Agrimony Extract

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Agrimony Extract is brown yellow powder. The extract of Agrimonia pilosa is the whole herb of the rose family plant Euphorbia crassifolia. In summer and autumn, when the branches and leaves are flourishing and not flowering, cut the whole grass, remove the soil, and dry it in the sun. Alias: Longya grass, stork's beak, mother grass, grass longya, father-son grass, wolf tooth grass.

Agrimonia pilosa Extrakt contains steroids, flavonoids, tannins, organic acids, lactones, and mushrooms. It has anti-tumor, hypoglycemic, analgesic, anti-inflammatory, hemostatic, hypotensive, antimalarial, antiarrhythmic, insecticidal and other pharmacological effects.

1.1 Chemical composition

Contains agrimonolide, agrimonolide, tannins (pyrocatechol tannins, gallin tannins, etc. (6.67%-13.71%)), sterols, organic acids, phenolic components, and saponins.

1.2 source
Agrimony is also known as Tuoli grass, melon vanilla, old beef tendon, wolf bud grass. The source is the aerial part of Agrimonia pilosa Ledeb., a plant of Rosaceae.  Harvest buds before new plants germinate in winter and spring. Plant form Perennial herb, up to 1m, the whole plant has long white hairs. The rhizome is short, often with 1 or several root buds (overwintering buds). Stem erect, sparsely pilose and glandular hairy. Pinnately compound leaves alternate, leaflets of different sizes, arranged at intervals, oval to obovate, 2.5-7cm long, 1.5-3.5cm wide, serrated at the edge, pilose on both sides; stipules nearly ovate. Raceme terminal; calyx obconic, 5-lobed, with many hooked bristles at base of lobes, persistent; petals 5, yellow; stamens 5-15; ovary semi-inferior, style prominent. Calyx tube thickened when the fruit is ripe, drooping, with a round of upright barbs at the top, and deep longitudinal grooves outside. It is shaped like a crane head, hence the name Longya. The flowering and fruiting period is from May to December.

Health Benefits

The main active ingredients of Agrimonia pilosa extract, which have many unique effects as below:

 Agrimonia pilosa Extrakt can promote blood coagulation

 Good for the cardiovascular system

 Effect on smooth muscle

 Anthelmintic effect

The winter buds and roots of Agrimony have a strong effect of repelling roundworms, and its active ingredient has been proved to be crane phenol. This product does not act on the nervous system, but directly acts on the insect body. It inhibits glycogenolysis, anaerobic and aerobic metabolism, and succinate production in worms. Therefore, it is believed that its anthelmintic effect is related to blocking the energy supply of worms. Cranetol also has a strong killing effect on solium cysticercosis spiders.

 Antibacterial and antiparasitic effects

The hot water or ethanol extract of Agrimony has certain inhibitory effects on Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, Salmonella typhimurium and Mycobacterium tuberculosis in vitro. External application of its tender stem and leaf decoction can inhibit and kill Trichomonas vaginalis. This product also has inhibitory effect on Schistosoma japonicum and Plasmodium murine.

 Anti-inflammatory and analgesic effect

The water extract, alcohol extract and water extract of Agrimony have good anti-inflammatory effects on experimental conjunctivitis. Its water extract, alcohol extract and water extract all have significant analgesic effect.

Application

Agrimony Extract is mainly used in the field of medicine. Agrimony can restrain bleeding, stop malaria, stop dysentery, and detoxify. It is clinically used for hemoptysis, uterine bleeding, malaria, dysentery, overstrain, carbuncle sores, and itching.

Take 1g of coarse sample powder (20-40 mesh) and 4 parts, put them in 50ml iodine bottle respectively, add petroleum ether (60-90℃), chloroform, absolute ethanol and distilled water 20ml, soak at room temperature for 2h, shake, After filtration, the filtrate was properly diluted with the corresponding solvent, and its ultraviolet spectrum was measured on a Shimadzu UV-3000 ultraviolet spectrophotometer. Test conditions: wavelength range 190-400nm, absorbance range 0-3A, slit 1nm, scanning speed 200nm/min, scale expansion 20nm/cm. Results Agrimony λmaxPet was 231.83, 255.83(sh), 288.83, 344.5(sh)nm, λmaxCHCl3 was 243.67, 290.33, 346.67(sh)nm, λmaxEtOH was 220.33, 284.83, 349.67(sh)nm, λmaxH2O was 210.0, 280.0, 303.0 (sh) nm.

1. Various hemorrhagic diseases can be used alone or in combination. In recent years, Agrimony has been used clinically to make hemostatic powder, which was used in 20 cases of traumatic bleeding, bleeding or oozing during visceral surgery (including intracranial surgery, thoracic and abdominal surgery), and the effect was remarkable, all of which stopped bleeding within 1 to 2 minutes.

2. Treat 108 cases of food poisoning caused by halophilic bacteria with Agrimony 30g decoction, and supplemented with fluid replacement, and all of them recovered within two days.

3. Agrimony 20-30g for acute bronchitis, 9g each of Trichosanthes barbatus, Scutellaria baicalensis, Baibu, Baiqian, 10g each of Polygonatum odoratum and Coltsfoot flower, 12g of Patrinia, decocted in water, 1 dose per day. 35 cases were treated, and 30 cases were cured after taking 2 to 3 doses.

4. Tumor Agrimony, Aurantii Fructus, Turmeric, Jinghuo Nitrate, Alum each 18g, dry lacquer 6g, Wu Chemicalbook Lingzhi 15g, Strychnis 12g, made into tablets (0.48g/tablet), take each time 4-8 tablets, 3 times a day, 3 months as a course of treatment. 180 cases of cancer were treated, and the curative effect was remarkable on lung cancer, gastric cancer, gastric tumor, esophageal cancer, liver cancer I and II tumors. Or decoct 50g each of Agrimony and Patrinia in water, and take it three times a day to treat 15 cases of malignant tumors (including nasopharyngeal cancer, rectal cancer, gastric cancer, cervical cancer, liver cancer, lung cancer, and bladder cancer), and 20% of them were markedly effective. %, the total effective rate is 73%. 5. Taeniasis 275 cases of taeniasis patients were treated with agrimony bud powder, extract or acrimonol monomer, all of which drove off the tapeworm, and 15 cases relapsed within half a year, and the cure rate was 94.5%. Those who took acrimonol monomer No recurrence occurred.

5.2  Alcohol extraction method Take 300g Agrimony, put it in a 5000mL round bottom flask, add 3000mL of 90% ethanol to reflux for extraction for 2 hours, filter with suction, add 90% ethanol to the residue and 2000mL of reflux to extract twice, each time for 1h, filter with suction and combine The filtrate was recovered with ethanol, concentrated to a concentration of 1g crude drug/mL, washed with an equal amount of pure water, and washed 3 times until there was no ethanol smell, and dried in a vacuum oven to obtain the ethanol extract of Agrimony.

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