Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of sodium azulene sulfonate in China. Please feel free to wholesale high quality sodium azulene sulfonate for sale here from our factory. For price consultation, contact us.
Sodium Azulene Sulfonate – 40 Years of Global Use, Now Available with Higher Purity and Stability
For nearly four decades, Sodium Azulene Sulfonate has been trusted worldwide for its anti-inflammatory, anti-allergic, mucosal repair, and skin care properties. Its safety and efficacy have been well established across pharmaceutical and cosmetic markets in numerous countries and regions. At kintaibio, we bring you this proven active ingredient in a form that raises the bar – with higher purity, better stability, and full quality traceability.
We are a manufacturer specialized in the R&D, production, and supply of bioactive plant-derived ingredients and functional actives. With over 14 years of experience in natural product synthesis and formulation development, we have full in-house control over the entire production chain for Sodium Azulene Sulfonate – from raw material quality assurance, sulfonation process optimization, to final purification and refining.
Key advantages of our Sodium Azulene Sulfonate
1. Synthetic process
A one-step sulfonation reaction under mild conditions generates minimal by-products, achieving a purity of >99.5%.
2. Impurity control
Residual guaiazulene (starting material) is strictly monitored using the pharmacopoeial transmittance method. Our typical transmittance value is 97.8% – well above the required minimum of ≥95.0%.
3. Formulation stabilization technology
To overcome the well-known sensitivity of Sodium Azulene Sulfonate to light and heat, kintaibio has developed a highly stable 1% pre-dissolved formulation. After 45 days of exposure to ambient light (without any light protection), the active ingredient retention rate remains 97.28% – solving a long-standing formulation challenge.
4. Quality systems
We maintain comprehensive quality management systems, including GMP, ISO9001, ISO22000, and HACCP. Every batch is tested, a Certificate of Analysis (COA) is provided with each shipment, and third-party test reports are available upon request.
Our Sodium Azulene Sulfonate are mainly exported to Japan, South Korea, Southeast Asia, Europe, and North America, meeting regulatory requirements in these regions. Whether you are developing a new formulation or optimizing an existing one, kintaibio is here to help you make scientifically sound and cost-effective sourcing and development decisions. Contact our team: sales@kintaibio.com
Sodium Azulene Sulfonate Information
| Item | Content |
| INCI Name | SODIUM GUAIAZULENE SULFONATE |
| CAS No. | 6223-35-4 |
| Molecular Formula | C₁₅H₁₇NaO₃S·½H₂O (hemihydrate) |
| Molecular Weight | 309.36 |
| UNII (FDA) | 19WSH095WP |
| CosIng Ref No. | 37880 |
| EINECS No. | 228-309-8 |
Chemical Structure
This product is a sodium sulfonate derivative of guaiazulene. The introduction of a sulfonate group (-SO₃Na) into the parent nucleus converts it from oil-soluble to water-soluble, while retaining its core activities: anti-inflammatory, anti-allergic, and pro-repair.
Structural features:
Azulene bicyclic skeleton as the parent nucleus, forming a blue conjugated system
Sodium sulfonate group at the 3-position confers water solubility
1,4-Dimethyl-7-isopropyl substituents influence biological activity
Physicochemical Properties
| Property | Description |
| Appearance | Dark blue to Oxford blue crystalline powder, odorless and tasteless |
| Solubility (Water) | Approx. 1.6 g/100 mL (20°C) |
| Solubility (Methanol) | Freely soluble |
| Solubility (95% Ethanol) | Slightly soluble |
| Solubility (1,2-Hexanediol, 1,2-Pentanediol) | Significantly improved; pre-dissolving in polyols is recommended |
| Solubility (Diethyl ether, n-Hexane) | Practically insoluble |
| pH (1% aqueous solution) | 6.0–9.0 (typically 8.5) |
| Melting Point | >200°C (decomposes) |
| UV Absorption Characteristics | Maximum absorption peak at 567–571 nm; secondary absorption at approx. 330 nm (UVA region) and 280–310 nm (UVB region) |
kintaibio's Sodium Azulene Sulfonate is manufactured using naturally sourced guaiazulene (primarily extracted from guaiacwood oil) as the starting material. The production process includes sulfonation, neutralization, decolorization, crystallization, and drying. The entire manufacturing process complies with GMP guidelines. No toxic solvents are used, and residual solvents meet pharmacopoeial limits.
Quality Specifications & Certificate of Analysis (COA)
kintaibio Sodium Azulene Sulfonate powder is tested against all specifications in strict accordance with the Japanese Standards of Quasi-Drug Ingredients (JSOQI) and the Standards for Quasi-Drug Raw Materials. Below is a typical batch COA.
Every batch of kintaibio Sodium Gualenate powder undergoes the full set of tests listed above, and a COA is provided with each shipment. Customers may request data from consecutive batches to evaluate batch-to-batch consistency. Typical inter-batch RSD (relative standard deviation) is <2.0%.
