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Artichoke Extract powder supplier/Manufacturer - kintaibio®
KINTAIBIO® Artichoke Extract is made from artichoke leaves (Cynara scolymus L.), which have higher levels of polyphenols and flavonoids than other parts of the plant. The leaves contain 2.97 times more polyphenols and 2.65 times more flavonoids than pedicels, and 2.13 times and 2.00 times more than flower buds, respectively. These leaves are rich in caffeoylquinic acid compounds, like chlorogenic acid and cynarin, ensuring the extract's high bioactivity.
Using PLC-DAD-ESI/MS/MS, we have qualitatively identified up to 27 polyphenols from the leaves. To ensure batch-to-batch consistency and predictable results, we rigorously standardize our core active ingredients and offer the following specifications:
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- Cynarin standardized to 2.5% - 5% (w/w)
- Chlorogenic Acid standardized to 5% - 10% (w/w)
- Total polyphenol content ≥ 2.5% (calculated as cynarin according to the European Pharmacopoeia method)
how to make Artichoke Extract powder ?
We utilize an ethyl acetate extraction process optimized through orthogonal experiments to efficiently enrich the target active ingredient, specifically cynarin. After systematic parameter screening and validation, we determined the following optimal extraction parameters, achieving a balance between yield and efficiency:
- Extraction time: 30 minutes
- Phase separation time: 80 minutes
- Extract concentration: 10.0 g/L
- Phase ratio (solvent ratio): 1.25:1
- Extraction temperature: 35°C
- pH: 4.0
Under these optimized conditions, a cynarin extraction yield of 67.37% was achieved. This process is stable and controllable, providing reliable support for large-scale production of high-quality extracts.
kintaibio® Artichoke Extract powder Quality Control and Testing Methods
We have established a comprehensive quality control system and utilize relevant technologies to ensure that our product quality meets your needs.
1. Qualitative Identification: HPTLC is used as a rapid and accurate method to ensure the presence of the hallmark ingredients chlorogenic acid and luteolin-7-glucoside.
2. Assay: UPLC and HPLC are used to accurately quantify chlorogenic acid and cynarin, respectively.
Our analytical methods demonstrate excellent linearity and reliable recoveries (e.g., an average recovery of 99.10% for chlorogenic acid). The results are accurate and highly reproducible, providing solid technical support for raw material procurement and finished product quality control.
2.1 Assay of Chlorogenic Acid: We have established a UPLC method. This method, using an Acquity BEH C18 column (2.1 mm × 100 mm, 1.7 μm), demonstrated excellent linearity over the concentration range of 0.013 to 1.3 mg/mL, with an average recovery of 99.10% (RSD = 1.87%). This method offers the advantages of rapid analysis, minimal solvent consumption, and accurate results, making it suitable for rapid quality control.
2.2 Assay of cynarin: We employed high-performance liquid chromatography (HPLC) for precise quantification. Using a Waters Symmetry C-18 column, this method demonstrated excellent linearity (r = 0.9994) over the concentration range of 38 μg/mL to 190 μg/mL, with average recoveries ranging from 97.4% to 102.3% (RSD = 3.0%). This method is simple to operate, offers accurate and reproducible results, and effectively guides raw material procurement and finished product quality control.
COA of Artichoke Leaf Extract
benefits of Artichoke Leaf Extract
artichoke extract weight loss
Studies have shown that long-term supplementation with artichoke leaf extract may support weight management and metabolic balance by regulating lipid metabolism pathways. In a mouse model of obesity induced by a high-fat diet, artichoke extract cynarin rich in luteolin was able to help reduce adipose tissue accumulation and dyslipidemia by reducing lipogenesis-related processes, promoting fatty acid oxidation, and improving cholesterol metabolism, while also improving hepatic steatosis.
