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Larch extract DHQ powder manufacturer
Based on in-depth development of larch resources in high-altitude and cold regions, KINTAIBIO® dihydroquercetin (taxifolin) powder is sourced strictly from the bark and roots of Siberian Larix trees in the pristine alpine ecosystems of Northeast China, Mongolia, and Siberia. The unique low temperatures and long days of this region allow larch trees to accumulate high concentrations of the natural protective flavonoid compound Larch Extract dihydroquercetin. Its unique five phenolic hydroxyl groups in its molecular structure endow this product with exceptional free radical scavenging and enzyme activity regulation capabilities, setting it apart from hundreds of antioxidants. Through years of process optimization, we have achieved a Taxifolin Dihydroquercetin purity of over 95% in our products, free from any artificial additives or impurities, ensuring that every batch meets stringent industry standards.
Regarding its mechanism of action and health support, numerous studies have confirmed that DHQ possesses significant antioxidant, anti-inflammatory, and immune-enhancing activities. Dihydroquercetin powder can be added to dietary supplements for oral administration, or conveniently added to various foods and beverages to help address common health issues such as allergies, hypertension, and abnormal glycemic metabolism. Its applications span functional ingredients in the food industry, adjuvant formulation development in the pharmaceutical field, and anti-aging formulation design in the cosmetics industry, with broad market demand.
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Choosing Larch Extract DHQ Powder offers you multiple advantages: Natural extracts derived from native tree species, guaranteed by a rigorous quality control system, free of impurities and with stable bioavailability; decades of experience in plant extraction and a comprehensive traceability system ensure transparency and controllability at every stage from raw material harvesting to finished product testing. As a trusted manufacturer, we not only provide high-specification dihydroquercetin powder but also comprehensive technical information and application support to help customers compliantly and efficiently integrate this natural super antioxidant into their end products.
COA Of Larch bark extract DHQ powder
How to make Larch bark extract DHQ powder?
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Raw Material Pretreatment and Preliminary Extraction
At the start of production, the larch wood raw material is first pulverized to increase the contact area between the raw material and the solvent, thereby improving the extraction efficiency of the active ingredients. The pulverized raw material enters the first extraction process, using food-grade ethanol as the extraction solvent. The extract is added at 6–12 times the weight of the raw material and subjected to thermal extraction at 70–90°C.
During this stage, dihydroquercetin and other soluble plant components in the raw material gradually dissolve into the ethanol solution, forming the extract. After extraction, a concentration process removes some of the solvent, increasing the concentration of the target components. Further cooling and crystallization then occurs, allowing for the preliminary separation of some impurities from the target components, laying the foundation for subsequent purification.
Secondary Extraction and Resin Purification
The material after preliminary crystallization enters the second extraction process. In this stage, ethyl acetate is used as the extraction solvent, added at 3–5 times the weight of the raw material. Utilizing the difference in solubility of different components in ethyl acetate, dihydroquercetin DHQ is further enriched, and the impurity content is reduced.
Subsequently, the extract is purified using a macroporous resin purification system. The macroporous resin selectively enriches the target flavonoids through adsorption and desorption, while removing pigments, sugars, and some non-target impurities, thus significantly improving product purity. This step is a crucial refining process for achieving high-purity DHQ in the entire production process.
Concentration, Crystallization, and Recrystallization Purification
The filtrate after resin purification is concentrated to a suitable supersaturated state, followed by crystallization to obtain coarse crystals.To further improve product purity, the obtained coarse crystals are dissolved in an ethanol solution by heating and then recrystallized and filtered. The recrystallization process effectively removes residual impurities, improves crystal quality and product content, and achieves a higher purity level for Larch Tree Extract dihydroquercetin.
Filtration, Drying, and Finished Product Inspection
The recrystallized crystals are filtered and separated, and then vacuum dried to remove residual moisture and trace solvents, yielding a stable dihydroquercetin crystal product. The dried material is then pulverized and granulated to obtain high-purity dihydroquercetin powder with uniform particle size.
