Let's learn some effects of Agricus blazei Extract!
1. Antitumor activity
There are many water-soluble and water-insoluble polysaccharides with obvious anti-tumor activity in Agaricus blazei extract. Among them, the water-soluble polysaccharide FA—Ⅰ—α—β, its main components are (1—6)β—D—glucan and (1—3)β—D—glucan. The main mechanism of anti-tumor is to stimulate the body's immune system, improve and adjust the body's internal defense system to play an anti-tumor effect indirectly, that is, it works through the host. By acting on immune cells, promoting cytokine production and activating complement, it has anti-tumor activity.
2. Enhance the immune function of the body
The polysaccharide extracted and separated from Agaricus blazei is an immune enhancer, which can not only activate the activity of T cells, B cells, MΦ, NK cells, CTL cells, LKA cells and other immune cells, but also activate the reticuloendothelial system (RES) to phagocytize and eliminate aging. The role of cells and foreign bodies and pathogens can also promote the production of IL-1, IL-2, TNF-α, INF-r, N0, etc., regulate the formation of body antibodies and complement, and improve the body's anti-tumor immunity. In addition, the anti-tumor, anti-radiation and anti-aging activities of polysaccharides are all related to the non-specific immune enhancement of polysaccharides.
3. Protect the liver
Agaricus blazei polysaccharide has anti-hepatitis effect. The anti-inflammatory effect of Agaricus blazei polysaccharide is mainly to inhibit the biosynthesis and release of prostaglandin E2, and also inhibit the production and release of inflammatory mediators such as histamine, 5-hydroxytryptamine and bradykinin. Polysaccharides also have the effect of protecting liver damage, and Agaricus blazei water extract has protective effects on hepatotoxicity induced by different doses of diethylnitrosamine and on the liver of rabbits exposed to carbon tetrachloride.
4. Antioxidant effect
Agaricus blazei polysaccharides can increase the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), reduce the content of lipid peroxides, and clear them at low concentrations The role of free radicals.
5. Inhibition of mutagenesis
Agaricus blazei extract has significant inhibitory effect on in vitro hair dye, strong carcinogen 2-AF, cyclophosphamide and benzo(a)pyrene mutagenesis.
6. Affect hematopoietic function
Agaricus blazei polysaccharide can promote the proliferation of normal hematopoietic stem and progenitor cells, and different doses of the same drug have different effects on hematopoietic stem and progenitor cells. The two pure polysaccharides, ABP-Ⅱ-α and ABP-Ⅱ-β extracted from it, have different degrees of inhibitory effects on human leukemia cells, and are positively correlated with the time of action and the dose of action.
7. Improve blood flow
The aqueous extract of Agaricus blazei can significantly reduce blood stasis whole blood viscosity and plasma viscosity, and has a certain effect on improving blood rheology in blood stasis model rats. Agaricus blazei ω-6 polyunsaturated fatty acid (ω-6APFA) can prolong the coagulation time of mice, increase blood fluidity, improve blood viscosity, inhibit thrombus formation and promote blood circulation and remove blood stasis.
