Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of citrus extract powder in China. Please feel free to wholesale high quality citrus extract powder for sale here from our factory. For price consultation, contact us.
Products Description
Citrus extract powder mainly exists in the outer skin of citrus fruits (including exocarp and capsule, and citrus has been used as traditional Chinese medicine for thousands of years in China. The research on the biological activity and anticancer activity of citrus flavonoids has been deepening. Citrus flavonoids According to the naming of flavonoid structure, it can be roughly divided into categories: flavonoid glycosides, such as naringenin, hesperidin, etc.
Citrus bioflavonoids are powerful antioxidants. In recent years, scientists have discovered that bioflavonoids have many biological effects, including anti-oxidation, anti-tumor, anti-inflammatory, anti-aging, and anti-mutation effects. Since it cannot be synthesized by the human body and must be obtained from food, the citrus flavonoid powder produced by KINTAI can be used as a nutritional supplement for the human body.
Product quality specification & standard
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Product name |
Citrus extract powder |
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Appearance |
Brown powder |
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Solubility |
Soluble in methanol, ethanol, ether |
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Heavy metals |
NMT 20 PPM |
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Loss On Drying |
NMT 5.0% |
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Powder size |
80Mesh, NLT90% |
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Assay |
Min. 98.0% |
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Microbiological Quality (Total viable aerobic count) |
|
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- Bacteria, CFU/g, not more than |
NMT 103 |
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- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
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- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
In a Tight, Light-resistant, and Dry Place. Avoid Direct Sunshine. |
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Shelf life |
24 months |
Benefits
1. Antioxidant effect of citrus flavonoids
- 1) In vitro antioxidant effect
The flavonoids and isoflavones contained in citrus have significant antioxidant activity. Polymethoxylated flavonoids are flavonoids with the strongest antioxidant activity found in citrus in recent years. Through research, it is found that citrus flavonoids have a significant effect of scavenging active oxygen free radicals in vitro, and the inhibitory effect on the autoxidation rate of pyrogallol is particularly significant.
Through the study, it was found that although there were significant differences in the reducing ability and scavenging effect on DPPH free radicals of 9 different varieties of citrus peel flavonoids, they all had antioxidant and free radical scavenging effects. Extracts of flavonoids from citrus peels have certain scavenging effects on hydroxyl radicals (·OH) and superoxide anions (O2-·). The above studies show that citrus flavonoids have strong anti-oxidation and scavenging free radicals in the body, can be used as natural antioxidants in food, health products, medicines, and cosmetics, and have a good application prospect.
- 2) Antioxidant effect on the cardiovascular system
In recent years, with the research on cardiovascular and cerebrovascular diseases, flavonoids have gradually become a hot spot in the research and development of natural medicines and functional foods. The World Health Organization pointed out in the report "Diet, Nutrition, and Prevention of Chronic Diseases" that citrus fruits can effectively prevent the occurrence of cardiovascular diseases. At present, the research on the role of citrus flavonoids in the cardiovascular system mainly focuses on strengthening the heart and reducing fat.
- 3) Antioxidant effect on the nervous system and immune system
A large amount of literature shows that nobiletin, a citrus flavonoid, is an effective compound for the treatment of neurodegenerative diseases. It has neurotrophic activity, can inhibit the neurotoxicity of β-amyloid protein (Aβ) on neurons, and reduce the damage of H2O2 to nerve cells. Oxidative damage, improve learning and memory impairment induced by cerebral ischemia, etc.
Citrus flavonoids can protect against oxidative stress by increasing the stability of the cell membrane system, enhancing the activity of cellular antioxidants, reducing the content of reactive oxygen species and lipid peroxide reaction products in cells, and reducing the activity of caspase-3. It can be used for the prevention and treatment of neurodegenerative diseases such as AD (Alzheimer's disease) and PD (Parkinson's disease). Both hesperidin and nobiletin in citrus flavonoids have an activation effect on NMU2R, and they have higher efficacy in a certain concentration range. Due to their multiple effects on nerve cells and the nervous system, citrus flavonoids are expected to be developed into safer and more efficient neurological disease drugs.
- 4) Hypoglycemic effect
According to the latest data released by the World Health Organization, diabetes has become the third major disease besides cardiovascular and cerebrovascular diseases and malignant tumors. Diabetic patients need long-term medication, and the side effects of hypoglycemic western medicine are relatively large. Therefore, the search for active ingredients with hypoglycemic effects from natural resources has attracted increasing attention. At present, research on the hypoglycemic effect of flavonoids has become a hot spot at home and abroad. Studies have found that citrus flavonoids play an important role in the process of preventing hyperglycemia. The regulation of blood sugar is partly through combining with starch to enhance the resistance of starch, promoting glycogen synthesis by increasing glycolysis and reducing gluconeogenesis. Promote the utilization of glucose by liver cells.
