Technology Name: One productive technology and preparation method of Lappaconitine Hydrobromide
Application (patent): XI'AN KINTAI BIOTECH INC.
Address：3rd Floor, Unit 3, Building 16, Zhongnan Hi tech Airport Industrial Port, Airport New City, Xixian New Area, Shaanxi Province, China.
Invention (design)：Zou Yuchi,Chen Jinfeng, Wang Pan
Patent owner: XI'AN KINTAI BIOTECH INC.
Abstract:
1. The invention relates to one preparation method of Lappaconitine Hydrobromide, Including the following steps:
2. Smash the root of Aconitum sinomontanum, add it to ethanol solvent to immersion and percolation;
3. The permeability liquid in vacuum 0.050 ~ 0.070 MPa, temperature 60 ~ 80℃ technology condition for concentrating;
4. Recycling ethanol, getting concentrated liquor;
5. Concentrated liquor on the temperature 20 ~ 60℃ technology condition, use acidification agent acidification to pH1 ~ 2, filter, getting acidification liquid;
6. Acidification liquid with alkaline agent to alkalization pH9 ~ 10, getting the alkaline fluid;
7. Alkaline fluid and chloroform extraction, add dehydrant dehydration, recycling chloroform, getting the extract liquid;
8. Extracting liquid add ethanol stalling, crystallization, washing with ethanol, getting the 93% Lappaconitine crystallization (test by acid-base titration) ;
9. use the conventional methods for Lappaconitine crystallization to make hydrobromide, getting 96%-98% Lappaconitine Hydrobromide(test by HPLC).
This invention is low energy consumption, less impurities, high purity; For large scale industrial production.
