1.Products Description

KINTAI is committed to becoming your best Inula extract supplier(Elecampane Root Extract),which is extracted from the root of Inula inula, a Compositae plant. It mainly contains sesquiterpene lactone compounds, along with inulin and a small amount of flavonoids, amino acids, etc.

Isolation of dehydrocreynosine, coynelide, 11β,13-dihydrocoynelide, santamanolide, 11β,13-dihydroreynosine, 11β,13-dihydroreynosine Tamane lactone, 11β,13-dihydromagnolide, 11β,13-dihydro-β-cyclophyllide, 1β-hydroxycolartine, 12( 13)-ene-Betulinic acid methyl ester, inulin esters (Alantolactone), 4(5), 11-diene-alantolactone, Isoalantolactone, 11αH,13-dihydroisoalantolactone, 3,11(13)-triene-8 ,12-Elemane lactone, 4-norisoelane lactone, 5β-hydroxyl-1(10), 4(15), 11-triene-12,8 gemaran lactone, 4α-hydroxyl-11(13), 10(14)-diene -12.8 guaiacolide, β-sitosterol, stigmasterol.

Other ingredients include approximately 40% inulin, a small amount of flavonoids, β-sitosterol, carrot sterol, dammadienol acetate, and amino acids, such as aspartic acid, in addition to its main compounds of lactone, threonine, serine, glutamic acid, proline, glycine, alanine, cystine, methionine, isoleucine, leucine, phenylalanine, lysine, arginine, amino acid group etc.

It has antibacterial, cytotoxic properties. , hepatoprotective, antitumor, vermifuge and hypoglycemic.

Inula inula

Elecampane Root

Elecampane extract product

Elecampane Root Extract

2.Introduction of plant extract source

[Alias] day lily, green wood incense, seven wood incense.

[Morphological characteristics] Inula helenium (Latin scientific name: Inula helenium L.) is a perennial herbaceous plant of the genus Inula helenium of the family Asteraceae, with a plant height of up to 250 cm. Rootstock stout, stem erect, stubby, leaves elliptical-lanceolate to lanceolate, flower heads few, corymbs or racemes; tetrahedral or pentahedral achenes, ribbed and wrinkled, glabrous. The flowering period is from June to September.

[Distribution range] Tulip growing conditions are not harsh, suitable for cultivation in most parts of my country.

[Main value] It has the effect of invigorating the spleen and harmonizing the stomach, regulating qi, relieving depression, relieving pain and preventing miscarriage. For chest and hypochondriac pain, abdominal distension and vomiting, diarrhea, chest and hypochondriac contusions, crotch pain, restless fetal movements.

Civil essential oils have sedative, bactericidal, antipyretic and vermifuge properties, and can be used as anti-inflammatory and antibacterial agents.

3.Product quality specification & standard

Product name	Elecampane Root Extract Powder
Extract source	Roots of Inula helenium L
Extraction Solvent	Water/Ethyl alcohol
Appearance	Brown yellow powder
Solubility	Soluble in water
Identification	TLC , HPLC
Sulphated Ash	NMT 0.5%
Heavy metals	NMT 20 PPM
Loss On Drying	NMT 5.0%
Powder size	80Mesh, NLT90%
Assay (HPLC test, percent, Standard in House)	Min. 98.0%
Microbiological Quality (Total viable aerobic count)
- Bacteria, CFU/g, not more than	NMT 10³
- Moulds and yeasts, CFU/g, not more than	NMT 10²
- E.coli, Salmonella, S. aureus, CFU/g	Absence
Shelf life	Powder storage at room temperature 24 months

4.KINTAI‘s Production Process Flow

KINTAI‘s Production Process Flow

5.Some main chemical structures of Inula helenium L roots.

Figure 1. Sesquiterpenes isolated from elecampane (Inula

helenium L.) roots.

Figure 2. Chemical structure of inulin.

6. About antioxidant activities

Table1.Total phenolic content (TPC) and antioxidant activities (μM TE/ g dw) in root extracts of Inula helenium L.

Name: Elecampane Root Extract
Brand: Kintaibio
SKU: 192463689

7.TLC Analysis

Figure 3.TLC analysis of 95% ethanol extracts from roots of Inula helenium L, where 1. fructose, 2. sucrose, 3. 1-kestose, 4. nystose, 5 to 8. fructooligosaccharides (respectively GF4, GF5, GF6, GF7).

8.HPLC Analysis

Figure 4. HPLC-RID chromatogram of 95 % (v/v) ethanol extracts obtained from Inula helenium roots, where: 1. inulin, 2. nystose, 3. 1-kestose, 4. sucrose, 5. glucose, 6 fructose.

Figure 5. HPLC-RID chromatogram of inulin from elecampane roots

9. Benefits and Application

Benefits

9.1. Antibacterial effect
Elecampane Root Extract has strong antibacterial activity against cucumber powdery mildew, cucumber downy mildew, cucumber anthracnose, tomato Botrytis cinerea, tomato leaf mold, etc. Its antibacterial mechanism may be related to the fact that the compound's sesquiterpene lactone structure can destroy bacterial cell membranes.

9.2. Deworming effect
Inulin and its derivatives contained in the volatile oil are easily soluble in alcohol but not in water, the impure taste is bitter and has many side effects (vomiting), the chemical structure is similar to Sandonian, and its deworming effect is better than that of Sandonian, but it is inferior toxic.

Deworming effect

9.3. Liver protection
Seven kinds of sesquiterpene lactones have been isolated from the n-hexane part of Eucalyptus edulis extract.Studies have shown that these compounds have strong inhibitory activity on the proliferation of MK-1, HeLa and B16F10 cells, and have hepatoprotective effects.

Liver protection

9.4. Anti-tumor effect
Inulin extracts show highly selective cytotoxicity against 4 different cancer cell lines (HT-29, MCF-7, Capan-2 and G1), but are toxic to normal human peripheral blood lymphocytes (PBL) but very small.

9.5. Studies have shown that it also has the effect of lowering blood sugar and regulating the cardiovascular and cerebrovascular system.

Clinical application

It is traditionally used for respiratory diseases, such as expectorant and cough relieving, to treat chronic bronchitis and asthma, and to help clear mucus in the chest. Its bitter taste is good for stomach and food digestion. It can be used to treat anorexia, indigestion, tonsillitis and other diseases.

Clinical application