Xi'an Kintai Biotech Inc is one of the most experienced manufacturers and suppliers of pure luteolin in China. Please feel free to wholesale high quality pure luteolin for sale here from our factory. For price consultation, contact us.
Products Description
pure luteolin is a natural flavonoid found in many plants. It has a variety of pharmacological activities, such as anti-inflammatory, anti-allergic, uric acid-lowering, anti-tumor, anti-bacterial, anti-viral, etc. It is mainly used clinically for relieving cough, eliminating phlegm, anti-inflammatory, lowering uric acid, treating cardiovascular diseases, and treating "amyotrophic spinal cord side cable sclerosis", SARS, hepatitis, e
Introduction to the extraction source of this product
cyanide is widely distributed in nature. It is named after it was originally isolated from the leaves, stems, and branches of the herb Resedaodorata L. in the family Resedaceae. It can be obtained from a variety of natural medicinal materials, isolated from vegetable fruits. It is mainly found in natural medicinal materials such as honeysuckle, chrysanthemum, nepeta, Prunella vulgaris, artichoke, perilla, Scutellaria, and purple pearl, as well as Brussels sprouts, cabbage, cauliflower, beets, broccoli, carrots, Vegetables and fruits such as celery, sweet peppers, peppers, and groundnuts, other plant products such as olive oil and red wine, as well as wild impatiens, thyme, whole-leaf green orchids of Labiatae plants, and sinensis also contain cyanide. cyanide powder produced by KINTAI is mainly derived from peanut shells.
Chemical & Physical Properties
| Common Name | pure luteolin | Flash Point | 239.5±25.0 °C |
| CAS Number | 491-70-3 | Molecular Weight | 286.236 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 616.1±55.0 °C at 760 mmHg |
| Molecular Formula | C15H10O6 | Melting Point | ~330 °C(lit.) |
Product quality specification & standard
|
Product name |
pure luteolin |
|
Extract source |
Peanut Shells |
|
Extraction Solvent |
Ethyl alcohol |
|
Appearance |
light yellow powder |
|
Solubility |
Soluble in alcohol and diethyl ether; slightly soluble in hot water, and insoluble in cold water. |
|
Identification |
HPLC |
|
Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NMT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay |
Min. 98.0% |
|
Microbiological Quality (Total viable aerobic count) |
|
|
- Bacteria, CFU/g, not more than |
NMT 103 |
|
- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
|
- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
Keep airtight in a cool, dry place, and avoid sunlight. |
Benefits
1. Anti-inflammatory
It is believed that the anti-inflammatory activity of cyanide is related to the inhibition of nitric oxide (NO) and other inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the inhibition of protein network Amino acid phosphorylation and gene expression mediated by nuclear transcription factor KB (NF-KB).
2. Anti-tumor
Cyanidenonainly inhibits tumor cell growth factors by changing cell signaling pathways or changes kinase activity to resist cancer cell invasion, and can also inhibit tumor cell growth by blocking the cell cycle and other methods. Studies have shown that: Cyanidenon can selectively inhibit the fatty acid synthase activity of prostate cancer and breast cancer cells, which is related to its anti-tumor cell growth and apoptosis; Cyanidenon can significantly reduce the incidence of colon cancer caused by dimethylhydrazine And the size of the tumor, which is related to its ability to regulate lipid peroxidation, anti-oxidation, and anti-proliferation; Cyanidenon can dose-dependently inhibit the invasion and movement ability of ovarian cancer cells HO8910PM in vitro, and its inhibition of matrix metalloproteinase-9 (MMP-9 ) secretion and down-regulate the expression of extracellular signal-regulated kinase 2 (ERK2).
3. Anti-allergic
Cyanidenonan inhibits the release of immunoglobulin E (IgE)-mediated allergy transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and monocyte-macrophage colony-stimulating factor. The effect may be related to the inhibition of Ca2+ influx and activation of protein kinase C (PKC) translocation.
