Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of kintaibio® dihydroquercetin taxifolin powder in China. Please feel free to wholesale high quality kintaibio® dihydroquercetin taxifolin powder for sale here from our factory. For price consultation, contact us.
Dihydroquercetin(DHQ)/Taxifolin(TFN) Manufacturer-Kintaibio®
Nature's Powerful Antioxidant
kintaibio® DHQ
Taxifolin (Dihydroquercetin or DHQ) is a potent natural antioxidant found in Taxus chinensis, Cedrus deodara, and larch trees. KINTAIBIO® DHQ is sourced from Siberian Dahurian Larch and Changbai Mountain Larch in China, available in 98% active form. Research suggests that Taxifolin may support immune, respiratory, skin, and cell health. Larch Bark Extract Taxifolin's powerful antioxidant properties also make it an excellent ingredient for dietary supplements and skincare products.
Product Advantages
FDA GRAS Certified; EU(EFSA) And Russia Approved; China NF Ingredients
GMP, HACCP, ISO9001, ISO22000, & HALAL Certified
Non-GMO, Vegan, And Non-Irradiated
KINTAI DUNS # : 7293
- Product Specs & Extraction Process
- Specifications &
- QC & Compliance
- Safety & Clinical Evidence
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Technical Specifications＆data Sheet (CAS No 480-18-2)
| Specification | Details | Method/Reference |
| Potency Assay (Active Purity) |
At least 98% (+) trans (2R,3R)-dihydroquercetin form. |
/ |
| Cis-form (2R,3S) is limited to no more than 2%. | / | |
| Physical & Chemical Properties | ||
| Appearance | ||
| Visual inspection | Off-white to pale yellow crystalline powder | / |
| Particle morphology | Irregular prismatic crystals | / |
| Solubility Profile | ||
| Water solubility |
0.78 ± 0.12 mg/mL < 1 mg/mL means slightly soluble or insoluble. |
25°C, pH 6.8, equilibrium solubility method, JP XVII |
| Ethanol solubility | 58.3 ± 3.5 mg/mL | 25°C, anhydrous ethanol, USP <1236> |
| DMSO solubility | 61 mg/mL | pharmaceutical grade DMSO, EP 10.0 |
| pH Determination | 1% w/v aqueous dispersion: 5.9 ± 0.3 | n=6, calibrated pH meter, NIST traceable buffers, EP 2.2.3 |
| Ash Content | 0.42 ± 0.07% w/w | USP <281>, 800°C, platinum crucible |
| Acid-insoluble ash | <0.05% w/w | EP 2.4.16, 3M HCl digestion |
| Molecular Weight | 304.25 Da | / |
| Melting Point | 234 ± 1.5°C | DSC, 10°C/min, N₂ atmosphere, USP <891> |
| Optical rotation | [α]25D = -13.2° ± 0.5° | c=1% in ethanol, polarimeter calibrated with sucrose |
| Bulk density | 0.38 ± 0.03 g/cm³ | USP <616> Method I, 100 mL graduated cylinder |
| True Density | 1.47 g/cm³ | helium pycnometry, ASTM B923 |
| Hygroscopicity | Non-hygroscopic | dynamic vapor sorption, 25°C/60% RH |
Kintaibio® specication: 98% Dihydroquercetin
Other specifications can be customized according to your business needs
|
Physical parameters |
Limits |
Method of analysis |
|
Compound analysis |
Taxifolin≥ 98.0% of the dry weight |
HPLC |
|
Moisture |
≤ 10% |
Ch.PC. Rule 52 |
|
Heavy metals |
||
|
Lead |
≤ 0.5 mg/kg |
ICP/MS |
|
Arsenic |
≤ 0.02 mg/kg |
ICP/MS |
|
Cadmium |
≤ 0.5 mg/kg |
ICP/MS |
|
Mercury |
≤ 0.1 mg/kg |
ICP/MS |
|
Pesticide |
||
|
Dichlorodiphenyltrichloroethane (DDT) |
≤ 0.05 mg/kg |
Method 2142-80 |
|
Residual solvent |
||
|
Ethanol |
< 5,000 mg/kg |
USP 32/NF27 <467> |
|
Microbial parameters |
||
|
Enterobacteria + div. Gram-negative bacteria |
≤ 100/g |
USP |
|
Yeast and mould |
≤ 100 CFU/g |
USP |
|
Escherichia coli |
Negative/1 g |
USP |
|
Salmonella spp. |
Negative/10 g |
USP |
|
Staphylococcus aureus |
Negative/1 g |
USP |
|
Pseudomonas spp. |
Negative/1 g |
USP |
how to make Dihydroquercetin Taxifolin Powder?
