supplier of bitter orange extract, KINTAIBIO^® offers bitter orange extract powder to overseas brands, nutritional supplement manufacturers, formulation developers, and ingredient distributors. We provide a range of options regarding synephrine content, testing standards, and product specifications, while supporting sample requests, custom specifications, and bulk purchasing to meet diverse needs-from R&D testing to large-scale production.

By partnering with us, you can obtain COAs, product specifications, TDS, SDS/MSDS, and relevant batch quality documentation to facilitate raw material evaluation, supplier audits, and product development. Whether you are planning small-scale trials or long-term procurement, please contact us to discuss product specifications, customization options, and supply details. If you wish to purchase bitter orange extract, please email sales@kintaibio.com with your requirements-including the desired synephrine content, order quantity, and intended application-and we will provide the relevant product information and a price quote tailored to your needs.

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