Shiso Leaf Extract

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KINTAI is committed to becoming your best supplier of Shiso Leaf Extract Powder.It is also called Perilla leaf extract,which is the extract of the dried leaf of Perilla frutescens (L.) Britt, a plant in the Labiatae family. The main active ingredient is perilla oil, which has various health functions and has been widely used in medicine, food, spice and preservation industries ,and there are many pharmacological effects.

Perilla frutescens (L.) Britt

Shiso Leaves

Shiso Leaf product

Shiso Leaf Powder

 

【Plant origin】Dry leaves of Perillafrutescens (L.) Britt, a plant of the Labiatae family. The perilla belongs to 1 species and 3 varieties in the world, produced in East Asia; it is produced in China and can be used in medicine. Also known as Su Ye, Red Su Ye and Fragrant Su Ye.

【Plant form】Annual herb. Stems 0.3-2 m high, green or purple, obtuse quadrangular, 4-grooved, densely villous. Leaves broadly ovate or round, 7-13 cm long, 4.5-10 cm wide, pointed at apex, round or broadly wedge-shaped at base, coarsely serrated at edge above base, green or violet on both sides, or underparts only violet, and slightly soft above Hairy, adnate below; petiole 3-5 cm long, flattened dorsally and ventrally, densely covered with villous hairs.

Two-flowered whorls, composed of terminal and axillary racemes 1.5-15 cm long, densely hairy, eccentric on one side; bracts broadly ovoid or nearly round, c. 4 mm long and wide, with short spikes at apex, covered with reddish-brown glandular spots, margin membranous; pedicels 1.5 mm long, densely hairy. Calyx campaniform, 10-veined, straight, villous below, mingled with yellow glandular tips, sparsely pubescent inside throat; corolla white to purple, 3-4 mm long, 3-4 mm wide, coronal tube short, 2 -2.5 mm long, obliquely bell-shaped throat, almost 2-lipped eaves, lip upper emarginate, lower lip with 3 lobes, middle lobe larger, lateral lobes similar to upper lip.

Stamens 4, front pair longer, inserted into throat, anthers 2 chambered, chambered parallel, then slightly divergent or extremely divergent; apex of style equal and 2 lobed; enlarged finger-shaped anterior disc. The nutlets are spherical, taupe, 1.5 mm in diameter, with a reticulate pattern, a flowering period from August to November and a fruiting period from August to December.

Contains volatile oil (perilla oil), the oil mainly contains: perillaldehyde (1-Peril-laldehyde), perilla alcohol (1-Perilla-alcohol), dihydroperilla alcohol (Dihydroperilla-alcohol), limonene, aromatic camphor, Menthol, Eugenene, Elsholtziaketone, Naginatake-tone, Perillaketone, Isoego-maketone, Elemicin, Nutmeg Myris-ticin, Dillapiol, α-pinene, β-pinene, menthone, eugenol, 3-octanol, 1-octen-3-ol, nerolidol , Spathulenol, phytoalcohol, etc.

In addition, it still contains: anthocyanin-3-(6-p-coumaroyl-β-D-glucose)-5-β-D-glucoside [Cyanidin-3-(6-p-coumaroyl-β-D-glucoside5 - β-D-glucoside], malonylperilloside {Mal-onylshisonine, i.e. 3-O-[6-O-(E)-p-coumaroyl-β-D-glucopyranose]-5-O-(6 -O-Propanyl-β-D-glucopyranoyl)anthocyanidin, 3-O-[6-O-(E)-p-coumaroyl-β-D-glucopyrano-syl]-5-O-(6-O-malonyl- β-D-glucopyranosyl)cyanidin}, Caffeyl-malonylcyanin, Malonyl-cis-shisonin, Caffeyl Anthocyanin (Caffeylcyanin), cis-Shisonin (cis-Shisonin), caffeic acid ester Ⅰ and Ⅱ (Caffeicester Ⅰ and Ⅱ) and apigenin 7-O-diglucuronide, luteolin 7-O-di Glucuronide and baicalein 7-O-diglucuronide; recently a monoterpene glycoside isolated from fresh leaves named Perilloside A (PerillosideA).

Perillaldehyde: molecular formula C10H14O, molecular weight 150.22, brown-red needle crystalline hydrate (methanol), melting point 180°C (effervescent). Soluble in hot water, orange solution, slightly soluble in absolute ethanol, ether and other organic solvents. Perillaldehyde has a choleretic effect and intravenous injection may increase bile secretion in rabbits; it can also restore blood flow in rats after retinal artery ischemia.

Figure 1. Chemical structures of major hydrophilic compounds identified in P. frutescens: (A) phenolic acids; Rosmarinic Acid, Rosmarinic Acid-3-O-Glucoside, Caffeic Acid, Caffeic Acid-3-O-Glucoside, Ferulic Acid (B) Flavonoids; catechin, apigenin, apigenin 7-O-glucuronide, apigenin 7-O-diglucuronide, luteolin, luteolin 7-O-glucuronide, luteolin 7-O-diglucuronide, breviscapin, breviscapin 7-O-glucuronic acid, breviscapin 7-O-acid diglucuronic, C) Anthocyanins; shikonin, malonylshikonin, anthocyanin 3-O-cafeoylglucoside-5-O-glucoside, anthocyanin 3-O-cafeoylglucoside-5-O-malonylglucoside.

