Salvia Miltiorrhiza Extract

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Salvia Miltiorrhiza extract is the dry root and rhizome extract of Salvia miliorrhiza. It contains not only Tanshinone, cryptotanshinone, isotanshinone, tanshinone, tanshinol and other bioactive substances, but also vitamin A, E, iron, potassium and other metal elements. Statin has the function similar to estrogen, which can contract the sebaceous glands and reduce the secretion of sebum. Therefore, the makeup cream made with Salvia miltiorhoza as the effective ingredient has therapeutic effect on acne caused by excessive secretion of androgen sebum.
Salvia miliorrhiza extract has many characteristics and functions: first, it can effectively reduce endothelial damage in terms of medicinal value, especially in patients with acute cerebral infarction or occlusion, atherosclerosis or diabetes, it can promote endothelial repair and effectively reduce endothelial damage. Moreover, it has very good anti-inflammatory effect and is widely used in clinic, especially in arthritis and viral myocarditis.
Salvia miltiorriza extract can remove oxygen free radicals from human body, inhibit lipid peroxidation, improve human immune function, cool blood and relieve pain, dredge meridians, activate lateral parts, and improve human cardiovascular and cerebrovascular atherosclerosis and heart failure. Vascular endothelial hypertrophy and other symptoms, anti-liver fibrosis, anti-tumor, anti-aging.
Salvia miltiorrhiza is bitter in taste and slightly cool in nature. It has the functions of promoting blood circulation, removing blood stasis, clearing the heart, eliminating discomfort, nourishing the heart and calming nerves. In addition to the causes related to lung heat, liver function decline and yin deficiency, the causes of macula are all inextricably related to qi stagnation and blood stasis. Salvia miliorrhiza promotes blood circulation, provides nutrition for blood, eliminates congestion and promotes regeneration.

1.1 Main ingredient

The main components are phenolic acids and diterpenoids. There are more than 50 components whose structures have been elucidated, and diterpenoids account for more than half.
Phenolic aromatic acids mainly include danshensu, namely D(+)-β-(3,4-dihydroxyphenyl) lactic acid (salvianic acid A), salvianic acid C, rosemarinic acid (Rosemarinic acid), rosmarinic acid Methyl ester, salvianolic acid (Sal-vianolic acid) A, B, C, G, salvianic acid B (Lithos-permicacid) and dimethyl shikonate. Among them, danshensu is effective for coronary heart disease, salvianolic acid has anticoagulant activity, and salvianolic acid B has the effects of increasing urine volume, lowering blood pressure, and reducing swelling, and is the main active ingredient in the treatment of chronic renal insufficiency. Most of the diterpenoids are tanshinone-type diterpene quinones. There are Tanshinone I (Tanshinone I), Tanshinone Ⅱ A (Tanshinone Ⅱ A), Tanshinone Ⅱ B, Cryptotanshinone (Cryptotanshinone), Methyltanshinonate (Methyltanshinonate), hydroxytanshinone Ⅱ A, isotanshinone, isotanshinone Ⅱ A, isocryptanshinone, tanshinone (Miltirone ), carnosol (Salviol), L-dihydrotanshinone I, Tanshinxinkun (Tansh-inxinkun) A, B, C. It also separates hypotanshinone, 1,2-dihydrotanshinone, salvia quinone with strong anti-platelet aggregation activity, ferruginol (Ferruginol), salvia quinone ding, salvia diol A, B, C, detox A tanshinone, 3α-hydroxytanshinone Ⅱ A, salvianolide, dihydroisotanshinone I, Danshensproketallactone (Danshensproketallactone), epidanshenspiralketalactone, salvilenone (Salvilenone), isotanshinone I, Tanshinquinone new ketone Ⅱ (Miltionone Ⅱ), tanshinquinone new ketone Ⅰ (Mil-tionone Ⅰ).
Other ingredients include baicalin, β-sitosterol, stigmasterol, ursolic acid, carotin, 5,3'-dihydroxy-7,4"-dimethylflavanone, protocatechualdehyde, isoferula acid, succinic acid, 3,4-dihydroxybenzaldehyde, vitamin E and tannins.

1.2  Introduction to extraction sources

Salvia miltiorrhiza Bunge (scientific name: Salvia miltiorrhiza Bunge) is a perennial erect herb of Lamiaceae and Salvia genus, with thick roots, vermilion outside, white inside, fleshy, leaves are often odd pinnate compound leaves, terminal or axillary racemes ; bracts lanceolate, calyx bell-shaped, with purple, corolla purple-blue, style far outstretched, nutlets black, oval, flowering from April to August, fruit after flowering.

This kind of root is used as medicine, containing tanshinone, which is a strong menstruation agent. It has the effects of removing blood stasis, promoting regeneration, promoting blood circulation, and regulating menstruation. It is an important medicine for gynecology. ,temple pain. In addition, it also treats neurasthenia, insomnia, joint pain, anemia, mastitis, lymphadenitis, arthritis, sores, boils, pain and swelling, erysipelas, acute and chronic hepatitis, nephritis, bruises, hepatosplenomegaly in advanced schistosomiasis, Epilepsy. External use can also wash paint sores.

The main component of Danshen extract is phenanthrenonequinone derivatives. In the culture of fibroblasts, etc., the extract can promote the proliferation of collagen, so it can enhance the metabolism of the dermis of the skin, and it can be used in skin revitalizing and anti-wrinkle cosmetics due to its antioxidant properties; It can be used as an antibacterial, anti-inflammatory, hair tonic, slimming agent and moisturizer.

Salvia miliorrhiza extract has anti-oxidation effect, can effectively remove oxygen free radicals in the human body, and can also enhance the immune function of the body. At the same time, the extract contains a large amount of vitamin C and vitamin E, so it can whiten the skin.

3.1 Health benefits

(1) Effects on coronary artery: treating coronary heart disease, improving coronary circulation and inhibiting the occurrence of thrombosis. Danshensu has the effects of significantly dilating coronary arteries, increasing coronary blood flow, reducing myocardial oxygen consumption, slowing heart rate and increasing myocardial contractility.

(2) Effects on myocardial repair: both danshensu and tanshinone IIA can significantly prolong the hypoxia tolerance time of mice, and alleviate hypoxia-induced damage.
At the same time, it improves myocardial contractility and promotes myocardial regeneration.

(3) Improve microcirculation: Salvia miliorrhiza extract can improve capillary blood flow, accelerate capillary expansion, increase the number of open capillaries, and help improve microcirculation.
(4) Effects on blood rheology: Danshensu and Tanshinone IIA can inhibit ADP-induced platelet aggregation, inhibit platelet

TXA2 synthesis and release of vasoconstrictor substances and promotion of fibrin degradation. Can reduce coronary heart disease, cerebral ischemic stroke and
Whole blood and plasma viscosity of myocardial infarction patients, reduce hematocrit, and make blood flow of patients through the effect of anticoagulation and viscosity reduction
Variable indicators returned to normal.

(5) Lowering blood lipids: Salvia miliorrhiza extract can inhibit the synthesis of endogenous cholesterol, reduce the generation of low-density lipoprotein, and help prevent hyperlipidemia;

(6) Anti-infection, used for purulent and surgical infection (acute tonsillitis, otitis externa, osteomyelitis, surgical infection, etc.).

(7) For the treatment of cervical erosion.

3.2 Application

Scope of application: Danshen tablets, injections, pills.

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