Dihydromyricetin (DMY or DHM ) is a natural flavonoid compound that is widely used in the health field for its powerful antioxidant and hepatoprotective properties. DMY exists in many plants, especially in Vitaceae and Rhamnaceae. It has been widely used in functional foods, health products and other fields because it has various biological activities such as antioxidant, antibacterial, and anti-tumor, and has significant effects in liver protection, neuroprotection, and improvement of symptoms of alcoholism. This article will discuss the main plant sources of DMY in detail to help you better understand the natural sources of DMY and the importance of purchasing high-quality DMY products.
plant sources of DMY
Currently, the known plant sources of DMY mainly include Ampelopsis grossedentata and Hovenia dulcis, which belong to the Vitaceae and Rhamnaceae families respectively. These two plants contain higher concentrations of DMY and are the main raw materials for commercial extraction.
1.1 vine tea: the natural plant source with the highest DMY content
Ampelopsis grossedentata is a plant of the Vitaceae family and is widely distributed in southern China. Its young stems and leaves contain up to 35% DMY, which is the plant source with the highest DMY content currently known. Vine tea has been used in traditional Chinese medicine for hundreds of years and is used to clear away heat and detoxify, lower blood pressure, and reduce swelling. Studies have shown that DMY in vine tea not only has the general properties of flavonoids, but also has superior antioxidant and antibacterial properties, and has important protective effects on the liver, cardiovascular system and nervous system.
The high content of DMY in vine tea makes the plant an ideal raw material for extracting high-purity DMY. The extraction process includes multiple water or alcohol extractions, resin adsorption, recrystallization and other steps, and finally obtains dihydromyricetin with a purity of 98%. Compared with DMY derived from other plants, the DMY extracted from vine tea has purer quality and higher yield, and is suitable for use in the production of high-end health care products and pharmaceuticals.
1.2 Hovenia dulcis: traditional liver-protective and hangover-relieving plant
Hovenia dulcis belongs to the Hovenia genus of the Rhamnaceae family and is also an important source of dihydromyricetin. Fructus Aurantii has a long history of medicinal use, and was first recorded in "Tang Materia Medica". In East Asian countries such as China, North Korea and Japan, hovenia foliage is widely used to protect the liver and relieve hangover, and has been used for thousands of years. Its fruits and seeds are rich in flavonoids, especially DMY.
The process of extracting DMY from Hovenia dulcis usually includes steps such as crushing of medicinal materials, extraction with low-polarity organic solvents, reflux extraction with aqueous alcohol solutions, resin separation, and concentration and crystallization. Through this process, 98% high purity DMY powder can be obtained. Studies have shown that DMY extracted from Hovenia dulcis has excellent hepatoprotective activity, especially against liver damage caused by alcohol and other chemicals, which makes it an important candidate in hangover and liver protection products. Be widely used.
Extraction and purification process of DMY
Extracting and purifying high-purity DMY from plants involves complex processes to ensure its quality and activity. These steps include: Kintai's extraction process of DMY from different sources
1. vine tea extraction process
vine tea contains high DMY content and is suitable for large-scale industrial extraction. Its extraction process is optimized to ensure high yield and purity. The following are the specific steps for extracting DMY from vine tea:
Pretreatment and crushing: After drying the young stems and leaves of the vine tea, crush them into fine powder to increase the contact area between the active ingredients and the solvent and improve the extraction efficiency.
Water extraction or alcohol extraction: Use water or low-polarity organic solvents for extraction, usually ethanol aqueous solution. Water extraction is suitable for ordinary DMY products, while alcohol extraction is used to obtain high-purity DMY ingredients. The extraction temperature is controlled at 90°C and the extraction time is about 1 hour to ensure the activity of DMY.
Resin separation: Separate DMY in the extract through a macroporous resin column. Resin adsorption technology can efficiently remove impurities and improve DMY purity. Usually, the extract is initially separated by macroporous resin and then eluted with water to remove polar impurities.
Recrystallization: Concentrate the extract and recrystallize it, so that the DMY content reaches 98%. The recrystallization process can gradually remove non-target substances through multiple dissolutions and filtrations to obtain high-purity DMY crystals.
