Cotinus Coggygria Extract Fisetin Powder

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As a professional manufacturer of plant extracts, KINTAIBIO^® offers Fisetin Powder, featuring fisetin as its core active ingredient. Fisetin is a naturally occurring flavonoid-specifically a flavonol-found in plant-based foods. It exhibits the structural characteristics typical of polyphenols, containing multiple phenolic hydroxyl groups and a conjugated system within its molecular structure. We provide Cotinus Coggygria Extract Fisetin Powder in various purity specifications-including 10%, 20%, 50%, 85%, and 98%-to meet diverse needs regarding R&D, formulation development, and raw material procurement. Customers can select the appropriate specification based on their target applications, quality standards, and production requirements.

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From a scientific research perspective, key areas of study regarding fisetin include its antioxidant properties, modulation of inflammation, effects on cellular senescence, and neuroprotective potential. Its mechanisms of action involve multiple cellular signaling pathways, including the regulation of oxidative stress, inflammation-related signaling, and molecular mechanisms governing cell survival and aging. In recent years, fisetin powder has emerged as a popular plant-derived active ingredient in the fields of dietary supplements, functional ingredient development, and life sciences research.

• fisetin solubility: Fisetin has low water solubility; its dissolution behavior is influenced by factors such as the solvent system, pH, temperature, raw material purity, and particle characteristics. Consequently, when developing water-based beverages, liquid formulations, or other products requiring high dispersibility, it is usually necessary to conduct specific tests for solubility, dispersibility, and stability tailored to the formulation.

• fisetin bioavailability: Oral absorption and systemic exposure to fisetin can be influenced by various factors, including solubility, intestinal absorption, metabolism, and the dosage form. Current research is exploring the impact of lipid-based delivery systems, nano-formulations, and other formulation technologies on fisetin's solubility and in vivo utilization.

As a professional manufacturer of Cotinus Coggygria Extract Fisetin Powder , we support sample requests, customized Fisetin Powder development, and bulk procurement. We also provide documentation-including COAs, product specifications, Technical Data Sheets (TDS), SDS/MSDS, and batch-specific quality records-to assist customers with raw material evaluation, formulation validation, and supply chain quality management. Please contact sales@kintaibio.com to learn more about the products.

One of the classic botanical sources for the Cotinus Coggygria Extract Fisetin Powder we produce is Cotinus coggygria, a plant belonging to the Cotinus genus within the Anacardiaceae family. Fisetin was first isolated from Cotinus plant material in the late 19th century; consequently, it is sometimes referred to as "cotinin" in certain literature. Cotinus coggygria is a deciduous small tree or shrub known for its strong adaptability and is distributed across regions including Southwest and North China. It is a popular ornamental plant, prized for the vibrant red color its leaves display in autumn.

From the perspectives of natural product research and raw material development, Cotinus coggygria holds significant value. Fisetin is a plant secondary metabolite; beyond Cotinus, it occurs naturally in various plant-based foods such as strawberries, apples, grapes, persimmons, onions, and cucumbers. However, fisetin content varies significantly depending on the plant species, the specific plant part, and growing conditions. Therefore, its natural presence in foods does not imply that raw fisetin material with stable specifications and high purity can be directly obtained. For industrial applications, selecting suitable plant raw materials-and producing fisetin powder with consistent potency through standardized extraction, purification, and quality control-is crucial to meeting the demands of R&D and large-scale procurement.

fisetin skin benefits

Animal studies indicate that fisetin may offer protection against UVB-induced skin damage by modulating signaling pathways associated with oxidative stress and inflammation. Research involving topical application on hairless mice has shown that fisetin mitigates UVB-induced erythema and wrinkle formation, inhibits excessive epidermal hyperplasia, and helps maintain dermal collagen levels. Mechanistically, these effects are linked to the inhibition of MMP-1, MMP-2, and COX-2 expression, the upregulation of Nrf2-mediated antioxidant responses, and increased filaggrin expression-processes that respectively influence extracellular matrix degradation, inflammatory responses, oxidative stress defense, and skin barrier function.

