yew extract

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of yew extract in China. Please feel free to wholesale high quality yew extract for sale here from our factory. For price consultation, contact us.

yew extract is extracted from the rare natural plant yew. Its leaves, stems, bark, and roots contain taxine diterpenoids as the main components, yewine, yewine A, yewine H, and yewine K, paclitaxel L, taxine, golden pine flavonoid, ponasterone A, ecdysterone, golden pine biflavone, volatile oil, taxane, polysaccharide, tannin, tannin, etc., also contains other polyphenols and amino acids , lignans, inorganic elements. Paclitaxel has anti-leukemia and tumor effects.

Taxus chinensis extract is the water extract or alcohol extract of the traditional Chinese medicine Taxus chinensis, and its main chemical component is paclitaxel, a diterpenoid compound. It has anti-tumor and anti-cancer effects.

1). Water solubility accounts for about 50%, including polysaccharides, tannins, phenols, polysaccharides, amino acids, inorganic elements and other substances.
2). Substances such as tannin that are insoluble in both water and organic solvents account for about 33%.
3). Containing 17% fat-soluble part, taking paclitaxel as the reference substance, which includes taxanes and contains compounds such as tricyclic diterpenes and lignans.

1). Chromatographic conditions

Chromatographic column: μ-Bondapak C18 column (300mm×3.9mm, 10μm); mobile phase: methanol-acetonitrile-water-tetrahydrofuran (15:40:40:5); flow rate: 1.2ml/min; column temperature: 30±1℃ .

2). Preparation of the test article

Take about 12mg of this product, carefully weigh it in the Chemicalbook, put it in a 100ml measuring bottle, add 55ml of methanol-acetonitrile (3:8) mixed solvent, shake fully to fully dissolve paclitaxel, then add water-tetrahydrofuran (8:1) to mix The solvent was diluted to the mark, and the above solution was taken quantitatively, centrifuged for 5 minutes, and the supernatant was taken for determination according to the chromatographic conditions of this method, and the results are shown in the figure below.

HPLC chart of Taxus Chinensis Extract

1 cephalomannine; 2 paclitaxel

1). Anti-tumor effect
Taxol, the most important anti-tumor component of Taxus Chinensis Extract powder, has three mechanisms of action:
① Microtubule depolymerization stabilization mechanism: Paclitaxel can inhibit the division of Hela cells in the logarithmic phase. By binding to free tubulin, it inhibits the depolymerization of the formed microtubules, blocks the cell cycle, causes abnormal or interrupted mitosis, and destroys cells. The dynamic regeneration of the microtubule system necessary for mitosis and interphase makes tumor cell replication and death.
②Immune mechanism: Similar to the role of bacterial polysaccharide (LPS), it activates macrophages, leading to the reduction of tumor necrosis factor (TNF-α) receptors and the release of TNF-α, killing or inhibiting tumor cells.
③ Induce cancer cell apoptosis: act on the Fas/Fasl pathway of the apoptosis receptor pathway, or activate the cysteine protease system to induce apoptosis.

2). Anti-inflammatory effect

3). Liver protection
Two flavonoids, ginkgetin, and sciadopitysin, isolated from the methanol extract of yew twigs, can significantly inhibit the regeneration of phosphatase (PRL-3) in liver cancer cells. This may provide a new effective way to study anti-tumor drugs by controlling PRL-3-mediated single channel.

4). Antihypertensive and hypoglycemic effect
Taxol isolated from Taxus chinensis has significant anti-diabetic activity and is non-toxic, so it has good research and development and application prospects.

5). Anti-oxidation, eliminate free radicals
yew extract are isolated from the heartwood and roots of yew. Through in vitro experiments, it has been found that it has strong antioxidant and free radical scavenging effects, can effectively act on various cardiovascular damage factors, and has low toxicity and no side effects.

Yew, also known as Chinese cypress pine, yew, and purple cypress pine, is a plant of the genus Taxus in the family Taxaceae. There are 11 species of yew in the world, distributed in the temperate to tropical regions of the northern hemisphere. There are 4 species and 1 variety in China, namely Chinese yew, northeast yew, Yunnan yew, southern yew, Tibetan yew, etc., distributed in northeast China , South China and Southwest China.

Yew is an ancient tree species left from the Quaternary glacier.It has been listed as the world's rare and endangered plants and the world's top ten endangered species. It is a national first-class protected tree species and is known as the "Plant Giant Panda". The soil and climate conditions in our county are suitable for the growth of the southern yew. According to preliminary investigations, the southern yew is widely distributed in the wild in our county, with more than 500,000 plants, and there are thousands of plants in the community (such as the five trees in the Huashan Forest Farm. Baiguo, Shangsifang, etc.), the largest single plant has a rice diameter of 164 cm, and four people can't hold it together. It is a thousand-year-old plant. It has luxuriant branches and leaves every autumn, and it is a rare sight.

In 1971, American chemists first discovered and extracted the cancer-preventing and cancer-curing substance paclitaxel on yew plants. According to relevant information, paclitaxel can improve the circulation and metabolic function of the human body, and remove the virus in the human body from the body through diuresis and defecation. , to prevent cancer; at the same time, it can inhibit the mitosis of cancer cells, thereby effectively preventing the growth of cancer cells. It has considerable curative effect on prostate cancer, rectal cancer, ovarian cancer, uterine cancer, bile duct cancer, and has certain effects on other cancer cells. Inhibition, known as "the last line of defense in advanced cancer". Yew also contains more than 90 kinds of ingredients needed by the human body, which can effectively improve human immunity and anti-virus ability, reduce blood sugar concentration in patients with hyperglycemia, and have significant curative effects on high blood pressure.

2）Kintai R&D center

3）Kintai factory

★ yew extract is one of our main products, and we have enough stock, if you are interested, welcome to contact us by email，E-mail:cheney@kintaibio.com

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