Aescin Extract Powder

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of Aescin Extract Powder in China. Please feel free to wholesale high quality Aescin Extract Powder for sale here from our factory. For price consultation, contact us.

As a leading global supplier of high-purity botanical active ingredients, KINTAIBIO^® specializes in providing pharmaceutical-grade 98% aescin and 98% Aescin Extract Powder suitable for the development of various dosage forms for pharmaceuticals, health products, and high-end skincare.

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Our raw materials are derived from the seeds of the historically used horse chestnut (Aesculus hippocastanum L.) and utilize modern extraction and purification technologies to achieve high purity and standardization. This stable and reliable ingredient helps enhance the efficacy and market competitiveness of your venous health and anti-inflammatory products.

Aesculus chinensis

Horse chesnut seed extract 20% Aescin

To help you quickly understand the advantages of our Aescin Extract Powder, the following table summarizes the core specifications:

 

product key technologies

Production Process

Raw Material Selection: We use mature seeds of Aesculus chinensis meeting strict standards to ensure quality and stable active ingredients.

 

Extraction: We use low-temperature ethanol extraction to efficiently collect saponins while preserving sensitive compounds.

 

Purification: The extract goes through multiple purification steps like resin chromatography and prep-HPLC to remove impurities, ensuring high purity of the active ingredient.

 

Drying: The extract is dried into a fine powder using spray or vacuum drying, ensuring stability and easy processing in a GMP-certified clean environment.
 

Sodium Aescinate

Raw Material Control: High-purity Aescin Extract Powder is sourced in-house, ensuring consistent product quality from the start.

 

Salting Reaction: Under controlled temperature, pH, and concentration, Aescin reacts with food/pharma-grade sodium hydroxide or carbonate in purified water to form water-soluble Sodium Aescinate.

 

Crystallization and Recrystallization: Initial crystals are obtained through solvent crystallization; recrystallization further purifies the product for higher purity and uniform crystal structure.

 

Freeze Drying (Key Step): Given the instability of Sodium Aescinate in solution, the reaction solution is directly freeze-dried without concentration.The process removes moisture through pre-freezing, sublimation, and desorption, yielding a white or off-white crystalline powder in an aseptic environment that meets injection-grade standards.

We provide a detailed Certificate of Analysis (CoA) with our Aescin Extract Powder and can provide a full set of registration support documents such as Material Safety Data Sheet (MSDS), test methods, genetic toxicity studies (if applicable), stability study data, etc. upon request. If you need samples, please contact sales@kintaibio.com

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Aescin Extract Powder for Venotonic Effect (Improved Venous Tone)

Aescin Extract Powder enhances venous tone and elasticity by stimulating the synthesis and release of prostaglandin F2α (PGF2α). This leads to vein constriction, reduced venous capacitance, and improved venous return, thereby decreasing blood pooling in the extremities.

Aescin Extract Powder for Anti-Edema and Capillary-Protective Effects

Aescin Extract Powder effectively reduces vascular permeability and prevents capillary fluid leakage, a major cause of edema. This is achieved through several mechanisms:

• Lysosomal Membrane Stabilization: Aescin fortifies lysosomal membranes in capillary endothelial cells, preventing the release of enzymes (e.g., proteases) that degrade capillary walls and increase permeability.
• Inhibition of Inflammatory Mediators: It suppresses enzymes such as hyaluronidase, which breaks down the glycocalyx and basement membrane of capillaries, maintaining their structural integrity and reducing fluid leakage.
• Enhanced Vasoconstriction: Aescin promotes PGF2α, inducing mild constriction of precapillary sphincters, further limiting fluid filtration into tissues.

Aescin Extract Powder for Anti-Inflammatory Activity

Aescin exhibits anti-inflammatory effects by:

• Inhibiting Leukocyte Activation: It reduces leukocyte adhesion and migration across the endothelium, limiting inflammatory infiltration.
• Modulating Signaling Pathways: Aescin influences NF-κB and other signaling pathways that regulate the expression of pro-inflammatory cytokines and adhesion molecules.

