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What is pinocinin powder?
Pinocembrin is a natural biologically active substance belonging to diterpenoids. It is extracted from the dried seeds of the cardamom plant and has several health benefits. It has been proved by research that chopinecin has strong antioxidant activity, which can reduce oxidative stress and free radical damage in the body, thus helping to prevent many diseases related to oxidative damage, such as cardiovascular disease, cancer, and other chronic diseases. In addition, it has also been reported to have various biological activities such as anti-inflammatory, antibacterial, antifungal, antitumor, and inhibition of allergic reactions. Therefore, it has broad application prospects in the fields of medicine and health food.


Physicochemical properties
| CAS Number | 480-39-7 | Molecular Weight | 256.25 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 511.1±50.0 °C at 760 mmHg |
| Molecular Formula | C15H12O4 | Melting Point | N/A |
| Common Name | Pinocembrin | Flash Point | 199.3±23.6 °C |
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Product quality specification & standard
|
Product name |
Pinocembrin |
|
Extract source |
Alpinia Katsumadai Seed |
|
Extraction Solvent |
ethanol |
|
Appearance |
White powder |
|
Solubility |
Soluble in hot methanol, DMSO, insoluble in petroleum ether, chloroform |
|
Identification |
HPLC |
|
Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NMT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay |
Min. 95.0% |
|
Residual Solvents |
|
|
- Ethanol |
NMT 5000 PPM |
|
Microbiological Quality (Total viable aerobic count) |
|
|
- Bacteria, CFU/g, not more than |
NMT 103 |
|
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
|
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
In a Tight, Light-resistant, and Dry Place. Avoid Direct Sunshine. Country of Origin: China |
|
Shelf life |
3 years |
Benefits
1. Antibacterial and disinfection: Katsumada galangal seed extract is a broad-spectrum antibacterial and disinfectant substance that can kill a variety of pathogenic bacteria, viruses, and fungi. Pinocinol has the effect of inhibiting the growth of bacteria, especially gram-positive bacteria, such as Staphylococcus aureus and Escherichia coli. Josonin can also effectively treat inflammatory infections in the oral cavity, skin, stomach, and other fields, and has no obvious toxic or side effects.
2. Regulating the immune system: Katsumada galangal seed extract is rich in many phenolic compounds, has strong antioxidant and anti-inflammatory effects, and can reduce inflammation and tissue damage. Qiao Songsu can also regulate the function of the human immune system, enhance the body's immunity, and improve arthritis, enteritis, and other diseases. In addition, pinocin can also inhibit the growth of cancer cells and has certain anticancer effects.

3. Healthy cardiovascular system: Katsumada galangal seed extract is rich in various antioxidants, which can reduce the level of low-density lipoprotein cholesterol in plasma and prevent oxidative damage of vascular endothelial cells. In addition, pinocetine can also increase the synthesis of nitric oxide, dilate blood vessels, lower blood pressure, and prevent heart disease. Josin also helps to reduce body weight and control blood sugar levels, thereby improving the symptoms of metabolic syndrome.
4. Whitening skin: Melanin is the main cause of skin dullness and pigmentation. Katsumada galangal seed extract has the effect of inhibiting the production of melanin, which can prevent the excessive synthesis of melanin caused by strong light stimulation and skin aging, and has a very good effect on whitening the skin. Pinocinin can inhibit the activity of melanocytes and cell signaling pathways, and promote the self-apoptosis of melanocytes, so as to achieve the effect of lightening spots.
5. Anti-aging effect: Katsumada galangal seed extract has strong anti-oxidation and anti-inflammatory effects, which can reduce oxidative stress and inflammatory response, and slow down the aging speed of the body. It can neutralize free radicals, enhance the self-repair ability of cells, and can also promote blood circulation, regulate endocrine, and lower blood sugar. Together, they can effectively resist aging and delay the aging process.

Application fields
(1)Pharmaceutical field: Katsumada galangal seed extract is beneficial to human health, has been widely used in the pharmaceutical field and can be used to make medicines to prevent heart disease, bronchitis, headache, loss of appetite, and other symptoms. In addition, it can also be used as a raw material for antibacterial, antiviral, anti-inflammatory, antioxidant drugs, etc.
(2)Nutrients and health care products field: Katsumada galangal seed extract contains many active ingredients, which can be used as nutrition and health care products. It has many functions such as anti-oxidation, anti-inflammatory, antibacterial, lowering cholesterol, lowering blood fat, promoting blood circulation, and delaying aging. It can enhance human immunity, improve cardiovascular disease, and resist the risk of cancer and other diseases.
(3)Cosmetics field: Katsumada galangal seed extract can be used as an active ingredient in cosmetics, and can be used in the production of cosmetics such as skin care products, beauty products, and facial cleansers. It has the functions of whitening, removing pigmentation, eliminating small fine lines, healing acne, improving dull skin tone, etc. It can improve the luster and elasticity of the skin and improve the texture of the skin.
(4)Field of food additives: Katsumada galangal seed extract can also be used as a food additive. It can be used in public food, health food, nutritional supplements, and other fields to increase the nutritional value and function of food, and it can also have good antiseptic, antibacterial, antioxidant, and taste-enhancing effects.

Safety
Internationally, there is no clear regulation on the daily allowable intake of jousting, but relevant personnel in Japan, Europe, and other regions have conducted certain safety assessments on it.
Among them, the Japan Science and Technology Agency has also established a toxicological data file of cardamom josonin, and has conducted a comprehensive evaluation of the toxicity of josonin. The results showed that the jocetin in the cardamom extract was within the safe concentration range and would not cause significant toxicity and adverse reactions to the human body.
Preparation
(1) Dried the aerial part of Glycyrrhizae glabra and crushed it through a 40-mesh sieve, heated and extracted with 80% ethanol (v/v) of 8-20 times the weight for 2 hours, filtered the supernatant, repeated the extraction three times, and combined the above The clear liquid was concentrated under reduced pressure and freeze-dried to obtain a powder;
(2) Dissolve the powder in water so that the concentration reaches 5-20 mg/mL, pass through a polyamide lipid column, and use 0-90% (v/v) ethanol solution for gradient elution, collect the eluents separately, freeze-dry, and sequentially Six components are obtained, which are sequentially recorded as A, B, C, D, E, and F;
(3) Dissolve the third component C in ethanol (the unspecified concentration refers to absolute ethanol) to make the concentration reach 30-50mg/mL, add 2-5 times the volume of distilled water, let it settle at 4°C, and centrifuge After drying, the precipitate C1 was obtained;
(4) Redissolve the precipitate C1 in ethanol so that the concentration reaches 30-50mg/mL, and let it stand for 1-3 days to obtain yellow crystals. After repeated washing and recrystallization with ethanol, the colorless needle-shaped cluster crystals of pinocin are obtained.
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