Drying and powdering: DMY is formed into powder through spray drying or vacuum drying. Spray drying can effectively maintain the active ingredients of DMY and facilitate subsequent packaging and storage.
This standardized extraction process ensures that the DMY extracted from vine tea has high activity and stable purity, providing high-quality raw materials for antioxidant, antibacterial and liver-protecting products.
2. Extraction process of Hovenia dulcis
The extraction of DMY from Hovenia semen is relatively complex. It mainly uses alcohol-water extraction and resin separation methods, combined with traditional Chinese medicine extraction technology, to ensure the output of high-purity DMY. The following are the specific steps for extracting DMY from Hovenia dulcis:
Crushing medicinal materials: Crush the fruits and seeds of Hovenia dulcis into powder. Sieve using a 80-100 mesh sieve to obtain a uniform powder.
Preliminary extraction: Use low-polarity organic solvents (such as n-hexane or petroleum ether) to extract to remove fat-soluble impurities. This step provides higher purity for subsequent alcohol extraction.
Alcohol aqueous solution reflux extraction: Use ethanol aqueous solution to reflux extract the crushed Hovenia dulcis. The reflux process can extract DMY and other active ingredients in Fructus Aurantii. This process is repeated 2-4 times to ensure DMY yield. The extraction temperature and solvent ratio will be fine-tuned according to different batches of Hovenia semen to achieve the best extraction effect.
Resin adsorption separation: Use macroporous resin column adsorption separation to remove impurities in the extract. In this process, polar impurities are first removed by washing with water, then further washed with 5-10% ethanol aqueous solution, and finally eluted with 20-30% ethanol aqueous solution to obtain a DMY-rich extract.
Concentration and recrystallization: The eluate is concentrated and then recrystallized to improve the purity of DMY. The number of times of recrystallization depends on product requirements. Generally, DMY powder with a purity of 98% can be obtained by recrystallizing more than 5 times.
Drying and powdering: The concentrated DMY extract is spray dried or vacuum freeze-dried to maintain the biological activity of DMY. Dried DMY powder facilitates storage and transportation and ensures long-term activity stability.
This standardized process ensures that the extracted DMY has stable quality and high active ingredients, making it very suitable for the production of high-end health products and functional foods.
Efficacy and application of DMY
1. Protect the liver: DMY has a protective effect on liver cells, can effectively reduce the damage to the liver caused by alcohol, drugs and chemicals, and promote the repair and regeneration of liver cells.
2. Antioxidant: DMY has significant antioxidant activity, can scavenge free radicals in the body, slow down the aging process, and has a preventive effect on cardiovascular diseases and other diseases related to oxidative stress.
3. Neuroprotection: Research shows that DMY has a potential protective effect on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It can also alleviate the symptoms of alcohol addiction and has broad application prospects for neuroprotection.
4. Anti-tumor: DMY has shown the effect of inhibiting tumor cell proliferation in various in vitro and in vivo studies, especially against breast cancer, liver cancer and ovarian cancer.
The importance of choosing high-purity DMY
The choice of high-purity DMY directly determines the quality and efficacy of the product, especially in functional foods and pharmaceutical products. For companies that need to ensure the efficacy of their products, it is particularly important to choose high-quality DMY raw materials, especially when used in fields such as functional foods, medicines and health care products. The purity and quality of raw materials are key factors that determine product effectiveness.
Kintai is one of the leading DMY manufacturers in China, focusing on the production of high-purity (98%) dihydromyricetin powder, ensuring the stable quality and purity standards of each batch of products. We use advanced extraction and purification processes to extract high-efficiency DMY from vine tea and hovenia foliage to meet customer needs in functional foods, liver protection products, anti-aging health products and other fields.
As a natural and multi-functional plant extract, DMY has broad application prospects in the health field. Choosing high-purity, high-quality DMY can not only effectively guarantee the efficacy of the product, but also an important manifestation of your responsibility for the health of end users. Relying on high-quality vine tea and hovenia fruit resources and using advanced production technology, we are committed to providing stable and reliable 98% high-purity dihydromyricetin powder to global customers, adding value to our customers' products. Customers in need are welcome to contact us for more detailed information and cooperation opportunities about DMY products. For related inquiries please contact: Email: sales@kintaibio.com