Furthermore, research has found that the active ingredients in artichoke leaves may improve obesity-related metabolic disorders, including decreased insulin sensitivity and chronic low-grade inflammation, by regulating the levels of inflammation-related factors. In conclusion, artichoke extract shows significant potential for supporting healthy lipid metabolism, maintaining normal weight, and developing dietary supplements for weight management.
artichoke extract for liver health
Artichoke leaf extract (ALE) has been extensively studied in the field of liver health in recent years. Related clinical studies have shown that ALE may have a positive supporting effect on liver function indicators and lipid metabolism in patients with non-alcoholic fatty liver disease (NAFLD). In a trial, subjects diagnosed with NAFLD supplemented with ALE daily. After two months, researchers observed improvements in liver ultrasound-related indicators and optimization of liver function indicators.
Furthermore, organic artichoke extract has shown the potential to help maintain healthy cholesterol and triglyceride levels, which may be related to its role in promoting lipid metabolism balance and reducing lipid accumulation in the liver. Research suggests that the polyphenols and flavonoids in artichokes can exert antioxidant and inflammatory modulatory effects, thereby providing protective support for hepatocytes.
artichoke extract for cholesterol
Studies have shown that standardized artichoke leaf extract may help maintain healthy cholesterol levels and support lipid metabolism balance. In a randomized, double-blind, placebo-controlled clinical trial, healthy adults with mild to moderate hypercholesterolemia who supplemented with artichoke leaf extract showed a decrease in plasma total cholesterol levels from baseline after a period of time, while the placebo group showed a slight upward trend.
Related research suggests that polyphenolic compounds in artichokes may exert their effects by promoting bile acid metabolism, regulating cholesterol synthesis, and enhancing lipid metabolism balance. Furthermore, natural artichoke extract has also shown potential to improve lipid parameters in studies related to non-alcoholic fatty liver disease (NAFLD), including helping to maintain healthy levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides.
artichoke extract benefits for skin
Artichoke leaf extract possesses strong antioxidant potential, helping skin resist oxidative damage from environmental stressors and supporting a healthy skin barrier. In a randomized, half-face controlled study, subjects who consistently used products containing artichoke standardized extract experienced improved skin condition, including reduced wrinkle depth, decreased skin roughness, and improved skin radiance. Simultaneously, total skin antioxidant capacity (FRAP) increased, and the level of the inflammation-related marker tumor necrosis factor-α (TNF-α) decreased.
These results demonstrate that artichoke leaf extract, through its natural polyphenolic components, exerts antioxidant and inflammatory modulatory effects, helping to mitigate the impact of external environmental factors on the skin. Therefore, standardized artichoke extract powder can serve as a natural plant-based active ingredient, providing scientific support for maintaining healthy skin and enhancing its antioxidant protective capacity.
artichoke extract for blood pressure
Artichoke leaf extract has garnered ongoing attention in the fields of cardiovascular health and metabolic regulation. Related studies have shown that the polyphenols in artichokes may support the maintenance of normal blood pressure levels through mechanisms such as antioxidation, regulation of vascular endothelial function, and promotion of nitric oxide (NO)-related pathways.
A study on the relationship between artichoke supplementation and blood pressure showed that while the overall effect of artichoke supplementation on systolic and diastolic blood pressure was not significant, subgroup analysis revealed that in hypertensive individuals, artichoke supplementation showed a trend towards improvement in both systolic and diastolic blood pressure, and may have a positive effect on diastolic blood pressure regulation. These findings suggest that artichoke extract may be more suitable as a natural nutritional support component in cardiovascular health management programs, rather than a replacement for antihypertensive treatments.
Artichoke extract digestion
The natural active ingredients in artichoke extract promote normal bile secretion, aiding in fat digestion and nutrient absorption, while supporting gastrointestinal balance. Because artichoke leaves contain dietary fiber and inulin, which help maintain the gut microbiota, pure artichoke extract for constipation is primarily used to support regular bowel movements and improve digestive comfort.
Artichoke extract benefits for women
For menopausal women's health concerns, artichoke extract for menopause is currently being studied primarily based on its antioxidant and metabolic support properties, and can be used as a plant-based ingredient in comprehensive nutritional management programs for women. Regarding artichoke extract and estrogen, some studies focus on the potential link between plant-based active substances and female hormone metabolism, but there is currently a lack of sufficient human clinical evidence to prove that artichoke leaf extract can directly regulate estrogen levels.