 

These findings suggest that Cotinus Coggygria Extract Fisetin Powder holds potential as an ingredient for research into anti-photodamage, antioxidant, and skin barrier care applications, and could be utilized in the development of skincare formulations and cosmetic active ingredients. However, current evidence is derived primarily from cell and animal studies and cannot be directly equated to anti-wrinkle, reparative, or photoprotective efficacy in humans.

fisetin testosterone

In recent years, the role of fisetin in the mammalian reproductive system has garnered attention. Reviews of existing research indicate that, owing to its antioxidant and anti-inflammatory properties, fisetin may exert protective effects on testicular tissue, sperm quality, and cellular homeostasis within the reproductive system in animal and cellular models; research in this area also encompasses the regulation of reproductive hormones.

 

Its potential mechanisms likely involve the mitigation of oxidative stress, the modulation of inflammation-related signaling pathways, and the improvement of the microenvironment for testicular cells; consequently, some studies are investigating it as a candidate natural compound for supporting male reproductive health and hormonal balance. However, evidence that Cotinus Coggygria Extract Fisetin Powder directly boosts testosterone levels in humans remains limited, and issues regarding its absorption and in vivo metabolism require further investigation.

fisetin and diabetes

Previous studies have shown that in streptozotocin (STZ)-induced diabetic rat models, continuous treatment with fisetin leads to a reduction in blood glucose and glycated hemoglobin (HbA1c) levels, accompanied by an increase in plasma insulin levels. Further molecular research indicates that fisetin reduces hepatic glucose production (HGP), suggesting it may regulate glucose homeostasis by modulating hepatic gluconeogenesis.

 

While this study provides experimental evidence supporting research into fisetin's role in metabolic health, the findings are primarily derived from STZ-induced diabetic rat models; the dosages and mechanisms of action observed in these animal experiments cannot be directly extrapolated to humans. Nevertheless, Cotinus Coggygria Extract Fisetin Powder holds potential as a plant-derived flavonoid for further research into formulation and application regarding the regulation of glucose metabolism and hepatic gluconeogenesis.

fisetin anti inflammatory

Fisetin is a natural flavonoid compound of significant research interest; its anti-inflammatory effects are primarily linked to the modulation of oxidative stress and inflammatory signaling pathways. Existing studies on cells and animals indicate that Cotinus Coggygria Extract Fisetin Powder can alleviate inflammatory responses under specific experimental conditions by reducing oxidative stress, regulating the release of inflammatory cytokines, and influencing cell signaling pathways associated with neuroinflammation.

 

In a study involving aluminum chloride (AlCl₃)-induced neurodegenerative damage in adult Wistar rats, Fisetin was investigated for its modulatory effects on oxidative stress and neuroinflammation; the findings further support its potential as a candidate compound for antioxidant and anti-inflammatory applications. Overall, Fisetin's anti-inflammatory potential stems from the interplay between oxidative stress and inflammatory responses, making it a promising plant-derived active ingredient for the development of products supporting neurological health, cellular health, healthy aging, and the management of inflammation-related conditions.

fisetin benefits brain

Brain tissue is highly sensitive to oxidative stress; excessive reactive oxygen species (ROS) can induce lipid peroxidation, DNA damage, mitochondrial dysfunction, and neuroinflammation, thereby impairing the normal survival and function of neurons. Existing reviews indicate that fisetin possesses antioxidant activity and may offer neuroprotection by mitigating ROS-induced oxidative damage, modulating redox balance, inhibiting nitric oxide (NO) production, and influencing processes related to neuroinflammation and apoptosis.

 

Research into molecular mechanisms reveals that fisetin modulates signaling pathways such as Nrf2, PI3K/Akt, NF-κB, PKC, and MAPK. These pathways are involved in cellular antioxidant defense, inflammatory responses, survival signaling, and stress responses, positioning Cotinus Coggygria Extract Fisetin Powder as a promising candidate for research into neuroprotection and brain health.

fisetin benefits for hair

Fisetin has also been investigated for its role in hair growth, with potential effects linked to hair follicle stem cell activity and the regulation of the hair follicle growth cycle. Relevant cellular and animal studies indicate that Fisetin enhances the expression of telomerase reverse transcriptase (TERT) in keratinocytes and modulates factors associated with the hair follicle microenvironment and hair growth-such as IGF-1, KGF, and TGF-β1-while potentially involving the regulation of the β-catenin signaling pathway.