Stability Studies & Formulation Solutions
1 Stability Challenges of Sodium Azulene Sulfonate
The molecular structure of Sodium Azulene Sulfonate contains a conjugated double bond system, making it sensitive to light, heat, and oxygen. Published literature and internal studies at kintaibio show:
- Light stability: Under natural light (especially UVA and visible light), aqueous solutions fade and active content declines.
- Heat stability: Prolonged heating above 40°C accelerates degradation, with faster degradation at lower pH.
- Oxidative stability: Contact with air may cause oxidative discoloration.
An unprotected standard aqueous solution retains only about 75.06% of its active substance after 45 days of unprotected light exposure. This characteristic has historically limited the use of this ingredient in transparent packaging and high-temperature processing.
2 kintaibio's Formulation Solution – 1% Sodium Azulene Sulfonate Pre-Solution
Our R&D team systematically screened surfactant systems, pH adjusters, antioxidants, and chelating agents, and successfully developed a highly stable 1% Sodium Azulene Sulfonate pre-solution (trade name: kintaibio® Stable Blue No.1).
This pre-solution can be used directly in cosmetic formulations or further diluted, greatly simplifying the customer's compounding process.
3 Stability Validation Data
Test conditions:
- Samples: kintaibio 1% pre-solution vs. standard 1% aqueous solution (control)
- Storage: On an indoor windowsill under ambient light (no protection) or completely protected from light
- Analytical method: HPLC for active content
- Time points: Day 0, Day 45
Results:
| Sample | Condition | Day 0 (%) | Day 45 (%) | Retention (%) |
|---|---|---|---|---|
| Standard solution (control) | Unprotected light | 100 | 75.06 | 75.06 |
| kintaibio 1% pre-solution | Unprotected light | 100 | 97.28 | 97.28 |
| kintaibio 1% pre-solution | Protected from light | 100 | 99.15 | 99.15 |
Visual description:
Left vial: 0.1% pre-solution (diluted to 0.1%) after 45 days on windowsill – still deep blue.
Right vial: Standard 0.1% Sodium Azulene Sulfonate aqueous solution after 45 days under same conditions – nearly colorless.
4. Conclusion
kintaibio's pre-solution achieves 97.28% active retention after 45 days under unprotected light, far exceeding the 75.06% retention of the standard aqueous solution. This demonstrates a significant improvement in photostability achieved by our formulation technology.
Under light-protected conditions, the retention reaches 99.15%, further highlighting the importance of opaque packaging when long-term stability is required.
Sodium Azulene Sulfonate Efficacy and Mechanism of Action
The application of Sodium Azulene Sulfonate in pharmaceutical and cosmetic products is supported by the following well-established pharmacological effects.
1 Anti-Inflammatory Activity
Mechanism: Directly inhibits the release of histamine from mast cells and inflammation-related cells. Also inhibits hyaluronidase activity, reduces capillary permeability, and decreases the exudation of inflammatory mediators.
Experimental evidence:
Subcutaneous or intraperitoneal injection in rat models inhibits dextran-induced edema, hyaluronidase-induced edema, and formalin-induced edema.
Topical application suppresses UV-induced erythema (rabbit), croton oil-induced dermatitis (rabbit), and burn inflammation (mouse).
Clinical relevance: Used to treat inflammatory skin conditions such as eczema, contact dermatitis, and solar dermatitis, as well as inflammatory reactions in ophthalmology and stomatology.
2 Anti-Allergic Activity
Mechanism: Suppresses histamine release from mast cells independently of the pituitary-adrenal system, acting directly on tissue cells to interfere with the release of allergic mediators.
Experimental evidence: Inhibits histamine release induced by various histamine liberators in rat tissues.
Clinical relevance: Indicated for conditions associated with type I hypersensitivity reactions, including allergic conjunctivitis, allergic dermatitis, and urticaria.
3 Tissue Repair and Regeneration
Mechanism: Promotes the synthesis of prostaglandin E₂ (PGE₂) in the mucosa, thereby stimulating granulation tissue formation and epithelial cell regeneration, accelerating wound healing. Also exhibits mild anti-pepsin activity (relevant for gastrointestinal applications).
Experimental evidence: In rabbit models of mechanical skin abrasion and burn wounds, topical application significantly accelerated wound closure.
Clinical relevance: Used for mucosal protection and repair in gastric and duodenal ulcers; promotes rapid healing of oral ulcers and gingivitis; enhances granulation tissue formation in burns.
4 Supplementary UV Protection
Mechanism: This compound has absorption peaks in the UVB region (280–310 nm) and the UVA region (approx. 330 nm), thereby reducing UV-induced skin damage by absorbing ultraviolet radiation.
Applications: Can be incorporated into sunscreens, makeup primers, and daily skincare products to help protect against UV-induced erythema and photoaging.
5 Inhibition of Hyperpigmentation (Skin Brightening Support)
Mechanism: Reduces post-inflammatory hyperpigmentation (PIH) through its anti-inflammatory activity, and may also moderately inhibit tyrosinase activity.
