Eucommia Bark Extract Powder

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KINTAI is committed to becoming your best supplier of Eucommia Bark Extract Powder,which comes from Eucommia ulmoides Oliv The bark of a tree，which belongs to the genus Eucommia ulmoides in the Eucommia family, a genus of small trees native to central China. The plant is widely cultivated on a large scale in China due to its medicinal properties. About 112 compounds have been isolated from EU, including lignans, phenols, iridoids, steroids and others.

It is used for tonifying liver and kidney, strengthening muscles and bones, and preventing miscarriage. Indications: weak waist and knees, flaccid feet and knees, residual urine, wet itching under the vagina, fetal leakage, hypertension, etc.

Eucommia ulmoides

Eucommia Bark

Eucommia Bark product

Eucommia Bark Extract

 

Eucommia ulmoides (also called "Eucommia" in Chinese) is a plant containing various chemical components, such as iridoids, lignans, phenols, steroids, flavonoids and other compounds. These EU constituents have various medicinal properties and have been used as folk drinks and functional foods in Traditional Chinese Medicine (TCM) for thousands of years. EU has various pharmacological properties such as antioxidant, anti-inflammatory, antiallergic, antibacterial, anticancer, antiaging, cardioprotective and neuroprotective properties. Therefore, it has been widely used alone or in combination with other compounds for the treatment of cardiovascular and cerebrovascular diseases, sexual dysfunctions, cancer, metabolic syndrome and diseases of the nervous system.

Morphological characteristics: Eucommia ulmoides is a deciduous tree, with a height of up to 20 meters and a diameter at breast height of about 50 cm.

The bark is grayish brown, rough, containing rubber, and there are many fine filaments when it is broken. The tender branch has yellowish brown hair and soon becomes bald. The old branch has obvious lenticels. The bud is ovoid, shiny outside, reddish brown, with 6-8 scales, and the edge has micro hairs.

Distribution area: It is distributed in the middle reaches of the Yangtze River and southern provinces, and is cultivated in Henan, Shaanxi, Gansu and other places. It is mainly produced in Sichuan, Shaanxi, Hubei, Henan, Guizhou and Yunnan. In addition, it is also produced in Jiangxi, Gansu, Hunan, Guangxi and other places.

6.1. Protective effect on the cardiovascular system
In traditional Chinese medicine, Eucommia is considered a major tonic for heart patients. Eucommia bark extract is an active ingredient used in antihypertensive preparations. It has been shown to be a vasodilator in a number of human and animal models. Antihypertensive effects on the parasympathetic nervous system have been reported after application in the EU. UE also acts as a nitric oxide dependent vasodilator and is thought to be involved in potassium channels. EU has a beta-blocking potential of 0.5% w/v, reducing isoproterenol-stimulated lipolysis from 2.67-fold to 1.4-fold in the buffer control. EU has been shown to prevent hypertensive remodeling associated with aldose reductase inhibition.

The use of EU lignans in hypertensive conditions induced by vascular remodeling has been reported as a novel therapeutic agent.EU also exhibits antihyperlipidemic properties by inhibiting hepatic biosynthesis of fatty acids and cholesterol.

6.2. Antioxidant activity
Antioxidant compounds in the Eucommia plant reduce free radical levels and improve disease conditions caused by oxidative stress. The strong antioxidant properties of EU have been demonstrated in in vivo and in vitro studies. EU extracts decreased hydrogen peroxide levels in MC3T3E1 cells expressing certain caspase proteins at half concentrations of 12.5–25 μg/mL. EU extracts have been reported to increase erythrocytes, superoxide disproportionation enzymes, catalase and glutathione peroxidase, and reduce the concentration of hydrogen peroxide and lipid peroxides in red blood cells, liver and blood cells. kidneys.

Eucommia can also increase levels of other antioxidant enzymes in the blood to neutralize free radicals.
The EU compound aucubin has been shown to be photoprotective against oxidative stress. Ultraviolet (UV) B radiation generates free radicals in the skin that induce the synthesis of metalloproteinases (MMPs), leading to skin photoaging, wrinkles and discoloration, all of which predispose to cancer. Aucubin plays an essential role in the defense mechanism against free radicals induced by UV exposure.

