Coptis Chinensis Root Extract

KINTAI is committed to being your best supplier of Coptis chinensis root extract, derived from the dried rhizome of Coptis chinensis. Its ingredient is berberine. As a traditional Chinese medicine ingredient, it has shown important clinical value in reducing blood sugar, regulating lipids, anti-inflammatory, anti-cancer, improving nerve function, etc. Through multiple mechanisms such as regulating insulin sensitivity, reducing insulin resistance, anti-inflammatory and anti-oxidation, it also shows a wide range of application prospects in modern clinical practice and provides an important intervention method for the treatment of diabetes, cardiovascular and cerebrovascular diseases, osteoporosis, neurodegenerative diseases, etc.

Coptis Chinensis

Specification: Berberine Hydrochloride

As a company specializing in the production of high-purity berberine extract, Xi'an Kintai Biotech Inc. has always been committed to researching and promoting the high-quality application of Coptis chinensis root extract. Our products use 97% berberine hydrochloride as the main specification, providing high-quality raw materials for many pharmaceutical and functional products.

1. Powerful antibacterial, significantly inhibiting intestinal pathogenic bacteria

Coptis chinensis root extract Berberine is well-known for its significant antibacterial effect. It has a strong inhibitory effect on bacteria such as Shigella dysenteriae and Escherichia coli, and has a significant effect on diarrhea caused by bacterial infections. In addition, the antibacterial scope of berberine also includes Staphylococcus aureus, Diphtheriae, Diphtheria pneumonia, Vibrio cholerae and other Gram-positive and negative bacteria. In antibacterial experiments, the minimum inhibitory concentration (MIC) of berberine against Shigella dysenteriae is about 5 mg/mL, which can destroy the bacterial cell membrane and affect its protein synthesis, thereby inhibiting bacterial growth. These antibacterial properties lay the foundation for berberine's widespread use in the treatment of diarrhea.

https://www.sciencedirect.com/science/article/abs/pii/S0882401020309086

In the field of modern medicine and health care, berberine with antibacterial properties is widely used in gastrointestinal health products to help prevent and control the outbreak of gastrointestinal diseases. For pharmaceutical companies, the high-purity berberine extract produced by Kintai can be used as an ideal natural antibacterial ingredient, providing a solid raw material basis for the preparation of gastrointestinal health products.

2. Regulate blood sugar and open a new way to treat diabetes

Berberine has shown significant effects in regulating blood sugar and improving diabetes-related symptoms. In a study involving 106 patients with type 2 diabetes, patients taking berberine extract experienced significant reductions in blood sugar levels and improvements in blood pressure and kidney function. Further animal experiments showed that berberine can improve insulin resistance in experimental mice in a dose-dependent manner, and this effect is even better than that of the commonly used hypoglycemic drug metformin. In addition, berberine activates the AMPK signaling pathway, thereby enhancing insulin sensitivity, reducing glucose production during hepatic gluconeogenesis, and achieving effective blood sugar control.

https://www.sciencedirect.com/science/article/pii/S0753332220311768

According to 2021 data from the International Diabetes Federation (IDF), the number of diabetic patients in China reaches 140.9 million, and the control rate is less than 50%. Berberine not only can lower blood sugar but also has a significant effect on the regulation of insulin resistance and lipid metabolism. In a clinical report, berberine hcl enabled diabetic patients to achieve a glycated hemoglobin (HbA1c) target rate of up to 80%, significantly exceeding the domestic and international average level of 30%.

The pathogenesis of diabetes is complex. In addition to blood sugar problems, it is also accompanied by metabolic syndrome and various complications. The mechanism of action of berberine hcl includes the dual regulation of glucose metabolism and lipid metabolism, which makes it no longer a simple hypoglycemic drug but regulates metabolic disorders from the root cause. For the pharmaceutical industry, Kintai's high-purity berberine hydrochloride can not only be used as an active ingredient in anti-diabetic drugs but can also be used to develop multi-functional products to prevent diabetic complications.

