Apigenin Powder

Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of apigenin powder in China. Please feel free to wholesale high quality apigenin powder for sale here from our factory. For price consultation, contact us.

Apigenin, the active ingredient in the powder produced by KINTAIBIO^®, possesses a well-defined chemical structure and significant research value. It is a natural flavonoid widely distributed in plants, commonly found in chamomile, parsley, celery, and lemon balm. To meet diverse product positioning needs, we offer two categories of apigenin raw materials: naturally derived options (chamomile extract containing 1% or 1.2% apigenin) and semi-synthetic options (90%, 95%, and 98% purity). Customers can select the appropriate purity specification based on their final formulations, cost constraints, and application requirements; specific product parameters can be further confirmed upon inquiry.

Regarding physicochemical properties, apigenin is a flavonoid that is extremely poorly soluble in water; it is sparingly soluble in hot ethanol but soluble in DMSO, DMA, and dilute alkaline solutions. Due to its limited water solubility, formulating liquid nutritional products or water-based cosmetics requires techniques such as solubilization or encapsulation for optimization. Conversely, it offers excellent potential for development in supplements, functional food ingredients, and oil-based or complex cosmetic systems. While our apigenin powder is relatively stable, it is sensitive to strong alkalis, high-temperature oxidation, and prolonged UV exposure; therefore, proper storage-including protection from light, temperature control, and suitable packaging-is essential.

Apigenin is a subject of significant scientific interest, with current research focusing on its antioxidant, anti-inflammatory, antimicrobial, and cytoprotective properties, as well as other mechanisms of biological activity. Our 98% apigenin is particularly suitable for the large-scale production of high-purity products, helping to manage raw material costs and ensure supply stability. We rigorously test apigenin content and quality parameters, and can provide relevant documentation-including COAs, specifications, MSDS, and batch test reports-upon request. For more detailed information, please contact sales@kintaibio.com.

apigenin for hair

In recent years, apigenin has garnered attention in the fields of scalp care and hair health research. A study utilizing a mouse model of androgenetic alopecia (AGA) investigated the potential effects of topical apigenin administration on the condition. Application of apigenin resulted in significantly improved hair growth in the mice; the compound appears to function by modulating the Wnt signaling pathway associated with hair follicle growth, with CDK5 identified as a potential target for its action.

These findings provide a new scientific basis for utilizing apigenin in the development of scalp care, hair care, and anti-hair loss products-particularly as an active ingredient in scalp serums, lotions, cleansing products, and other topical formulations. Given apigenin's inherently low water solubility, the use of topical administration also serves to enhance its bioavailability, making it a promising candidate for further research into scalp-targeted formulations, delivery systems, and combination products.

apigenin sleep

Existing research indicates that apigenin may participate in sleep-related processes through various biological pathways, serving as a natural molecule that links sleep and aging; animal studies have observed that it possesses sedative properties and potential sleep-promoting effects, with mechanisms likely involving the GABAergic system as well as pathways related to oxidative stress and inflammation. Furthermore, studies on rodents have shown that apigenin intervention can influence markers associated with neurological function and sleep, such as BDNF, CREB, and serotonin.

Additionally, apigenin has been reported to inhibit CD38-an enzyme that consumes NAD⁺-thereby increasing NAD⁺ levels in animal models; this mechanism positions it as a significant natural molecule in research at the intersection of sleep and healthy aging. Consequently, apigenin is a promising plant-derived bioactive compound for research into sleep health and neurological function, making it suitable for development as an ingredient in sleep-focused nutritional products and functional formulations.

apigenin for anxiety

Apigenin shows promise in research regarding its protective role against neurodegenerative conditions. Current studies suggest that apigenin may modulate nervous system function through neuroprotective, antioxidant, and anti-inflammatory effects; its mechanisms of action likely involve the GABAergic system, the PI3K/Akt signaling pathway, and various molecular targets associated with neuroinflammation and oxidative stress.

Notably, in animal studies, apigenin has demonstrated sedative and anxiolytic-like effects, suggesting it may help maintain the functional balance of the nervous system by regulating neurotransmitters and related signaling pathways. Furthermore, its ability to modulate reactive oxygen species (ROS), pro-inflammatory factors, and microglial activation provides a potential mechanistic basis for research into its role in emotional health.

apigenin testosterone

In recent years, apigenin has garnered attention in research concerning male health, testicular function, and testosterone synthesis. Studies have shown that apigenin intervention can improve body weight, lipid metabolism, and pathological changes in testicular tissue in animal models; it achieves this by modulating endoplasmic reticulum (ER) stress to influence the expression of proteins and enzymes associated with testosterone synthesis. Mechanistic studies further suggest that these effects may be linked to the PERK-related ER stress pathway and the regulation of STAR (steroidogenic acute regulatory protein) expression by CHOP.

Given that STAR is a critical protein in cholesterol transport and steroid hormone synthesis, these findings provide a potential molecular basis for apigenin's role in regulating testosterone synthesis. Apigenin is best characterized as a natural plant flavonoid with promising potential in the study of male reproductive health, testicular function, and testosterone synthesis; furthermore, the associations between apigenin and metabolic health, oxidative stress, and ER stress warrant further investigation through human clinical trials.

apigenin and blood pressure

In recent years, apigenin has garnered significant attention for its role in blood pressure regulation and cardiovascular health. Research indicates that apigenin intervention can attenuate hypertension-associated aortic remodeling, reducing medial thickness, vessel wall diameter, and the wall-to-lumen ratio. Further *in vitro* studies demonstrate that apigenin inhibits angiotensin II (Ang II)-induced abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) and downregulates the expression of proteins associated with vascular remodeling, such as PCNA, MMP-2, and MMP-9.