Applications: Used in brightening serums and spot-correction products, particularly suitable for inflammatory pigmentation such as acne marks and sun-induced spots.
6 Other Effects
Mild antibacterial activity: Active against certain Gram-positive and Gram-negative bacteria.
Protection against radiation and chapping: Clinically used to prevent skin damage from high-heat radiation and to prevent skin chapping.
sodium gualenate uses - Formulation Usage Guide of Sodium Azulene Sulfonate
6.1 Recommended Use Levels (based on powder)
| Product Type | Recommended Addition (w/w) | Key Benefits |
|---|---|---|
| Facial cleansers, shampoos | 0.05%–0.15% | Soothing cleansing, scalp anti-inflammatory |
| Toners, lotions | 0.05%–0.15% | Calms redness, hydrating, anti-allergy |
| Serums, ampoules | 0.15%–0.3% | High-concentration anti-inflammatory & repair |
| Creams, night creams | 0.15%–0.3% | Deep repair, improves sensitivity |
| Eye creams | 0.15%–0.3% | Soothes eye area inflammation and fatigue |
| Face masks (sheet/wash-off) | 0.1%–0.3% | Intensive calming, immediate soothing |
| Toothpastes, mouthwashes | 0.02%–0.1% | Promotes mucosal healing, anti-inflammatory |
| Sunscreens, sun sprays | 0.05%–0.15% | Supplementary UV absorption, post-sun soothing |
Note: For first-time use, start with the lower end of the recommended range and conduct stability and efficacy testing.
Key Formulation Handling Points
| Key Point | Specific Recommendation | Reason |
|---|---|---|
| Addition temperature | Keep below 40°C; add at the final stage | High temperatures accelerate degradation; decomposition is noticeable within 1 week above 40°C |
| pH adjustment | Adjust final product pH to 7.0–9.0 (weakly alkaline to neutral) | Stability significantly decreases in acidic conditions (pH <6.0) |
| Pre-dissolution | First dissolve powder in a small amount of 1,2-hexanediol or 1,2-pentanediol, then add to water phase | Solubility in polyols is much higher than in pure water |
| Surfactants | Non-ionic or cationic surfactants recommended in the formulation | Helps form micellar protection, enhancing photostability |
| Antioxidants | Tocopherol (Vitamin E), tocopheryl acetate, BHT, etc. can be added | Reduces oxidative degradation |
| UV absorbers | In sunscreens, combine with physical/chemical UV filters; in non-sunscreens, small amounts of UV absorbers can be added | Absorbs incident light, protecting the active ingredient |
| Packaging material | Dark glass bottles, aluminum tubes, opaque plastic; avoid clear PET bottles | Blocks UVA and visible light |
| Manufacturing equipment | Use 316L stainless steel or PTFE-lined surfaces for product-contact parts; avoid iron and copper | Metal ions catalyze oxidation |
Synergistic Combinations & Incompatibilities
| Compatible Ingredient | Synergistic Effect |
|---|---|
| Allantoin, Bisabolol, Centella asiatica extract | Enhanced anti-inflammatory and soothing effects |
| Panthenol (Vitamin B5), Ceramides, Hyaluronic acid | Enhanced barrier repair and hydration |
| Tocopherol, Rosemary extract | Antioxidant, stabilizes the active |
| Niacinamide, Tranexamic acid, Kojic acid | Anti-inflammatory + skin brightening, improves post-acne hyperpigmentation |
Incompatibilities:
Avoid prolonged direct contact with strongly acidic ingredients (e.g., high concentrations of AHAs, salicylic acid, or citric acid adjusting pH below 6.0)
Avoid co-formulation with strong oxidizing agents (e.g., high-concentration hydrogen peroxide, hypochlorous acid)
Avoid direct contact with iron or copper ions (e.g., certain iron-based colorants)
Sodium Azulene Sulfonate supplier
Sodium Azulene Sulfonate is an active ingredient with nearly four decades of global market validation. Its efficacy in anti-inflammatory, anti-allergic, mucosal repair, and supplementary UV protection has been thoroughly demonstrated through extensive pharmaceutical and cosmetic applications.
At kintaibio, we don't try to reinvent this ingredient. What we do is make it purer, more stable, and easier to use.
Our product consistently delivers purity above 99%. For the key impurity indicator – residual guaiazulene – we achieve a transmittance of 97.8%, well above the pharmacopoeial pass limit. We have also solved the long-standing problem of poor photostability: our 1% pre-solution retains over 97% of the active ingredient after 45 days of unprotected light exposure. These are not idealized lab results – they are the actual levels achieved with every batch.
We also provide clear, practical formulation guidance: addition temperature, pH range, packaging choices, and synergistic combinations – all documented in our technical literature and available for one-on-one discussion. Our goal is simple: to give you a Sodium Azulene Sulfonate that is reliable, compliant, and technically supported – so you can focus on your formulation with complete confidence.
If you are looking for a stable, compliant, and well-supported source of Sodium Gualenate powder, we would love to hear from you.
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