Aescin Extract Powder for Enhanced Lymphatic Drainage

Some evidence suggests that Aescin Extract Powder improves lymphatic flow, aiding in the removal of excess interstitial fluid and proteins, thereby further reducing edema.

• Clinical Relevance
• Due to these mechanisms, aescin-particularly in the form of β-aescinate sodium-is widely used to manage:
• Chronic venous insufficiency (CVI)
• Varicose veins
• Hemorrhoids
• Post-operative or post-traumatic edema

The combined venotonic, anti-edema, anti-inflammatory, and antioxidant properties make aescin a versatile agent for improving vascular health and alleviating swelling and inflammation associated with venous disorders.

Our 98% Aescin Extract Powder ingredients are suitable for a range of premium applications across various industries:

Aescin Extract Powder for Pharmaceuticals (Prescription & OTC):

• Venous Insufficiency Treatment: Used to alleviate symptoms of chronic venous insufficiency (CVI), such as leg heaviness, pain, and edema.
• Anti-Inflammatory and Edema-Reducing Formulations: Effective in treating brain edema and swelling caused by trauma or surgery.
• Topical Gels/Creams: Designed to relieve symptoms of varicose veins, hemorrhoids, and bruises.

Aescin Extract Powder Health Products and Aescin Extract Powder Supplements:

• Leg Circulation Supplements: Available in capsule or tablet form, these supplements help relieve discomfort from prolonged standing or sitting and support venous health.
• Sports Recovery Products: Topical gels or sprays for rapid relief of muscle fatigue and swelling post-exercise.

Aescin Extract Powder for Functional Skincare:

• Eye Care Products: Leveraging its microcirculation-improving and anti-inflammatory properties, ideal for eye creams and serums to reduce dark circles and puffiness.
• Facial Serums and Lotions: Products designed to brighten skin tone, reduce facial puffiness, and enhance skin firmness.

Yes, Aescin Extract Powder is a natural compound. It is primarily extracted from the dried ripe fruit of Aesculus hippocastanum L., commonly known as horse chestnut, which is recognized in official monographs such as the German Pharmacopoeia. In traditional Chinese medicine, it is also derived from "Su Luozi," as documented in the Chinese Pharmacopoeia.

One of its key active constituents, β-aescinate, helps reduce vascular permeability and inhibits lysosomal activity. By stabilizing lysosomal membranes and slowing protease metabolism, it minimizes capillary leakage and alleviates venous congestion, offering effective anti-edema benefits. Thanks to these mechanisms, aescin is widely used clinically in the management of peripheral vascular diseases.

KINTAIBIO^® specializes in the research, development, production, and distribution of high-quality natural ingredients for the pharmaceutical, health supplement, food and beverage, and cosmetics industries. With 11 years of expertise in plant science, the company has established itself as a global leader in the natural ingredient sector.

We have established a rigorous quality management system and has obtained numerous international certifications, ensuring its products meet global regulatory requirements:

• GMP (Good Manufacturing Practice)
• ISO9001:2015 (Quality Management System)
• ISO22000:2018 (Food Safety Management System)
• HACCP (Hazard Analysis And Critical Control Points)
• HALAL (Halal Certification)

In addition, the company has obtained a Dun & Bradstreet Number (Dun & Bradstreet Number: 729375905), enhancing its credibility and transparency in international business.

The company independently tests for heavy metals, up to 413 different pesticides, and other critical safety parameters. Its products also meet relevant standards required by the market, such as Gluten-free, No Allergen, non-GMO, Paraben-free, No Colors, and BSE/TSE-free (no risk of mad cow disease and transmissible spongiform encephalopathy).

If you want to get high-quality Aescin Extract Powder and Horse Chestnut Extract Aescin Powder, please feel free to contact us at sales@kintaibio.com or feedback in the next page.

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