- Raw materials: Larch wood is used for cutting, peeling, chopping and scraping.
- Drying: The scraped wood chips are dried.
- Extraction process: The wood chips are extracted with 75–80% ethanol aqueous solution.
- Distillation to remove solvents: Vacuum distillation is used to remove the ethanol solvent in the extract.
- Crystallization: Water is added to the extract to crystallize Taxifolin Dihydroquercetin to further improve the purity of the product.
- Quality inspection: The finished product is quality controlled by HPLC and other analytical methods to ensure the content of active ingredients in the product.
-
Drying And Packaging:The crystallized Taxifolin is further dried by vacuum distillation to ensure that the moisture content of the final product is less than 2%.
The final content of Taxifolin is guaranteed to be no less than 98%, and then it is packaged. -
Packaging: 1kg/aluminum foil bag, 5kg/carton, 10kg/cardboard drum, 25kg/cardboard drum. Storage: 4-10℃, sealed and protected from light, valid for 2 years.
Taxifolin Dihydroquercetin Plant extraction source
Extraction Process files available
Kintaibio® Dihydroquercetin Extraction Process.pdf
Production process flow chart.pdf
Our Dihydroquercetin Taxifolin Powder Service Processes
Please contact at sales@kintaibio.com to process your order
Pre-sales Consultancy
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Confirmation of order
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Production
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Multi-Channel Shipping
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Confirmation of recei
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After-sale Services
taxifolin benefits:Boost Your Health With Powerful Antioxidant Protection!
Neuroprotective
Protects against oxidative injury
Improves memory, reduces headaches, vertigo, and fatigability
Enhances cognitive function
Cardioprotective
Supports heart health, normalizes blood pressure
Reduces cholesterol, triglycerides, and plaque formation in arteries
Immunomodulatory
Exhibits anti-inflammatory, antibacterial, and antimicrobial properties. Shows antiviral activity (e.g., against herpes simplex, poliovirus)
Dermatology
Protects skin cells from oxidative damage and environmental stress
Benefits skin under UV radiation or other stresses
Ophthalmoprotective
Improves vision and stabilizes eye conditions like diabetic retinopathy
Enhances tissue regeneration in the eye
Circulation Enhancer
Strengthens blood vessels, lowers blood viscosity, and stimulates microcirculation
Reduces capillary permeability and erythrocyte aggregation
Diabetes Mellitus
Protects the liver from toxins, accelerates regeneration of damaged liver tissue
Hepatoprotective
Protects the liver from toxins, accelerates regeneration of damaged liver tissue
Available documents:
Health Benefits Summary.pdf
Safety Data Sheet (SDS/MSDS).pdf
dihydroquercetin uses
Material Control---Production Process Control---Finished Product Inspection Standards
1. Larch Tree Raw Material Control
►Supplier Qualification Review---Required Documents
- FSC Forest Certification (proof of sustainable harvesting)
- Pesticide Usage Records
On-Site Audit: Evaluate raw material storage conditions: moisture control, pest prevention, and transportation methods (to prevent contamination).
►Raw Material In-Factory Inspection Process
Sampling Rules: Samples taken according to ISO 2859-1, 5 sample points mixed for each batch.
Key Testing Items:
- Heavy Metals (Pb, Cd, As, Hg): ICP-MS, compliant with EU 1881/2006 limits (e.g., Pb ≤1.0 ppm).
- Pesticide Residues (e.g., chlorpyrifos, glyphosate): GC-MS/MS, compliant with EU 396/2005 Annex B.
- Microorganisms: Aerobic bacteria count ≤10⁴ CFU/g (ISO 4833-1), no Salmonella/E. coli (USP<62>).
2. Production Process Quality Control (Key Steps)
►Raw Material Preprocessing
Washing and Grinding: Record the conductivity of washing water (≤50 μS/cm) and microbial load (≤100 CFU/mL).
Grinding Granularity Control: Pass through a 20 mesh sieve (particle size ≤850 μm) to ensure extraction efficiency.
►Solvent Extraction and Concentration
►Purification and Crystallization
Column Chromatography Purification:
- Resin Type: Large-pore adsorbent resin.
- Elution Monitoring: UV detector (280 nm), collect DHQ main peak (retention time ±5%).
Crystallization Control:
- Crystallization Temperature: 0-5°C (slow cooling to improve purity).
- Crystal Drying: Vacuum drying (40°C/24h), moisture ≤5% (Karl Fischer method).