4. Anti-inflammatory demyelinating diseases
Cyanidenon can dose-dependently protect oligodendrocytes against hydrogen peroxide-induced oxidative damage in vitro, strongly inhibit the phagocytosis of myelin sheath by macrophages, significantly reduce the generation of reactive oxygen species in cells, and reduce the expression of iNOS protein. At low doses, the level of NO produced by macrophages was significantly reduced.
5. Anti-fibrosis
Cyanidenon can reduce the degree of liver fibrosis, reduce the content of hydroxyproline (HYP), malondialdehyde (MDA), and the expression of type I procollagen mRNA in liver tissue, and inhibit the growth of hepatic stellate cells (HSC) in vitro. Proliferation and collagen synthesis. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce the lung weight index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue, in vitro can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis.
Application
Food: Cyanidenon can be used as a natural food additive to improve the antioxidant and freshness of food. It can also be used in some processed foods, such as bread, candy, juice, etc.
Drugs: Cyanidenon has various pharmacological effects such as anti-oxidation, anti-inflammation, anti-allergic, hypoglycemic, and hypolipidemic. Extensive research has been carried out in the field of pharmaceutical research, including the prevention and treatment of cancer, cardiovascular disease, diabetes, liver disease, etc.
Cosmetics: Because pure luteolin has strong antioxidant properties, it can resist free radicals and ultraviolet rays, and has a protective effect on the skin. Therefore, cyanide has been widely used in skincare products and cosmetics.
Nutritional supplements: Cyanidenon can be used as nutritional supplements or components of health care products. After entering the human body, it can play the role of anti-oxidation, lowering blood fat, lowering blood sugar, and anti-allergy.
Safety
1. Acute and long-term toxicity experiments: In animal experiments, the dose of cyanide powder is generally given within 2000 mg/kg body weight, and no relevant acute or long-term toxic reactions have been found. Therefore, from laboratory data, cyanidenon powder may be safe.
2. Human trials: In some small-scale human trials, cyanidenon powder was used to treat varicose veins, diabetes, edema, and other diseases, and there was no obvious negative reaction. Although this research is preliminary, the results suggest that cyanidenon powder may be a safe herbal supplement.
3. Toxicological data: According to reports, cyanidenon powder did not cause adverse reactions at an oral dose of 2000 mg/kg. Relatively, toxicological studies did not have significant adverse reactions to the cardiovascular, central nervous system, immune system, etc., and its effect on DNA and RNA has no damaging effect.
In conclusion, although more research is needed to confirm the safety of cyanidenon powder, the available evidence shows that cyanidenon powder is relatively safe when used in moderation.
Formulation and Dosage
Dosage recommendations:
Since the dosage of cyanidenon powder has not been confirmed by clinical trials, the current recommended dosage is mainly based on some relevant small-scale studies and traditional Chinese medicine, which usually recommends a daily dosage of 50-500 mg.
Reference formulations of nutritional supplements, each containing cyanidenon powder:
- Cyanidenon Vitamin C Tablets
Cyanidenon (100mg) Vitamin C (500mg)
Mix the above ingredients and make tablets, it is recommended to use once a day, 1-2 tablets each time, it is recommended to use after meals.
- Cyanidenon Grape Seed Softgels
Cyanidenon (50mg) Grape Seed Extract (50mg) Gelatin, Glycerin, Water, Color QS
The above ingredients are mixed and filled into soft capsules. It is recommended to use once a day, 1-2 capsules each time, and it is recommended to use after meals.
- Cyanidenon Multivitamin Tablets
Cyanidenon (75 mg) Vitamin C (75 mg) Vitamin E (50 mg) Vitamin B6 (10 mg) Vitamin B12 (10 micrograms Ammonium (10 mg) Riboflavin (10 mg) Pantothenic acid (10 mg) Folic acid ( 400 micrograms) Biotin (100 micrograms)
The above ingredients are mixed and made into tablets. It is recommended to use once a day, 1-2 tablets each time, and it is recommended to use after meals. The above are nutritional supplements for adults, please adjust the dosage for children. It is recommended to consult a doctor before use and use according to the doctor's advice.
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