Let's try to understand the pharmacological activity of Tribulus Terrestris Extract powder！
Part1. Pharmacology of Traditional Chinese Medicine
Nature, flavor and meridian distribution: pungent, bitter, slightly warm; slightly poisonous. Return liver channel. Functions and indications: Pinggan Jieyu. Promoting blood circulation and expelling wind, improving eyesight, and relieving itching. For headache and dizziness, distending pain in the chest and hypochondriac, mastitis, red eyes and nebula, rubella and itching. Materia Medica Records: It was first recorded in "Shen Nong's Materia Medica", which is a traditional Chinese medicine recorded in the Pharmacopoeia. Usage: Oral administration: decoction, 6-9 grams; or into pills, scattered. External application: crushed for applying or powdered for spreading.
Contraindications: Blood deficiency and weak Qi and pregnant women should take it with caution, and those with liver deficiency and dizziness should not use it.
Part2. Pharmacological effects
1. The effect on the cardiovascular system
Anti-arteriosclerosis and anti-platelet aggregation: The thick saponin preparation of stems and leaves of Tribulus terrestris has a vagal effect on the cardiovascular system of cats and rabbits, can enhance myocardial contractility, slow down heart rate, expand coronary arteries and peripheral blood vessels, and show relaxation. antihypertensive effect.
Lower cholesterol: Tribulus terrestris extract can significantly reduce the cholesterol level in experimental hypercholesterolemia, and inhibit the lipid deposition in arteries, myocardium and liver.
Lower blood pressure: Tribulus terrestris water extract, ethanol-water extract and 30% ethanol extract have hypotensive effect on anesthetized animals. Its alkaloid part has no effect on blood pressure of dogs, but it can inhibit frog heart, and the water-soluble part has moderate antihypertensive effect.
Anti-myocardial ischemia: saponins still have obvious anti-cardiac ischemia effect. Cardioprotective effect: Tribulus terrestris extract can significantly reduce the damage of rat myocardial mitochondria caused by ADR, and has a protective effect on ADR cardiotoxicity.
2. Strong and anti-aging effect
Tribulus terrestris extract has obvious protective effect on mice subjected to stress stimuli such as high temperature, low temperature, hypoxia and swimming. It can also significantly reduce the VC content in the adrenal gland of rats, and can also inhibit the "exhaustion" phenomenon caused by high-dose hydrocortisone, and has a protective effect on the decrease of VC content caused by ACTH. After the removal of bilateral adrenal glands in mice, the hypoxia tolerance effect was no longer reproduced. These effects may be related to the function of the adrenal cortex.
3. Anti-inflammatory and anti-fatigue effects
Tribulus terrestris extract has obvious inhibitory effect on mouse ear shell swelling caused by xylene, prolongs the survival time of mice under hypoxic conditions and the swimming time of mice under weight-bearing conditions has a significant difference compared with the control group. Conclusion Tribulus terrestris extract has certain anti-inflammatory, hypoxia-resistant and anti-fatigue effects. The extract can prolong the exhaustive exercise time of endurance exercise rats.
4. Sexual strengthening effect
Oral administration of Tribulus terrestris extract to rats can significantly stimulate sperm formation, excite the activity of sertoli cells, and increase libido. Tribestan, another new preparation extracted from crude saponins from the stems and leaves of Tribulus terrestris, can significantly stimulate sperm formation, excite the activity of Sertolicell cells, and increase libido when administered orally to male rats; it can promote estrus when administered to female rats. Improves fertility.
5. Diuretic effect
Tribulus terrestris is used in Indian folk as a diuretic. In the rat test of saline load, the diuretic effect is not ideal, and the diuretic effect of its ash water extract and plant decoction.
6. Other functions
Both alkaloids and water-soluble parts of Tribulus terrestris can inhibit the movement of the small intestine of rats and antagonize with acetylcholine. Plant extracts can inhibit the growth of Staphylococcus aureus and Escherichia coli. Tribulus terrestris extract has a relaxing effect on the duodenum of rabbits.
Part3. Modern Applications
Tribulus is commonly used in the former Soviet Union and Eastern European countries to strengthen the body. Athletes in some countries often take Tribulus extract to enhance physical strength. It is a natural food without toxic side effects. In the current FDA regulations, there is no requirement to limit or prohibit ingredients. Tribulus is listed as a prescription drug in Ireland. Tribulus terrestris extract and its preparations are clinically used to treat arteriosclerosis, prevent and treat coronary heart disease, angina pectoris, prevent and treat ischemic cerebrovascular disease, enhance sexual function, and anti-aging. Foreign countries have developed "Tribustan" and " "Vitanone" and "Tribusaponin" for softening blood vessels. my country has developed "Xinnaoshutong" and other preparations using stems and leaves as raw materials.
Tribulus terrestris extract has become the mainstream nutritional supplement for regulating sports endocrine function in the sports nutrition market, and has the potential effect of promoting the secretion of testosterone in athletes.