►Grinding and Packaging
- Granularity Control: Airflow grinding to 80-100 mesh (180-150 μm), measure particle size distribution (laser diffraction method).
- Packaging Environment: Clean room (ISO 8), nitrogen-filled aluminum foil bags (oxygen ≤1%), moisture-proof labels.
3. Finished Product Testing and Release Standards
►Comprehensive Testing Items
►Identity Confirmation
1H NMR: Compare characteristic peaks with reference standard (e.g., aromatic region δ 6.0-7.5 ppm).
Specific Rotation: +12° to +15° (c=1% in MeOH, 25°C), confirm chiral purity.
►Other Components
Trace Components:
- Ethanol Residue: ≤3000 ppm (GC-FID).
- Saponins: ≤0.5% (HPLC-ELSD, compared to taxifolin standard).
- Inorganic Salts: Ash ≤0.5% (Chinese Pharmacopoeia General Rule 2302).
Usual range of components of DHQ
►Actual test data (Dihydroquercetin Active ingredient ±2% range).
Available documents:
Certificate of Analysis (CoA).pdf
HPLC Chromatogram Report.pdf
98%DHQ Potency Assay Test method(HPLC,GC-MS).pdf
Quality Assurance of Dihydroquercetin- Stability Test
Batch Analysis Results from Five Non-Consecutive Batches Extracted from Larch.pdf
Compliance Management
International Certifications and Regulations
-
USA: FDA GRAS ---Approved
-
EU: EFSA Novel Food---Approved; Russia Approved
-
China: New Food Ingredient (NF) Registration--- Approved
-
Religious Certifications: Halal/Kosher
-
Factory Certification: GMP, HACCP ISO9001 ISO 22000
-
Batch Records: Full traceability from raw material batch
-
Third-Party Reports
Stability Management
Accelerated Conditions---Long-Term Conditions---Out-of-Specification (OOS) Investigation
Study Design
Accelerated Conditions
Long-Term Conditions
Storage under conditions
40°C/75% RH for 6 months 25°C/60% RH for 36 months
shelf life validation
1 week 98.2%, 24 weeks 98.5%
supports a 24-month shelf life
Key Equipment and Calibration
HPLC ---------- GC-MS ---------- Laser Particle Size Analyzer
Kintaibio® Key Equipment
| Equipment | Purpose | Calibration Frequency | |
| HPLC (Agilent 1260) | DHQ Content and Impurity Analysis | Monthly | |
| GC-MS (Thermo) | Solvent Residue | Testing Quarterly | |
| Laser Particle Size Analyzer (Malvern) | Finished Product Granularity Control | Semi-Annually | |
Dihydroquercetin(DHQ) Taxifolin Safety,side effects,Dosage
Dihydroquercetin Taxifolin Powder Toxicology Studies
►Subacute Toxicity Study (OECD 407 Standard):
- Rat Study: Oral dose of 1000 mg/kg body weight (equivalent to 50 times the recommended human dose), administered daily for 28 days.
- No abnormalities observed in blood biochemistry, organ weight, or tissue pathology. (Source: Russian National Pharmacopoeia Committee, 2005).
- 90-Day Subacute Toxicity Study In Rats: No toxic effects were observed at the highest dose of 1500 mg/kg body weight, and the NOAEL (no observable adverse effect level) was 1500 mg/kg body weight.
- NOAEL (No Observed Adverse Effect Level): ≥1000 mg/kg/day (in the rat model).
►Genotoxicity:
- Ames Test (OECD 471): Tested on 5 bacterial strains, no mutagenic effects (negative result).
- Chromosome Aberration Test (in vitro mammalian cells): No genotoxicity observed (Supporting Literature: Food Chem Toxicol. 2010).
►Human Tolerance Studies:
- Clinical Trial (Double-blind, n=60): Daily intake of 500 mg DHQ for 12 weeks, no serious adverse reactions reported. Minor side effects (such as gastrointestinal discomfort) occurred in less than 3% of participants (Study Source: Phytother Res. 2018).
Dihydroquercetin Taxifolin Powder Allergenicity and Sensitization
- Sensitization Assessment: The molecular weight of DHQ (304.25 Da) is below the common allergen threshold (>5000 Da), and it does not contain any known protein allergens (compliant with EFSA allergen assessment guidelines).
- Clinical Reports: No cases of allergic reactions to DHQ have been reported in the scientific literature.
Dihydroquercetin Taxifolin Powder Regulatory Safety Certifications
- FDA GRAS: Evaluated by an independent expert panel (GRAS Notice No. GRN 000994), confirming safety for use in dietary supplements at ≤500 mg/day.