Mechanistic studies suggest that apigenin may inhibit abnormal vascular cell proliferation and migration-thereby slowing vascular structural changes associated with hypertension-by activating the TP53 (p53) signaling pathway and inducing G0/G1 cell cycle arrest in VSMCs. These findings provide a scientific basis for the cardiovascular protective potential of apigenin, supported by evidence from animal models, cellular experiments, and molecular mechanism analyses.

apigenin benefits for women

Existing research indicates that apigenin may exert multifaceted effects on the female reproductive system by modulating oxidative stress, inflammatory responses, cell proliferation and apoptosis, cell viability, ovarian blood supply, and processes related to reproductive hormones. Relevant *in vitro* and animal studies suggest that apigenin may be involved in ovarian follicle development, ovarian cell viability, and embryonic cell proliferation, and may influence regulatory mechanisms associated with reproductive hormones such as estrogen and progesterone.

Furthermore, the antioxidant and anti-inflammatory properties of apigenin have made it a subject of research regarding conditions such as polycystic ovary syndrome (PCOS), endometriosis, ovarian dysfunction, and reproductive system damage caused by environmental factors. Additionally, some studies have focused on the impact of apigenin on processes related to the proliferation and survival of ovarian cancer cells, providing a potential basis for further research into its role in female reproductive health.

Relying on the structural characteristics of natural flavonoids and its extensive research base in antioxidants, inflammation regulation, and neurological health, apigenin can be used as a plant-derived active ingredient in dietary supplements, nutritional foods, functional foods, cosmetics, and scientific research product development and other fields.

Is apigenin safe?
Existing reviews generally consider apigenin to have low intrinsic toxicity and a solid safety profile based on research; it also occurs naturally in common plants and foods such as parsley, celery, and chamomile. However, it is important to note that clinical safety data regarding the long-term, high-dose oral use of high-purity apigenin as a single active ingredient remain limited. Consequently, further human studies are needed to confirm its pharmacokinetics, long-term safety, and clinically effective dosage.

Apigenin side effects
There is currently insufficient human clinical data to establish a profile of common adverse reactions or a definitive safe dosage range; therefore, caution should be exercised regarding high-dose or long-term use. If gastrointestinal discomfort, dizziness, drowsiness, or other abnormal reactions occur, use should be discontinued, and a doctor or pharmacist consulted. Regarding side effects in women: There is currently no sufficient human evidence indicating a specific adverse reaction profile for women; however, female consumers who are pregnant, planning to conceive, or breastfeeding should exercise particular caution.

Apigenin dosage
There is currently no standard recommended dosage that has been fully validated in human clinical trials and is universally applicable to healthy adults. Dosages used in animal studies within research papers cannot be directly converted into dosages for human supplements. Therefore, product development and end-use decisions should be based on specific regulatory requirements, raw material purity, dosage forms, and human safety data.

Is apigenin safe during pregnancy?
There is a lack of sufficiently reliable human studies on safety during pregnancy; therefore, pregnant women or those planning to conceive are advised against self-administering high-dose apigenin supplements without prior evaluation by a doctor or other qualified healthcare professional.

Apigenin contraindications
A standardized list of contraindications fully validated by human clinical trials has not yet been established. However, individuals with allergies to apigenin or related plant-derived ingredients, as well as those undergoing medical treatment, suffering from chronic diseases, or preparing for surgery, should consult a healthcare professional before use.

Apigenin drug interactions / Does apigenin interact with any medications?
In vitro and animal studies indicate that apigenin may affect certain drug-metabolizing enzymes and transporters-including CYP450-related metabolic pathways and transport systems such as P-gp and OAT-thereby potentially altering the absorption or metabolism of certain drugs; however, it cannot currently be determined whether interactions of the same magnitude occur in humans. Therefore, consumers taking prescription medications-particularly those with a narrow therapeutic window-should not use high doses of apigenin concurrently with their medication without professional guidance.

If you are seeking a reliable apigenin supplier or wish to purchase apigenin powder directly, KINTAIBIO^® offers bulk B2B supplies of apigenin powder to clients worldwide across the nutrition, health, food, cosmetics, and raw material trading sectors. Our product range includes high-purity apigenin (90%, 95%, and 98%) as well as chamomile-derived apigenin (1% and 1.2%), allowing clients to select the ideal raw material solution based on product positioning, purity requirements, and target markets. As a professional manufacturer of bulk apigenin powder, we facilitate sample evaluation, volume purchasing, and long-term supply arrangements tailored to specific order quantities, packaging specifications, and project needs.

We provide comprehensive quality documentation-including COAs, specifications, and MSDSs-along with relevant technical support. For brands, formulators, traders, and dietary supplement ingredient buyers, we offer not only a stable supply of apigenin powder but also OEM/ODM and customization services, providing product specifications and export documentation aligned with your end-use applications, order volumes, and target markets. Please contact sales@kintaibio.com to request samples, specifications, and pricing, or to discuss bulk purchasing solutions tailored to your project.

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