Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of podophylline podophyllum resin powder in China. Please feel free to wholesale high quality podophylline podophyllum resin powder for sale here from our factory. For price consultation, contact us.
Podophylline Podophyllum Resin powder Manufacturer
KINTAIBIO®'s Podophyllum extract powder is a natural powder extracted from the Berberidaceae plant Podophyllum. Its core active ingredients and main specifications are 90%, 98%, and 99% podophyllotoxin, 25% and 50% podophylline, and 98% picropodophyllotoxin. Our Podophylline Podophyllum Resin Powder specifications can be customized upon request, exhibiting good batch-to-batch stability and suitable for standardized production of topical formulations and pharmaceutical intermediates.
(Note: For products containing 50% Podophylline, we offer both US standard (USP29) and British standard (BP2018) specifications. US standard specifications typically contain between 42% and 50% Podophylline, and it's impossible to achieve over 50% in every batch, but the price will be relatively more favorable.)
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This ingredient has a long history of medicinal use, having been included in the United States Pharmacopeia in 1820. Its mechanism of action is clear: it exerts an anti-mitotic effect by reversibly binding to microtubules and has a destructive effect on human papillomavirus (HPV) particles, possessing both cell-inhibiting and antiviral properties. Modern research further confirms that topical podophyllin is primarily used to treat condyloma acuminata, and it has also demonstrated clear anti-tumor potential in various cancer fields, including lung cancer, breast cancer, colorectal cancer, and leukemia.
COA Of Podophylline Podophyllum Resin powder
How to make Podophylline Podophyllum Resin powder?
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Raw Material Pretreatment and Grinding
Select dried rhizomes of Podophyllum hexandrum that meet quality standards. After selection and removal of impurities, grind them into a coarse powder of 20-40 mesh using a grinder to increase the contact area and improve subsequent extraction efficiency.
Ethanol Reflux Extraction
Place the ground raw material into a multi-functional extraction tank and add 90% ethanol solution (the material-to-liquid ratio is typically controlled at 1:6-1:10, adjusted according to actual equipment). Turn on steam heating and maintain the tank temperature at 70℃ for reflux extraction. Repeat the extraction three times according to patent requirements, each extraction lasting approximately 1.5-2 hours to ensure sufficient dissolution of fat-soluble components. Combine the three extracts and transfer them to a concentration tank.
Vacuum Concentration
Concentrate the combined extract under reduced pressure (temperature controlled at 60-65℃, vacuum degree -0.06 to -0.08 MPa) to recover the ethanol solvent until a relatively dense, brownish-red slurry (fluid extract) is obtained.
Extraction and Crystallization (Crude Product Preparation)
Add petroleum ether (boiling range 60-90℃) to the concentrated brownish-red slurry and stir for liquid-liquid extraction to remove some lipid-soluble impurities using polarity differences. After standing and separating the layers, discard the lower brownish-red liquid and retain the upper pale yellow liquid. Crystallize this pale yellow liquid at low temperature (4-10℃, standing for 24-48 hours). After the crystals have fully separated, centrifuge and filter to obtain white to pale yellow crude Podophyllum Resin.
Column Chromatography Purification (Core Purification Step)
Dissolve the crude Podophyllum Resin in an appropriate amount of chloroform. Prepare a vacuum chromatography column (industrial equipment uses a jacketed column with a filter plate). The column inner diameter is designed to be 15-50 cm according to the production volume, and the diameter-to-height ratio is controlled at 1:3-10. The column is packed with 200-300 mesh silica gel. Negative pressure (0.01~0.2 MPa) is used to accelerate the flow of the mobile phase and improve separation efficiency.
Gradient elution is performed using a mixture of alcohols (methanol/ethanol) or ketones (acetone) and chloroform, with a volume ratio of organic solvent to chloroform of 1~4:10. During elution, an online UV detector is used to monitor and collect the eluent with strong absorption at 292 nm.
Concentration and Drying
The collected target eluent is concentrated under reduced pressure to recover the organic solvent. The concentrate is then concentrated to dryness to obtain a white to off-white extract. This extract is then vacuum dried (40~50℃), pulverized, and sieved to obtain a high-quality Podophyllum Resin powder.
what are the benefits of Podophylline Podophyllum Resin powder?
Podophylline Podophyllum Resin Powder for Skin Tags/Warts
In the treatment of skin growths and warts, the value of podophyllum extract lies in its irreplaceable status as a classic topical preparation. Since Kaplan first described its clinical application in 1942, topical products with podophylline or purified podophyllotoxin as the active ingredient have consistently been the first-line choice for treating genital warts, perianal warts, and plantar warts. Its mechanism of action is clear-through reversible binding to microtubules, it exerts an antimitotic effect, arresting wart tissue cells in metaphase, while simultaneously destroying human papillomavirus (HPV) viral particles, achieving direct cytotoxicity.
Source:https://www.sciencedirect.com/
Modern purification processes yield podophyllotoxin that is not only homogeneous in composition and standardized in efficacy, but also significantly reduces local irritation and the risk of systemic absorption. Clinical data show that patients using 0.5% podophyllotoxin can achieve a wart clearance rate of 37%–71%, especially effective on mucosal surfaces, with a recurrence rate controlled between 20% and 30%.