Finally, the product is tested according to quality control standards, including appearance, content, purity, moisture content, and other relevant indicators. After passing inspection, it enters the finished product storage stage, completing the entire production process of dihydroquercetin (DHQ) powder.
larch tree extract benefits
larch extract for Antioxidant
Based on a study, Larch bark extract DHQ powder demonstrated significant advantages in enhancing intestinal antioxidant defense. The study found that treatment with 5 mg/L taxane significantly upregulated the expression levels of key antioxidant enzyme genes in intestinal tissue, including glutathione S-transferase (GST), glutathione peroxidase 4 (GPx4), superoxide dismutase 1 (SOD1), and catalase (CAT).
The enhancement of GST and CAT expression was even superior to that of the same concentration of quercetin and the combined treatment of both. This suggests that Larch bark extract DHQ powder helps activate the endogenous antioxidant system, reduce oxidative stress damage, and thus maintain intestinal health.
larch extract for cancer
Studies have shown that DHQ can effectively inhibit tumor cell proliferation, migration, and invasion by regulating key signaling pathways such as cGMP-PKG, inducing G1 phase cell cycle arrest and apoptosis, while downregulating the expression of HIF-1α, VEGF, and AKT, thus exerting anti-angiogenic and pro-apoptotic effects.
More importantly, Larch Extract DHQ can synergistically enhance the effects of traditional chemotherapy drugs by inhibiting P-glycoprotein expression to alleviate drug resistance and improve chemotherapy efficacy. Furthermore, its excellent cytoprotective effect-inhibiting ferroptosis-can reduce the nephrotoxicity, hepatotoxicity, cardiotoxicity, and oral mucositis induced by drugs such as cisplatin, cyclophosphamide, methotrexate, and doxorubicin. In addition, DHQ can enhance the immune response in the tumor microenvironment and increase the sensitivity of tumors to immune checkpoint inhibitors, providing a natural and multifunctional adjuvant option for comprehensive anti-cancer strategies.
larch extract for liver
Studies have shown that DHQ exhibits remarkable preventative and therapeutic activity against various types of liver injury, including viral, drug-induced, alcoholic, non-alcoholic, fatty, and immune-mediated liver injury. Its mechanism of action involves inhibiting the proliferation of hepatocellular carcinoma cells after administration, restoring oxidative stress markers such as superoxide dismutase (SOD) and glutathione (GSH) in liver tissue to normal levels, downregulating the expression of pro-inflammatory molecules such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and exerting dual anti-inflammatory and antioxidant effects by regulating key molecular signaling pathways such as NF-κB and Nrf2.
This means that Larch Extract DHQ not only helps alleviate oxidative damage and inflammatory responses in the liver but can also provide protective intervention in various liver disease models, offering a valuable natural solution for the prevention and treatment of liver diseases.
larch extract for brain
Based on recent preclinical studies of the neuroprotective effects of DHQ, the core active ingredient in Larch wood extract powder, pretreatment with DHQ (5 mg/kg) significantly improved memory and learning abilities, reversing cognitive impairments in behavioral tests such as the Y-maze and Morris water maze in model animals. Its mechanism of action includes: effectively inhibiting acetylcholinesterase activity in brain tissue, reducing oxidative stress, restoring the activity of endogenous antioxidant enzymes such as superoxide dismutase, catalase, and reduced glutathione, and inhibiting the activity of the inflammatory marker myeloperoxidase.
These results indicate that Larch Extract DHQ can alleviate Alzheimer's disease-related cholinergic deficiencies, oxidative damage, and neuroinflammation through multiple pathways, and computer simulation studies have confirmed its favorable pharmacokinetic and toxicological characteristics.
In addition to the benefits mentioned above, Larch wood extract powder offers the following advantages:
In terms of anti-inflammation, Larch wood extract powder effectively downregulates the expression of pro-inflammatory factors (such as IL-6 and TNF-α), upregulates the anti-inflammatory factor IL-10, and alleviates liver damage, intestinal inflammation, and neuroinflammation by regulating the NF-κB pathway.
In terms of overall health promotion, Larch wood extract powder enhances the activity of endogenous antioxidant enzymes such as SOD, CAT, and GSH by activating the Nrf2 pathway, while simultaneously inhibiting tumor proliferation, protecting against chemotherapy-induced organ toxicity, and improving gut microbiota and cognitive function, achieving multi-system synergistic support.
For hair care, the potent antioxidant and anti-inflammatory properties of Larch wood extract powder help reduce oxidative stress and chronic inflammation around hair follicles, creating a healthy microenvironment for the scalp, thereby indirectly supporting hair follicle function and normal hair growth.