 

Research findings suggest that Cotinus Coggygria Extract Fisetin Powder may promote the transition of hair follicles from the resting phase (telogen) to the growth phase (anagen) and support the proliferation of hair follicle stem cells and related cell types, thereby demonstrating potential hair growth-promoting effects. Consequently, Fisetin serves as a plant-derived active ingredient with promising potential for research into hair follicle health and hair growth, making it suitable for the development of scalp care products, hair care formulations, and related functional products.

fisetin benefits for women

In recent years, Fisetin has garnered attention in the fields of women's health and female reproductive system research. Studies indicate that Fisetin may influence cellular processes associated with oxidative stress and chronic inflammation by reducing reactive oxygen species (ROS) levels, enhancing antioxidant defenses (such as SOD1 and CAT), and modulating inflammation-related signaling pathways (such as NF-κB).

 

Research into female reproductive health has also examined Fisetin in the contexts of ovarian aging, ovarian function, fibrosis, angiogenesis, and hormonal regulation; some *in vitro* and animal studies suggest it holds potential value for maintaining ovarian tissue homeostasis and associated cellular functions. Furthermore, as a potential senolytic agent, Cotinus Coggygria Extract Fisetin Powder is being investigated for its role in age-related changes in ovarian function and the aging process of the female reproductive system. However, current research remains primarily at the stage of *in vitro* experiments and animal studies.

fisetin blood pressure

Fisetin, a natural flavonoid, may exert a regulatory effect on hypertension-associated cardiac hypertrophy and structural cardiac changes. Studies involving H9c2 cardiomyocytes and spontaneously hypertensive rats (SHR) have demonstrated that Fisetin treatment attenuates angiotensin II (Ang II)-induced cardiac hypertrophy and inhibits pathological changes associated with the Calcineurin-NFATC3 signaling pathway.

 

In animal experiments, treatment with Fisetin was also associated with improvements in cardiac morphology and functional parameters. These findings suggest that Fisetin Powder-by ​​influencing cardiomyocyte hypertrophy and related cellular signaling processes-may offer a new direction for research into hypertension-associated cardiac remodeling.

fisetin depression

Depressive moods and depression-related cognitive changes are associated with various physiological processes-such as oxidative stress, chronic inflammation, neuroinflammation, mitochondrial dysfunction, and neuronal damage-making fisetin, with its multi-target biological activity, a promising plant-derived bioactive compound for research into emotional and brain health.

 

Animal studies have shown that fisetin acts on multiple physiological factors linked to an increased risk of dementia and exhibits direct neuroprotective effects; this suggests it may influence age-related changes in brain function by reducing oxidative stress and neuroinflammation, improving cellular homeostasis, and supporting neuronal function.

• Fisetin and fertility: Existing research primarily focuses on the relationship between its antioxidant, anti-inflammatory, and cellular senescence-regulating properties and reproductive health in both men and women. Studies cover areas such as ovarian function, spermatogenesis, and the reproductive microenvironment; however, current findings are largely based on cell and animal models and cannot be directly equated to enhanced human fertility.

• Fisetin antioxidant : Fisetin powder contributes to cellular protection by modulating ROS, SOD, CAT, and related oxidative stress signaling pathways, establishing a solid foundation for its role as an antioxidant.

• Fisetin antiviral : Experimental studies suggest it may function by influencing processes related to viral replication and host cell inflammatory responses; however, specific viral targets, mechanisms of action, and efficacy in humans require further validation.

• Fisetin for dogs: It serves primarily as a research ingredient for pet nutrition, healthy aging, and antioxidant applications. Clinical evidence regarding direct Fisetin supplement in dogs remains limited, making it best suited as a candidate ingredient for the development of pet nutrition products.

• Fisetin arthritis: Its antioxidant and inflammation-modulating properties make it a promising plant-derived ingredient for research into arthritis and inflammation-related conditions, though existing evidence requires further confirmation through more extensive animal and human studies.

Overall, our Cotinus Coggygria Extract Fisetin Powder offers the advantage of multi-pathway and multi-target potential in basic research, making it suitable for formulation and R&D exploration across sectors such as nutritional health, healthy aging, pet nutrition, sports recovery, and functional foods.

