In the field of modern skin care, anti-aging has become a hot topic that has attracted much attention. With the improvement of living standards and the increasing demand of consumers for healthy and youthful skin, various anti-aging skin care products have appeared on the market. Many brands continue to explore different anti-aging mechanisms, such as achieving more comprehensive skin care effects through cell energy supply, DNA repair, and improving the skin's self-repair ability. In this process, scientific research continues to deepen, and some emerging ingredients have begun to emerge in the field of anti-aging, including dihydromyricetin DHM.
Common anti-aging ingredients on the market
The anti-aging ingredients on the market can be mainly classified into the following categories:
Antioxidants: such as vitamin C, vitamin E, coenzyme Q10 and resveratrol, etc. These ingredients reduce oxidative stress damage and protect skin cells by neutralizing free radicals. The combined use of vitamins C and E has been shown to reduce skin photodamage and reduce wrinkle formation.
Peptides: such as copper peptides, hexapeptides, heptapeptides, etc., increase the elasticity and firmness of the skin by promoting collagen synthesis. This type of ingredient is usually used to improve wrinkles and fine lines.
Cell growth factors: such as epidermal growth factor (EGF), which can promote the proliferation and repair of skin cells, help increase the renewal rate of the skin, and thus improve skin quality.
Plant extracts: such as Centella asiatica extract, ginseng extract, green tea extract, etc., have antioxidant, anti-inflammatory and skin barrier function improvement effects, and can fight against photoaging and environmental pollution damage to the skin.
Ceramide: This ingredient is a component of the skin barrier, which can lock in moisture, protect the skin from external stimuli, and keep the skin hydrated.
Retinol and its derivatives: including retinoic acid and retinol aldehyde, can promote cell renewal and collagen synthesis.
Efficacy and mechanism of action of dihydromyricetin
Dihydromyricetin is a flavonoid compound that was first extracted from the traditional Chinese medicinal plant Ampelopsis grossedentata. Dihydromyricetin is widely used for its significant antioxidant and anti-inflammatory properties.
It can effectively remove reactive oxygen species (ROS) and free radicals, protecting cells from oxidative stress. Compared with other common antioxidants such as vitamin C and E, DHM has a stronger effect in specific free radical scavenging ability. Glycation is another important factor in skin aging. High blood sugar can cause non-enzymatic glycation reactions between proteins and sugars to form AGEs (advanced glycation end products), thereby damaging skin elasticity. Studies have shown that dihydromyricetin has good anti-glycation effects, can reduce the formation of AGEs, and help maintain skin firmness and elasticity. As we age, the increase in skin inflammation is also one of the causes of aging. DHM can reduce the inflammatory response by inhibiting the activity of the NF-κB pathway, thereby reducing skin damage caused by inflammation and improving skin barrier function, thereby effectively delaying this process.
Identification of dihydromyricetin (DHM) as a DNMT1 inhibitor
In recent years, more and more studies have introduced DHM into the field of skin care to explore its potential in anti-aging. In particular, the study found that dihydromyricetin has a unique effect on inhibiting DNA methylase DNMT1, thus providing a new idea for anti-aging at the cellular epigenetic level.
DNA methylation and aging
DNA methylation is a core mechanism of epigenetic regulation. Simply put, DNA methylation is the addition of a methyl group to a specific site on the DNA molecule, a process catalyzed by DNA methyltransferases (such as DNMT1). The increase or decrease in methylation directly affects gene expression, and then affects the state of skin cells. For example, with age, many genes related to the youthful state will gradually be silenced by methylation, leading to cell function decline and skin aging. Therefore, controlling or reversing the methylation process of these genes has become an important direction for anti-aging research.
DHM inhibits DNA methylation in primary human keratinocytes
How does dihydromyricetin delay skin aging?
In recent years, studies have shown that dihydromyricetin can effectively inhibit DNMT1 activity, thereby reducing DNA methylation at the cellular level. This means that DHM may help the skin restore its youthful state from the root by inhibiting the methylation of certain aging-related genes.
A study published in Frontiers in Aging showed that DHM can reduce the overall DNA methylation level in human keratinocytes while inhibiting DNMT1. This moderate methylation inhibition helps to reactivate those "young genes" that are silenced due to aging and reduce age-related epidermal thinning in a three-dimensional skin model.
In vivo and functional effects of DHM on skin aging phenotypes
In addition, dihydromyricetin also shows antioxidant properties, which is also crucial for anti-aging. Oxidative stress is one of the main factors leading to skin aging, and excessive free radical damage can damage the structure of skin cells. As a powerful antioxidant, DHM can effectively scavenge free radicals, prevent their damage to skin cells, reduce pigmentation, and improve the gloss and elasticity of the skin.
Application prospects in skin care products
Due to its excellent antioxidant, anti-inflammatory and epigenetic regulatory properties, dihydromyricetin has begun to be used in skin care products in recent years. With scientifically extracted high-purity dihydromyricetin powder, brands can add this ingredient to skin care products to help consumers achieve anti-aging effects at the epigenetic level. Unlike traditional anti-aging ingredients such as bosaicin and bifida yeast extract, DHM has a deeper anti-aging mechanism and provides more powerful cell repair and rejuvenation support.
At present, many skincare brands have paid attention to the potential of DHM and use it in anti-aging products such as serums and creams to achieve more comprehensive anti-aging effects. In the future, with the advancement of technology and the continuous deepening of scientific research, DHM is expected to be widely used in skin care products and may become a new favorite in the skin care industry.
About us - 98% dihydromyricetin powder from Xi'an kintai biotech inc.
As a professional natural plant extract manufacturer, KINTAI focuses on the production of high-purity dihydromyricetin. We provide 98% pure dihydromyricetin powder, which is reliable, high-purity, and fat-soluble, suitable for various skin care formulations. Whether added to creams, serums, or masks, our products can help brands create high-end anti-aging skin care products. All major brands are welcome to contact us at Email: sales@kintaibio.com to learn more about dihydromyricetin powder product information and cooperation plans.