Artichoke extract and kidneys
Existing research mainly focuses on the supportive effects of artichoke on liver health, lipid metabolism, and antioxidant function, while direct clinical studies on kidney function are still relatively limited. Therefore, it is currently considered more of a holistic metabolic health support ingredient than a raw material for specific kidney health products.
Artichoke extract for dogs
In addition, artichoke leaf extract is gradually gaining attention in the field of pet nutrition. Its natural plant active ingredients can be used to support dogs' digestive function, liver health, and antioxidant nutritional needs.
Reference:https://pmc.ncbi.nlm.nih.gov/articles/PMC6115887/
https://pubmed.ncbi.nlm.nih.gov/29520889/
https://www.sciencedirect.com/science/article/abs/pii/S0944711308000305
https://www.mdpi.com/2079-9284/11/3/69
https://www.sciencedirect.com/science/article/pii/S0965229921000091
what is artichoke extract used for ?
Artichoke extract supplement
Artichoke extract is an important plant-based ingredient in the development of liver health and metabolic support products, commonly used in formulations such as artichoke extract capsules, Artichoke Extract pills, and Artichoke Extract tablets. Its natural plant polyphenols help support liver health, promote normal bile secretion, and maintain lipid metabolism balance.
Artichoke extract foods and beverages
Due to its good compatibility and natural antioxidant properties, artichoke extract powder can be added to solid beverages, plant-based drinks, nutrition bars, cereals, yogurt, and other health foods to enhance their nutritional value. Its polyphenols have antioxidant potential, helping to slow down the oxidation process in food; simultaneously, the plant-derived dietary fiber can be used to develop gut health-related products.
Artichoke extract cosmetics
The natural antioxidants in artichoke extract help combat oxidative stress caused by free radicals and support skin health, therefore it can be used in anti-aging skincare products, repair serums, masks, and other plant-based active formulations.
Artichoke Leaf Extract side effects,dosage,safety
Artichoke leaf extract dosage
When used in appropriate amounts, artichoke leaf extract generally has a good safety profile. The specific dosage needs to be adjusted based on the product's standardization, active ingredient content, and intended use.
Artichoke extract side effects
For most adults, taking organic artichoke extract at the recommended dosage usually does not cause significant adverse reactions. A small number of individuals may experience mild gastrointestinal discomfort, such as bloating, nausea, diarrhea, or abdominal discomfort.
Is artichoke extract safe?
Current research indicates that artichoke leaf extract is generally well-tolerated at study doses and under short- to medium-term use conditions. However, pregnant women, breastfeeding women, children, and individuals with bile duct obstruction, gallbladder disease, or undergoing specific treatments are advised to consult a healthcare professional before use.
Is artichoke extract safe during pregnancy?
There is currently insufficient human clinical data to prove its safety during pregnancy. Therefore, it is not recommended for pregnant women to use it long-term without a doctor's evaluation. Furthermore, because natural artichoke extract may affect bile secretion, individuals at risk of gallstones or biliary tract disease should use it under professional guidance.
where to buy artichoke extract ?
KINTAIBIO® is a professional artichoke extract powder supplier and manufacturer, specializing in providing high-quality artichoke standardized extract powder and other natural plant active ingredients. Customers can purchase artichoke extract directly from the source manufacturer, obtaining more competitive prices, more stable quality control, and professional technical support. For customers requiring long-term, stable procurement, we offer professional wholesale artichoke extract supply solutions, and can provide customized packaging, specification adjustments, and complete technical information according to market demand.
As a trustworthy artichoke extract powder factory, our bulk artichoke extract powder boasts advantages such as stable purity, high batch consistency, and ease of application. We can provide products in different specifications and customized OEM/ODM services according to customer needs, helping global brands develop high-quality natural health products. KINTAIBIO® relies on GMP and ISO quality management systems to ensure that each batch of products meets international market requirements for safety, stability, and consistency of active ingredients.Please contact sales@kintaibio.com for more technical information and collaboration details.
If you want to purchase high-quality Artichoke Extract Powder, please feel free to contact us at Sales@Kintaibio.Com or provide feedback on the next page. Site web: www.kintai-bio.com
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