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What is Ash bark extract?
Esculin powder is a natural compound extracted from the fruit of the Horse chestnut tree. It has various pharmacological effects such as antibacterial, antioxidation, hypoglycemic, weight loss, antithrombotic, and pain relief. Ash bark extract has high safety and good tolerance, so it is widely used in the field of medicine and health products.
In addition, escin can also be used in cosmetics as a natural moisturizer and antioxidant, which helps to improve dry skin, spots, wrinkles, and other problems.


Chemical & Physical Properties
| CAS Number | 531-75-9 | Molecular Weight | 340.29 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 697.7±55.0 °C at 760 mmHg |
| Molecular Formula | C15H16O9 | Melting Point | 203 °C |
| Common Name | Esculin powder | Flash Point | 262.8±25.0 °C |
Product quality specification & standard
|
Product name |
Esculin powder |
|
Extract source |
The bark of the ash tree of the Oleaceae family. |
|
Extraction Solvent |
ethanol |
|
Appearance |
White powder |
|
Solubility |
Soluble in hot alcohol, methanol, pyridine, ethyl acetate, and acetic acid (hydrate). |
|
Identification |
HPLC |
|
Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NMT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay |
Min. 95.0% |
|
Residual Solvents |
|
|
- Ethanol |
NMT 5000 PPM |
|
Microbiological Quality (Total viable aerobic count) |
|
|
- Bacteria, CFU/g, not more than |
NMT 103 |
|
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
|
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
In a Tight, Light-resistant, and Dry Place. Avoid Direct Sunshine. Country of Origin: China |
|
Shelf life |
3 years |
Benefits
- Antioxidant effect: Ash bark extract has an obvious antioxidant effect because it contains various active compounds, such as anthocyanins and flavonoids. These substances reduce the production of free radicals, thereby preventing oxidative damage to cells. Free radicals are one of the main causes of DNA mutation and cell damage, so improving the body's antioxidant capacity can prevent many diseases, such as arteriosclerosis, cancer, and neurodegenerative diseases.
- Reduces high blood sugar: The active ingredient in escin can lower blood sugar levels. These ingredients act as α-glucosidase inhibitors, which can inhibit the breakdown of glucose in the intestinal tract and prevent excess sugar from entering the blood circulation, thereby reducing blood sugar levels. Escin can also increase the secretion of insulin and the sensitivity of cells to insulin, which helps to prevent and treat diabetes and metabolic syndrome.

- Improve circulatory system: Ash bark extract can improve the circulatory system. It has the effect of promoting the production of triglyceride enzymes in vascular endothelial cells, which helps to reduce blood fat, lower cholesterol levels, and prevent arteriosclerosis. In addition, escin can also increase blood vessel elasticity and improve blood flow, lower blood pressure, and prevent circulatory diseases such as heart disease and stroke.
- Pain relief: Escin can relieve many types of pain, especially pain associated with conditions such as varicose veins and psoriasis. It reduces inflammation and swelling, promotes microcirculation, and accelerates wound recovery.
- Antibacterial effect: Escin has antibacterial, antifungal, and antiviral effects, can kill common germs, such as coliform bacteria, staphylococcus aureus, and hepatitis B virus, etc., and helps to treat various infections and inflammatory diseases, such as Mouth inflammation, skin infection, etc.

Application fields
- Medical Field
In the medical field, Ash bark extract can be used to prevent and treat cardiovascular diseases. Studies have shown that escin has pharmacological effects such as lowering blood pressure, expanding coronary arteries, anti-oxidation, and anti-inflammation, and can effectively improve cardiovascular health, prevent and treat high blood pressure, and relieve angina, myocardial infarction, and other diseases. In addition, Ash bark extract also has the effects of improving memory, anti-aging, and promoting sleep, and is also widely used to regulate nervous system functions.
- Health Products Field
The health benefits of escin have also been widely recognized and are used in various health products. For example, Ash bark extract can regulate blood lipids, lower cholesterol, lower blood sugar, protect the liver, and enhance immunity. In addition, Ash bark extract can also adjust the body's metabolic state, and promote the excretion of waste in the body, so as to achieve the effect of health care.
- Cosmetics
Escin is widely used in the field of cosmetics for its anti-oxidation, moisturizing, promoting skin metabolism, and anti-inflammatory effects. For example, escin can be used as an active ingredient in skin care products such as face creams, masks, eye creams, etc., which can improve skin texture, reduce fine lines, improve skin elasticity, etc., while keeping the skin moist and shiny.
- Food Field
Ash bark extract is also widely used in food additives. For example, Ash bark extract can be added to functional drinks, alcohol, healthy food, etc. to achieve health effects such as regulating body metabolism, lowering blood lipids, and enhancing immunity.

Safety
The results of empirical research on the safety test of escin powder are as follows:
- Acute toxicity: The results of animal experiments show that Ash bark extracts no obvious toxic reaction within the recommended dose range.
- Chronic toxicity: Long-term oral administration of high-dose Ash bark extract mice shows that there is no obvious chronic toxicity within the recommended dose range.
- Reproductive and developmental toxicity: Animal experiments showed that escin powder had no effect on the reproduction and development of rats.
- Genotoxicity: In vitro test results show that Ash bark extracts have no mutagenic effect.
- Carcinogenicity: Animal experiment results show that Ash bark extracts have no carcinogenic effect.
- Allergy: In vitro and in vivo test results show that escin powder is non-allergenic and sensitizing.
- Clinical safety: The results of clinical trials show that escin powder is safe within the recommended dosage range, and the adverse reaction rate is low.
Overall, the safety of escin powder has been verified by multiple experiments and clinical studies, but it still needs to be used under the condition of correct use and quality control.
Dosage and formulation
1. Drug Formulation
Ash bark extracts a natural antioxidant substance that is often used in the preparation of traditional Chinese medicine formulas. Ginkgo biloba is a traditional Chinese medicine formulation containing Ash bark extract, which is often used to improve memory and improve nerve function. Among them, Ash bark extracts are used as a component of the formula drug, and its effects include improving oxygen supply, anti-oxidation, and improving cardiovascular function. In addition, escin powder can also be used in combination with other traditional Chinese medicines, such as Dendrobium, Chuanbei, and other medicinal materials, which can help improve respiratory problems such as cough and asthma.
It should be noted that Ash bark extract should not be used with certain drugs at the same time, such as anticoagulants, antihypertensive drugs, etc. Therefore, when using Ash bark extract, you should inform your doctor or Chinese pharmacist about your personal medical history and drug use, so as to obtain a better user experience and reduce unnecessary risks.
2. Cosmetic Formula
Escin powder is also beneficial to the skin, and it is often added to cosmetic formulations in recent years. Escin powder can be used in cosmetics to increase the moisturizing effect, promote metabolism, improve skin blood circulation, etc. When using Ash bark extract in cosmetics, it can generally be added within the content range of 0.1~2% according to the needs of the product. It should be noted that the use of escin powder in cosmetics should follow the safety standards stipulated by the state to ensure the safety and health of users.
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