6.3. Antibacterial, antiviral and anti-inflammatory activities
EU has been reported to inhibit the growth of bacteria and reduce the secretion of pro-inflammatory cytokines in a few studies. A 95% (v/v) ethanol extract of EU at doses of 0.1 and 1.0 mg/mL showed antibacterial (against Acinetobacter baumannii and Staphylococcus aureus) and antifungal (against Aspergillus fumigatus). Additionally, EU extract at the same concentration of 0.1 mg/mL has been reported to reduce the secretion of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), l interleukin-8 (IL-8) and IL-1β via Human mononuclear cells (THP-1) pretreated with heat-killed Propionibacterium acnes. Aqueous extracts of UE significantly reduced cyclooxygenase 2 (COX-2) with IC 50 = 9.92 mg/mL, although the effect was reduced compared to NSAIDs. EU cortex at concentrations of 0.1 and 0.5 mg/mL reduced (TNF-α, IL-6, and COX-2) prostaglandin E and nitric oxide production.

Daily intake of EU extract or its alkaline extract in tea formulations has also been reported to inhibit HIV infection. Alkaline EU leaf extract combined with 22% uronic acid, 27% reducing sugar and 46% neutral sugar reduced HIV-induced cytopathy (HTLV-III) against infected MT-4 cells (EC 50 ) with extremely low cytotoxicity. Lu et al. Samples from EU Oliver also demonstrated potent inhibitory activity against HIV gp41 six-helix bundle formation.

6.4. Anti-obesity effect
Previous studies have shown that UE has anti-obesity and anti-metabolic syndrome properties.The anti-obesity effect of Eucommia eucommia green leaf extract (EGLE) is associated with various compounds such as gardedic acid, asperuloside and original green acid.
Administration of EU extract at concentrations of 300 to 1600 mg/kg intake has been reported to enhance fat oxidation gene expression. Administration of the extract has been shown to increase fat oxidation in the liver . The increase in fat oxidation in the liver after administration of EU extract has been attributed to the rate-limiting phases of β-oxidation (CPT1A, ACOX1 and ACADVL), α-oxidation and ω-oxidation (CYP4A1).

6.5. Neuroprotective effect
The EU stem bark extract showed acetylcholinesterase (172   μg/mL) IC 50 inhibitory properties and neuroprotective effects against β-amyloid in vitro. It also inhibited the efficacy of cytotoxic and oxidative biomarkers by 30-70% when used at a concentration of 2.5 μg/mL.

6.6. Metabolic regulation and bone
Eucommia extract can be used to control osteoporosis. Indeed, Eucommia extract actively participates in the activation mechanism of osteoblasts, improving osteogenesis, reducing osteoclasts and thus preventing osteolysis.
Eucommia bark extract has been reported to induce the release of growth hormone (GH) responsible for bone maturation and bone remodeling. Alcoholic products derived from the bark of Eucommia have been shown to be very effective in releasing growth hormone secretagogues. Increasing estrogen receptor alpha signaling has been shown to increase bone growth.

6.7. Properties of phytoestrogens
EU has been reported to have phytoestrogenic and androgenic properties. Eucommia bark contains isoflavones, which have estrogen-like properties and bind to estrogen receptors in the body. None of these isoflavones have the androgenic effect of interacting with the human androgen receptor. Eucommia bark has been reported to exhibit phytoandrogenic and hormonal bimodal effects. The androgen receptor plays a key role in male and female physiology, such as skeletal muscle development, bone density, and libido.

6.8. Liver protection
EU extract significantly reduced CCl4-induced hepatic lipid accumulation. EU enhances lysosomal enzyme activity and alleviates protein folding requirements, thereby alleviating ER stress. The effects of endoplasmic reticulum stress enhance ApoB secretion; at the same time, it regulates the biotransformation of CCl4 and its inhibition of ROS accumulation.

Application

Eucommia Bark Extract is widely used in medicine or health care products.

It is mainly used to treat waist and spinal pain, flaccid feet and knees, residual urine, wet itching under the vagina, abortion due to fetal leakage, restless fetal movements, and hypertension.

7.What can KINTAI do?

 

 

 

8.KINTAI'S PROCESSING

 

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