- 5) Antibacterial, antiviral, and anti-inflammatory activities
The significant antibacterial, antiviral, and anti-inflammatory activities of citrus flavonoids have been confirmed with the continuous reports of research results. The study found that five flavonoids in the ethanol extract of citrus peel had a good antibacterial effect on the pathogenic bacteria of tea leaf blight. According to the in vitro antibacterial activity of citrus flavonoids, citrus flavonoids have the strongest effect on Staphylococcus aureus and Bacillus subtilis, followed by Escherichia coli, Pseudomonas aeruginosa, and Salmonella paratyphi B. Citrus peel total flavonoids can also antagonize the progression of adjuvant arthritis in rats.
2. Antitumor activity
Citrus flavonoids have anticancer activity, and their remarkable anticancer effect has been confirmed with the continuous reports of research results, mainly involving liver cancer, lung cancer, breast cancer, colon cancer, pancreatic cancer, gastric cancer, and so on. Study the anti-proliferation activity of citrus flavonoids on 4 kinds of tumor cells, and found that citrus flavonoids have a good inhibitory effect on ovarian cancer and breast cancer cells. Through the study, it was found that citrus flavonoids Nobiradine can effectively inhibit the in vivo proliferation of chronic myelogenous leukemia cells K562 Growth and proliferation in vitro, and can inhibit angiogenesis of tumor tissue.
Safety
- Citrus flavonoids are a natural ingredient that does not cause harmful effects on the human body;
A number of clinical trials have confirmed that the body's absorption and metabolism of citrus flavonoids are in good condition, and will not affect the normal operation of any metabolic mechanism in the body;
- The LD50 value of citrus flavonoids is higher than 2000mg/kg, with low toxicity;
- According to the results of multiple animal toxicity tests, citrus flavonoids have no obvious subacute or chronic toxicity, nor will they cause reproductive toxicity, carcinogenicity, or mutagenicity;
- A large number of clinical trials have confirmed that the long-term use of citrus flavonoids has no adverse effects on the human body.
Formulation and Dosage
Dosage recommendations:
Depending on the purpose and scope, the recommended dosage of citrus flavonoid powder products will also vary. Some studies have shown that a daily intake of 300-600 mg of citrus flavonoids can effectively provide health benefits. Dosage adjustments may be required for specific populations.
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Reference formula:
The following is a reference to the formula of oral health food containing citrus flavonoids:
Ingredient Weight (mg/tablet) Citrus flavonoids 300 Vitamin C 50 Vitamin E 20 Zinc element 5 Selenium element 50 Coenzyme Q10 10 Grape seed extract 50 The above ingredients are combined according to the recommended ratio. This is for reference only, and the specific ratio should be reasonably adjusted according to the purpose, scope, use, and specification of the product, and should not exceed the upper limit stipulated by the State Food and Drug Administration.
Preparation
(1) Put citrus peel and ethanol aqueous solution in the extractor at a weight ratio of 1:1 to 5, extract under reflux for 0.5 to 1 hour, filter, concentrate the filtrate to obtain citrus peel extract, and then extract the obtained citrus peel Suspend the extract in water and centrifuge to obtain a clarified filtrate;
(2) Under the condition of 20 ~ 30 ℃, the clarified filtrate obtained by step (1) is first adsorbed by polystyrene type or cross-linked acrylonitrile adsorption resin, and then the eluent is used to carry out a gradient according to its concentration from low to high Elution, collecting the eluate and concentrating to obtain the target substance, that is, water-soluble flavone-flavonoid glycoside flavonoid extract; fat-soluble flavone-poly ethoxy flavonoid extract;
Wherein: said eluent is C1～C4 monohydric alcohol or C3～C6 monohydric ketone, or/and its aqueous solution; said clarified filtrate in step (2) is mixed with polystyrene type or cross-linked acrylonitrile Adsorption resin adsorption adopts the mode that clarified filtrate flows through polystyrene type or cross-linked acrylonitrile adsorption resin, and the flow rate of clarified filtrate is 1.5～8BV/h; Said elution in step (2) adopts eluent flow It is carried out by means of polystyrene type or cross-linked acrylonitrile type adsorption resin, and the flow rate of the eluent is 2-10BV/h.
2. The extraction method according to claim 1, is characterized in that, the aqueous ethanol solution in step (1) is an aqueous ethanol solution with a concentration of 50-95v/v%.
3. The extraction method according to claim 1, is characterized in that the particle diameter of the polystyrene type or cross-linked acrylonitrile adsorption resin used in step (2) is 0.3-1.25 mm.
4. The extraction method according to claim 1, wherein said eluent is methanol, ethanol, or acetone, or/and an aqueous solution thereof.
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