3. Regulation of blood lipids and cardiovascular protection

Coptis chinensis root extract Berberine has a significant effect in regulating blood lipids. The research team from Nanjing First Hospital found that berberine can reduce total cholesterol and low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL), thereby reducing the risk of cardiovascular disease. In a molecular-level study, berberine bark extract was able to significantly reduce blood lipid levels by accelerating the breakdown of cholesterol in the liver. Studies have found that after using berberine, patients' low-density lipoprotein dropped by an average of 15%, while high-density lipoprotein increased by 10%. In addition, berberine can also improve arteriosclerosis and reduce the risk of myocardial fibrosis and myocardial infarction.

https://www.sciencedirect.com/science/article/abs/pii/S0944711323000740

In modern life, dyslipidemia has become one of the major problems endangering public health. berberine hcl produced by Kintai can be widely used in functional foods and health products to support blood lipid management and cardiovascular and cerebrovascular health, which provides customers with strong support for the development of high-value-added health products.

4. Potential anti-cancer effect: reduce the risk of colorectal adenoma recurrence

A recent study published in The Lancet Gastroenterology and Hepatology pointed out that coptis extract berberine showed good results in preventing the recurrence of colorectal adenomas after resection. The study was led by Shanghai Renji Hospital and included 1,108 patients, including 553 patients in the berberine group and 555 patients in the placebo group. After follow-up, the recurrence rate in the berberine group was 36.1%, while that in the placebo group reached 46.8%. The unadjusted relative risk (unadjusted RR) was 0.77, which significantly reduced the risk of recurrence. In addition, berberine's role in inhibiting cancer cell proliferation and metastasis has been further verified, showing its potential in anti-tumor applications.

https://www.sciencedirect.com/science/article/abs/pii/S0378874121008461

Kintai's high-purity berberine pure extract provides a high-quality choice for drug research and development in the field of cancer prevention, helping customers seize the opportunity in the develop of anti-cancer drugs.

1. Pharmaceutical preparations: antibacterial, hypoglycemic, and lipid-lowering drugs
At present, berberine hydrochloride powder has been widely used in pharmaceutical preparations such as diarrhea and diabetes. In the future, with the deepening of research, it will show a wider application potential in cardiovascular and cerebrovascular diseases, anti-cancer, and immune regulation.

2. Functional foods and health products: support metabolic health and immune regulation
The natural efficacy advantages of berberine hcl provide rich innovation opportunities for the functional food market. Many healthcare products and functional food companies use berberine root extract as a core ingredient for hypoglycemic, lipid-lowering, and immune regulation, and are expected to develop healthier metabolic support products through this ingredient.

3. Feed additives and veterinary medicine fields
Because berberine extract has excellent antibacterial effects, it is also widely used in feed additives and veterinary medicines to replace antibiotics for animal health management. In the future, Kintai's berberine pure extract can show a broad application space in the global animal husbandry and pet health fields.

Rich experience: more than 20 years of experience in the research and development and production of natural plant extracts. At present, the purity of Coptis chinensis root extract berberine hydrochloride products is as high as 98%, with relevant impurity identification and third-party content test reports, which can ensure stable efficacy and safety.

Multiple certifications: GMP, ISO22000, ISO9001, HACCP, HALAL and KOSHER certifications have been obtained.
Advanced facilities: It has a nationally certified standardized laboratory and six advanced production lines with a daily output of up to ten tons.

Quality assurance: It has an independent R&D laboratory and continuously innovates products to meet the diverse needs of customers. And from raw materials to final testing, production management is strictly carried out by ISO and GMP standards.

Storage: Store in a cool, dry and clean place, avoid moisture and direct sunlight.
Packaging: The standard packaging is 25 kg/barrel, which can be customized according to needs.
Delivery time: 3-7 days.
Shelf life: 2 years.

The berberine hydrochloride products of kintai are widely used in pharmaceutical preparations, functional foods, feed additives, and other fields with their excellent quality and multiple pharmacological effects. We are committed to providing customers with high-purity, high-efficiency, and high-stability berberine hydrochloride products with advanced extraction technology and high-standard production processes.

If your company is looking for high-quality berberine hydrochloride raw materials, Kintai will be your trusted partner. Our professional team will wholeheartedly provide you with customized services, jointly expand the application potential of berberine hydrochloride, and escort the health of consumers. If you want to get high-quality bulk Coptis chinensis root extract, please feel free to contact us at sales@kintaibio.com or feedback on the next page.

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