Reference:https://www.sciencedirect.com/science/article/pii/S2352513424000991
https://www.sciencedirect.com/science/article/abs/pii/S0944711324005920
https://www.mdpi.com/1420-3049/29/15/3537
https://www.sciencedirect.com/science/article/pii/S266645932500023X
larch wood extract dihydroquercetin uses
Global demand for taxifolin dihydroquercetin is growing significantly. With increasing health awareness and consumers' growing preference for natural, safe, and effective ingredients, DHQ is poised to capture a larger market share in the dietary supplement industry. The global market size reached approximately $170 million in 2021 and is projected to grow to $200 million by 2027.
The continued rise in consumer demand for natural plant extracts is driving trends in "Clean Beauty," functional foods, and holistic wellness. Dihydroquercetin Taxifolin Powder, with its multifunctional properties, can be widely used in pharmaceuticals, food and beverages, dietary supplements, and cosmetics.
- Dietary Supplements: Can be formulated into capsules for consumer consumption.
- Functional Foods: Can be added to snacks, beverages, and health bars to promote overall wellness.
- Cosmetics: Due to its excellent skin-regenerating effects, it is frequently used in anti-aging creams and serums.
Larch bark extract DHQ powder side effects
A Long History of Research and Widespread Recognition
As early as 1936, Hungarian scientists first discovered the antioxidant properties of Larch Extract DHQ. After years of in-depth research and practical application, DHQ has gained widespread recognition worldwide. In 2017, DHQ was approved by the European Union, officially entering the European market as a novel food ingredient. Previously, it was initially listed as a pharmaceutical raw material in the United States and Russia, and its application has gradually expanded to the food industry. Japan, South Korea, Thailand, Canada, and other countries have also widely used DHQ in pharmaceuticals, functional foods, special dietary products, and cosmetics.
Key Milestones:
- 2003: Larch bark extract DHQ was officially registered as a pharmaceutical raw material in Russia.
- 2010: Approved by the US FDA as a source of vitamin P in dietary supplements.
- 2017: The European Food Safety Authority (EFSA) confirmed DHQ as a novel food ingredient and approved its use in the European market.
- 2021: China's National Health Commission approved DHQ as a new food ingredient, greatly promoting the expansion and development of DHQ production. In June 2024, the official website of China's National Medical Products Administration (NMPA) showed that "Dihydroquercetin Taxifolin Powder" had completed its new ingredient registration, indicating its broad application prospects in the food and cosmetics fields. We believe that Kintai's DHQ will bring more health benefits to consumers.
Based on existing research and authoritative assessments, dihydroquercetin (taxanthin) has low toxicity and is well-tolerated.
Larch Extract Dihydroquercetin Powder Side Effects:
A small number of individuals may experience mild gastrointestinal discomfort such as bloating and nausea after fasting or high-dose intake; it is recommended to take it with meals. Allergic reactions have occasionally occurred in individuals sensitive to flavonoids.
Larch Extract Dihydroquercetin Powder Safety:
Regarding safety, the European Food Safety Authority has confirmed its adequate safety window based on the no-adverse-effect level (1,500 mg/kg body weight) in subchronic studies.
Larch Extract Dihydroquercetin Powder for Pregnant Women/Drug Interactions:
No related adverse events have been registered in clinical applications, and no adverse reactions have been reported with commercial long-term supplementation (25–100 mg daily).
Women taking anticoagulants, pregnant women, and breastfeeding women should consult a doctor before use.
Where to Buy Larch extract DHQ powder?
If you are planning your Taxifolin Dihydroquercetin purchase, KINTAIBIO®, as China's largest supplier of Dihydroquercetin Taxifolin Powder, is a reliable choice. We closely monitor the larch market and offer competitive prices while ensuring consistent product quality that meets the high standards of the high-purity larch market.
KINTAIBIO® sources its raw materials from sustainably managed larch forests, protecting the ecosystem from the source. Decades of industry experience and extensive research data ensure the efficacy of every batch of our products. Our extracts excel in the larch wood extract for hair category, opening up new product avenues for our clients. If you are interested in purchasing high-quality larch extract DHQ powder, please feel free to contact us at sales@kintaibio.com or submit your feedback on the next page.
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