Cytisine is a quinolone alkaloid primarily extracted from legumes. As a high-affinity nicotinic acetylcholine receptor ligand, Thermopsis Lanceolata Extract cytisine partially activates β2 receptors while fully activating α7 and β4 receptors. Notably, it has a long history of clinical use in Eastern Europe as a smoking cessation medication, with representative products including Tabex and Desmoxan. Its safety, efficacy, and cost-effectiveness have been fully validated in long-term clinical practice.
As a manufacturer of high-purity cytisine powder, KINTAIBIO® is committed to providing high-quality raw materials to the global pharmaceutical market, supporting not only traditional smoking cessation treatments but also actively exploring new applications of this classic molecule in modern medicine.
What is Cytisine Used For?
The most important and mature clinical application of cytisine is helping smokers quit tobacco dependence. Sophora Alopecuroides Extract Cytisine is a partial agonist of the α4β2 nicotinic acetylcholine receptor, moderately stimulating the receptor to alleviate withdrawal symptoms without producing the highly addictive effects of nicotine. It competes with nicotine for the same receptor but binds more strongly, blocking nicotine from binding to the receptor and thus reducing the pleasure and reward effects of smoking. This cytisine mechanism of action can both alleviate discomfort during smoking cessation and weaken the intrinsic motivation for relapse.
Source:https://www.sciencedirect.com
Recent nonclinical studies and reviews suggest that Thermopsis Lanceolata Extract cytisine may have broader pharmacological activities, including: alcohol use disorder, antidepressant effects, neuroprotection, weight management, antitumor activity, anti-osteoporosis, and cardiovascular protection. It is important to emphasize that these expanded applications are primarily based on nonclinical studies and in vitro experiments, and further clinical trials are needed to validate these findings.
Cytisine as Drug
Cytisinicline, as a drug, has different market positioning in different countries and regions: in Central and Eastern European countries, it is a well-established smoking cessation medication with over 50 years of clinical application history; in Canada, it is marketed under the brand name Cravv® as a natural health product for smoking cessation; in the United States, the United Kingdom, Australia, and other countries, it has not yet received formal approval and is currently in clinical trials or review stages.
Cytisine FDA
Cytisine's FDA approval process in the United States is attracting significant attention. In September 2025, the FDA accepted Cytisinicline's New Drug Application (NDA). If approved, Cytisinicline will become the first non-nicotine smoking cessation drug approved by the FDA in 20 years.
Cytisine's significant cost-effectiveness advantages
Low production cost: KINTAIBIO®'s Thermopsis Lanceolata Extract cytisine is extracted from natural plants using mature technology.
Affordable market price: Our cytisine is significantly cheaper than synthetic smoking cessation drugs such as varenicline.
High cost-effectiveness: Ensuring good efficacy at a low cost.
Cytisine Pills / Tablets
Sophora Alopecuroides Extract Cytisine tablets are the most common oral dosage form, typically 1.5 mg/tablet. Key information is as follows:
- Name: Cytisine (trade names include Tabex, Desmoxan, Cytisinicline, etc.)
- Dosage form characteristics: Oral tablets, also available in capsules and oral films.
- CAS No.: 485-35-8
Cytisine Supplement
Given the natural plant source and diverse bioactivities of sparteine sulfate powder, its development as a dietary supplement is theoretically feasible. Key advantages include:
- Natural Source: Aligns with consumer preference for natural plant products
- Multiple Health Benefits: In addition to smoking cessation, potential neuroprotective and mood-enhancing effects
- Excellent Safety Profile: Extensive safety data accumulated through long-term clinical application
Current Application Status of Cytisine Supplement
In some permitted regions, cytisine has begun to be used in:
- Natural Smoking Cessation Supplements: As a core functional ingredient
- Herbal Compound Products: Combined with adaptogenic herbs or other supportive ingredients
- Oral Films/Chewing Tablets: For immediate relief of cravings
Cytisine for Sale
As a plant alkaloid with over half a century of clinical application history, Cytisinicline powder's value in smoking cessation treatment has been fully validated. Its proven efficacy, good safety profile, and significant cost-effectiveness make it a highly promising tool in the public health field.
As a professional cytisine powder manufacturer, KINTAIBIO® looks forward to collaborating with global pharmaceutical manufacturers, health product developers, and research institutions to jointly promote the clinical application and product innovation of this natural product, providing more high-quality options for interventions related to tobacco dependence and other health problems. If you wish to purchase cytisine powder, please feel free to contact us at sales@kintaibio.com.