Figure 2. Chemical structures of certain volatile compounds identified in P. frutescens: perillaldehyde, limonene, geraniol, perillene, benzaldehyde, perillone, isoegomaketone, anisole, apigenol, egomaketone, myristicin, elemisin.

Figure 3. Chemical structures of triterpene acids identified in P. frutescens: tormentic acid, oleanolic acid, ursolic acid, corosolic acid, 3-epicorosolic acid, pomolic acid, hyptadiene acid, augustic acid, 3-epimaslinic acid.

Figure 4. Chemical structures of the main hydrophobic compounds identified in P. frutescens: (A) fatty acids, palmitic, stearic, lauric, oleic, linoleic, linolenic acids (B) tocopherol, α-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol and (C) phytosterols; campesterol, stigmasterol, beta-sitosterol, beta-myringin.

Security Statement: (Europe) 24/25

NONH for all modes of transport

Customs code: 1302199099

1.Chromatographic conditions
Chromatographic column: Spherisob ODS column (250mm×4.6mm, 5μm); mobile phase: acetonitrile-1.25% phosphoric acid aqueous solution (86:14); flow rate: 0.5ml/min; detection wavelength: 206nm.

2.Preparation of the test article
Take 5g of this product, reflux extraction with methanol at 80°C for 3 times (25ml, 20ml×2), each time for 1h, combine the extracts, filter while hot, evaporate to dryness, dilute with methanol and dilute to 10ml, filter through a microporous membrane ( 0.45μm) filter. Determined according to the chromatographic conditions of this method.

Fig. 1 The HPLC chart of perilla leaf extract :1. Potentinic acid; 2. Oleanolic acid; 3. Ursolic acid

Perilla frutescens leaf special extract – HPLC chromatogram. 1: Caffeic Acid; 2: Vicenin 2 (Apigenin 6,8-di-C-diglucoside); 3: Luteolin 7-O-[β-glucuronosyl(1➔2) β-glucuronide];4: Apigenin 7-O-[β-glucuronosyl(1➔2) β-glucuronide]; 5: Luteolin 7-O- β-glucuronide; 6: Scutellarein 7-O- β-glucuronide; 7: Rosmaric Acid; 8: Apigenin 7-O- β-glucuronide; 9: Luteolin; 10: Apigenin.

Benefits

8.1. Sedative and analgesic effects
Perillaldehyde and stigmasterol have synergistic sedative and analgesic activity.

8.2. Anti-tumor effect
Perillyl alcohol can inhibit the activity of virus-induced carcinogenesis, can significantly inhibit the incidence of breast cancer caused by chemical carcinogens or subcutaneous transplanted tumor strains, reduce weight and volume of tumors, prolong the time for tumors to appear, and inhibit the growth and enlargement of breast cancer Growth of mouse liver tumor cells.

8.3. Antipyretic effect
Oral administration of perilla leaf decoction and intravenous infusion have a slight antipyretic effect on rabbits with experimental fever caused by mixed typhoid vaccine. This may be related to the stimulation of sweat gland secretion.

8.4. The effect on blood sugar
Perilla oil (containing mostly perillaldehyde) can help dilate blood vessels in your skin, which can raise blood sugar. After making oxime (Oxim) with perillaldehyde, the effect of oral administration is better than that of perilla oil.

8.5. Antibacterial and antiviral effects
Perilla leaf extract, perillaldehyde and citral, also have an antibacterial effect on pathogenic fungi in the skin. The volatile oil of perilla leaf extract has a strong antibacterial effect on Staphylococcus aureus in Gram-positive bacteria and Escherichia coli in Gram-negative bacteria, especially Staphylococcus aureus. Perilla stem and leaf extract has an inhibiting effect on common bacteria. Additionally, perillaldehyde, pinene and limonene have anti-Pseudomonas aeruginosa activity.

8.6. Anti-allergic effect
The anti-allergic substance of perilla leaf is water soluble and heat resistant. It is a non-volatile fragrance component and has the ability to directly inhibit the production of TNF by macrophages in vitro. Perilla leaf extract can also inhibit IgE production, inhibit the production of DNP-IgE antibodies and total IgE antibodies, but has no effect on DNP-IgG antibodies.

8.7. Anti-inflammatory effect
By observing the effect of perilla leaf juice on tumor necrosis factor (TNF), it was found that perilla leaf juice can reduce the high level of TNF in the blood by 50% to 75%. TNF is primarily a cytokine secreted by macrophages, which plays an important role in the inflammatory antibody response and immune defense. However, when TNF is in excess, it causes tissue damage, pathological changes and symptoms, such as fever, anemia, hemorrhage and necrosis, and even shock. Therefore, when excess TNF is suppressed, the above pathological changes and symptoms may be weakened or disappear.

8.8. The effect on the respiratory system
Kechuan Biwen'an, mainly composed of perilla leaf extract, has good antitussive and antiasthmatic effect through the delivery of medicinal gases and inhalation.

8.9. Haemostatic effect
Perilla has a promoting effect on the endogenous coagulation system

8.10. Other functions
The perilla aldehyde contained in perilla oil is a unique aromatic component of perilla leaves. Perilla leaves can improve macrophage phagocytosis, induce interferon in the body, and have the effect of immune function. Perilla leaves can reduce bronchial mucus secretion and relieve bronchospasm. Perilla leaves also have a strong antiseptic effect.

Application

It is widely used in the medical field,health products and cosmetics.For cold, cough, vomiting, vomiting during pregnancy, fish and crab poisoning.

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