Part1. What is forskohlii extract?
The Coleus forskohlii extract is the water or alcohol extract of Coleus forskohlii, and the index active ingredient is forskolin. It has the effects of strengthening the heart, lowering blood pressure, and relieving spasm.
Part2. Pharmacological effects
1. Reduce intraocular pressure
Anti-glaucoma basic and clinical pharmacology studies on the three forskolin analogues isoforskolin, deacetylforskolin, and 1-acetyl-forskolin isolated from Coleus forskolin have shown that these three compounds have the activity of activating cyclic AMP in vitro, and all of them have It can reduce the intraocular pressure of normal rabbits or inhibit the high intraocular pressure of water-loaded rabbits to varying degrees, and it is speculated that 1-acetylforksolin has activity after being metabolized in vivo.
2. Asthma and antispasmodic effect
Coleus forskohlii ethyl acetate extract has powerful antiasthma and antispasmodic effects, and the antiasthma pharmacodynamics and acute toxicity experiments have been analyzed and evaluated. The results show that its antispasmodic potency is 145 times that of aminophylline, while The toxicity is far lower than that of aminophylline.
3. Lower blood pressure
Coleus forskohlii extract 1-acetoxyforskolin and isofuskolin can effectively reduce the blood pressure of anesthetized rats, and the effect is rapid and long-lasting, showing a dose-dependent relationship, while there is no significant effect on heart rate and other parameters. No effect or statistically significant difference.
4. Inhibition of platelet aggregation
Iveskolin can inhibit ADP, and the inhibitory effect has no obvious selectivity on the three activation pathways of platelets. Its mechanism of action may be related to the direct activation of adenylate cyclase by Isofaskolin and the increase of cAMP level in platelets. Its anticoagulant effect and bleeding risk need to be further evaluated and investigated.
5. Anti-tumor effect
Coleus forskohlii extract has significant anti-tumor activity. According to reports, the research on its anti-tumor effect has focused on forskolin, and the similar effects of other ingredients have not been reported. Forskolin can significantly increase the activity of cell adenylyl cyclase and the accumulation of cAMP, and the maintenance of cAMP level can effectively regulate cell proliferation and differentiation.