Reference:https://www.mdpi.com/1422-0067/18/10/2118

https://www.mdpi.com/2306-7381/13/5/438

https://www.sciencedirect.com/science/article/abs/pii/S0014299914005354

https://www.sciencedirect.com/science/article/pii/S2214750024001951

https://pmc.ncbi.nlm.nih.gov/articles/PMC9589363/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7593534/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12899922/

https://www.sciencedirect.com/science/article/abs/pii/S1756464618305656

https://pmc.ncbi.nlm.nih.gov/articles/PMC11304624/

Fisetin powder produced by KINTAIBIO^® serves as a natural flavonol active ingredient suitable for use in dietary supplements, functional foods, nutritional health products, and cosmetic formulations.

Fisetin Supplements

Given its activity in areas such as antioxidant defense, inflammation modulation, and cellular senescence research, Fisetin is a promising candidate for formulations targeting healthy aging, cellular health, and neurological health. Depending on product positioning, it can be developed into solid dosage forms such as tablets, capsules, and pills.

Fisetin Senolytic

Fisetin's potential as a senolytic agent has garnered significant interest in the healthy aging sector. However, as human clinical validation is still in the early stages, it is best positioned scientifically as a research-oriented functional ingredient during product development.

Fisetin in Beauty and Personal Care

Research into Fisetin's antioxidant and cytoprotective properties highlights its value for skin health formulations, making it a candidate for active ingredients in products such as skin creams. Additionally, its structure as a natural flavonoid makes it a viable raw material for research into food applications and natural active ingredients.

However, Cotinus Coggygria Extract Fisetin Powder is not a widely used food coloring agent in the traditional sense. Its practical application in food requires evaluation based on purity, solubility, stability, the food matrix, and target market regulations; it cannot simply be equated with approved natural food colorants. Due to product development challenges-such as low water solubility and limited oral bioavailability-practical applications may involve formulation optimization using techniques like micronization, encapsulation, or other delivery systems to enhance dispersibility, stability, and performance.

Fisetin safety / Is fisetin safe? / Fisetin toxicity

While there is some existing basic research and early-stage human research, there is insufficient evidence regarding the long-term safety of high-dose fisetin in humans; therefore, it should not be characterized as an ingredient with fully established safety.

Fisetin dosage

Clinical studies have employed intermittent, higher-dose regimens-such as approximately 20 mg/kg/day for two consecutive days-to investigate safety, pharmacokinetics, and senescent cells; however, these represent research dosages used in clinical trials and do not equate to recommended intake levels for general dietary supplements. Currently, there is no standard fisetin dosage established by the FDA.

Fisetin side effects

Existing early-stage human data have not shown clear or widespread serious adverse reactions; however, some clinical study protocols prioritize monitoring renal function, laboratory markers, and tolerability, and studies have documented transient changes in renal function markers that warrant further attention.

Fisetin drug interactions / Fisetin interactions

Research suggests that Cotinus Coggygria Extract Fisetin Powder and other flavonoids may affect enzymes involved in drug metabolism-such as those in the CYP450 pathway-and could theoretically alter the exposure levels of certain medications. Individuals undergoing prescription drug therapy-particularly those taking anticoagulants or other medications sensitive to metabolic interactions-should consult a healthcare professional to evaluate potential interactions.

If you are seeking a reliable Fisetin powder supplier or wish to buy Fisetin powder for use in dietary supplements, functional foods, cosmetics, or research projects, KINTAIBIO^® offers Fisetin powder in various purity specifications and supports sample evaluation, custom development, and bulk supply. As a professional Cotinus Coggygria Extract Fisetin Powder manufacturer, we prioritize raw material specifications, batch quality control, and supply stability, offering tailored product solutions based on your requirements regarding purity, application, order volume, and quality documentation.

Overseas clients interested in purchasing Fisetin powder-whether for wholesale or long-term procurement-are welcome to contact us directly for information on pricing, MOQs, packaging, and bulk supply options. As a Chinese Fisetin powder manufacturer, we provide overseas dietary supplement brands, ingredient traders, formulators, and research institutions with samples, COAs, specifications, TDS, SDS/MSDS, and relevant batch quality data to facilitate raw material evaluation and supplier audits. Please feel free to contact sales@kintaibio.com to request a quote.

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