Part1：What is Androtec andrographolide?
Androtec andrographolide is an organic substance with molecular formula C20H30O5, white square prism or flake crystal. The main active ingredient of the natural plant Andrographis paniculata has the functions of dispelling heat and detoxification, reducing inflammation and relieving pain, and has special effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. This product is a diterpenoid lactone compound, which is insoluble in water, and can only be administered orally.
Part2:Pharmacological action
1.Anti-pathogenic microorganisms
Animal experiments show that both androtec andrographolide and neoandrotec andrographolide can inhibit
and delay the increase in body temperature caused by pneumococcus or hemolytic streptococcus, but androtec andrographolide is stronger than neoandrotec andrographolide.
In vitro experiments show that Andrographis paniculata has a certain anti-HIV effect.
2.Antipyretic effect
androtec andrographolide has different degrees of antipyretic effect on rabbit endotoxin fever, fever caused by pneumococcus or hemolytic streptococcus. The antipyretic effects of andrographis A, B, C and D in rabbits with fever caused by typhoid and paratyphoid vaccines or in rats with fever caused by 2,4-dinitrophenol were weakened in turn.
3.Anti-inflammatory effect
Andrographis paniculata A, B, C, and D have different degrees of anti-inflammatory effects. 1g/kg administration can inhibit the increase in the permeability of the skin or abdominal capillaries in mice caused by xylene or acetic acid, and reduce the concentration of croton oil in the granulation sac of Selye. Caused acute exudate volume, but had no significant effect on granulation tissue hyperplasia. It can inhibit the development of egg-white rat foot swelling, but the effect disappears after the adrenal gland is removed. Din has the strongest anti-inflammatory effect, followed by C, A and B.
4.Influence on the body's immune function
It has been reported that Andrographis paniculata may have a role in some aspects of cellular immunity. Its water decoction can improve the ability of human leukocytes to phagocytose Staphylococcus aureus in vitro, and oral administration of andrographis paniculata can enhance the skin delayed hypersensitivity reaction caused by old tuberculin. Andrographis paniculata preparation Xinyandeping (containing esters and ketones) can increase the level of serum lysozyme in mice and enhance the phagocytic ability of peritoneal macrophages and neutrophils. Continuous administration of androtec andrographolide sulfonate to rabbits or mice can significantly increase the phagocytic ability of peripheral blood phagocytes to pneumococcus or staphylococcus aureus. androtec andrographolide A injection and Xiyanping injection can also enhance phagocytic function. . Anhydroandrotec andrographolide succinate half ester also has inhibitory effect on delayed-type hypersensitivity reaction induced by 2,4-dinitrochlorobenzene in mice.
5.Antifertility
Andrographis paniculata has obvious effect of aborting pregnancy. Oral administration of Andrographis paniculata can prevent contraception in mice and abortion in pregnant rabbits. Intraperitoneal injection of water decoction can significantly stop the implantation, early pregnancy, middle pregnancy and late pregnancy of mice. Intramuscular injection, subcutaneous injection, oral administration, intraperitoneal injection, intravenous injection and intrauterine injection can all produce anti-early pregnancy effects, among which intraperitoneal, intravenous and intrauterine injections are the best. Intrauterine injection, the dosage is small and the effect is good. If exogenous progesterone or luteinizing hormone-releasing hormone (LH-RH) is injected at the same time with andrographis paniculata, it can prevent miscarriage. Some people think that Andrographis paniculata has a certain inhibitory effect on the growth of placental villous trophoblast cells cultured in vitro. Studies have shown that some semi-synthetic derivatives of androtec andrographolide also have anti-early pregnancy effects to varying degrees, and the dehydrated androtec andrographolide derivative - Chuan-4 has a good anti-early pregnancy effect on mice and rats, which is worthy of further study. A new contraceptive drug, the drug has a significant effect on placental trophoblastic cells, which can atrophy the placental villi, reduce the number of cells, disappear syncytium cells and Langerhans cells, and cause interstitial edema and hemorrhage.
6.Gallbladder and hepatoprotective effect
Andrographis paniculata has a choleretic effect on rats, and can increase the liver weight of rats and shorten the sleep time caused by sodium cyclohexylbarbital. Pre-administration of androtec andrographolide can counteract the hepatotoxic effects caused by carbon tetrachloride, D-galactosamine and acetamidophenol, and can significantly reduce the levels of SGPT, SGOT, SALP, and HTG, respectively. It has been reported that the methanol extract of Andrographis paniculata is toxic and can promote the death of rats with liver injury.
7.Antitumor effect
Anhydroandrotec andrographolide succinate half ester has a certain inhibitory effect on W256 transplanted tumor. Anhydroandrotec andrographolide disuccinic acid half ester hydrogen potassium is made into arginine double salt (referred to as transsuccinic acid), no matter large, medium or small doses have inhibitory effect on tumor cells, and the effect is enhanced with the increase of dose, The anti-tumor effect is reliable and stable. In vitro experiments have shown that andrographis paniculata can inhibit DNA synthesis in cultured breast cancer cells.
8.Other role
Yanhuning and Chuanhuning injections have obvious sedative effects, can shorten the incubation period of pentobarbital sodium for anesthesia in mice, prolong the anesthesia time, and can cause subthreshold sodium pentobarbital to induce anesthesia.
androtec andrographolide can increase adrenal cortex function, and Andrographis A, B, C, and D can atrophy the thymus in young mice at higher doses.
9.Toxic side effect
Clinical application of this product has less toxic and side effects. The median lethal dose of Andrographis paniculata extract administered to mice was 13.19g/kg (calculated by androtec andrographolide)