- EFSA: Listed in the Novel Food Catalogue (EU 2017/2470), approved for use in specific food categories (e.g., beverages, dairy products).
Safety Assessment Report.pdf
Application And Safety Assessment Of Kintaibio® Dihydroquercetin Powder In Food
Within The Recommended Intake Range, The Intake Of Dihydroquercetin Does Not Pose A Risk To Health
Dihydroquercetin Taxifolin Powder Clinical Evidence
►Antioxidant and Anti-inflammatory Effects
Randomized Controlled Trial (RCT):
Study Design: 120 healthy participants, daily supplementation of 250 mg DHQ for 8 weeks.
Results: Plasma total antioxidant capacity (ORAC) increased by 28%, and inflammation markers (IL-6, CRP) were significantly reduced (J Med Food. 2016).
►Cardiovascular Health
Improvement of Endothelial Function:
Clinical Trial (n=45, pre-hypertensive patients): Daily intake of 300 mg DHQ for 12 weeks significantly improved flow-mediated dilation (FMD) by 11.2% (Cardiovasc Ther. 2019).
►Metabolic Support
Blood Sugar Management:
- Animal Model: Diabetic rats receiving 50 mg/kg DHQ daily showed a 24% reduction in blood glucose levels and improved insulin sensitivity (Biomed Pharmacother. 2020).
- Human Study: Preliminary trial (n=30, type 2 diabetes patients) indicated that DHQ combined with metformin reduced HbA1c by 0.8% (larger sample sizes needed for confirmation).
►Skin Health
UV Protection:
In Vitro Study: DHQ inhibited UVB-induced collagen degradation (inhibited MMP-1 activity by 40%).
Human Study (n=50): Topical application of a 1% DHQ cream for 8 weeks led to an 18% improvement in skin elasticity (J Cosmet Dermatol. 2021).
dihydroquercetin Safety Statement and Usage dosage Recommendations
►Application Scope
Non-Alcoholic Beverages: maximum added concentration 0.02 g/L.
Yogurt: maximum added concentration 0.02 g/kg.
Chocolate Candy: maximum added concentration 0.07 g/kg.
Food Supplements: The recommended daily dose is 100 mg, suitable for people aged 14 and above.
►Target Population:
- 9 Years Old And Above: suitable for non-alcoholic beverages, yogurt and chocolate candy containing Taxifolin Dihydroquercetin.
- 14 Years Old And Above: suitable for food supplements containing dihydroquercetin.Recommended dose of 100 mg/day (as per product label).
- Contraindications: Pregnant and breastfeeding women, as well as individuals with autoimmune diseases, should consult a healthcare professional (insufficient data available).
- Drug Interactions:May enhance the effects of anticoagulants (e.g., warfarin); coagulation parameters should be monitored (theoretical, no clinical cases reported).
►Intake And Effectiveness Measure (MOE) Assessment
- Adults (70 Kg Body Weight): The combined intake of food and food supplements is 158 mg, and the MOE is about 660.
- Adolescents (14-18 Years Old, 45 Kg Body Weight): The combined intake is 146 mg, and the MOE is about 460.
- Children (10-14 Years Old, 29.4 Kg Body Weight): Based on P97.5 estimation, the food intake is 46 mg/day, and the MOE is about 960.
Bioavailability & Metabolism Studies.pdf
Taxifolin dihydroquercetin powder Bioavailability And Metabolism Studies.pdf
Ongoing Research and Limitations
Ongoing Clinical Trials:
NCT04853199: Evaluating the effects of DHQ on oxidative stress in post-COVID-19 patients (Phase II, expected completion in 2024).
NCT05123716: Application of DHQ in non-alcoholic fatty liver disease (NAFLD) (Phase III, results expected in 2025).
Limitations of Evidence:
Some studies have small sample sizes or are based on animal models, and further large-scale, multicenter, long-term human trials are needed.
References
Food Chem Toxicol. 2010;48(6):1603-8.
Phytother Res. 2018;32(3):564-571.
J Med Food. 2016;19(3):211-8.
Cardiovasc Ther. 2019;37(2):e12281.
EFSA Novel Food Summary: Taxifolin-rich extract from larch (2021).
where to buy Dihydroquercetin Taxifolin Powder?
Samples: Send an inquiry.
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Our address
West 16-3-1, Zhongnan Hi-tech Airport Industrial Port, Airport New City, Xixian New Area, Shaanxi, P.R.China.
Phone Number or whatsApp
+86-181 8259 4708
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