Podophylline Podophyllum Resin Powder for Cancer
In the field of anti-tumor applications, podophyllotoxin, the core active ingredient of Podophylline Podophyllum Resin Powder, and its semi-synthetic derivatives, have become an important component of modern anti-tumor drugs. Classic chemotherapy drugs such as etoposide and teniposide are structurally modified based on the podophyllotoxin pharmacophore and are widely used in the clinical treatment of various malignant tumors, including lung cancer, nephroblastoma, non-Hodgkin's lymphoma, glioblastoma multiforme, and non-lymphocytic leukemia.
Source:https://www.mdpi.com/
More importantly, podophyllotoxin derivatives also show inhibitory activity against multidrug-resistant tumor cells. For example, 4-β-aniline podophyllotoxin derivatives effectively inhibited the growth of KB/VCR resistant cell lines in both in vitro and in vivo experiments, demonstrating the potential to overcome tumor drug resistance. In recent years, podophyllotoxin analogues have remained a key focus of novel anticancer drug development, with continuous progress in research on hepatocellular carcinoma, colorectal cancer, pancreatic cancer, head and neck squamous cell carcinoma, and neuroblastoma.
Reference:https://www.sciencedirect.com/topics/medicine-and-dentistry/podophyllin
https://www.mdpi.com/2218-273X/11/4/603
what are Podophylline Podophyllum Resin powder uses?
Podophylline Podophyllum Resin Powder cream/drugs
Podophylline Podophyllum Resin Powder has a mature application in the field of topical dermatological preparations and is the core active ingredient in the preparation of podophyllotoxin ointments, gels, solutions, and tinctures. These preparations are mainly used to treat genital warts, anal warts, and plantar warts in adults. In clinical applications, purified podophyllotoxin is formulated into ointments or gels for patients to apply at home. It is important to note that due to the mutagenicity and potential neurotoxicity of podophyllum resin, these preparations are explicitly contraindicated in pregnant and lactating women, and should not be used on mucous membranes such as the cervix, vagina, rectum, and urethra.
what are the Podophylline Podophyllum Resin powder side effects?
In clinical application, topical preparations made from podophyllum extract powder may cause local and systemic adverse reactions after absorption through the skin. Common side effects include redness, swelling, itching, burning, and tenderness at the application site. Serious side effects are more common when applied to excessively large areas, at excessively high concentrations, or on broken skin, and may manifest as vomiting, abdominal pain, diarrhea, bone marrow suppression, confusion, altered consciousness, seizures, dyspnea, severe constipation, decreased urine output, numbness and weakness in the extremities, abnormal bleeding, and systemic toxicity symptoms such as arrhythmia.
Furthermore, some adverse reactions may be delayed and last for more than a week. Severe burning or stinging sensations at the application site require immediate medical attention.
is podophyllin safe in pregnancy?
Due to its well-defined mechanism of action-inhibition of cell division through podophyllotoxin-it is strictly contraindicated in pregnant and lactating women, and should not be used on mucous membranes such as the cervix, vagina, rectum, or urethra, or applied over large areas to broken skin.
where to buy Podophylline Podophyllum Resin powder?
As a professional manufacturer of Podophylline Podophyllum Resin powder, we are committed to providing high-quality plant-derived medicinal raw materials to customers worldwide. KINTAIBIO® focuses on the research and production of highly active ingredients, possessing a complete traceable supply chain and a rigorous quality management system to ensure that each batch of products meets high standards in terms of purity, stability, and compliance.
We offer a long-term, stable supply of Podophylline Podophyllum Resin powder for sale and provide customized support for raw materials and formulations such as podophyllotoxin and Podophylline Podophyllum Resin powder. Customers can consult and purchase through our official channel, podophyllotoxin buy online. For specific information on Podophylline Podophyllum Resin powder price, podophyllotoxin price, etc., please contact our sales team directly at sales@kintaibio.com for the latest quotations and technical support.
FAQ
Q: How long does podophyllin take to work?
A: The effects of podophyllin resin and its purified component, podophyllotoxin, typically begin to appear within a few days of the first application. In standard intermittent therapy (3 days of continuous application followed by 4 days of observation), patients usually observe necrosis, softening, or shedding of the wart tissue on the 2nd to 3rd day after application, with local redness, swelling, and mild erosion.
Q: Is podophyllin cream painful?
A: Podophyllotoxin ointment is usually painless upon initial application. However, as the drug takes effect, predictable local reactions typically appear on the 2nd to 3rd day after application, including mild to moderate tenderness, redness, swelling, itching, burning sensation, and superficial ulceration of the skin surface. These are normal signs of the drug's action. However, if severe pain, intense burning sensation, or extensive erosion occurs, it indicates a possible overdose or contact with normal skin, requiring immediate discontinuation of the medication and consultation with a doctor.
Q: Can podophyllin cause cancer?
A: Purified podophyllotoxin preparations have removed the aforementioned impurities, significantly improving their safety. Currently, 0.5% podophyllotoxin gel or solution used clinically is considered to have good safety under standardized use. It is important to emphasize that long-term use or repeated irritation may still cause local histological changes; therefore, the course and frequency of use should be controlled under the guidance of a professional physician.
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